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Borderline Fallopian Tube Neoplasm

MedGen UID:
307297
•Concept ID:
C1511256
•
Neoplastic Process
Synonyms: Borderline Fallopian Tube Tumor; Fallopian Tube Neoplasm of Low Malignant Potential

Definition

A rare epithelial tumor arising from the fallopian tube without definitive morphologic characteristics of malignancy. This category includes borderline mucinous and serous neoplasms and borderline endometrioid tumor. [from NCI]

Professional guidelines

PubMed

The 2020 Japan Society of Gynecologic Oncology guidelines for the treatment of ovarian cancer, fallopian tube cancer, and primary peritoneal cancer.
Tokunaga H, Mikami M, Nagase S, Kobayashi Y, Tabata T, Kaneuchi M, Satoh T, Hirashima Y, Matsumura N, Yokoyama Y, Kawana K, Kyo S, Aoki D, Katabuchi H
J Gynecol Oncol 2021 Mar;32(2):e49. doi: 10.3802/jgo.2021.32.e49. PMID: 33650343Free PMC Article
Ovarian Cancer, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology.
Armstrong DK, Alvarez RD, Bakkum-Gamez JN, Barroilhet L, Behbakht K, Berchuck A, Chen LM, Cristea M, DeRosa M, Eisenhauer EL, Gershenson DM, Gray HJ, Grisham R, Hakam A, Jain A, Karam A, Konecny GE, Leath CA, Liu J, Mahdi H, Martin L, Matei D, McHale M, McLean K, Miller DS, O'Malley DM, Percac-Lima S, Ratner E, Remmenga SW, Vargas R, Werner TL, Zsiros E, Burns JL, Engh AM
J Natl Compr Canc Netw 2021 Feb 2;19(2):191-226. doi: 10.6004/jnccn.2021.0007. PMID: 33545690
Current perspectives on recommendations for BRCA genetic testing in ovarian cancer patients.
Vergote I, Banerjee S, Gerdes AM, van Asperen C, Marth C, Vaz F, Ray-Coquard I, Stoppa-Lyonnet D, Gonzalez-Martin A, Sehouli J, Colombo N
Eur J Cancer 2016 Dec;69:127-134. Epub 2016 Nov 4 doi: 10.1016/j.ejca.2016.10.006. PMID: 27821315

Recent clinical studies

Etiology

OvaPrint-A Cell-free DNA Methylation Liquid Biopsy for the Risk Assessment of High-grade Serous Ovarian Cancer.
Buckley DN, Lewinger JP, Gooden G, Spillman M, Neuman M, Guo XM, Tew BY, Miller H, Khetan VU, Shulman LP, Roman L, Salhia B
Clin Cancer Res 2023 Dec 15;29(24):5196-5206. doi: 10.1158/1078-0432.CCR-23-1197. PMID: 37812492Free PMC Article
How and where to expect endosalpingiosis intraoperatively.
Burla L, Kalaitzopoulos DR, Mrozek A, Eberhard M, Samartzis N
Fertil Steril 2022 Feb;117(2):461-462. Epub 2022 Jan 2 doi: 10.1016/j.fertnstert.2021.11.016. PMID: 34986982
Recent concepts of ovarian carcinogenesis: type I and type II.
Koshiyama M, Matsumura N, Konishi I
Biomed Res Int 2014;2014:934261. Epub 2014 Apr 23 doi: 10.1155/2014/934261. PMID: 24868556Free PMC Article
Origin and molecular pathogenesis of ovarian high-grade serous carcinoma.
Kurman RJ
Ann Oncol 2013 Dec;24 Suppl 10:x16-21. doi: 10.1093/annonc/mdt463. PMID: 24265397
The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory.
Kurman RJ, Shih IeM
Am J Surg Pathol 2010 Mar;34(3):433-43. doi: 10.1097/PAS.0b013e3181cf3d79. PMID: 20154587Free PMC Article

Diagnosis

OvaPrint-A Cell-free DNA Methylation Liquid Biopsy for the Risk Assessment of High-grade Serous Ovarian Cancer.
Buckley DN, Lewinger JP, Gooden G, Spillman M, Neuman M, Guo XM, Tew BY, Miller H, Khetan VU, Shulman LP, Roman L, Salhia B
Clin Cancer Res 2023 Dec 15;29(24):5196-5206. doi: 10.1158/1078-0432.CCR-23-1197. PMID: 37812492Free PMC Article
Ovarian Cancer, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology.
Armstrong DK, Alvarez RD, Bakkum-Gamez JN, Barroilhet L, Behbakht K, Berchuck A, Chen LM, Cristea M, DeRosa M, Eisenhauer EL, Gershenson DM, Gray HJ, Grisham R, Hakam A, Jain A, Karam A, Konecny GE, Leath CA, Liu J, Mahdi H, Martin L, Matei D, McHale M, McLean K, Miller DS, O'Malley DM, Percac-Lima S, Ratner E, Remmenga SW, Vargas R, Werner TL, Zsiros E, Burns JL, Engh AM
J Natl Compr Canc Netw 2021 Feb 2;19(2):191-226. doi: 10.6004/jnccn.2021.0007. PMID: 33545690
Interventions to reduce the risk of ovarian and fallopian tube cancer: A European Menopause and Andropause Society Postition Statement.
Pérez-López FR, Ceausu I, Depypere H, Kehoe S, Lambrinoudaki I, Mueck A, Senturk LM, Simoncini T, Stevenson JC, Stute P, Rees M
Maturitas 2017 Jun;100:86-91. Epub 2017 Mar 15 doi: 10.1016/j.maturitas.2017.03.003. PMID: 28389043
Primary Mucinous Carcinoma of the Fallopian Tube: Case Report and Review of Literature.
Wheal A, Jenkins R, Mikami Y, Das N, Hirschowitz L
Int J Gynecol Pathol 2017 Jul;36(4):393-399. doi: 10.1097/PGP.0000000000000330. PMID: 27662036
Origin and molecular pathogenesis of ovarian high-grade serous carcinoma.
Kurman RJ
Ann Oncol 2013 Dec;24 Suppl 10:x16-21. doi: 10.1093/annonc/mdt463. PMID: 24265397

