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DNA Single Strand Break

MedGen UID:
307403
Concept ID:
C1511698
Cell or Molecular Dysfunction
Synonyms: Break, Single-Strand DNA; Break, Single-Stranded DNA; Breaks, Single-Strand DNA; Breaks, Single-Stranded DNA; DNA Break, Single-Strand; DNA Break, Single-Stranded; DNA Breaks, Single Stranded; DNA Breaks, Single-Strand; DNA Breaks, Single-Stranded; DNA Nick; DNA Nicks; Nick, DNA; Nicks, DNA; Single Strand DNA Breaks; Single Stranded DNA Break; Single Stranded DNA Breaks; Single-Strand DNA Break; Single-Strand DNA Breaks; Single-Stranded DNA Break; Single-Stranded DNA Breaks

Definition

A DNA Single Strand Break involves one or more disruptions of the covalent linkages among phosphodeoxyribose moieties within the sugar-phosphate backbone in one strand of a DNA molecule. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDNA Single Strand Break

Professional guidelines

PubMed

Catalano M, Francesco Iannone L, Cosso F, Generali D, Mini E, Roviello G
Expert Opin Ther Targets 2022 Nov;26(11):923-936. Epub 2022 Dec 22 doi: 10.1080/14728222.2022.2158813. PMID: 36519314
Mangoni M, Sottili M, Salvatore G, Campanacci D, Scoccianti G, Beltrami G, Delli Paoli C, Dominici L, Maragna V, Olmetto E, Meattini I, Desideri I, Bonomo P, Greto D, Livi L
Radiol Med 2019 Apr;124(4):282-289. Epub 2018 Mar 26 doi: 10.1007/s11547-018-0877-4. PMID: 29582320
Sandhu SK, Yap TA, de Bono JS
Curr Drug Targets 2011 Dec;12(14):2034-44. doi: 10.2174/138945011798829438. PMID: 21777194

Recent clinical studies

Etiology

Thuresson AC, Brazina J, Akram T, Albrecht J, Dahl N, Soussi Zander C, Caldecott KW
Mol Genet Genomic Med 2024 Jan;12(1):e2295. Epub 2023 Nov 2 doi: 10.1002/mgg3.2295. PMID: 37916443Free PMC Article
Sendra M, Štampar M, Fras K, Novoa B, Figueras A, Žegura B
Environ Int 2023 Jan;171:107721. Epub 2022 Dec 24 doi: 10.1016/j.envint.2022.107721. PMID: 36580735Free PMC Article
Kalasova I, Hailstone R, Bublitz J, Bogantes J, Hofmann W, Leal A, Hanzlikova H, Caldecott KW
Nucleic Acids Res 2020 Jul 9;48(12):6672-6684. doi: 10.1093/nar/gkaa489. PMID: 32504494Free PMC Article
Mangoni M, Sottili M, Salvatore G, Campanacci D, Scoccianti G, Beltrami G, Delli Paoli C, Dominici L, Maragna V, Olmetto E, Meattini I, Desideri I, Bonomo P, Greto D, Livi L
Radiol Med 2019 Apr;124(4):282-289. Epub 2018 Mar 26 doi: 10.1007/s11547-018-0877-4. PMID: 29582320
Abbotts R, Wilson DM 3rd
Free Radic Biol Med 2017 Jun;107:228-244. Epub 2016 Nov 24 doi: 10.1016/j.freeradbiomed.2016.11.039. PMID: 27890643Free PMC Article

Diagnosis

Andronikou C, Burdova K, Dibitetto D, Lieftink C, Malzer E, Kuiken HJ, Gogola E, Ray Chaudhuri A, Beijersbergen RL, Hanzlikova H, Jonkers J, Rottenberg S
EMBO J 2024 Mar;43(6):1015-1042. Epub 2024 Feb 15 doi: 10.1038/s44318-024-00043-2. PMID: 38360994Free PMC Article
Imamura R, Saito M, Shimada M, Kobayashi J, Ishiai M, Matsumoto Y
J Radiat Res 2023 May 25;64(3):485-495. doi: 10.1093/jrr/rrad007. PMID: 36940705Free PMC Article
Chalmers AJ, Lakshman M, Chan N, Bristow RG
Semin Radiat Oncol 2010 Oct;20(4):274-81. doi: 10.1016/j.semradonc.2010.06.001. PMID: 20832020
Teicher BA
Biochem Pharmacol 2008 Mar 15;75(6):1262-71. Epub 2007 Oct 22 doi: 10.1016/j.bcp.2007.10.016. PMID: 18061144
Jackson SP
Carcinogenesis 2002 May;23(5):687-96. doi: 10.1093/carcin/23.5.687. PMID: 12016139

