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Angiogenic Switch

MedGen UID:
307205
•Concept ID:
C1510885
•
Neoplastic Process

Definition

Loss of the balance between stimulation and inhibition of new blood vessel growth. A required early step in cancer growth and metastasis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAngiogenic Switch

Professional guidelines

PubMed

The long and winding road for the development of tasquinimod as an oral second-generation quinoline-3-carboxamide antiangiogenic drug for the treatment of prostate cancer.
Isaacs JT
Expert Opin Investig Drugs 2010 Oct;19(10):1235-43. doi: 10.1517/13543784.2010.514262. PMID: 20836618Free PMC Article
Autophagy inhibition in combination cancer treatment.
Livesey KM, Tang D, Zeh HJ, Lotze MT
Curr Opin Investig Drugs 2009 Dec;10(12):1269-79. PMID: 19943199
Anti-angiogenic therapy: Prospects for treatment of ocular tumors.
Rosenblatt MI, Azar DT
Semin Ophthalmol 2006 Jul-Sep;21(3):151-60. doi: 10.1080/08820530500350787. PMID: 16912013

Recent clinical studies

Etiology

Oncostatin M is overexpressed in NASH-related hepatocellular carcinoma and promotes cancer cell invasiveness and angiogenesis.
Di Maira G, Foglia B, Napione L, Turato C, Maggiora M, Sutti S, Novo E, Alvaro M, Autelli R, Colombatto S, Bussolino F, Carucci P, Gaia S, Rosso C, Biasiolo A, Pontisso P, Bugianesi E, Albano E, Marra F, Parola M, Cannito S
J Pathol 2022 May;257(1):82-95. Epub 2022 Mar 7 doi: 10.1002/path.5871. PMID: 35064579Free PMC Article
CXCL8 Signaling in the Tumor Microenvironment.
Asokan S, Bandapalli OR
Adv Exp Med Biol 2021;1302:25-39. doi: 10.1007/978-3-030-62658-7_3. PMID: 34286439
The Role of Selected Chemokines and Their Receptors in the Development of Gliomas.
Groblewska M, Litman-Zawadzka A, Mroczko B
Int J Mol Sci 2020 May 24;21(10) doi: 10.3390/ijms21103704. PMID: 32456359Free PMC Article
Circulating pro- and anti-angiogenic factors in multi-stage liver disease and hepatocellular carcinoma progression.
Joo YY, Jang JW, Lee SW, Yoo SH, Kwon JH, Nam SW, Bae SH, Choi JY, Yoon SK
Sci Rep 2019 Jun 24;9(1):9137. doi: 10.1038/s41598-019-45537-w. PMID: 31235729Free PMC Article
Antiangiogenesis drug design: multiple pathways targeting tumor vasculature.
Zhong H, Bowen JP
Curr Med Chem 2006;13(8):849-62. doi: 10.2174/092986706776361085. PMID: 16611071

Diagnosis

Regulation of redox signaling in HIF-1-dependent tumor angiogenesis.
Manuelli V, Pecorari C, Filomeni G, Zito E
FEBS J 2022 Sep;289(18):5413-5425. Epub 2021 Jul 16 doi: 10.1111/febs.16110. PMID: 34228878
The Acidic Brain-Glycolytic Switch in the Microenvironment of Malignant Glioma.
Reuss AM, Groos D, Buchfelder M, Savaskan N
Int J Mol Sci 2021 May 24;22(11) doi: 10.3390/ijms22115518. PMID: 34073734Free PMC Article
Cross-Talk between NADPH Oxidase and Mitochondria: Role in ROS Signaling and Angiogenesis.
Fukai T, Ushio-Fukai M
Cells 2020 Aug 6;9(8) doi: 10.3390/cells9081849. PMID: 32781794Free PMC Article
Tumour innervation and neurosignalling in prostate cancer.
March B, Faulkner S, Jobling P, Steigler A, Blatt A, Denham J, Hondermarck H
Nat Rev Urol 2020 Feb;17(2):119-130. Epub 2020 Jan 14 doi: 10.1038/s41585-019-0274-3. PMID: 31937919
The roles and role-players in thyroid cancer angiogenesis.
Rajabi S, Dehghan MH, Dastmalchi R, Jalali Mashayekhi F, Salami S, Hedayati M
Endocr J 2019 Apr 25;66(4):277-293. Epub 2019 Mar 6 doi: 10.1507/endocrj.EJ18-0537. PMID: 30842365

