U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Grade II meningioma

MedGen UID:
307517
•Concept ID:
C1512259
•
Neoplastic Process
Synonyms: Grade 2 Meningioma; grade 2 meningioma; Grade II Meningioma; grade II meningioma; WHO Grade 2 Meningioma; WHO Grade II Meningioma; WHO grade II meningioma
 
Monarch Initiative: MONDO:0045056

Definition

An atypical meningioma which may recur in approximately 29-40% of the cases. This category includes the atypical meningioma, chordoid meningioma, and clear cell meningioma. [from NCI]

Professional guidelines

PubMed

Treatment and follow-up results of WHO grade II meningiomas.
Güdük M, Ekşi MŞ, Bozkurt B, Usseli Mİ, Erşen Danyeli A, Pamir MN
J Clin Neurosci 2021 Sep;91:354-364. Epub 2021 Jul 30 doi: 10.1016/j.jocn.2021.07.022. PMID: 34373052
Review of controversies in management of non-benign meningioma.
Paldor I, Awad M, Sufaro YZ, Kaye AH, Shoshan Y
J Clin Neurosci 2016 Sep;31:37-46. Epub 2016 Jun 20 doi: 10.1016/j.jocn.2016.03.014. PMID: 27338209
An evidence-based treatment algorithm for the management of WHO Grade II and III meningiomas.
Sun SQ, Hawasli AH, Huang J, Chicoine MR, Kim AH
Neurosurg Focus 2015 Mar;38(3):E3. doi: 10.3171/2015.1.FOCUS14757. PMID: 25727225

Recent clinical studies

Etiology

Sporadic and neurofibromatosis type 2-associated meningioma in children and adolescents.
Wagener K, Beckhaus J, Boekhoff S, Friedrich C, Müller HL
J Neurooncol 2023 Jul;163(3):555-563. Epub 2023 Jul 4 doi: 10.1007/s11060-023-04344-0. PMID: 37402092
Treatment and follow-up results of WHO grade II meningiomas.
Güdük M, Ekşi MŞ, Bozkurt B, Usseli Mİ, Erşen Danyeli A, Pamir MN
J Clin Neurosci 2021 Sep;91:354-364. Epub 2021 Jul 30 doi: 10.1016/j.jocn.2021.07.022. PMID: 34373052
External beam radiation therapy for meningioma.
Chao S, Rogers L
Handb Clin Neurol 2020;170:259-278. doi: 10.1016/B978-0-12-822198-3.00046-X. PMID: 32586499
Intermediate-risk meningioma: initial outcomes from NRG Oncology RTOG 0539.
Rogers L, Zhang P, Vogelbaum MA, Perry A, Ashby LS, Modi JM, Alleman AM, Galvin J, Brachman D, Jenrette JM, De Groot J, Bovi JA, Werner-Wasik M, Knisely JPS, Mehta MP
J Neurosurg 2018 Jul;129(1):35-47. Epub 2017 Oct 6 doi: 10.3171/2016.11.JNS161170. PMID: 28984517Free PMC Article
An evidence-based treatment algorithm for the management of WHO Grade II and III meningiomas.
Sun SQ, Hawasli AH, Huang J, Chicoine MR, Kim AH
Neurosurg Focus 2015 Mar;38(3):E3. doi: 10.3171/2015.1.FOCUS14757. PMID: 25727225

