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Polysomy 10

MedGen UID:
307987
•Concept ID:
C1514213
•
Cell or Molecular Dysfunction

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPolysomy 10

Professional guidelines

PubMed

Genetic findings in treatment-naïve and proton-beam-radiated iris melanomas.
Krishna Y, Kalirai H, Thornton S, Damato BE, Heimann H, Coupland SE
Br J Ophthalmol 2016 Jul;100(7):1012-1016. Epub 2016 Apr 20 doi: 10.1136/bjophthalmol-2015-308301. PMID: 27098748
Primary sclerosing cholangitis with equivocal cytology: fluorescence in situ hybridization and serum CA 19-9 predict risk of malignancy.
Barr Fritcher EG, Voss JS, Jenkins SM, Lingineni RK, Clayton AC, Roberts LR, Halling KC, Talwalkar JA, Gores GJ, Kipp BR
Cancer Cytopathol 2013 Dec;121(12):708-17. Epub 2013 Jul 9 doi: 10.1002/cncy.21331. PMID: 23839915
Prenatal diagnosis and management of sex chromosome aneuploidy: a report on 98 cases.
Brun JL, Gangbo F, Wen ZQ, Galant K, Taine L, Maugey-Laulom B, Roux D, Mangione R, Horovitz J, Saura R
Prenat Diagn 2004 Mar;24(3):213-8. doi: 10.1002/pd.834. PMID: 15057956

Recent clinical studies

Etiology

Clinical, immunophenotypic, cytogenetic, and molecular genetic features in 117 adult patients with mixed-phenotype acute leukemia defined by WHO-2008 classification.
Yan L, Ping N, Zhu M, Sun A, Xue Y, Ruan C, Drexler HG, Macleod RA, Wu D, Chen S
Haematologica 2012 Nov;97(11):1708-12. Epub 2012 May 11 doi: 10.3324/haematol.2012.064485. PMID: 22581002Free PMC Article
Assessment of HER2 gene status in breast carcinomas with polysomy of chromosome 17.
Vranic S, Teruya B, Repertinger S, Ulmer P, Hagenkord J, Gatalica Z
Cancer 2011 Jan 1;117(1):48-53. Epub 2010 Aug 27 doi: 10.1002/cncr.25580. PMID: 20803611
Clinical significance of epidermal growth factor receptors in non-small cell lung cancer and a prognostic role for HER2 gene copy number in female patients.
Al-Saad S, Al-Shibli K, Donnem T, Andersen S, Bremnes RM, Busund LT
J Thorac Oncol 2010 Oct;5(10):1536-43. doi: 10.1097/JTO.0b013e3181ea510a. PMID: 20802349
Non-Hodgkin's lymphomas with Burkitt-like cells are associated with c-Myc amplification and poor prognosis.
Mossafa H, Damotte D, Jenabian A, Delarue R, Vincenneau A, Amouroux I, Jeandel R, Khoury E, Martelli JM, Samson T, Tapia S, Flandrin G, Troussard X
Leuk Lymphoma 2006 Sep;47(9):1885-93. doi: 10.1080/10428190600687547. PMID: 17065002
Low rates of pregnancy termination for prenatally diagnosed Klinefelter syndrome and other sex chromosome polysomies.
Meschede D, Louwen F, Nippert I, Holzgreve W, Miny P, Horst J
Am J Med Genet 1998 Dec 4;80(4):330-4. doi: 10.1002/(sici)1096-8628(19981204)80:4<330::aid-ajmg6>3.0.co;2-7. PMID: 9856559

