Mixed epithelial/mesenchymal metaplastic breast carcinoma

MedGen UID:: 307769
•Concept ID:: C1513365
•: Neoplastic Process

Synonyms:	Breast Carcinosarcoma; breast carcinosarcoma; Breast Mixed Epithelial/Mesenchymal Metaplastic Carcinoma; Mixed Epithelial/Mesenchymal Metaplastic Breast Carcinoma; mixed epithelial/mesenchymal metaplastic breast carcinoma; mixed type metaplastic breast cancer

Monarch Initiative:	MONDO:0004274

Definition

An invasive breast carcinoma characterized by the presence of a mesenchymal cellular component. The mesenchymal cellular component ranges from cartilaginous and osseous, to purely sarcomatous. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVMixed epithelial/mesenchymal metaplastic breast carcinoma

Abnormality of the breast
- Abnormal breast morphology
  - Breast neoplasm
    - Breast carcinoma
      - Invasive breast carcinoma
        Metaplastic breast carcinoma
        Mixed epithelial/mesenchymal metaplastic breast carcinoma
        Breast Carcinoma with Chondroid Metaplasia
        Breast Carcinoma with Osseous Metaplasia

Recent clinical studies

Prognosis

Clinicopathologic characteristics of mixed epithelial/mesenchymal metaplastic breast carcinoma (carcinosarcoma): a meta-analysis of Chinese patients.

Xu D, Hou L
Pol J Pathol 2019;70(3):174-182. doi: 10.5114/pjp.2019.90393. PMID: 31820860

Phenotypic and molecular dissection of metaplastic breast cancer and the prognostic implications.

McCart Reed AE, Kalaw E, Nones K, Bettington M, Lim M, Bennett J, Johnstone K, Kutasovic JR, Saunus JM, Kazakoff S, Xu Q, Wood S, Holmes O, Leonard C, Reid LE, Black D, Niland C, Ferguson K, Gresshoff I, Raghavendra A, Harvey K, Cooper C, Liu C, Kalinowski L, Reid AS, Davidson M, Pearson JV, Pathmanathan N, Tse G, Papadimos D, Pathmanathan R, Harris G, Yamaguchi R, Tan PH, Fox SB, O'Toole SA, Simpson PT, Waddell N, Lakhani SR
J Pathol 2019 Feb;247(2):214-227. Epub 2018 Dec 20 doi: 10.1002/path.5184. PMID: 30350370

Carcinosarcoma of the Pancreas: Case Report With Comprehensive Literature Review.

Ruess DA, Kayser C, Neubauer J, Fichtner-Feigl S, Hopt UT, Wittel UA
Pancreas 2017 Oct;46(9):1225-1233. doi: 10.1097/MPA.0000000000000904. PMID: 28902796

Metaplastic carcinoma show different expression pattern of YAP compared to triple-negative breast cancer.

Min Kim H, Kim SK, Jung WH, Koo JS
Tumour Biol 2015 Feb;36(2):1207-12. Epub 2014 Oct 25 doi: 10.1007/s13277-014-2735-x. PMID: 25344213

Clinicopathologic features of the mixed epithelial and mesenchymal type metaplastic breast carcinoma with myoepithelial differentiation in a subset of six cases.

Yigit S, Pehlivan FS, Evcim G, Etit D
Pathol Res Pract 2012 Mar 15;208(3):147-50. Epub 2012 Feb 21 doi: 10.1016/j.prp.2011.12.014. PMID: 22361036

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