Diagnosis

Sporadic and neurofibromatosis type 2-associated meningioma in children and adolescents.
Wagener K, Beckhaus J, Boekhoff S, Friedrich C, Müller HL
J Neurooncol 2023 Jul;163(3):555-563. Epub 2023 Jul 4 doi: 10.1007/s11060-023-04344-0. PMID: 37402092
External beam radiation therapy for meningioma.
Chao S, Rogers L
Handb Clin Neurol 2020;170:259-278. doi: 10.1016/B978-0-12-822198-3.00046-X. PMID: 32586499
Intermediate-risk meningioma: initial outcomes from NRG Oncology RTOG 0539.
Rogers L, Zhang P, Vogelbaum MA, Perry A, Ashby LS, Modi JM, Alleman AM, Galvin J, Brachman D, Jenrette JM, De Groot J, Bovi JA, Werner-Wasik M, Knisely JPS, Mehta MP
J Neurosurg 2018 Jul;129(1):35-47. Epub 2017 Oct 6 doi: 10.3171/2016.11.JNS161170. PMID: 28984517Free PMC Article
WHO grade II meningioma: a retrospective study for outcome and prognostic factor assessment.
Champeaux C, Wilson E, Shieff C, Khan AA, Thorne L
J Neurooncol 2016 Sep;129(2):337-45. Epub 2016 Jun 16 doi: 10.1007/s11060-016-2181-2. PMID: 27311726
An evidence-based treatment algorithm for the management of WHO Grade II and III meningiomas.
Sun SQ, Hawasli AH, Huang J, Chicoine MR, Kim AH
Neurosurg Focus 2015 Mar;38(3):E3. doi: 10.3171/2015.1.FOCUS14757. PMID: 25727225

Therapy

Sporadic and neurofibromatosis type 2-associated meningioma in children and adolescents.
Wagener K, Beckhaus J, Boekhoff S, Friedrich C, Müller HL
J Neurooncol 2023 Jul;163(3):555-563. Epub 2023 Jul 4 doi: 10.1007/s11060-023-04344-0. PMID: 37402092
Extent of resection and survival outcomes in World Health Organization grade II meningiomas.
Soni P, Davison MA, Shao J, Momin A, Lopez D, Angelov L, Barnett GH, Lee JH, Mohammadi AM, Kshettry VR, Recinos PF
J Neurooncol 2021 Jan;151(2):173-179. Epub 2020 Nov 17 doi: 10.1007/s11060-020-03632-3. PMID: 33205354
Intermediate-risk meningioma: initial outcomes from NRG Oncology RTOG 0539.
Rogers L, Zhang P, Vogelbaum MA, Perry A, Ashby LS, Modi JM, Alleman AM, Galvin J, Brachman D, Jenrette JM, De Groot J, Bovi JA, Werner-Wasik M, Knisely JPS, Mehta MP
J Neurosurg 2018 Jul;129(1):35-47. Epub 2017 Oct 6 doi: 10.3171/2016.11.JNS161170. PMID: 28984517Free PMC Article
Review of controversies in management of non-benign meningioma.
Paldor I, Awad M, Sufaro YZ, Kaye AH, Shoshan Y
J Clin Neurosci 2016 Sep;31:37-46. Epub 2016 Jun 20 doi: 10.1016/j.jocn.2016.03.014. PMID: 27338209
World Health Organization Grade II Meningioma: A 10-Year Retrospective Study for Recurrence and Prognostic Factor Assessment.
Champeaux C, Dunn L
World Neurosurg 2016 May;89:180-6. Epub 2016 Feb 2 doi: 10.1016/j.wneu.2016.01.055. PMID: 26850975

