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Testicular pure germ cell tumor

MedGen UID:
308089
•Concept ID:
C1514608
•
Neoplastic Process
Synonyms: Testicular Pure Germ Cell Tumor; testicular pure germ cell tumor; testicular Pure germ cell tumor; testicular Pure germ cell tumour
 
Monarch Initiative: MONDO:0002874

Definition

A germ cell tumor that arises from the testis and is characterized by the presence of one histologic component. This category includes seminoma, teratoma, embryonal carcinoma, yolk sac tumor, and choriocarcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTesticular pure germ cell tumor

Professional guidelines

PubMed

French AFU Cancer Committee Guidelines - Update 2022-2024: testicular germ cell cancer.
Murez T, Fléchon A, Branger N, Savoie PH, Rocher L, Camparo P, Neuville P, Ferretti L, Van Hove A, Roupret M
Prog Urol 2022 Nov;32(15):1066-1101. doi: 10.1016/j.purol.2022.09.009. PMID: 36400478
Testicular seminoma: Are clinical features and treatment outcomes any different in India?
Anjanappa M, Kumar A, Mathews S, Joseph J, Jagathnathkrishna KM, James FV
Indian J Cancer 2017 Jan-Mar;54(1):385-387. doi: 10.4103/ijc.IJC_100_17. PMID: 29199728
Testicular germ cell tumors: pathogenesis, diagnosis and treatment.
Winter C, Albers P
Nat Rev Endocrinol 2011 Jan;7(1):43-53. Epub 2010 Nov 30 doi: 10.1038/nrendo.2010.196. PMID: 21116298

Recent clinical studies

Etiology

French AFU Cancer Committee Guidelines - Update 2022-2024: testicular germ cell cancer.
Murez T, Fléchon A, Branger N, Savoie PH, Rocher L, Camparo P, Neuville P, Ferretti L, Van Hove A, Roupret M
Prog Urol 2022 Nov;32(15):1066-1101. doi: 10.1016/j.purol.2022.09.009. PMID: 36400478
Ovarian germ cell tumour classification: views from the testis.
Berney DM, Stoneham S, Arora R, Shamash J, Lockley M
Histopathology 2020 Jan;76(1):25-36. doi: 10.1111/his.14016. PMID: 31846529
Pathogenesis of Testicular Germ Cell Neoplasia: A Conceptual Approach.
Baraban EG, Cooper K
Adv Anat Pathol 2019 Jul;26(4):241-245. doi: 10.1097/PAP.0000000000000233. PMID: 30950848
Current urologic care for testicular germ cell tumors in pediatric and adolescent patients.
Grantham EC, Caldwell BT, Cost NG
Urol Oncol 2016 Feb;34(2):65-75. Epub 2015 Jul 15 doi: 10.1016/j.urolonc.2015.06.008. PMID: 26187598
Testicular germ cell tumors: pathogenesis, diagnosis and treatment.
Winter C, Albers P
Nat Rev Endocrinol 2011 Jan;7(1):43-53. Epub 2010 Nov 30 doi: 10.1038/nrendo.2010.196. PMID: 21116298