Diagnosis

Clinical, radiological and genomic features and targeted therapy in BRAF V600E mutant adult glioblastoma.
Lim-Fat MJ, Song KW, Iorgulescu JB, Andersen BM, Forst DA, Jordan JT, Gerstner ER, Reardon DA, Wen PY, Arrillaga-Romany I
J Neurooncol 2021 May;152(3):515-522. Epub 2021 Mar 1 doi: 10.1007/s11060-021-03719-5. PMID: 33646525Free PMC Article
A clinical perspective on the 2016 WHO brain tumor classification and routine molecular diagnostics.
van den Bent MJ, Weller M, Wen PY, Kros JM, Aldape K, Chang S
Neuro Oncol 2017 May 1;19(5):614-624. doi: 10.1093/neuonc/now277. PMID: 28339700Free PMC Article
Cystic and necrotic papillary renal cell carcinoma: prognosis, morphology, immunohistochemical, and molecular-genetic profile of 10 cases.
Peckova K, Martinek P, Pivovarcikova K, Vanecek T, Alaghehbandan R, Prochazkova K, Montiel DP, Hora M, Skenderi F, Ulamec M, Rotterova P, Daum O, Ferda J, Davidson W, Ondic O, Dubova M, Michal M, Hes O
Ann Diagn Pathol 2017 Feb;26:23-30. Epub 2016 Oct 20 doi: 10.1016/j.anndiagpath.2016.10.007. PMID: 28038707
Breast cancer biomarkers and HER2 testing after 10 years of anti-HER2 therapy.
Ross JS
Drug News Perspect 2009 Mar;22(2):93-106. doi: 10.1358/dnp.2009.22.2.1334452. PMID: 19330168
Chromosomal aberrations accumulate in polyploid cells of high-grade squamous intraepithelial lesions (HSIL).
Méhes G, Speich N, Bollmann M, Bollmann R
Pathol Oncol Res 2004;10(3):142-8. Epub 2004 Sep 25 doi: 10.1007/BF03033742. PMID: 15448749

Therapy

Clinical, immunophenotypic, cytogenetic, and molecular genetic features in 117 adult patients with mixed-phenotype acute leukemia defined by WHO-2008 classification.
Yan L, Ping N, Zhu M, Sun A, Xue Y, Ruan C, Drexler HG, Macleod RA, Wu D, Chen S
Haematologica 2012 Nov;97(11):1708-12. Epub 2012 May 11 doi: 10.3324/haematol.2012.064485. PMID: 22581002Free PMC Article
Clinical significance of epidermal growth factor receptors in non-small cell lung cancer and a prognostic role for HER2 gene copy number in female patients.
Al-Saad S, Al-Shibli K, Donnem T, Andersen S, Bremnes RM, Busund LT
J Thorac Oncol 2010 Oct;5(10):1536-43. doi: 10.1097/JTO.0b013e3181ea510a. PMID: 20802349
Epidermal growth factor receptor structural alterations in gastric cancer.
Moutinho C, Mateus AR, Milanezi F, Carneiro F, Seruca R, Suriano G
BMC Cancer 2008 Jan 16;8:10. doi: 10.1186/1471-2407-8-10. PMID: 18199332Free PMC Article
Chromosomal aberrations accumulate in polyploid cells of high-grade squamous intraepithelial lesions (HSIL).
Méhes G, Speich N, Bollmann M, Bollmann R
Pathol Oncol Res 2004;10(3):142-8. Epub 2004 Sep 25 doi: 10.1007/BF03033742. PMID: 15448749
Numerical aberrations of chromosome 7 detected in 15 microns paraffin-embedded tissue sections of primary cutaneous melanomas by fluorescence in situ hybridization and confocal laser scanning microscopy.
D'Alessandro I, Zitzelsberger H, Hutzler P, Lehmann L, Braselmann H, Chimenti S, Höfler H
J Cutan Pathol 1997 Feb;24(2):70-5. doi: 10.1111/j.1600-0560.1997.tb01099.x. PMID: 9162738

