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Oxyphilic adenoma

MedGen UID:
307150
Concept ID:
C1510502
Neoplastic Process
Synonyms: Oncocytic adenoma; Oncocytoma
SNOMED CT: Oxyphilic adenoma (89439007); Oncocytic adenoma (89439007); Oncocytoma (89439007); Follicular adenoma, oxyphilic cell (89439007)
 
Monarch Initiative: MONDO:0003424
OMIM®: 553000

Definition

Oncocytomas are usually benign tumors that occur in various organs but particularly in the kidneys. Histologic evaluation of renal oncocytomas shows that they are composed entirely of peculiar epithelial cells with granular eosinophilic cytoplasm. Ultrastructural characterization exhibits densely packed cells with mitochondria, which show morphologic differences from those in normal cells. On the average they are larger than those in renal carcinoma cells and their shape is abnormal (summary by Welter et al., 1989). [from OMIM]

Clinical features

From HPO
Oncocytoma of kidney
MedGen UID:
91094
Concept ID:
C0346255
Neoplastic Process
A renal tumor originating from an oncocyte, which is an epithelial cell characterized by an excessive amount of mitochondria, resulting in an abundant acidophilic, granular cytoplasm.

Professional guidelines

PubMed

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Recent clinical studies

Etiology

Ganly I, McFadden DG
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Diagnosis

McCarthy M, Whaley RD, Erickson LA
Mayo Clin Proc 2022 Nov;97(11):2168-2169. doi: 10.1016/j.mayocp.2022.09.015. PMID: 36333022
McFadden DG, Sadow PM
Front Endocrinol (Lausanne) 2021;12:696386. Epub 2021 Jun 10 doi: 10.3389/fendo.2021.696386. PMID: 34177816Free PMC Article
Abdessater M, Kanbar A, Comperat E, Dupont-Athenor A, Alechinsky L, Mouton M, Sebe P
Urology 2020 Sep;143:173-180. Epub 2020 Jun 5 doi: 10.1016/j.urology.2020.05.047. PMID: 32512107
Doghri R, Znaidi N, Blel A, Aloui R, Lahyeni R, Ben Salah M, Rammeh S
Tunis Med 2018 Mar;96(3):219-223. PMID: 30325491
Sobrinho-Simões M, Eloy C, Magalhães J, Lobo C, Amaro T
Mod Pathol 2011 Apr;24 Suppl 2:S10-8. doi: 10.1038/modpathol.2010.133. PMID: 21455197

Therapy

Ronen N, Suster D
Ann Diagn Pathol 2023 Feb;62:152061. Epub 2022 Nov 22 doi: 10.1016/j.anndiagpath.2022.152061. PMID: 36459776
Fallahi P, Ferrari SM, Elia G, Ragusa F, Patrizio A, Paparo SR, Marone G, Galdiero MR, Guglielmi G, Foddis R, Cristaudo A, Antonelli A
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Yutan E, Clark OH
Curr Treat Options Oncol 2001 Aug;2(4):331-5. doi: 10.1007/s11864-001-0026-4. PMID: 12057113

Prognosis

Asa SL, Mete O
Front Endocrinol (Lausanne) 2021;12:678119. Epub 2021 May 3 doi: 10.3389/fendo.2021.678119. PMID: 34012422Free PMC Article
Doghri R, Znaidi N, Blel A, Aloui R, Lahyeni R, Ben Salah M, Rammeh S
Tunis Med 2018 Mar;96(3):219-223. PMID: 30325491
Kallen ME, Naini BV
Arch Pathol Lab Med 2016 Sep;140(9):992-6. doi: 10.5858/arpa.2014-0595-RS. PMID: 27575268
Sobrinho-Simões M, Eloy C, Magalhães J, Lobo C, Amaro T
Mod Pathol 2011 Apr;24 Suppl 2:S10-8. doi: 10.1038/modpathol.2010.133. PMID: 21455197
Yutan E, Clark OH
Curr Treat Options Oncol 2001 Aug;2(4):331-5. doi: 10.1007/s11864-001-0026-4. PMID: 12057113

Clinical prediction guides

Bischoff LA, Ganly I, Fugazzola L, Buczek E, Faquin WC, Haugen BR, McIver B, McMullen CP, Newbold K, Rocke DJ, Russell MD, Ryder M, Sadow PM, Sherman E, Shindo M, Shonka DC Jr, Singer MC, Stack BC Jr, Wirth LJ, Wong RJ, Randolph GW
JAMA Otolaryngol Head Neck Surg 2024 Mar 1;150(3):265-272. doi: 10.1001/jamaoto.2023.4323. PMID: 38206595
Asa SL, Mete O
Front Endocrinol (Lausanne) 2021;12:678119. Epub 2021 May 3 doi: 10.3389/fendo.2021.678119. PMID: 34012422Free PMC Article
Corvino A, Caruso M, Varelli C, Di Gennaro F, Pignata S, Corvino F, Vallone G, Catalano O
J Ultrasound 2021 Sep;24(3):241-247. Epub 2020 Jul 24 doi: 10.1007/s40477-020-00511-5. PMID: 32710434Free PMC Article
Doghri R, Znaidi N, Blel A, Aloui R, Lahyeni R, Ben Salah M, Rammeh S
Tunis Med 2018 Mar;96(3):219-223. PMID: 30325491
Sobrinho-Simões M, Eloy C, Magalhães J, Lobo C, Amaro T
Mod Pathol 2011 Apr;24 Suppl 2:S10-8. doi: 10.1038/modpathol.2010.133. PMID: 21455197

Recent systematic reviews

Dehghani Firouzabadi F, Gopal N, Homayounieh F, Anari PY, Li X, Ball MW, Jones EC, Samimi S, Turkbey E, Malayeri AA
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Urol Int 2013;91(2):125-33. Epub 2012 Nov 8 doi: 10.1159/000345141. PMID: 23147196

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