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Breast large cell neuroendocrine carcinoma

MedGen UID:
307310
•Concept ID:
C1511316
•
Neoplastic Process
Synonyms: Breast Large Cell Neuroendocrine Carcinoma; breast large cell neuroendocrine carcinoma; large cell neuroendocrine carcinoma of breast
 
Monarch Initiative: MONDO:0003959

Definition

A poorly differentiated neuroendocrine carcinoma that arises from the breast. It is characterized by the presence of large neuroendocrine cells and high mitotic activity. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast large cell neuroendocrine carcinoma

Professional guidelines

PubMed

Multidisciplinary Management of Orbital Metastasis and Survival Outcomes.
El-Hadad C, Koka K, Dong W, Do T, Haider M, Ursua JD, Ning J, Debnam JM, Esmaeli B
Ophthalmic Plast Reconstr Surg 2021 Nov-Dec 01;37(6):541-545. doi: 10.1097/IOP.0000000000001939. PMID: 33587417
Superficial Ewing's sarcoma family of tumors: a clinicopathological study with differential diagnoses.
Machado I, Llombart B, Calabuig-Fariñas S, Llombart-Bosch A
J Cutan Pathol 2011 Aug;38(8):636-43. Epub 2011 Jun 7 doi: 10.1111/j.1600-0560.2011.01705.x. PMID: 21649689
Regional treatment of hepatic metastases and hepatocellular carcinoma.
Kemeny N, Schneider A
Curr Probl Cancer 1989 Jul-Aug;13(4):197-283. doi: 10.1016/0147-0272(89)90007-x. PMID: 2548812

Recent clinical studies

Etiology

Analysis of 25 surgical cases of thymic neuroendocrine tumors and thymic carcinoma.
Midorikawa K, Miyahara S, Nishino N, Ueda Y, Waseda R, Shiraishi T, Sato T
J Cardiothorac Surg 2024 Apr 16;19(1):225. doi: 10.1186/s13019-024-02723-w. PMID: 38627811Free PMC Article
Neuroendocrine neoplasms of the breast: diagnostic agreement and impact on outcome.
Metovic J, Cascardi E, Uccella S, Maragliano R, Querzoli G, Osella-Abate S, Pittaro A, La Rosa S, Bogina G, Cassoni P, Marchiò C, Sapino A, Castellano I, Papotti M
Virchows Arch 2022 Dec;481(6):839-846. Epub 2022 Oct 15 doi: 10.1007/s00428-022-03426-0. PMID: 36243799Free PMC Article
Lorlatinib and compound mutations in ALK+ large-cell neuroendocrine lung carcinoma: a case report.
Wiedemann C, Kazdal D, Cvetkovic J, Kunz J, Fisch D, Kirchner M, Kriegsmann M, Sültmann H, Heussel CP, Bischoff H, Thomas M, Stenzinger A, Christopoulos P
Cold Spring Harb Mol Case Stud 2022 Oct;8(6) Epub 2022 Oct 28 doi: 10.1101/mcs.a006234. PMID: 36207130Free PMC Article
Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Liver resection for non-colorectal, non-carcinoid, non-sarcoma metastases: a multicenter study.
Martel G, Hawel J, Rekman J, Croome KP, Bertens K, Balaa FK, Hernandez-Alejandro R
PLoS One 2015;10(3):e0120569. Epub 2015 Mar 26 doi: 10.1371/journal.pone.0120569. PMID: 25811923Free PMC Article

Diagnosis

Neuroendocrine neoplasms of the breast: diagnostic agreement and impact on outcome.
Metovic J, Cascardi E, Uccella S, Maragliano R, Querzoli G, Osella-Abate S, Pittaro A, La Rosa S, Bogina G, Cassoni P, Marchiò C, Sapino A, Castellano I, Papotti M
Virchows Arch 2022 Dec;481(6):839-846. Epub 2022 Oct 15 doi: 10.1007/s00428-022-03426-0. PMID: 36243799Free PMC Article
PAX8 Expression in Breast Cancer.
Lu S, Yakirevich E, Hart J, Wang L, Wang Y
Appl Immunohistochem Mol Morphol 2021 Apr 1;29(4):293-298. doi: 10.1097/PAI.0000000000000883. PMID: 33208672
Asymptomatic Infiltrated Erythematous Skin Patch on the Breast.
Zanelli M, Zizzo M, Ascani S
JAMA Dermatol 2019 Dec 1;155(12):1420-1421. doi: 10.1001/jamadermatol.2019.3273. PMID: 31693054
P-glycoprotein Mediates Ceritinib Resistance in Anaplastic Lymphoma Kinase-rearranged Non-small Cell Lung Cancer.
Katayama R, Sakashita T, Yanagitani N, Ninomiya H, Horiike A, Friboulet L, Gainor JF, Motoi N, Dobashi A, Sakata S, Tambo Y, Kitazono S, Sato S, Koike S, John Iafrate A, Mino-Kenudson M, Ishikawa Y, Shaw AT, Engelman JA, Takeuchi K, Nishio M, Fujita N
EBioMedicine 2016 Jan;3:54-66. Epub 2015 Dec 12 doi: 10.1016/j.ebiom.2015.12.009. PMID: 26870817Free PMC Article
Primary neuroendocrine breast cancer, how much do we know so far?
Alkaied H, Harris K, Azab B, Dai Q
Med Oncol 2012 Dec;29(4):2613-8. Epub 2012 Apr 1 doi: 10.1007/s12032-012-0222-z. PMID: 22467078

