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Micrometastasis

MedGen UID:
307751
•Concept ID:
C1513276
•
Finding
Synonyms: Micrometastase, Neoplasm; Micrometastases; Micrometastases, Neoplasm; Micrometastasis, Neoplasm; Neoplasm Micrometastase; Neoplasm Micrometastases; Neoplasm Micrometastasis

Definition

Metastasis in the form of small clusters of malignant cells identifiable only under the microscope. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMicrometastasis

Professional guidelines

PubMed

Rationale of Treatment for Peritoneal Metastasis.
Yonemura Y, Ishibashi H, Mizumoto A, Fujita T, Liu Y, Wakama S, Sako S, Takao N, Kitai T, Katayama K, Kamada Y, Taniguchi K, Fujimoto D
Gan To Kagaku Ryoho 2022 Dec;49(13):1723-1726. PMID: 36732979
Nanotechnology for colorectal cancer detection and treatment.
Gogoi P, Kaur G, Singh NK
World J Gastroenterol 2022 Dec 14;28(46):6497-6511. doi: 10.3748/wjg.v28.i46.6497. PMID: 36569271Free PMC Article
The Diagnosis and Treatment of Penile Cancer.
Hakenberg OW, Dräger DL, Erbersdobler A, Naumann CM, Jünemann KP, Protzel C
Dtsch Arztebl Int 2018 Sep 28;115(39):646-652. doi: 10.3238/arztebl.2018.0646. PMID: 30375327Free PMC Article

Recent clinical studies

Etiology

Oncofertility Perspectives for Girls with Cancer.
van der Perk MEM, van der Kooi ALF, Bos AME, Broer SL, Veening MA, van Leeuwen J, van Santen HM, van Dorp W, van den Heuvel-Eibrink MM
J Pediatr Adolesc Gynecol 2022 Oct;35(5):523-526. Epub 2022 Mar 28 doi: 10.1016/j.jpag.2022.03.005. PMID: 35358705
Lymph node micrometastasis in non-small cell lung cancer.
Sun J, Wu S, Jin Z, Ren S, Cho WC, Zhu C, Shen J
Biomed Pharmacother 2022 May;149:112817. Epub 2022 Mar 15 doi: 10.1016/j.biopha.2022.112817. PMID: 35303567
Anesthetic care influences long-term outcomes: What is the evidence?
Ramirez MF, Cata JP
Best Pract Res Clin Anaesthesiol 2021 Dec;35(4):491-505. Epub 2021 Feb 3 doi: 10.1016/j.bpa.2021.01.004. PMID: 34801212
Surgery for Cancer: A Trigger for Metastases.
Tohme S, Simmons RL, Tsung A
Cancer Res 2017 Apr 1;77(7):1548-1552. Epub 2017 Mar 22 doi: 10.1158/0008-5472.CAN-16-1536. PMID: 28330928Free PMC Article
Breast cancer micrometastasis and axillary sentinel lymph nodes frozen section. Our experience and review of literature.
Sanguinetti A, Polistena A, Lucchini R, Monacelli M, Triola R, Avenia S, Barillaro I, Di Patrizi MS, Boccolini A, Conti C, Bistoni G, Avenia N
Int J Surg 2014;12 Suppl 1:S12-5. Epub 2014 May 22 doi: 10.1016/j.ijsu.2014.05.044. PMID: 24859398

Diagnosis

Lymph node micrometastasis in non-small cell lung cancer.
Sun J, Wu S, Jin Z, Ren S, Cho WC, Zhu C, Shen J
Biomed Pharmacother 2022 May;149:112817. Epub 2022 Mar 15 doi: 10.1016/j.biopha.2022.112817. PMID: 35303567
Myeloid derived suppressor cells and the release of micro-metastases from dormancy.
Khadge S, Cole K, Talmadge JE
Clin Exp Metastasis 2021 Jun;38(3):279-293. Epub 2021 May 20 doi: 10.1007/s10585-021-10098-8. PMID: 34014424Free PMC Article
Breast cancer micrometastasis and axillary sentinel lymph nodes frozen section. Our experience and review of literature.
Sanguinetti A, Polistena A, Lucchini R, Monacelli M, Triola R, Avenia S, Barillaro I, Di Patrizi MS, Boccolini A, Conti C, Bistoni G, Avenia N
Int J Surg 2014;12 Suppl 1:S12-5. Epub 2014 May 22 doi: 10.1016/j.ijsu.2014.05.044. PMID: 24859398
Micrometastasis in gastric cancer.
Zhang ZY, Ge HY
Cancer Lett 2013 Aug 9;336(1):34-45. Epub 2013 Apr 23 doi: 10.1016/j.canlet.2013.04.021. PMID: 23624301
Biomarkers in cancer micrometastasis: where are we at?
Gerges N, Jabado N
Bioanalysis 2010 May;2(5):881-99. doi: 10.4155/bio.10.49. PMID: 21083219