Diagnosis

Pure post-pubertal yolk sac tumor of the testis: An extremely rare and aggressive entity.
Patel S, Satturwar S, Khan W, Ashman D, Quiroga-Garza GM
Ann Diagn Pathol 2023 Apr;63:152086. Epub 2022 Dec 23 doi: 10.1016/j.anndiagpath.2022.152086. PMID: 36580878
French AFU Cancer Committee Guidelines - Update 2022-2024: testicular germ cell cancer.
Murez T, Fléchon A, Branger N, Savoie PH, Rocher L, Camparo P, Neuville P, Ferretti L, Van Hove A, Roupret M
Prog Urol 2022 Nov;32(15):1066-1101. doi: 10.1016/j.purol.2022.09.009. PMID: 36400478
Pathogenesis of Testicular Germ Cell Neoplasia: A Conceptual Approach.
Baraban EG, Cooper K
Adv Anat Pathol 2019 Jul;26(4):241-245. doi: 10.1097/PAP.0000000000000233. PMID: 30950848
Serum tumor markers and testicular germ cell tumors: a primer for radiologists.
Marshall C, Enzerra M, Rahnemai-Azar AA, Ramaiya NH
Abdom Radiol (NY) 2019 Mar;44(3):1083-1090. doi: 10.1007/s00261-018-1846-z. PMID: 30539249
Testicular germ cell tumors: pathogenesis, diagnosis and treatment.
Winter C, Albers P
Nat Rev Endocrinol 2011 Jan;7(1):43-53. Epub 2010 Nov 30 doi: 10.1038/nrendo.2010.196. PMID: 21116298

Therapy

Subsets of preoperative sex hormones in testicular germ cell cancer: a retrospective multicenter study.
Törzsök P, Oswald D, Dieckmann KP, Angerer M, Scherer LC, Tymoszuk P, Kunz Y, Pinggera GM, Lusuardi L, Horninger W, Pichler R
Sci Rep 2023 Sep 5;13(1):14604. doi: 10.1038/s41598-023-41915-7. PMID: 37669975Free PMC Article
French AFU Cancer Committee Guidelines - Update 2022-2024: testicular germ cell cancer.
Murez T, Fléchon A, Branger N, Savoie PH, Rocher L, Camparo P, Neuville P, Ferretti L, Van Hove A, Roupret M
Prog Urol 2022 Nov;32(15):1066-1101. doi: 10.1016/j.purol.2022.09.009. PMID: 36400478
Outcomes and prognostic variables of extracranial germ cell tumors in children and adolescents treated over a decade: A developing world perspective.
Ramanathan S, Prasad M, Vora T, Parambil BC, Kembhavi S, Ramadwar M, Khanna N, Laskar S, Kurkure P, Qureshi S, Banavali S, Chinnaswamy G
Pediatr Blood Cancer 2022 Jul;69(7):e29765. Epub 2022 May 13 doi: 10.1002/pbc.29765. PMID: 35561025
The Role of Postchemotherapy Surgery in Germ Cell Tumors.
Chéry L, Dash A
Urol Clin North Am 2015 Aug;42(3):331-42. Epub 2015 Jun 19 doi: 10.1016/j.ucl.2015.04.007. PMID: 26216820
Adult and pediatric testicular teratoma.
Carver BS, Al-Ahmadie H, Sheinfeld J
Urol Clin North Am 2007 May;34(2):245-51; abstract x. doi: 10.1016/j.ucl.2007.02.013. PMID: 17484929

Prognosis

Subsets of preoperative sex hormones in testicular germ cell cancer: a retrospective multicenter study.
Törzsök P, Oswald D, Dieckmann KP, Angerer M, Scherer LC, Tymoszuk P, Kunz Y, Pinggera GM, Lusuardi L, Horninger W, Pichler R
Sci Rep 2023 Sep 5;13(1):14604. doi: 10.1038/s41598-023-41915-7. PMID: 37669975Free PMC Article
French AFU Cancer Committee Guidelines - Update 2022-2024: testicular germ cell cancer.
Murez T, Fléchon A, Branger N, Savoie PH, Rocher L, Camparo P, Neuville P, Ferretti L, Van Hove A, Roupret M
Prog Urol 2022 Nov;32(15):1066-1101. doi: 10.1016/j.purol.2022.09.009. PMID: 36400478
Serum tumor markers and testicular germ cell tumors: a primer for radiologists.
Marshall C, Enzerra M, Rahnemai-Azar AA, Ramaiya NH
Abdom Radiol (NY) 2019 Mar;44(3):1083-1090. doi: 10.1007/s00261-018-1846-z. PMID: 30539249
The present and future of serum diagnostic tests for testicular germ cell tumours.
Murray MJ, Huddart RA, Coleman N
Nat Rev Urol 2016 Dec;13(12):715-725. Epub 2016 Oct 18 doi: 10.1038/nrurol.2016.170. PMID: 27754472
MicroRNAs in testicular cancer: implications for pathogenesis, diagnosis, prognosis and therapy.
Bezan A, Gerger A, Pichler M
Anticancer Res 2014 Jun;34(6):2709-13. PMID: 24922631

