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Rh Incompatibility

MedGen UID:
306156
Concept ID:
C1504421
Pathologic Function
Synonyms: Incompatibility, Rh; Rh Incompatibilities

Definition

A complication during pregnancy; it occurs when the mother is Rh-negative and the infant is Rh-positive. This complication generally does not affect first-born Rh-positive babies. Rh-positive newborn babies from subsequent pregnancies develop complications of Rh incompatibility which include hemolysis, jaundice, enlarged liver and spleen, petechiae, hypotonia, neurologic damage, and heart problems. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRh Incompatibility

Professional guidelines

PubMed

Gidi NW, Siebeck M
Ethiop J Health Sci 2021 Jan;31(1):55-62. doi: 10.4314/ejhs.v31i1.7. PMID: 34158752Free PMC Article
Spiess BD
J Cardiothorac Vasc Anesth 1994 Feb;8(1 Suppl 1):19-22. doi: 10.1016/1053-0770(94)90612-2. PMID: 8167299
Lozińska D
Arch Immunol Ther Exp (Warsz) 1978;26(1-6):1111-5. PMID: 107912

Recent clinical studies

Etiology

Belay HG, Debebe GA, Ayele AD, Kassa BG, Mihretie GN, Worke MD
World J Pediatr 2022 Nov;18(11):725-733. Epub 2022 Sep 16 doi: 10.1007/s12519-022-00597-3. PMID: 36114364
Afrose R, Mirza TT, Sarker K, Shamsi S, Chowdhury UW, Shikha SS, Akhter S, Jahan R, Fatema S, Dey S
Mymensingh Med J 2021 Jan;30(1):6-12. PMID: 33397844
Mishra JP, Mishra J, Padhi RK, Mishra S, Manjareeka M
J Basic Clin Physiol Pharmacol 2014 May 1;25(2):225-8. doi: 10.1515/jbcpp-2013-0087. PMID: 24114906
Gardener H, Spiegelman D, Buka SL
Pediatrics 2011 Aug;128(2):344-55. Epub 2011 Jul 11 doi: 10.1542/peds.2010-1036. PMID: 21746727Free PMC Article
Brown AS
Prog Neurobiol 2011 Jan;93(1):23-58. Epub 2010 Oct 16 doi: 10.1016/j.pneurobio.2010.09.003. PMID: 20955757Free PMC Article

Diagnosis

Ustun H, Oncel MY, Kefeli M, Akar M, Engür D
Klin Padiatr 2023 Sep;235(5):265-269. Epub 2022 Dec 20 doi: 10.1055/a-1816-5878. PMID: 36539195
Gönenç G, Işçi H, Yiğiter AB, Hançer V, Büyükdoğan M, Güdücü N, Dünder I
Clin Exp Obstet Gynecol 2015;42(3):344-6. PMID: 26152007
Mishra JP, Mishra J, Padhi RK, Mishra S, Manjareeka M
J Basic Clin Physiol Pharmacol 2014 May 1;25(2):225-8. doi: 10.1515/jbcpp-2013-0087. PMID: 24114906
Kostakis ID, Cholidou KG, Kallianidis K, Perrea D, Antsaklis A
Eur J Obstet Gynecol Reprod Biol 2010 Jul;151(1):3-9. Epub 2010 Apr 7 doi: 10.1016/j.ejogrb.2010.03.006. PMID: 20378239
Steiner RD
Semin Perinatol 1995 Dec;19(6):516-24. doi: 10.1016/s0146-0005(05)80058-8. PMID: 8822335

Therapy

Belay HG, Debebe GA, Ayele AD, Kassa BG, Mihretie GN, Worke MD
World J Pediatr 2022 Nov;18(11):725-733. Epub 2022 Sep 16 doi: 10.1007/s12519-022-00597-3. PMID: 36114364
Kuzdan C, Çoban AÇ, İnce Z, Can G, Türkoğlu Ü
J Matern Fetal Neonatal Med 2014 Feb;27(3):265-9. Epub 2013 Jul 12 doi: 10.3109/14767058.2013.811229. PMID: 23763371
Gardener H, Spiegelman D, Buka SL
Pediatrics 2011 Aug;128(2):344-55. Epub 2011 Jul 11 doi: 10.1542/peds.2010-1036. PMID: 21746727Free PMC Article
Brown AS
Prog Neurobiol 2011 Jan;93(1):23-58. Epub 2010 Oct 16 doi: 10.1016/j.pneurobio.2010.09.003. PMID: 20955757Free PMC Article
Downes K, Sarode R
Indian J Pediatr 2001 Feb;68(2):145-9. doi: 10.1007/BF02722034. PMID: 11284183

Prognosis

Gao K, Zhao W, Chen L, Zeng K, Wang J, Yu X, Li Z
Medicine (Baltimore) 2023 Dec 8;102(49):e36346. doi: 10.1097/MD.0000000000036346. PMID: 38065921Free PMC Article
Afrose R, Mirza TT, Sarker K, Shamsi S, Chowdhury UW, Shikha SS, Akhter S, Jahan R, Fatema S, Dey S
Mymensingh Med J 2021 Jan;30(1):6-12. PMID: 33397844
Jain M, Bang A, Tiwari A, Jain S
World J Pediatr 2017 Jun;13(3):222-227. Epub 2016 Nov 23 doi: 10.1007/s12519-016-0067-1. PMID: 27878783
Kostakis ID, Cholidou KG, Kallianidis K, Perrea D, Antsaklis A
Eur J Obstet Gynecol Reprod Biol 2010 Jul;151(1):3-9. Epub 2010 Apr 7 doi: 10.1016/j.ejogrb.2010.03.006. PMID: 20378239
Steiner RD
Semin Perinatol 1995 Dec;19(6):516-24. doi: 10.1016/s0146-0005(05)80058-8. PMID: 8822335

Clinical prediction guides

Gidi NW, Siebeck M
Ethiop J Health Sci 2021 Jan;31(1):55-62. doi: 10.4314/ejhs.v31i1.7. PMID: 34158752Free PMC Article
Afrose R, Mirza TT, Sarker K, Shamsi S, Chowdhury UW, Shikha SS, Akhter S, Jahan R, Fatema S, Dey S
Mymensingh Med J 2021 Jan;30(1):6-12. PMID: 33397844
Jain M, Bang A, Tiwari A, Jain S
World J Pediatr 2017 Jun;13(3):222-227. Epub 2016 Nov 23 doi: 10.1007/s12519-016-0067-1. PMID: 27878783
Gardener H, Spiegelman D, Buka SL
Pediatrics 2011 Aug;128(2):344-55. Epub 2011 Jul 11 doi: 10.1542/peds.2010-1036. PMID: 21746727Free PMC Article
Brown AS
Prog Neurobiol 2011 Jan;93(1):23-58. Epub 2010 Oct 16 doi: 10.1016/j.pneurobio.2010.09.003. PMID: 20955757Free PMC Article

Recent systematic reviews

Belay HG, Debebe GA, Ayele AD, Kassa BG, Mihretie GN, Worke MD
World J Pediatr 2022 Nov;18(11):725-733. Epub 2022 Sep 16 doi: 10.1007/s12519-022-00597-3. PMID: 36114364

Supplemental Content

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