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Cervical adenosarcoma

MedGen UID:
308948
Concept ID:
C1516426
Neoplastic Process
Synonyms: Adenosarcoma of cervix uteri; adenosarcoma of the cervix uteri; Adenosarcoma of the cervix uteri; adenosarcoma of uterine cervix; Cervical Adenosarcoma; cervical adenosarcoma; cervical Muellerian adenosarcoma; Cervical Mullerian Adenosarcoma; cervical Mullerian adenosarcoma; Cervical Müllerian Adenosarcoma; cervical Müllerian adenosarcoma; uterine cervix adenosarcoma
SNOMED CT: Adenosarcoma of cervix uteri (764847000); Cervical adenosarcoma (764847000)
 
Monarch Initiative: MONDO:0002876
Orphanet: ORPHA213792

Definition

A rare subtype of malignant mixed epithelial and mesenchymal tumor composed of benign or mildly atypical glandular elements and a surrounding low-grade malignant stroma, often containing heterologous elements, such as areas of sex-cord-like or smooth muscle differentiation. It usually presents with vaginal bleeding or discharge, lower abdominal pain and/or a cervical mass or polyp. The tumor may arise from pre-existing endometriosis and patients may have a history of recurrent cervical polyps. [from ORDO]

Professional guidelines

PubMed

Devins KM, Young RH, Ghioni M, Burandt E, Bennett JA, Oliva E
Am J Surg Pathol 2022 Nov 1;46(11):1477-1489. Epub 2022 Aug 9 doi: 10.1097/PAS.0000000000001933. PMID: 35941719
Han LM, Weiel JJ, Longacre TA, Folkins AK
Adv Anat Pathol 2022 Sep 1;29(5):297-308. Epub 2022 Jul 1 doi: 10.1097/PAP.0000000000000351. PMID: 35778792
Chin PS, Chia YN, Lim YK, Yam KL
Int J Gynaecol Obstet 2013 Jun;121(3):229-32. Epub 2013 Mar 13 doi: 10.1016/j.ijgo.2012.12.015. PMID: 23490428

Recent clinical studies

Etiology

Yuan Z, Cao D, Yu M, Shen K, He Y
Oncologist 2019 Sep;24(9):e870-e879. Epub 2019 May 24 doi: 10.1634/theoncologist.2018-0791. PMID: 31127022Free PMC Article
Jones MW, Lefkowitz M
Int J Gynecol Pathol 1995 Jul;14(3):223-9. doi: 10.1097/00004347-199507000-00005. PMID: 8600073

Diagnosis

Chen JW, Huang YJ, Wang LL, Liu JJ, Shi MM, Li N
BMC Womens Health 2024 May 23;24(1):308. doi: 10.1186/s12905-024-03140-w. PMID: 38783282Free PMC Article
Ruiz-Echeverría FR, Beltrán-Salazar MI, Caicedo-Páez LM, Palencia-Palacios M, Salazar-Silva C, Viveros-Carreño D
Rev Colomb Obstet Ginecol 2023 Sep 30;74(3):225-236. doi: 10.18597/rcog.4011. PMID: 37937912Free PMC Article
Toyoda S, Sado T, Ito F, Taniguchi M, Kita T
Cytopathology 2022 May;33(3):409-411. Epub 2021 Dec 21 doi: 10.1111/cyt.13088. PMID: 34890128
Frías-Sánchez Z, Pantoja-Garrido M, Gutiérrez-Domingo Á, Jiménez-Gallardo J, Polo-Velasco A, Rodríguez-Jiménez I
Rev Colomb Obstet Ginecol 2019 Jun;70(2):122-128. doi: 10.18597/rcog.3258. PMID: 31613077
Jones MW, Lefkowitz M
Int J Gynecol Pathol 1995 Jul;14(3):223-9. doi: 10.1097/00004347-199507000-00005. PMID: 8600073

Prognosis

Ruiz-Echeverría FR, Beltrán-Salazar MI, Caicedo-Páez LM, Palencia-Palacios M, Salazar-Silva C, Viveros-Carreño D
Rev Colomb Obstet Ginecol 2023 Sep 30;74(3):225-236. doi: 10.18597/rcog.4011. PMID: 37937912Free PMC Article
Yuan Z, Cao D, Yu M, Shen K, He Y
Oncologist 2019 Sep;24(9):e870-e879. Epub 2019 May 24 doi: 10.1634/theoncologist.2018-0791. PMID: 31127022Free PMC Article
Buyukkurt S, Guzel AB, Gumurdulu D, Vardar MA, Zeren H, Sucu M
J Pediatr Adolesc Gynecol 2010 Feb;23(1):e13-5. Epub 2009 Jul 29 doi: 10.1016/j.jpag.2009.05.008. PMID: 19643645
Jones MW, Lefkowitz M
Int J Gynecol Pathol 1995 Jul;14(3):223-9. doi: 10.1097/00004347-199507000-00005. PMID: 8600073
Gal D, Kerner H, Beck D, Peretz BA, Eyal A, Paldi E
Gynecol Oncol 1988 Nov;31(3):445-53. doi: 10.1016/s0090-8258(88)80030-1. PMID: 2846415

Clinical prediction guides

Amant F, Schurmans K, Steenkiste E, Verbist L, Abeler VM, Tulunay G, De Jonge E, Massuger L, Moerman P, Vergote I
Gynecol Oncol 2004 Jun;93(3):680-5. doi: 10.1016/j.ygyno.2004.03.021. PMID: 15196864

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