Therapy

A comprehensive review of pancreatic cancer and its therapeutic challenges.
Jiang S, Fagman JB, Ma Y, Liu J, Vihav C, Engstrom C, Liu B, Chen C
Aging (Albany NY) 2022 Sep 28;14(18):7635-7649. doi: 10.18632/aging.204310. PMID: 36173644Free PMC Article
Total Neoadjuvant Therapy vs Standard Therapy in Locally Advanced Rectal Cancer: A Systematic Review and Meta-analysis.
Kasi A, Abbasi S, Handa S, Al-Rajabi R, Saeed A, Baranda J, Sun W
JAMA Netw Open 2020 Dec 1;3(12):e2030097. doi: 10.1001/jamanetworkopen.2020.30097. PMID: 33326026Free PMC Article
Paget's "Seed and Soil" Theory of Cancer Metastasis: An Idea Whose Time has Come.
Akhtar M, Haider A, Rashid S, Al-Nabet ADMH
Adv Anat Pathol 2019 Jan;26(1):69-74. doi: 10.1097/PAP.0000000000000219. PMID: 30339548
Axillary dissection versus no axillary dissection in patients with sentinel-node micrometastases (IBCSG 23-01): a phase 3 randomised controlled trial.
Galimberti V, Cole BF, Zurrida S, Viale G, Luini A, Veronesi P, Baratella P, Chifu C, Sargenti M, Intra M, Gentilini O, Mastropasqua MG, Mazzarol G, Massarut S, Garbay JR, Zgajnar J, Galatius H, Recalcati A, Littlejohn D, Bamert M, Colleoni M, Price KN, Regan MM, Goldhirsch A, Coates AS, Gelber RD, Veronesi U; International Breast Cancer Study Group Trial 23-01 investigators
Lancet Oncol 2013 Apr;14(4):297-305. Epub 2013 Mar 11 doi: 10.1016/S1470-2045(13)70035-4. PMID: 23491275Free PMC Article
Feasibility of preoperative chemotherapy for locally advanced, operable colon cancer: the pilot phase of a randomised controlled trial.
Foxtrot Collaborative Group
Lancet Oncol 2012 Nov;13(11):1152-60. Epub 2012 Sep 25 doi: 10.1016/S1470-2045(12)70348-0. PMID: 23017669Free PMC Article

Prognosis

Lymph Node Mapping for Tumor Micrometastasis.
Han M, Kang R, Zhang C
ACS Biomater Sci Eng 2022 Jun 13;8(6):2307-2320. Epub 2022 May 12 doi: 10.1021/acsbiomaterials.2c00111. PMID: 35548973
Lymph node micrometastasis in non-small cell lung cancer.
Sun J, Wu S, Jin Z, Ren S, Cho WC, Zhu C, Shen J
Biomed Pharmacother 2022 May;149:112817. Epub 2022 Mar 15 doi: 10.1016/j.biopha.2022.112817. PMID: 35303567
Lymph Node Metastasis in Colorectal Cancer.
Jin M, Frankel WL
Surg Oncol Clin N Am 2018 Apr;27(2):401-412. Epub 2017 Dec 15 doi: 10.1016/j.soc.2017.11.011. PMID: 29496097
Micrometastasis in gastric cancer.
Zhang ZY, Ge HY
Cancer Lett 2013 Aug 9;336(1):34-45. Epub 2013 Apr 23 doi: 10.1016/j.canlet.2013.04.021. PMID: 23624301
Axillary dissection versus no axillary dissection in patients with sentinel-node micrometastases (IBCSG 23-01): a phase 3 randomised controlled trial.
Galimberti V, Cole BF, Zurrida S, Viale G, Luini A, Veronesi P, Baratella P, Chifu C, Sargenti M, Intra M, Gentilini O, Mastropasqua MG, Mazzarol G, Massarut S, Garbay JR, Zgajnar J, Galatius H, Recalcati A, Littlejohn D, Bamert M, Colleoni M, Price KN, Regan MM, Goldhirsch A, Coates AS, Gelber RD, Veronesi U; International Breast Cancer Study Group Trial 23-01 investigators
Lancet Oncol 2013 Apr;14(4):297-305. Epub 2013 Mar 11 doi: 10.1016/S1470-2045(13)70035-4. PMID: 23491275Free PMC Article

