U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Oxyphilic adenoma

MedGen UID:
307150
•Concept ID:
C1510502
•
Neoplastic Process
Synonym: Oncocytoma
SNOMED CT: Oxyphilic adenoma (89439007); Oncocytic adenoma (89439007); Oncocytoma (89439007); Follicular adenoma, oxyphilic cell (89439007)
 
Monarch Initiative: MONDO:0003424
OMIM®: 553000

Definition

Oncocytomas are usually benign tumors that occur in various organs but particularly in the kidneys. Histologic evaluation of renal oncocytomas shows that they are composed entirely of peculiar epithelial cells with granular eosinophilic cytoplasm. Ultrastructural characterization exhibits densely packed cells with mitochondria, which show morphologic differences from those in normal cells. On the average they are larger than those in renal carcinoma cells and their shape is abnormal (summary by Welter et al., 1989). [from OMIM]

Clinical features

From HPO
Oncocytoma of kidney
MedGen UID:
91094
•Concept ID:
C0346255
•
Neoplastic Process
A renal tumor originating from an oncocyte, which is an epithelial cell characterized by an excessive amount of mitochondria, resulting in an abundant acidophilic, granular cytoplasm.
See: Feature record | Search on this feature

Professional guidelines

PubMed

Fine needle aspiration biopsy in the preoperative management of patients with thyroid nodules.
Giovagnoli MR, Pisani T, Drusco A, Scardella L, Antonaci A, Vecchione A
Anticancer Res 1998 Sep-Oct;18(5B):3741-5. PMID: 9854487

Recent clinical studies

Etiology

Thyroid oncocytic neoplasms.
Doghri R, Znaidi N, Blel A, Aloui R, Lahyeni R, Ben Salah M, Rammeh S
Tunis Med 2018 Mar;96(3):219-223. PMID: 30325491
Clinical utility of EZH1 mutations in the diagnosis of follicular-patterned thyroid tumors.
Jung CK, Kim Y, Jeon S, Jo K, Lee S, Bae JS
Hum Pathol 2018 Nov;81:9-17. Epub 2018 May 1 doi: 10.1016/j.humpath.2018.04.018. PMID: 29723601
Molecular profiles of oxyphilic and chief cell parathyroid adenoma.
Lu M, Kjellin H, Fotouhi O, Lee L, Nilsson IL, Haglund F, Höög A, Lehtiö J, Larsson C
Mol Cell Endocrinol 2018 Jul 15;470:84-95. Epub 2017 Oct 3 doi: 10.1016/j.mce.2017.10.001. PMID: 28986304
Oncocytic tumours.
Tallini G
Virchows Arch 1998 Jul;433(1):5-12. doi: 10.1007/s004280050209. PMID: 9692819
Oxyphilic papillary thyroid carcinomas.
Beckner ME, Heffess CS, Oertel JE
Am J Clin Pathol 1995 Mar;103(3):280-7. doi: 10.1093/ajcp/103.3.280. PMID: 7872249

Diagnosis

Oncocytic Parathyroid Adenoma.
McCarthy M, Whaley RD, Erickson LA
Mayo Clin Proc 2022 Nov;97(11):2168-2169. doi: 10.1016/j.mayocp.2022.09.015. PMID: 36333022
Genetics, Diagnosis, and Management of Hürthle Cell Thyroid Neoplasms.
McFadden DG, Sadow PM
Front Endocrinol (Lausanne) 2021;12:696386. Epub 2021 Jun 10 doi: 10.3389/fendo.2021.696386. PMID: 34177816Free PMC Article
Renal Oncocytoma: An Algorithm for Diagnosis and Management.
Abdessater M, Kanbar A, Comperat E, Dupont-Athenor A, Alechinsky L, Mouton M, Sebe P
Urology 2020 Sep;143:173-180. Epub 2020 Jun 5 doi: 10.1016/j.urology.2020.05.047. PMID: 32512107
Thyroid oncocytic neoplasms.
Doghri R, Znaidi N, Blel A, Aloui R, Lahyeni R, Ben Salah M, Rammeh S
Tunis Med 2018 Mar;96(3):219-223. PMID: 30325491
Follicular thyroid carcinoma.
Sobrinho-Simões M, Eloy C, Magalhães J, Lobo C, Amaro T
Mod Pathol 2011 Apr;24 Suppl 2:S10-8. doi: 10.1038/modpathol.2010.133. PMID: 21455197

Therapy

Primary cell cultures for the personalized therapy in aggressive thyroid cancer of follicular origin.
Fallahi P, Ferrari SM, Elia G, Ragusa F, Patrizio A, Paparo SR, Marone G, Galdiero MR, Guglielmi G, Foddis R, Cristaudo A, Antonelli A
Semin Cancer Biol 2022 Feb;79:203-216. Epub 2020 Jun 20 doi: 10.1016/j.semcancer.2020.06.013. PMID: 32569821
EVOLUTION OF TARGETED THERAPIES FOR THYROID CARCINOMA.
Sherman SI
Trans Am Clin Climatol Assoc 2019;130:255-265. PMID: 31516190Free PMC Article
Percutaneous renal tumour biopsy.
Delahunt B, Samaratunga H, Martignoni G, Srigley JR, Evans AJ, Brunelli M
Histopathology 2014 Sep;65(3):295-308. doi: 10.1111/his.12495. PMID: 25041600
Management of invasive and advanced thyroid cancer.
Favia G, Iacobone M, Zanella S, Ciarleglio FA
Minerva Endocrinol 2009 Mar;34(1):37-55. PMID: 19209127
Hürthle cell carcinoma.
Yutan E, Clark OH
Curr Treat Options Oncol 2001 Aug;2(4):331-5. doi: 10.1007/s11864-001-0026-4. PMID: 12057113

