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del(11q23)

MedGen UID:
308328
•Concept ID:
C1515576
•
Cell or Molecular Dysfunction
Synonyms: 11q23 Deletion; del(11)(q23)

Definition

A cytogenetic abnormality that refers to the deletion of the chromosomal band 11q23. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVdel(11q23)

Professional guidelines

PubMed

11q23 balanced chromosome aberrations in treatment-related myelodysplastic syndromes and acute leukemia: report from an international workshop.
Bloomfield CD, Archer KJ, Mrózek K, Lillington DM, Kaneko Y, Head DR, Dal Cin P, Raimondi SC
Genes Chromosomes Cancer 2002 Apr;33(4):362-78. doi: 10.1002/gcc.10046. PMID: 11921271
Early secondary acute myelogenous leukemia in breast cancer patients after treatment with mitoxantrone, cyclophosphamide, fluorouracil and radiation therapy.
Linassier C, Barin C, Calais G, Letortorec S, Brémond JL, Delain M, Petit A, Georget MT, Cartron G, Raban N, Benboubker L, Leloup R, Binet C, Lamagnère JP, Colombat P
Ann Oncol 2000 Oct;11(10):1289-94. doi: 10.1023/a:1008375016038. PMID: 11106118
Correlation of cytogenetic results with immunophenotype, genotype, clinical features, and ras mutation in acute myeloid leukemia. A study of 235 Chinese patients in Taiwan.
Tien HF, Wang CH, Lin MT, Lee FY, Liu MC, Chuang SM, Chen YC, Shen MC, Lin KH, Lin DT
Cancer Genet Cytogenet 1995 Oct 1;84(1):60-8. doi: 10.1016/0165-4608(95)00084-4. PMID: 7497445

Recent clinical studies

Etiology

Deep sequencing identifies genetic heterogeneity and recurrent convergent evolution in chronic lymphocytic leukemia.
Ojha J, Ayres J, Secreto C, Tschumper R, Rabe K, Van Dyke D, Slager S, Shanafelt T, Fonseca R, Kay NE, Braggio E
Blood 2015 Jan 15;125(3):492-8. Epub 2014 Nov 6 doi: 10.1182/blood-2014-06-580563. PMID: 25377784Free PMC Article
Comprehensive assessment of prognostic factors predicting outcome in Chinese patients with chronic lymphocytic leukemia treated with fludarabine and cyclophosphamide.
Xu M, Fan L, Miao KR, Liu P, Xu W, Li JY
Med Oncol 2012 Sep;29(3):2102-10. Epub 2011 Sep 1 doi: 10.1007/s12032-011-0054-2. PMID: 21881978
Acute myeloid leukemia of donor origin after allogeneic stem cell transplantation from a sibling who harbors germline XPD and XRCC3 homozygous polymorphisms.
Diamond HR, Ornellas MH, Orfao A, Gomes BE, Campos MM, Fernandez TS, da Silva RI, Alves G, Lage C, da Silva DA, Moellmann-Coelho A, da Cruz GS, Bouzas LF, Abdelhay E
J Hematol Oncol 2011 Sep 27;4:39. doi: 10.1186/1756-8722-4-39. PMID: 21951951Free PMC Article
Clonal evolution in chronic lymphocytic leukemia: acquisition of high-risk genomic aberrations associated with unmutated VH, resistance to therapy, and short survival.
Stilgenbauer S, Sander S, Bullinger L, Benner A, Leupolt E, Winkler D, Kröber A, Kienle D, Lichter P, Döhner H
Haematologica 2007 Sep;92(9):1242-5. Epub 2007 Aug 1 doi: 10.3324/haematol.10720. PMID: 17666364
Severe TMD/AMKL with GATA1 mutation in a stillborn fetus with Down syndrome.
Heald B, Hilden JM, Zbuk K, Norton A, Vyas P, Theil KS, Eng C
Nat Clin Pract Oncol 2007 Jul;4(7):433-8. doi: 10.1038/ncponc0876. PMID: 17597708

Diagnosis

Deep sequencing identifies genetic heterogeneity and recurrent convergent evolution in chronic lymphocytic leukemia.
Ojha J, Ayres J, Secreto C, Tschumper R, Rabe K, Van Dyke D, Slager S, Shanafelt T, Fonseca R, Kay NE, Braggio E
Blood 2015 Jan 15;125(3):492-8. Epub 2014 Nov 6 doi: 10.1182/blood-2014-06-580563. PMID: 25377784Free PMC Article
Clinical and laboratory prognostic indicators in chronic lymphocytic leukemia.
Sagatys EM, Zhang L
Cancer Control 2012 Jan;19(1):18-25. doi: 10.1177/107327481201900103. PMID: 22143059
Severe TMD/AMKL with GATA1 mutation in a stillborn fetus with Down syndrome.
Heald B, Hilden JM, Zbuk K, Norton A, Vyas P, Theil KS, Eng C
Nat Clin Pract Oncol 2007 Jul;4(7):433-8. doi: 10.1038/ncponc0876. PMID: 17597708
Comparison of cytogenetics with FISH in 40 myelodysplastic syndrome patients.
Romeo M, Chauffaille Mde L, Silva MR, Bahia DM, Kerbauy J
Leuk Res 2002 Nov;26(11):993-6. doi: 10.1016/s0145-2126(02)00047-4. PMID: 12363467
Hematological malignancies with a deletion of 11q23: cytogenetic and clinical aspects. European 11q23 Workshop participants.
Harbott J, Mancini M, Verellen-Dumoulin C, Moorman AV, Secker-Walker LM
Leukemia 1998 May;12(5):823-7. doi: 10.1038/sj.leu.2401018. PMID: 9593287