Clinical prediction guides

Lymph node micrometastasis in non-small cell lung cancer.
Sun J, Wu S, Jin Z, Ren S, Cho WC, Zhu C, Shen J
Biomed Pharmacother 2022 May;149:112817. Epub 2022 Mar 15 doi: 10.1016/j.biopha.2022.112817. PMID: 35303567
Lymph Node Metastasis in Colorectal Cancer.
Jin M, Frankel WL
Surg Oncol Clin N Am 2018 Apr;27(2):401-412. Epub 2017 Dec 15 doi: 10.1016/j.soc.2017.11.011. PMID: 29496097
Early stage colon cancer.
Freeman HJ
World J Gastroenterol 2013 Dec 14;19(46):8468-73. doi: 10.3748/wjg.v19.i46.8468. PMID: 24379564Free PMC Article
Micrometastasis in gastric cancer.
Zhang ZY, Ge HY
Cancer Lett 2013 Aug 9;336(1):34-45. Epub 2013 Apr 23 doi: 10.1016/j.canlet.2013.04.021. PMID: 23624301
Micrometastasis: detection methods and clinical importance.
Balic M, Williams A, Dandachi N, Cote RJ
Cancer Biomark 2010;9(1-6):397-419. doi: 10.3233/CBM-2011-0161. PMID: 22112487

Recent systematic reviews

Total Neoadjuvant Therapy vs Standard Therapy in Locally Advanced Rectal Cancer: A Systematic Review and Meta-analysis.
Kasi A, Abbasi S, Handa S, Al-Rajabi R, Saeed A, Baranda J, Sun W
JAMA Netw Open 2020 Dec 1;3(12):e2030097. doi: 10.1001/jamanetworkopen.2020.30097. PMID: 33326026Free PMC Article
Advances with pharmacotherapy for peritoneal metastasis.
Yonemura Y, Iahibashi H, Sako S, Mizumoto A, Takao N, Ichinose M, Motoi S, Liu Y, Wakama S, Kamada Y, Nishihara K
Expert Opin Pharmacother 2020 Nov;21(16):2057-2066. Epub 2020 Aug 12 doi: 10.1080/14656566.2020.1793957. PMID: 32783786
Neoadjuvant therapy or upfront surgery? A systematic review and meta-analysis of T2N0 esophageal cancer treatment options.
Mota FC, Cecconello I, Takeda FR, Tustumi F, Sallum RAA, Bernardo WM
Int J Surg 2018 Jun;54(Pt A):176-181. Epub 2018 May 3 doi: 10.1016/j.ijsu.2018.04.053. PMID: 29730075
Systematic review of the clinical significance of lymph node micrometastases of pancreatic adenocarcinoma following surgical resection.
Choi SB, Han HJ, Park P, Kim WB, Song TJ, Choi SY
Pancreatology 2017 May-Jun;17(3):342-349. Epub 2017 Mar 18 doi: 10.1016/j.pan.2017.03.008. PMID: 28336226
Recommendation for axillary lymph node dissection in women with early breast cancer and sentinel node metastasis: A systematic review and meta-analysis of randomized controlled trials using the GRADE system.
Huang TW, Kuo KN, Chen KH, Chen C, Hou WH, Lee WH, Chao TY, Tsai JT, Su CM, Huang MT, Tam KW
Int J Surg 2016 Oct;34:73-80. Epub 2016 Aug 22 doi: 10.1016/j.ijsu.2016.08.022. PMID: 27562691

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