Therapy

Lorlatinib and compound mutations in ALK+ large-cell neuroendocrine lung carcinoma: a case report.
Wiedemann C, Kazdal D, Cvetkovic J, Kunz J, Fisch D, Kirchner M, Kriegsmann M, Sültmann H, Heussel CP, Bischoff H, Thomas M, Stenzinger A, Christopoulos P
Cold Spring Harb Mol Case Stud 2022 Oct;8(6) Epub 2022 Oct 28 doi: 10.1101/mcs.a006234. PMID: 36207130Free PMC Article
Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Breast metastasis and lung large-cell neuroendocrine carcinoma: first clinical observation.
Papa A, Rossi L, Verrico M, Di Cristofano C, Moretti V, Strudel M, Zoratto F, Minozzi M, Tomao S
Clin Respir J 2017 Sep;11(5):574-578. Epub 2015 Oct 20 doi: 10.1111/crj.12385. PMID: 26365150
P-glycoprotein Mediates Ceritinib Resistance in Anaplastic Lymphoma Kinase-rearranged Non-small Cell Lung Cancer.
Katayama R, Sakashita T, Yanagitani N, Ninomiya H, Horiike A, Friboulet L, Gainor JF, Motoi N, Dobashi A, Sakata S, Tambo Y, Kitazono S, Sato S, Koike S, John Iafrate A, Mino-Kenudson M, Ishikawa Y, Shaw AT, Engelman JA, Takeuchi K, Nishio M, Fujita N
EBioMedicine 2016 Jan;3:54-66. Epub 2015 Dec 12 doi: 10.1016/j.ebiom.2015.12.009. PMID: 26870817Free PMC Article
Primary neuroendocrine breast cancer, how much do we know so far?
Alkaied H, Harris K, Azab B, Dai Q
Med Oncol 2012 Dec;29(4):2613-8. Epub 2012 Apr 1 doi: 10.1007/s12032-012-0222-z. PMID: 22467078

Prognosis

Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Asymptomatic Infiltrated Erythematous Skin Patch on the Breast.
Zanelli M, Zizzo M, Ascani S
JAMA Dermatol 2019 Dec 1;155(12):1420-1421. doi: 10.1001/jamadermatol.2019.3273. PMID: 31693054
Metastatic non-small cell lung carcinoma a mimic of primary breast carcinoma-case series and literature review.
Ali RH, Taraboanta C, Mohammad T, Hayes MM, Ionescu DN
Virchows Arch 2018 May;472(5):771-777. Epub 2017 Nov 5 doi: 10.1007/s00428-017-2262-4. PMID: 29105026
Liver resection for non-colorectal, non-carcinoid, non-sarcoma metastases: a multicenter study.
Martel G, Hawel J, Rekman J, Croome KP, Bertens K, Balaa FK, Hernandez-Alejandro R
PLoS One 2015;10(3):e0120569. Epub 2015 Mar 26 doi: 10.1371/journal.pone.0120569. PMID: 25811923Free PMC Article
Primary neuroendocrine breast cancer, how much do we know so far?
Alkaied H, Harris K, Azab B, Dai Q
Med Oncol 2012 Dec;29(4):2613-8. Epub 2012 Apr 1 doi: 10.1007/s12032-012-0222-z. PMID: 22467078

Clinical prediction guides

Analysis of 25 surgical cases of thymic neuroendocrine tumors and thymic carcinoma.
Midorikawa K, Miyahara S, Nishino N, Ueda Y, Waseda R, Shiraishi T, Sato T
J Cardiothorac Surg 2024 Apr 16;19(1):225. doi: 10.1186/s13019-024-02723-w. PMID: 38627811Free PMC Article
Neuroendocrine neoplasms of the breast: diagnostic agreement and impact on outcome.
Metovic J, Cascardi E, Uccella S, Maragliano R, Querzoli G, Osella-Abate S, Pittaro A, La Rosa S, Bogina G, Cassoni P, Marchiò C, Sapino A, Castellano I, Papotti M
Virchows Arch 2022 Dec;481(6):839-846. Epub 2022 Oct 15 doi: 10.1007/s00428-022-03426-0. PMID: 36243799Free PMC Article
PAX8 Expression in Breast Cancer.
Lu S, Yakirevich E, Hart J, Wang L, Wang Y
Appl Immunohistochem Mol Morphol 2021 Apr 1;29(4):293-298. doi: 10.1097/PAI.0000000000000883. PMID: 33208672
Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Primary neuroendocrine breast cancer, how much do we know so far?
Alkaied H, Harris K, Azab B, Dai Q
Med Oncol 2012 Dec;29(4):2613-8. Epub 2012 Apr 1 doi: 10.1007/s12032-012-0222-z. PMID: 22467078

Recent systematic reviews

Utility of KI-67 as a prognostic biomarker in pulmonary neuroendocrine neoplasms: a systematic review and meta-analysis.
Naheed S, Holden C, Tanno L, Pattini L, Pearce NW, Green B, Jaynes E, Cave J, Ottensmeier CH, Pelosi G
BMJ Open 2022 Mar 3;12(3):e041961. doi: 10.1136/bmjopen-2020-041961. PMID: 35241462Free PMC Article

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