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Benign Ovarian Clear Cell Tumor

MedGen UID:
307263
•Concept ID:
C1511098
•
Neoplastic Process
Synonym: Benign Ovarian Clear Cell Neoplasm

Definition

A non-metastasizing neoplasm that arises from the ovary. It is characterized by a predominance of clear and hobnail benign epithelial cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign Ovarian Clear Cell Tumor

Professional guidelines

PubMed

Magnetic resonance imaging findings of cystic ovarian tumors: major differential diagnoses in five types frequently encountered in daily clinical practice.
Ohya A, Fujinaga Y
Jpn J Radiol 2022 Dec;40(12):1213-1234. Epub 2022 Aug 2 doi: 10.1007/s11604-022-01321-x. PMID: 35916971Free PMC Article
Expression profile analysis in multiple human tumors identifies L1 (CD171) as a molecular marker for differential diagnosis and targeted therapy.
Huszar M, Moldenhauer G, Gschwend V, Ben-Arie A, Altevogt P, Fogel M
Hum Pathol 2006 Aug;37(8):1000-8. Epub 2006 Jun 21 doi: 10.1016/j.humpath.2006.03.014. PMID: 16867862
Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues.
Ulbright TM
Mod Pathol 2005 Feb;18 Suppl 2:S61-79. doi: 10.1038/modpathol.3800310. PMID: 15761467

Recent clinical studies

Etiology

Transcriptomic analyses of ovarian clear-cell carcinoma with concurrent endometriosis.
Collins KE, Wang X, Klymenko Y, Davis NB, Martinez MC, Zhang C, So K, Buechlein A, Rusch DB, Creighton CJ, Hawkins SM
Front Endocrinol (Lausanne) 2023;14:1162786. Epub 2023 Aug 9 doi: 10.3389/fendo.2023.1162786. PMID: 37621654Free PMC Article
Pathology of borderline and invasive cancers.
Prat J
Best Pract Res Clin Obstet Gynaecol 2017 May;41:15-30. Epub 2016 Oct 3 doi: 10.1016/j.bpobgyn.2016.08.007. PMID: 28277307
Cancer Implications for Patients with Endometriosis.
Wilbur MA, Shih IM, Segars JH, Fader AN
Semin Reprod Med 2017 Jan;35(1):110-116. Epub 2017 Jan 3 doi: 10.1055/s-0036-1597120. PMID: 28049216
The Dualistic Model of Ovarian Carcinogenesis: Revisited, Revised, and Expanded.
Kurman RJ, Shih IeM
Am J Pathol 2016 Apr;186(4):733-47. doi: 10.1016/j.ajpath.2015.11.011. PMID: 27012190Free PMC Article
The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory.
Kurman RJ, Shih IeM
Am J Surg Pathol 2010 Mar;34(3):433-43. doi: 10.1097/PAS.0b013e3181cf3d79. PMID: 20154587Free PMC Article

Diagnosis

Frozen Section Diagnosis of Ovarian Epithelial Tumors: Diagnostic Pearls and Pitfalls.
Buza N
Arch Pathol Lab Med 2019 Jan;143(1):47-64. doi: 10.5858/arpa.2018-0289-RA. PMID: 30785337
Pathology of borderline and invasive cancers.
Prat J
Best Pract Res Clin Obstet Gynaecol 2017 May;41:15-30. Epub 2016 Oct 3 doi: 10.1016/j.bpobgyn.2016.08.007. PMID: 28277307
Cancer Implications for Patients with Endometriosis.
Wilbur MA, Shih IM, Segars JH, Fader AN
Semin Reprod Med 2017 Jan;35(1):110-116. Epub 2017 Jan 3 doi: 10.1055/s-0036-1597120. PMID: 28049216
Pathology of the adnexal mass.
Bennett JA, Oliva E
Clin Obstet Gynecol 2015 Mar;58(1):3-27. doi: 10.1097/GRF.0000000000000082. PMID: 25608250
Ovarian cancer molecular pathology.
Longuespée R, Boyon C, Desmons A, Vinatier D, Leblanc E, Farré I, Wisztorski M, Ly K, D'Anjou F, Day R, Fournier I, Salzet M
Cancer Metastasis Rev 2012 Dec;31(3-4):713-32. doi: 10.1007/s10555-012-9383-7. PMID: 22729278