Therapy

Comprehensive assessment of prognostic factors predicting outcome in Chinese patients with chronic lymphocytic leukemia treated with fludarabine and cyclophosphamide.
Xu M, Fan L, Miao KR, Liu P, Xu W, Li JY
Med Oncol 2012 Sep;29(3):2102-10. Epub 2011 Sep 1 doi: 10.1007/s12032-011-0054-2. PMID: 21881978
Acute myeloid leukemia of donor origin after allogeneic stem cell transplantation from a sibling who harbors germline XPD and XRCC3 homozygous polymorphisms.
Diamond HR, Ornellas MH, Orfao A, Gomes BE, Campos MM, Fernandez TS, da Silva RI, Alves G, Lage C, da Silva DA, Moellmann-Coelho A, da Cruz GS, Bouzas LF, Abdelhay E
J Hematol Oncol 2011 Sep 27;4:39. doi: 10.1186/1756-8722-4-39. PMID: 21951951Free PMC Article
Donor leukemia following allogeneic bone marrow transplantation.
Mc Cann SR, Lawler M, Gardiner N, O'Riordan J, Humphries P, De Arce M
Leukemia 1994 Apr;8 Suppl 1:S133-5. PMID: 8152280

Prognosis

Deep sequencing identifies genetic heterogeneity and recurrent convergent evolution in chronic lymphocytic leukemia.
Ojha J, Ayres J, Secreto C, Tschumper R, Rabe K, Van Dyke D, Slager S, Shanafelt T, Fonseca R, Kay NE, Braggio E
Blood 2015 Jan 15;125(3):492-8. Epub 2014 Nov 6 doi: 10.1182/blood-2014-06-580563. PMID: 25377784Free PMC Article
Clinical and laboratory prognostic indicators in chronic lymphocytic leukemia.
Sagatys EM, Zhang L
Cancer Control 2012 Jan;19(1):18-25. doi: 10.1177/107327481201900103. PMID: 22143059
Comprehensive assessment of prognostic factors predicting outcome in Chinese patients with chronic lymphocytic leukemia treated with fludarabine and cyclophosphamide.
Xu M, Fan L, Miao KR, Liu P, Xu W, Li JY
Med Oncol 2012 Sep;29(3):2102-10. Epub 2011 Sep 1 doi: 10.1007/s12032-011-0054-2. PMID: 21881978
Comparison of cytogenetics with FISH in 40 myelodysplastic syndrome patients.
Romeo M, Chauffaille Mde L, Silva MR, Bahia DM, Kerbauy J
Leuk Res 2002 Nov;26(11):993-6. doi: 10.1016/s0145-2126(02)00047-4. PMID: 12363467
Hematological malignancies with a deletion of 11q23: cytogenetic and clinical aspects. European 11q23 Workshop participants.
Harbott J, Mancini M, Verellen-Dumoulin C, Moorman AV, Secker-Walker LM
Leukemia 1998 May;12(5):823-7. doi: 10.1038/sj.leu.2401018. PMID: 9593287

Clinical prediction guides

Clinical and laboratory prognostic indicators in chronic lymphocytic leukemia.
Sagatys EM, Zhang L
Cancer Control 2012 Jan;19(1):18-25. doi: 10.1177/107327481201900103. PMID: 22143059
Comprehensive assessment of prognostic factors predicting outcome in Chinese patients with chronic lymphocytic leukemia treated with fludarabine and cyclophosphamide.
Xu M, Fan L, Miao KR, Liu P, Xu W, Li JY
Med Oncol 2012 Sep;29(3):2102-10. Epub 2011 Sep 1 doi: 10.1007/s12032-011-0054-2. PMID: 21881978
Clonal evolution in chronic lymphocytic leukemia: acquisition of high-risk genomic aberrations associated with unmutated VH, resistance to therapy, and short survival.
Stilgenbauer S, Sander S, Bullinger L, Benner A, Leupolt E, Winkler D, Kröber A, Kienle D, Lichter P, Döhner H
Haematologica 2007 Sep;92(9):1242-5. Epub 2007 Aug 1 doi: 10.3324/haematol.10720. PMID: 17666364

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