Prognosis

Tetrasomy and pentasomy of the X chromosome.
Schoubben E, Decaestecker K, Quaegebeur K, Danneels L, Mortier G, Cornette L
Eur J Pediatr 2011 Oct;170(10):1325-7. Epub 2011 May 18 doi: 10.1007/s00431-011-1491-9. PMID: 21590264
Clinical significance of epidermal growth factor receptors in non-small cell lung cancer and a prognostic role for HER2 gene copy number in female patients.
Al-Saad S, Al-Shibli K, Donnem T, Andersen S, Bremnes RM, Busund LT
J Thorac Oncol 2010 Oct;5(10):1536-43. doi: 10.1097/JTO.0b013e3181ea510a. PMID: 20802349
EGFR and KRAS status of primary sarcomatoid carcinomas of the lung: implications for anti-EGFR treatment of a rare lung malignancy.
Italiano A, Cortot AB, Ilie M, Martel-Planche G, Fabas T, Pop D, Mouroux J, Hofman V, Hofman P, Pedeutour F
Int J Cancer 2009 Nov 15;125(10):2479-82. doi: 10.1002/ijc.24610. PMID: 19681124
Clinical utility of fluorescence in situ hybridization (FISH) in nonbrainstem glioblastomas of childhood.
Korshunov A, Sycheva R, Gorelyshev S, Golanov A
Mod Pathol 2005 Sep;18(9):1258-63. doi: 10.1038/modpathol.3800415. PMID: 15832192
Low rates of pregnancy termination for prenatally diagnosed Klinefelter syndrome and other sex chromosome polysomies.
Meschede D, Louwen F, Nippert I, Holzgreve W, Miny P, Horst J
Am J Med Genet 1998 Dec 4;80(4):330-4. doi: 10.1002/(sici)1096-8628(19981204)80:4<330::aid-ajmg6>3.0.co;2-7. PMID: 9856559

Clinical prediction guides

The clinical and prognostic role of ALK in glioblastoma.
Franceschi E, De Biase D, Di Nunno V, Pession A, Tosoni A, Gatto L, Tallini G, Visani M, Lodi R, Bartolini S, Brandes AA
Pathol Res Pract 2021 May;221:153447. Epub 2021 Apr 15 doi: 10.1016/j.prp.2021.153447. PMID: 33887544
Glioblastoma-derived spheroid cultures as an experimental model for analysis of EGFR anomalies.
Witusik-Perkowska M, Rieske P, Hułas-Bigoszewska K, Zakrzewska M, Stawski R, Kulczycka-Wojdala D, Bieńkowski M, Stoczyńska-Fidelus E, Grešner SM, Piaskowski S, Jaskólski DJ, Papierz W, Zakrzewski K, Kolasa M, Ironside JW, Liberski PP
J Neurooncol 2011 May;102(3):395-407. Epub 2010 Aug 29 doi: 10.1007/s11060-010-0352-0. PMID: 20803305Free PMC Article
Clinical significance of epidermal growth factor receptors in non-small cell lung cancer and a prognostic role for HER2 gene copy number in female patients.
Al-Saad S, Al-Shibli K, Donnem T, Andersen S, Bremnes RM, Busund LT
J Thorac Oncol 2010 Oct;5(10):1536-43. doi: 10.1097/JTO.0b013e3181ea510a. PMID: 20802349
Epidermal growth factor receptor expression and gene copy number in fibrolamellar hepatocellular carcinoma.
Buckley AF, Burgart LJ, Kakar S
Hum Pathol 2006 Apr;37(4):410-4. doi: 10.1016/j.humpath.2005.12.009. PMID: 16564914
Chromosomal patterns in human malignant astrocytomas.
Rey JA, Bello MJ, de Campos JM, Kusak ME, Ramos C, Benitez J
Cancer Genet Cytogenet 1987 Dec;29(2):201-21. doi: 10.1016/0165-4608(87)90232-9. PMID: 2824025

Recent systematic reviews

EGFR mutation testing on cytological and histological samples in non-small cell lung cancer: a Polish, single institution study and systematic review of European incidence.
Szumera-Ciećkiewicz A, Olszewski WT, Tysarowski A, Kowalski DM, Głogowski M, Krzakowski M, Siedlecki JA, Wągrodzki M, Prochorec-Sobieszek M
Int J Clin Exp Pathol 2013;6(12):2800-12. Epub 2013 Nov 15 PMID: 24294366Free PMC Article

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