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Chorioamnionitis

MedGen UID:
3056
•Concept ID:
C0008495
•
Disease or Syndrome
Synonym: Chorioamnionitides
SNOMED CT: Chorioamnionitis (11612004); Membranitis (11612004)
 
Monarch Initiative: MONDO:0000409

Definition

A morphologic finding indicating inflammation of the fetal sac membranes. It is characterized by neutrophilic infiltration of the amnion and chorion. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChorioamnionitis

Professional guidelines

PubMed

Guideline No. 430: Diagnosis and management of preterm prelabour rupture of membranes.
Ronzoni S, Boucoiran I, Yudin MH, Coolen J, Pylypjuk C, Melamed N, Holden AC, Smith G, Barrett J
J Obstet Gynaecol Can 2022 Nov;44(11):1193-1208.e1. Epub 2022 Oct 2 doi: 10.1016/j.jogc.2022.08.014. PMID: 36410937
Management of clinical chorioamnionitis: an evidence-based approach.
Conde-Agudelo A, Romero R, Jung EJ, Garcia Sánchez ÁJ
Am J Obstet Gynecol 2020 Dec;223(6):848-869. Epub 2020 Sep 29 doi: 10.1016/j.ajog.2020.09.044. PMID: 33007269Free PMC Article
Diagnosis and management of clinical chorioamnionitis.
Tita AT, Andrews WW
Clin Perinatol 2010 Jun;37(2):339-54. doi: 10.1016/j.clp.2010.02.003. PMID: 20569811Free PMC Article

Curated

UK NICE Guideline NG195, Neonatal infection: antibiotics for prevention and treatment, 2021

Recent clinical studies

Etiology

Chorioamnionitis and Risk for Maternal and Neonatal Sepsis: A Systematic Review and Meta-analysis.
Beck C, Gallagher K, Taylor LA, Goldstein JA, Mithal LB, Gernand AD
Obstet Gynecol 2021 Jun 1;137(6):1007-1022. doi: 10.1097/AOG.0000000000004377. PMID: 33957655Free PMC Article
Evaluation and Management of Women and Newborns With a Maternal Diagnosis of Chorioamnionitis: Summary of a Workshop.
Higgins RD, Saade G, Polin RA, Grobman WA, Buhimschi IA, Watterberg K, Silver RM, Raju TNK; Chorioamnionitis Workshop Participants
Obstet Gynecol 2016 Mar;127(3):426-436. doi: 10.1097/AOG.0000000000001246. PMID: 26855098Free PMC Article
Acute chorioamnionitis and funisitis: definition, pathologic features, and clinical significance.
Kim CJ, Romero R, Chaemsaithong P, Chaiyasit N, Yoon BH, Kim YM
Am J Obstet Gynecol 2015 Oct;213(4 Suppl):S29-52. doi: 10.1016/j.ajog.2015.08.040. PMID: 26428501Free PMC Article
Diagnosis and management of clinical chorioamnionitis.
Tita AT, Andrews WW
Clin Perinatol 2010 Jun;37(2):339-54. doi: 10.1016/j.clp.2010.02.003. PMID: 20569811Free PMC Article
Chorioamnionitis and endometritis.
Casey BM, Cox SM
Infect Dis Clin North Am 1997 Mar;11(1):203-22. doi: 10.1016/s0891-5520(05)70349-4. PMID: 9067792

Diagnosis

Screening and diagnosis of women for chorioamnionitis: An integrative literature review.
Du Plessis AH, van Rooyen DRM, Jardien-Baboo S, Ten Ham-Baloyi W
Midwifery 2022 Oct;113:103417. Epub 2022 Jul 14 doi: 10.1016/j.midw.2022.103417. PMID: 35863118
Erythromycin vs azithromycin for treatment of preterm prelabor rupture of membranes: a systematic review and meta-analysis.
Seaman RD, Kopkin RH, Turrentine MA
Am J Obstet Gynecol 2022 Jun;226(6):794-801.e1. Epub 2021 Dec 29 doi: 10.1016/j.ajog.2021.12.262. PMID: 34973176
Intrauterine inflammation, infection, or both (Triple I): A new concept for chorioamnionitis.
Peng CC, Chang JH, Lin HY, Cheng PJ, Su BH
Pediatr Neonatol 2018 Jun;59(3):231-237. Epub 2017 Sep 19 doi: 10.1016/j.pedneo.2017.09.001. PMID: 29066072
Evaluation and Management of Women and Newborns With a Maternal Diagnosis of Chorioamnionitis: Summary of a Workshop.
Higgins RD, Saade G, Polin RA, Grobman WA, Buhimschi IA, Watterberg K, Silver RM, Raju TNK; Chorioamnionitis Workshop Participants
Obstet Gynecol 2016 Mar;127(3):426-436. doi: 10.1097/AOG.0000000000001246. PMID: 26855098Free PMC Article
Diagnosis and management of clinical chorioamnionitis.
Tita AT, Andrews WW
Clin Perinatol 2010 Jun;37(2):339-54. doi: 10.1016/j.clp.2010.02.003. PMID: 20569811Free PMC Article