Therapy

Angiopoietin inhibitors: A review on targeting tumor angiogenesis.
Parmar D, Apte M
Eur J Pharmacol 2021 May 15;899:174021. Epub 2021 Mar 16 doi: 10.1016/j.ejphar.2021.174021. PMID: 33741382
The dark side of tumor-associated endothelial cells.
De Sanctis F, Ugel S, Facciponte J, Facciabene A
Semin Immunol 2018 Feb;35:35-47. Epub 2018 Feb 26 doi: 10.1016/j.smim.2018.02.002. PMID: 29490888
Broad targeting of angiogenesis for cancer prevention and therapy.
Wang Z, Dabrosin C, Yin X, Fuster MM, Arreola A, Rathmell WK, Generali D, Nagaraju GP, El-Rayes B, Ribatti D, Chen YC, Honoki K, Fujii H, Georgakilas AG, Nowsheen S, Amedei A, Niccolai E, Amin A, Ashraf SS, Helferich B, Yang X, Guha G, Bhakta D, Ciriolo MR, Aquilano K, Chen S, Halicka D, Mohammed SI, Azmi AS, Bilsland A, Keith WN, Jensen LD
Semin Cancer Biol 2015 Dec;35 Suppl(Suppl):S224-S243. Epub 2015 Jan 16 doi: 10.1016/j.semcancer.2015.01.001. PMID: 25600295Free PMC Article
Antiangiogenic therapy.
Albo D, Wang TN, Tuszynski GP
Curr Pharm Des 2004;10(1):27-37. doi: 10.2174/1381612043453522. PMID: 14754403
Role of angiogenesis in tumor growth and metastasis.
Folkman J
Semin Oncol 2002 Dec;29(6 Suppl 16):15-8. doi: 10.1053/sonc.2002.37263. PMID: 12516034

Prognosis

Oncostatin M is overexpressed in NASH-related hepatocellular carcinoma and promotes cancer cell invasiveness and angiogenesis.
Di Maira G, Foglia B, Napione L, Turato C, Maggiora M, Sutti S, Novo E, Alvaro M, Autelli R, Colombatto S, Bussolino F, Carucci P, Gaia S, Rosso C, Biasiolo A, Pontisso P, Bugianesi E, Albano E, Marra F, Parola M, Cannito S
J Pathol 2022 May;257(1):82-95. Epub 2022 Mar 7 doi: 10.1002/path.5871. PMID: 35064579Free PMC Article
LncRNAs and the Angiogenic Switch in Cancer: Clinical Significance and Therapeutic Opportunities.
Mabeta P, Hull R, Dlamini Z
Genes (Basel) 2022 Jan 15;13(1) doi: 10.3390/genes13010152. PMID: 35052495Free PMC Article
The Acidic Brain-Glycolytic Switch in the Microenvironment of Malignant Glioma.
Reuss AM, Groos D, Buchfelder M, Savaskan N
Int J Mol Sci 2021 May 24;22(11) doi: 10.3390/ijms22115518. PMID: 34073734Free PMC Article
The roles and role-players in thyroid cancer angiogenesis.
Rajabi S, Dehghan MH, Dastmalchi R, Jalali Mashayekhi F, Salami S, Hedayati M
Endocr J 2019 Apr 25;66(4):277-293. Epub 2019 Mar 6 doi: 10.1507/endocrj.EJ18-0537. PMID: 30842365
Angiopoietins in angiogenesis.
Fagiani E, Christofori G
Cancer Lett 2013 Jan 1;328(1):18-26. Epub 2012 Aug 23 doi: 10.1016/j.canlet.2012.08.018. PMID: 22922303

Clinical prediction guides

Tumour innervation and neurosignalling in prostate cancer.
March B, Faulkner S, Jobling P, Steigler A, Blatt A, Denham J, Hondermarck H
Nat Rev Urol 2020 Feb;17(2):119-130. Epub 2020 Jan 14 doi: 10.1038/s41585-019-0274-3. PMID: 31937919
Circulating pro- and anti-angiogenic factors in multi-stage liver disease and hepatocellular carcinoma progression.
Joo YY, Jang JW, Lee SW, Yoo SH, Kwon JH, Nam SW, Bae SH, Choi JY, Yoon SK
Sci Rep 2019 Jun 24;9(1):9137. doi: 10.1038/s41598-019-45537-w. PMID: 31235729Free PMC Article
Role of Endothelial Cells and Fibroblasts in Multiple Myeloma Angiogenic Switch.
Ribatti D, Vacca A
Cancer Treat Res 2016;169:51-61. doi: 10.1007/978-3-319-40320-5_5. PMID: 27696258
Metastasis dormancy in estrogen receptor-positive breast cancer.
Zhang XH, Giuliano M, Trivedi MV, Schiff R, Osborne CK
Clin Cancer Res 2013 Dec 1;19(23):6389-97. doi: 10.1158/1078-0432.CCR-13-0838. PMID: 24298069Free PMC Article
Molecular mechanisms underlying tumor dormancy.
Almog N
Cancer Lett 2010 Aug 28;294(2):139-46. Epub 2010 Apr 2 doi: 10.1016/j.canlet.2010.03.004. PMID: 20363069

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