Prognosis

Oncocytic Change in Thyroid Pathology.
Asa SL, Mete O
Front Endocrinol (Lausanne) 2021;12:678119. Epub 2021 May 3 doi: 10.3389/fendo.2021.678119. PMID: 34012422Free PMC Article
Thyroid oncocytic neoplasms.
Doghri R, Znaidi N, Blel A, Aloui R, Lahyeni R, Ben Salah M, Rammeh S
Tunis Med 2018 Mar;96(3):219-223. PMID: 30325491
Intraductal Oncocytic Papillary Neoplasms of the Pancreas.
Kallen ME, Naini BV
Arch Pathol Lab Med 2016 Sep;140(9):992-6. doi: 10.5858/arpa.2014-0595-RS. PMID: 27575268
Follicular thyroid carcinoma.
Sobrinho-Simões M, Eloy C, Magalhães J, Lobo C, Amaro T
Mod Pathol 2011 Apr;24 Suppl 2:S10-8. doi: 10.1038/modpathol.2010.133. PMID: 21455197
Oxyphilic papillary thyroid carcinomas.
Beckner ME, Heffess CS, Oertel JE
Am J Clin Pathol 1995 Mar;103(3):280-7. doi: 10.1093/ajcp/103.3.280. PMID: 7872249

Clinical prediction guides

Oncocytic Change in Thyroid Pathology.
Asa SL, Mete O
Front Endocrinol (Lausanne) 2021;12:678119. Epub 2021 May 3 doi: 10.3389/fendo.2021.678119. PMID: 34012422Free PMC Article
Thyroid oncocytic neoplasms.
Doghri R, Znaidi N, Blel A, Aloui R, Lahyeni R, Ben Salah M, Rammeh S
Tunis Med 2018 Mar;96(3):219-223. PMID: 30325491
The biology and the genetics of Hurthle cell tumors of the thyroid.
Máximo V, Lima J, Prazeres H, Soares P, Sobrinho-Simões M
Endocr Relat Cancer 2012 Aug;19(4):R131-47. Epub 2012 Jul 18 doi: 10.1530/ERC-11-0354. PMID: 22514109
Follicular thyroid carcinoma.
Sobrinho-Simões M, Eloy C, Magalhães J, Lobo C, Amaro T
Mod Pathol 2011 Apr;24 Suppl 2:S10-8. doi: 10.1038/modpathol.2010.133. PMID: 21455197
Hürthle cell tumors.
Hillman N, Hardisson D, Herranz L, Martinez Olmos MA, Hernandez Bayo JA, Nistal M, Pallardo LF
Ann Med Interne (Paris) 1997;148(6):434-9. PMID: 9538377

Recent systematic reviews

A systematic review of sinonasal oncocytomas and oncocytic carcinomas: Diagnosis, management, and technical considerations.
Hodzic Z, Rowan NR, Kashiwazaki R, Willson TJ, Wang EW, Lee SE
Int Forum Allergy Rhinol 2017 May;7(5):514-524. Epub 2017 Jan 16 doi: 10.1002/alr.21902. PMID: 28092140
Rare metastases of well-differentiated thyroid cancers: a systematic review.
Madani A, Jozaghi Y, Tabah R, How J, Mitmaker E
Ann Surg Oncol 2015 Feb;22(2):460-6. Epub 2014 Sep 6 doi: 10.1245/s10434-014-4058-y. PMID: 25192681
Understanding pathologic variants of renal cell carcinoma: distilling therapeutic opportunities from biologic complexity.
Shuch B, Amin A, Armstrong AJ, Eble JN, Ficarra V, Lopez-Beltran A, Martignoni G, Rini BI, Kutikov A
Eur Urol 2015 Jan;67(1):85-97. Epub 2014 May 21 doi: 10.1016/j.eururo.2014.04.029. PMID: 24857407
Gender differences in benign renal masses.
Mauermann J, de Martino M, Waldert M, Haitel A, Klingler HC, Remzi M, Klatte T
World J Urol 2013 Oct;31(5):1051-7. Epub 2013 Feb 16 doi: 10.1007/s00345-013-1032-4. PMID: 23417319
Adrenal oncocytic neoplasm: a systematic review.
Mearini L, Del Sordo R, Costantini E, Nunzi E, Porena M
Urol Int 2013;91(2):125-33. Epub 2012 Nov 8 doi: 10.1159/000345141. PMID: 23147196

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • MeSH
      Related Medical Subject Headings
    • OMIM
      Related records in OMIM
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed
    • PubMed (OMIM)
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...