Therapy

Plummer R
Cancer Treat Res 2023;186:1-11. doi: 10.1007/978-3-031-30065-3_1. PMID: 37978127
Derby SJ, Chalmers AJ, Carruthers RD
Semin Radiat Oncol 2022 Jan;32(1):15-28. doi: 10.1016/j.semradonc.2021.09.005. PMID: 34861992
Mei C, Lei L, Tan LM, Xu XJ, He BM, Luo C, Yin JY, Li X, Zhang W, Zhou HH, Liu ZQ
Biomed Pharmacother 2020 May;125:109875. Epub 2020 Feb 6 doi: 10.1016/j.biopha.2020.109875. PMID: 32036211
Mangoni M, Sottili M, Salvatore G, Campanacci D, Scoccianti G, Beltrami G, Delli Paoli C, Dominici L, Maragna V, Olmetto E, Meattini I, Desideri I, Bonomo P, Greto D, Livi L
Radiol Med 2019 Apr;124(4):282-289. Epub 2018 Mar 26 doi: 10.1007/s11547-018-0877-4. PMID: 29582320
Chalmers AJ, Lakshman M, Chan N, Bristow RG
Semin Radiat Oncol 2010 Oct;20(4):274-81. doi: 10.1016/j.semradonc.2010.06.001. PMID: 20832020

Prognosis

Catalano M, Francesco Iannone L, Cosso F, Generali D, Mini E, Roviello G
Expert Opin Ther Targets 2022 Nov;26(11):923-936. Epub 2022 Dec 22 doi: 10.1080/14728222.2022.2158813. PMID: 36519314
Derby SJ, Chalmers AJ, Carruthers RD
Semin Radiat Oncol 2022 Jan;32(1):15-28. doi: 10.1016/j.semradonc.2021.09.005. PMID: 34861992
Wang Z, Song Y, Li S, Kurian S, Xiang R, Chiba T, Wu X
J Biol Chem 2019 Mar 15;294(11):3909-3919. Epub 2019 Jan 17 doi: 10.1074/jbc.RA118.005188. PMID: 30655289Free PMC Article
Brosey CA, Ahmed Z, Lees-Miller SP, Tainer JA
Methods Enzymol 2017;592:417-455. Epub 2017 May 29 doi: 10.1016/bs.mie.2017.04.005. PMID: 28668129Free PMC Article
Teicher BA
Biochem Pharmacol 2008 Mar 15;75(6):1262-71. Epub 2007 Oct 22 doi: 10.1016/j.bcp.2007.10.016. PMID: 18061144

Clinical prediction guides

Catalano M, Francesco Iannone L, Cosso F, Generali D, Mini E, Roviello G
Expert Opin Ther Targets 2022 Nov;26(11):923-936. Epub 2022 Dec 22 doi: 10.1080/14728222.2022.2158813. PMID: 36519314
Derby SJ, Chalmers AJ, Carruthers RD
Semin Radiat Oncol 2022 Jan;32(1):15-28. doi: 10.1016/j.semradonc.2021.09.005. PMID: 34861992
Brosey CA, Ahmed Z, Lees-Miller SP, Tainer JA
Methods Enzymol 2017;592:417-455. Epub 2017 May 29 doi: 10.1016/bs.mie.2017.04.005. PMID: 28668129Free PMC Article
Teicher BA
Biochem Pharmacol 2008 Mar 15;75(6):1262-71. Epub 2007 Oct 22 doi: 10.1016/j.bcp.2007.10.016. PMID: 18061144
Hirano M, Yamamoto A, Mori T, Lan L, Iwamoto TA, Aoki M, Shimada K, Furiya Y, Kariya S, Asai H, Yasui A, Nishiwaki T, Imoto K, Kobayashi N, Kiriyama T, Nagata T, Konishi N, Itoyama Y, Ueno S
Ann Neurol 2007 Feb;61(2):162-74. doi: 10.1002/ana.21078. PMID: 17315206

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