Therapy

Low grade serous ovarian cancer - A rare disease with increasing therapeutic options.
Zwimpfer TA, Tal O, Geissler F, Coelho R, Rimmer N, Jacob F, Heinzelmann-Schwarz V
Cancer Treat Rev 2023 Jan;112:102497. Epub 2022 Dec 10 doi: 10.1016/j.ctrv.2022.102497. PMID: 36525716
Current perspectives on recommendations for BRCA genetic testing in ovarian cancer patients.
Vergote I, Banerjee S, Gerdes AM, van Asperen C, Marth C, Vaz F, Ray-Coquard I, Stoppa-Lyonnet D, Gonzalez-Martin A, Sehouli J, Colombo N
Eur J Cancer 2016 Dec;69:127-134. Epub 2016 Nov 4 doi: 10.1016/j.ejca.2016.10.006. PMID: 27821315
Origin and molecular pathogenesis of ovarian high-grade serous carcinoma.
Kurman RJ
Ann Oncol 2013 Dec;24 Suppl 10:x16-21. doi: 10.1093/annonc/mdt463. PMID: 24265397
Cancerous ovarian stem cells: obscure targets for therapy but relevant to chemoresistance.
Ahmed N, Abubaker K, Findlay J, Quinn M
J Cell Biochem 2013 Jan;114(1):21-34. doi: 10.1002/jcb.24317. PMID: 22887554
Pathogenesis of ovarian cancer: lessons from morphology and molecular biology and their clinical implications.
Kurman RJ, Shih IeM
Int J Gynecol Pathol 2008 Apr;27(2):151-60. doi: 10.1097/PGP.0b013e318161e4f5. PMID: 18317228Free PMC Article

Prognosis

OvaPrint-A Cell-free DNA Methylation Liquid Biopsy for the Risk Assessment of High-grade Serous Ovarian Cancer.
Buckley DN, Lewinger JP, Gooden G, Spillman M, Neuman M, Guo XM, Tew BY, Miller H, Khetan VU, Shulman LP, Roman L, Salhia B
Clin Cancer Res 2023 Dec 15;29(24):5196-5206. doi: 10.1158/1078-0432.CCR-23-1197. PMID: 37812492Free PMC Article
Recent concepts of ovarian carcinogenesis: type I and type II.
Koshiyama M, Matsumura N, Konishi I
Biomed Res Int 2014;2014:934261. Epub 2014 Apr 23 doi: 10.1155/2014/934261. PMID: 24868556Free PMC Article
Origin and molecular pathogenesis of ovarian high-grade serous carcinoma.
Kurman RJ
Ann Oncol 2013 Dec;24 Suppl 10:x16-21. doi: 10.1093/annonc/mdt463. PMID: 24265397
Precursors and pathogenesis of ovarian carcinoma.
Lim D, Oliva E
Pathology 2013 Apr;45(3):229-42. doi: 10.1097/PAT.0b013e32835f2264. PMID: 23478230
Peritoneal carcinoma in women with genetic susceptibility: implications for Jewish populations.
Casey MJ, Bewtra C
Fam Cancer 2004;3(3-4):265-81. doi: 10.1007/s10689-004-9554-y. PMID: 15516851

Clinical prediction guides

OvaPrint-A Cell-free DNA Methylation Liquid Biopsy for the Risk Assessment of High-grade Serous Ovarian Cancer.
Buckley DN, Lewinger JP, Gooden G, Spillman M, Neuman M, Guo XM, Tew BY, Miller H, Khetan VU, Shulman LP, Roman L, Salhia B
Clin Cancer Res 2023 Dec 15;29(24):5196-5206. doi: 10.1158/1078-0432.CCR-23-1197. PMID: 37812492Free PMC Article
Ciliated Cells in Ovarian Cancer Decrease with Increasing Tumor Grade and Disease Progression.
Richardson MT, Recouvreux MS, Karlan BY, Walts AE, Orsulic S
Cells 2022 Dec 11;11(24) doi: 10.3390/cells11244009. PMID: 36552773Free PMC Article
Differential epithelial and stromal LGR5 expression in ovarian carcinogenesis.
Kim H, Lee DH, Park E, Myung JK, Park JH, Kim DI, Kim SI, Lee M, Kim Y, Park CM, Hyun CL, Maeng YH, Lee C, Jang B
Sci Rep 2022 Jul 1;12(1):11200. doi: 10.1038/s41598-022-15234-2. PMID: 35778589Free PMC Article
How and where to expect endosalpingiosis intraoperatively.
Burla L, Kalaitzopoulos DR, Mrozek A, Eberhard M, Samartzis N
Fertil Steril 2022 Feb;117(2):461-462. Epub 2022 Jan 2 doi: 10.1016/j.fertnstert.2021.11.016. PMID: 34986982
Endosalpingiosis: More than just an incidental finding at the time of gynecologic surgery?
Esselen KM, Terry KL, Samuel A, Elias KM, Davis M, Welch WR, Muto MG, Ng SW, Berkowitz RS
Gynecol Oncol 2016 Aug;142(2):255-60. Epub 2016 Jun 3 doi: 10.1016/j.ygyno.2016.05.036. PMID: 27261327

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