Clinical prediction guides

SOX2 and PRAME in the "reprogramming" of seminoma cells.
Orsatti A, Sirolli M, Ambrosi F, Franceschini T, Giunchi F, Franchini E, Grillini M, Massari F, Mollica V, Bianchi FM, Colecchia M, Fiorentino M, Ricci C
Pathol Res Pract 2022 Sep;237:154044. Epub 2022 Jul 28 doi: 10.1016/j.prp.2022.154044. PMID: 35930824
Primary intracranial pure endodermal sinus tumor: A retrospective series of 6 cases in a single center and a systematic review of overall survival.
Raynald, Yang H, Zhang X, Ma'ruf L, Li C, Jiang T
Neurochirurgie 2021 Nov;67(6):587-598. Epub 2021 Mar 19 doi: 10.1016/j.neuchi.2021.02.014. PMID: 33753128
Detection of Circulating Tumor Cells (CTCs) in Patients with Testicular Germ Cell Tumors.
Nastały P, Honecker F, Pantel K, Riethdorf S
Methods Mol Biol 2021;2195:245-261. doi: 10.1007/978-1-0716-0860-9_16. PMID: 32852768
K-RAS and N-RAS mutations in testicular germ cell tumors.
Hacioglu BM, Kodaz H, Erdogan B, Cinkaya A, Tastekin E, Hacibekiroglu I, Turkmen E, Kostek O, Genc E, Uzunoglu S, Cicin I
Bosn J Basic Med Sci 2017 May 20;17(2):159-163. doi: 10.17305/bjbms.2017.1764. PMID: 28426398Free PMC Article
Testicular microlithiasis: prevalence and association with primary testicular neoplasm.
Heller HT, Oliff MC, Doubilet PM, O'Leary MP, Benson CB
J Clin Ultrasound 2014 Sep;42(7):423-6. Epub 2014 Feb 28 doi: 10.1002/jcu.22144. PMID: 24585495

Recent systematic reviews

Testicular germ cell tumours' clinical stage I: comparison of surveillance with adjuvant treatment strategies regarding recurrence rates and overall survival-a systematic review.
Ruf CG, Schmidt S, Kliesch S, Oing C, Pfister D, Busch J, Heinzelbecker J, Winter C, Zengerling F, Albers P, Oechsle K, Krege S, Lackner J, Dieckmann KP
World J Urol 2022 Dec;40(12):2889-2900. Epub 2022 Sep 15 doi: 10.1007/s00345-022-04145-6. PMID: 36107211Free PMC Article
Prognostic factors in patients with clinical stage I nonseminoma-beyond lymphovascular invasion: a systematic review.
Zengerling F, Beyersdorff D, Busch J, Heinzelbecker J, Pfister D, Ruf C, Winter C, Albers P, Kliesch S, Schmidt S
World J Urol 2022 Dec;40(12):2879-2887. Epub 2022 Jul 29 doi: 10.1007/s00345-022-04063-7. PMID: 35906286Free PMC Article
Primary intracranial pure endodermal sinus tumor: A retrospective series of 6 cases in a single center and a systematic review of overall survival.
Raynald, Yang H, Zhang X, Ma'ruf L, Li C, Jiang T
Neurochirurgie 2021 Nov;67(6):587-598. Epub 2021 Mar 19 doi: 10.1016/j.neuchi.2021.02.014. PMID: 33753128

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