Therapy

Maternal fever in labor: etiologies, consequences, and clinical management.
Goetzl L
Am J Obstet Gynecol 2023 May;228(5S):S1274-S1282. Epub 2023 Mar 20 doi: 10.1016/j.ajog.2022.11.002. PMID: 36997396
Erythromycin vs azithromycin for treatment of preterm prelabor rupture of membranes: a systematic review and meta-analysis.
Seaman RD, Kopkin RH, Turrentine MA
Am J Obstet Gynecol 2022 Jun;226(6):794-801.e1. Epub 2021 Dec 29 doi: 10.1016/j.ajog.2021.12.262. PMID: 34973176
Chorioamnionitis and Risk for Maternal and Neonatal Sepsis: A Systematic Review and Meta-analysis.
Beck C, Gallagher K, Taylor LA, Goldstein JA, Mithal LB, Gernand AD
Obstet Gynecol 2021 Jun 1;137(6):1007-1022. doi: 10.1097/AOG.0000000000004377. PMID: 33957655Free PMC Article
Management of clinical chorioamnionitis: an evidence-based approach.
Conde-Agudelo A, Romero R, Jung EJ, Garcia Sánchez ÁJ
Am J Obstet Gynecol 2020 Dec;223(6):848-869. Epub 2020 Sep 29 doi: 10.1016/j.ajog.2020.09.044. PMID: 33007269Free PMC Article
Evaluation and Management of Women and Newborns With a Maternal Diagnosis of Chorioamnionitis: Summary of a Workshop.
Higgins RD, Saade G, Polin RA, Grobman WA, Buhimschi IA, Watterberg K, Silver RM, Raju TNK; Chorioamnionitis Workshop Participants
Obstet Gynecol 2016 Mar;127(3):426-436. doi: 10.1097/AOG.0000000000001246. PMID: 26855098Free PMC Article

Prognosis

Association of Pregnancy Characteristics and Maternal Mortality With Amniotic Fluid Embolism.
Mazza GR, Youssefzadeh AC, Klar M, Kunze M, Matsuzaki S, Mandelbaum RS, Ouzounian JG, Matsuo K
JAMA Netw Open 2022 Nov 1;5(11):e2242842. doi: 10.1001/jamanetworkopen.2022.42842. PMID: 36399343Free PMC Article
Chorioamnionitis and Risk for Maternal and Neonatal Sepsis: A Systematic Review and Meta-analysis.
Beck C, Gallagher K, Taylor LA, Goldstein JA, Mithal LB, Gernand AD
Obstet Gynecol 2021 Jun 1;137(6):1007-1022. doi: 10.1097/AOG.0000000000004377. PMID: 33957655Free PMC Article
Preterm Brain Injury, Antenatal Triggers, and Therapeutics: Timing Is Key.
Ophelders DRMG, Gussenhoven R, Klein L, Jellema RK, Westerlaken RJJ, Hütten MC, Vermeulen J, Wassink G, Gunn AJ, Wolfs TGAM
Cells 2020 Aug 10;9(8) doi: 10.3390/cells9081871. PMID: 32785181Free PMC Article
Physical examination-indicated cerclage in twin pregnancy: a randomized controlled trial.
Roman A, Zork N, Haeri S, Schoen CN, Saccone G, Colihan S, Zelig C, Gimovsky AC, Seligman NS, Zullo F, Berghella V
Am J Obstet Gynecol 2020 Dec;223(6):902.e1-902.e11. Epub 2020 Jun 25 doi: 10.1016/j.ajog.2020.06.047. PMID: 32592693
Bronchopulmonary dysplasia: A review of pathogenesis and pathophysiology.
Kalikkot Thekkeveedu R, Guaman MC, Shivanna B
Respir Med 2017 Nov;132:170-177. Epub 2017 Oct 24 doi: 10.1016/j.rmed.2017.10.014. PMID: 29229093Free PMC Article