Therapy

Clear cell carcinoma arising in an ovarian remnant 19 years after oophoerctomy: case report.
Yao TT, Zhao SJ, Zhang B
BMC Womens Health 2023 Oct 27;23(1):559. doi: 10.1186/s12905-023-02695-4. PMID: 37891576Free PMC Article
Malignant risk of pelvic mass after hysterectomy for adenomyosis or endometriosis.
Chao X, Liu Y, Ji M, Wang S, Shi H, Fan Q, Lang J
Medicine (Baltimore) 2020 Apr;99(15):e19712. doi: 10.1097/MD.0000000000019712. PMID: 32282727Free PMC Article
Hysterectomy and risk of ovarian cancer: a systematic review and meta-analysis.
Huo X, Yao L, Han X, Li W, Liu J, Zhou L, Gou Y, Yang K, Liu H
Arch Gynecol Obstet 2019 Mar;299(3):599-607. Epub 2019 Jan 4 doi: 10.1007/s00404-018-5020-1. PMID: 30607584
Ovarian cancer in endometriosis: epidemiology, natural history, and clinical diagnosis.
Kobayashi H
Int J Clin Oncol 2009 Oct;14(5):378-82. Epub 2009 Oct 25 doi: 10.1007/s10147-009-0931-2. PMID: 19856043
Endometriosis and the development of malignant tumours of the pelvis. A review of literature.
Van Gorp T, Amant F, Neven P, Vergote I, Moerman P
Best Pract Res Clin Obstet Gynaecol 2004 Apr;18(2):349-71. doi: 10.1016/j.bpobgyn.2003.03.001. PMID: 15157647

Prognosis

Transcriptomic analyses of ovarian clear-cell carcinoma with concurrent endometriosis.
Collins KE, Wang X, Klymenko Y, Davis NB, Martinez MC, Zhang C, So K, Buechlein A, Rusch DB, Creighton CJ, Hawkins SM
Front Endocrinol (Lausanne) 2023;14:1162786. Epub 2023 Aug 9 doi: 10.3389/fendo.2023.1162786. PMID: 37621654Free PMC Article
Pathology of borderline and invasive cancers.
Prat J
Best Pract Res Clin Obstet Gynaecol 2017 May;41:15-30. Epub 2016 Oct 3 doi: 10.1016/j.bpobgyn.2016.08.007. PMID: 28277307
Recent concepts of ovarian carcinogenesis: type I and type II.
Koshiyama M, Matsumura N, Konishi I
Biomed Res Int 2014;2014:934261. Epub 2014 Apr 23 doi: 10.1155/2014/934261. PMID: 24868556Free PMC Article
Ovarian cancer molecular pathology.
Longuespée R, Boyon C, Desmons A, Vinatier D, Leblanc E, Farré I, Wisztorski M, Ly K, D'Anjou F, Day R, Fournier I, Salzet M
Cancer Metastasis Rev 2012 Dec;31(3-4):713-32. doi: 10.1007/s10555-012-9383-7. PMID: 22729278
TP53 and ovarian cancer.
Schuijer M, Berns EM
Hum Mutat 2003 Mar;21(3):285-91. doi: 10.1002/humu.10181. PMID: 12619114

Clinical prediction guides

Transcriptomic analyses of ovarian clear-cell carcinoma with concurrent endometriosis.
Collins KE, Wang X, Klymenko Y, Davis NB, Martinez MC, Zhang C, So K, Buechlein A, Rusch DB, Creighton CJ, Hawkins SM
Front Endocrinol (Lausanne) 2023;14:1162786. Epub 2023 Aug 9 doi: 10.3389/fendo.2023.1162786. PMID: 37621654Free PMC Article
Hysterectomy and risk of ovarian cancer: a systematic review and meta-analysis.
Huo X, Yao L, Han X, Li W, Liu J, Zhou L, Gou Y, Yang K, Liu H
Arch Gynecol Obstet 2019 Mar;299(3):599-607. Epub 2019 Jan 4 doi: 10.1007/s00404-018-5020-1. PMID: 30607584
Dysregulated expression of long noncoding RNAs in gynecologic cancers.
Hosseini ES, Meryet-Figuiere M, Sabzalipoor H, Kashani HH, Nikzad H, Asemi Z
Mol Cancer 2017 Jun 21;16(1):107. doi: 10.1186/s12943-017-0671-2. PMID: 28637507Free PMC Article
Ovarian cancer in endometriosis: epidemiology, natural history, and clinical diagnosis.
Kobayashi H
Int J Clin Oncol 2009 Oct;14(5):378-82. Epub 2009 Oct 25 doi: 10.1007/s10147-009-0931-2. PMID: 19856043
TP53 and ovarian cancer.
Schuijer M, Berns EM
Hum Mutat 2003 Mar;21(3):285-91. doi: 10.1002/humu.10181. PMID: 12619114

Recent systematic reviews

Identification of biomarkers for the diagnosis and targets for therapy in patients with clear cell ovarian cancer: a systematic literature review.
Butler H, Saulat O, Guinn BA
Carcinogenesis 2022 Apr 25;43(3):183-189. doi: 10.1093/carcin/bgac012. PMID: 35104328Free PMC Article
Hysterectomy and risk of ovarian cancer: a systematic review and meta-analysis.
Huo X, Yao L, Han X, Li W, Liu J, Zhou L, Gou Y, Yang K, Liu H
Arch Gynecol Obstet 2019 Mar;299(3):599-607. Epub 2019 Jan 4 doi: 10.1007/s00404-018-5020-1. PMID: 30607584
A systematic review of papers examining the use of intraoperative frozen section in predicting the final diagnosis of ovarian lesions.
Heatley MK
Int J Gynecol Pathol 2012 Mar;31(2):111-5. doi: 10.1097/PGP.0b013e318226043b. PMID: 22317865

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