Prognosis

Treatment and follow-up results of WHO grade II meningiomas.
Güdük M, Ekşi MŞ, Bozkurt B, Usseli Mİ, Erşen Danyeli A, Pamir MN
J Clin Neurosci 2021 Sep;91:354-364. Epub 2021 Jul 30 doi: 10.1016/j.jocn.2021.07.022. PMID: 34373052
Biomarkers for differentiating grade II meningiomas from grade I: a systematic review.
Sofela AA, McGavin L, Whitfield PC, Hanemann CO
Br J Neurosurg 2021 Dec;35(6):696-702. Epub 2021 Jun 21 doi: 10.1080/02688697.2021.1940853. PMID: 34148477
Relationship between tumor location, size, and WHO grade in meningioma.
Magill ST, Young JS, Chae R, Aghi MK, Theodosopoulos PV, McDermott MW
Neurosurg Focus 2018 Apr;44(4):E4. doi: 10.3171/2018.1.FOCUS17752. PMID: 29606048
Intermediate-risk meningioma: initial outcomes from NRG Oncology RTOG 0539.
Rogers L, Zhang P, Vogelbaum MA, Perry A, Ashby LS, Modi JM, Alleman AM, Galvin J, Brachman D, Jenrette JM, De Groot J, Bovi JA, Werner-Wasik M, Knisely JPS, Mehta MP
J Neurosurg 2018 Jul;129(1):35-47. Epub 2017 Oct 6 doi: 10.3171/2016.11.JNS161170. PMID: 28984517Free PMC Article
WHO grade II meningioma: a retrospective study for outcome and prognostic factor assessment.
Champeaux C, Wilson E, Shieff C, Khan AA, Thorne L
J Neurooncol 2016 Sep;129(2):337-45. Epub 2016 Jun 16 doi: 10.1007/s11060-016-2181-2. PMID: 27311726

Clinical prediction guides

Biomarkers for differentiating grade II meningiomas from grade I: a systematic review.
Sofela AA, McGavin L, Whitfield PC, Hanemann CO
Br J Neurosurg 2021 Dec;35(6):696-702. Epub 2021 Jun 21 doi: 10.1080/02688697.2021.1940853. PMID: 34148477
Fibulin-2: A Novel Biomarker for Differentiating Grade II from Grade I Meningiomas.
Sofela AA, Hilton DA, Ammoun S, Baiz D, Adams CL, Ercolano E, Jenkinson MD, Kurian KM, Teo M, Whitfield PC, Sahm F, Hanemann CO
Int J Mol Sci 2021 Jan 8;22(2) doi: 10.3390/ijms22020560. PMID: 33429944Free PMC Article
Extent of resection and survival outcomes in World Health Organization grade II meningiomas.
Soni P, Davison MA, Shao J, Momin A, Lopez D, Angelov L, Barnett GH, Lee JH, Mohammadi AM, Kshettry VR, Recinos PF
J Neurooncol 2021 Jan;151(2):173-179. Epub 2020 Nov 17 doi: 10.1007/s11060-020-03632-3. PMID: 33205354
Relationship between tumor location, size, and WHO grade in meningioma.
Magill ST, Young JS, Chae R, Aghi MK, Theodosopoulos PV, McDermott MW
Neurosurg Focus 2018 Apr;44(4):E4. doi: 10.3171/2018.1.FOCUS17752. PMID: 29606048
World Health Organization Grade II Meningioma: A 10-Year Retrospective Study for Recurrence and Prognostic Factor Assessment.
Champeaux C, Dunn L
World Neurosurg 2016 May;89:180-6. Epub 2016 Feb 2 doi: 10.1016/j.wneu.2016.01.055. PMID: 26850975

Recent systematic reviews

Biomarkers for differentiating grade II meningiomas from grade I: a systematic review.
Sofela AA, McGavin L, Whitfield PC, Hanemann CO
Br J Neurosurg 2021 Dec;35(6):696-702. Epub 2021 Jun 21 doi: 10.1080/02688697.2021.1940853. PMID: 34148477
Prognostic significance of brain invasion in meningiomas: systematic review and meta-analysis.
Nakasu S, Nakasu Y
Brain Tumor Pathol 2021 Apr;38(2):81-95. Epub 2021 Jan 6 doi: 10.1007/s10014-020-00390-y. PMID: 33403457
Radiotherapy as an adjuvant in the management of intracranial meningiomas: are we practising evidence-based medicine?
Marcus HJ, Price SJ, Wilby M, Santarius T, Kirollos RW
Br J Neurosurg 2008 Aug;22(4):520-8. doi: 10.1080/02688690802308687. PMID: 18803079

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...