Clinical prediction guides

Tdap vaccination during pregnancy and risk of chorioamnionitis and related infant outcomes.
Greenberg V, Vazquez-Benitez G, Kharbanda EO, Daley MF, Fu Tseng H, Klein NP, Naleway AL, Williams JTB, Donahue J, Jackson L, Weintraub E, Lipkind H, DeSilva MB
Vaccine 2023 May 22;41(22):3429-3435. Epub 2023 Apr 26 doi: 10.1016/j.vaccine.2023.04.043. PMID: 37117057Free PMC Article
Association of clinical signs of chorioamnionitis with histological chorioamnionitis and neonatal outcomes.
Ajayi SO, Morris J, Aleem S, Pease ME, Wang A, Mowes A, Welles SL, Anday EK, Bhandari V
J Matern Fetal Neonatal Med 2022 Dec;35(26):10337-10347. Epub 2022 Oct 4 doi: 10.1080/14767058.2022.2128648. PMID: 36195455
Should the diagnostic criteria for suspected clinical chorioamnionitis be changed?
Sung JH, Choi SJ, Oh SY, Roh CR
J Matern Fetal Neonatal Med 2021 Mar;34(5):824-833. Epub 2019 Jun 3 doi: 10.1080/14767058.2019.1618822. PMID: 31084245
Chorioamnionitis and neonatal outcome in preterm infants: a clinical overview.
Pugni L, Pietrasanta C, Acaia B, Merlo D, Ronchi A, Ossola MW, Bosari S, Mosca F
J Matern Fetal Neonatal Med 2016;29(9):1525-9. Epub 2015 Jul 1 doi: 10.3109/14767058.2015.1053862. PMID: 26135227
Sequelae of chorioamnionitis.
Hagberg H, Wennerholm UB, Sävman K
Curr Opin Infect Dis 2002 Jun;15(3):301-6. doi: 10.1097/00001432-200206000-00014. PMID: 12015466

Recent systematic reviews

Meconium-stained amniotic fluid.
Gallo DM, Romero R, Bosco M, Gotsch F, Jaiman S, Jung E, Suksai M, Ramón Y Cajal CL, Yoon BH, Chaiworapongsa T
Am J Obstet Gynecol 2023 May;228(5S):S1158-S1178. Epub 2023 Apr 1 doi: 10.1016/j.ajog.2022.11.1283. PMID: 37012128Free PMC Article
Erythromycin vs azithromycin for treatment of preterm prelabor rupture of membranes: a systematic review and meta-analysis.
Seaman RD, Kopkin RH, Turrentine MA
Am J Obstet Gynecol 2022 Jun;226(6):794-801.e1. Epub 2021 Dec 29 doi: 10.1016/j.ajog.2021.12.262. PMID: 34973176
Chorioamnionitis and Risk for Maternal and Neonatal Sepsis: A Systematic Review and Meta-analysis.
Beck C, Gallagher K, Taylor LA, Goldstein JA, Mithal LB, Gernand AD
Obstet Gynecol 2021 Jun 1;137(6):1007-1022. doi: 10.1097/AOG.0000000000004377. PMID: 33957655Free PMC Article
Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth.
Roberts D, Brown J, Medley N, Dalziel SR
Cochrane Database Syst Rev 2017 Mar 21;3(3):CD004454. doi: 10.1002/14651858.CD004454.pub3. PMID: 28321847Free PMC Article
Adverse obstetric outcomes after local treatment for cervical preinvasive and early invasive disease according to cone depth: systematic review and meta-analysis.
Kyrgiou M, Athanasiou A, Paraskevaidi M, Mitra A, Kalliala I, Martin-Hirsch P, Arbyn M, Bennett P, Paraskevaidis E
BMJ 2016 Jul 28;354:i3633. doi: 10.1136/bmj.i3633. PMID: 27469988Free PMC Article

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    Curated

    • NICE, 2021
      UK NICE Guideline NG195, Neonatal infection: antibiotics for prevention and treatment, 2021

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    Reviews

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