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Clonal BCL2 Gene Rearrangement

MedGen UID:
309013
•Concept ID:
C1516664
•
Cell or Molecular Dysfunction
Synonyms: Clonal BCL-2 Gene Rearrangement; Monoclonal BCL-2 Gene Rearrangement

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVClonal BCL2 Gene Rearrangement

Professional guidelines

PubMed

Hepatitis C virus-associated mixed cryoglobulinemia. Clinical manifestations, histopathological changes, mechanisms of cryoprecipitation and options of treatment.
Schott P, Hartmann H, Ramadori G
Histol Histopathol 2001 Oct;16(4):1275-85. doi: 10.14670/HH-16.1275. PMID: 11642746
Follicular lymphoma with involvement of the splenic marginal zone: a pitfall in the differential diagnosis of splenic marginal zone cell lymphoma.
Alkan S, Ross CW, Hanson CA, Schnitzer B
Hum Pathol 1996 May;27(5):503-6. doi: 10.1016/s0046-8177(96)90093-3. PMID: 8621189
Bcl-2 oncoprotein is widespread in lymphoid tissue and lymphomas but its differential expression in benign versus malignant follicles and monocytoid B-cell proliferations is of diagnostic value.
Wang T, Lasota J, Hanau CA, Miettinen M
APMIS 1995 Sep;103(9):655-62. doi: 10.1111/j.1699-0463.1995.tb01419.x. PMID: 7488387

Recent clinical studies

Etiology

Tracing Founder Mutations in Circulating and Tissue-Resident Follicular Lymphoma Precursors.
Schroers-Martin JG, Soo J, Brisou G, Scherer F, Kurtz DM, Sworder BJ, Khodadoust MS, Jin MC, Bru A, Liu CL, Stehr H, Vineis P; EPIC Consortium, Natkunam Y, Teras LR, Song JY, Nadel B, Diehn M, Roulland S, Alizadeh AA
Cancer Discov 2023 Jun 2;13(6):1310-1323. doi: 10.1158/2159-8290.CD-23-0111. PMID: 36939219Free PMC Article
Morphologic and molecular analysis of Richter syndrome in chronic lymphocytic leukaemia patients treated with ibrutinib or venetoclax.
Gángó A, Kiss R, Farkas P, Hanna E, Demeter J, Deák B, Lévai D, Kotmayer L, Alpár D, Matolcsy A, Bödör C, Mátrai Z, Timár B
Pathology 2022 Feb;54(1):95-103. Epub 2021 Jul 28 doi: 10.1016/j.pathol.2021.04.008. PMID: 34332791
New developments in non-Hodgkin lymphoid malignancies.
Ganapathi KA, Brown LE, Prakash S, Bhargava P
Pathology 2021 Apr;53(3):349-366. Epub 2021 Mar 5 doi: 10.1016/j.pathol.2021.01.002. PMID: 33685720
Anaplastic large cell lymphoma, ALK-negative.
Ferreri AJ, Govi S, Pileri SA, Savage KJ
Crit Rev Oncol Hematol 2013 Feb;85(2):206-15. Epub 2012 Jul 11 doi: 10.1016/j.critrevonc.2012.06.004. PMID: 22789917
Molecular aspects of multiple myeloma.
Kastrinakis NG, Gorgoulis VG, Foukas PG, Dimopoulos MA, Kittas C
Ann Oncol 2000 Oct;11(10):1217-28. doi: 10.1023/a:1008331714186. PMID: 11106109

Diagnosis

Tracing Founder Mutations in Circulating and Tissue-Resident Follicular Lymphoma Precursors.
Schroers-Martin JG, Soo J, Brisou G, Scherer F, Kurtz DM, Sworder BJ, Khodadoust MS, Jin MC, Bru A, Liu CL, Stehr H, Vineis P; EPIC Consortium, Natkunam Y, Teras LR, Song JY, Nadel B, Diehn M, Roulland S, Alizadeh AA
Cancer Discov 2023 Jun 2;13(6):1310-1323. doi: 10.1158/2159-8290.CD-23-0111. PMID: 36939219Free PMC Article
New developments in non-Hodgkin lymphoid malignancies.
Ganapathi KA, Brown LE, Prakash S, Bhargava P
Pathology 2021 Apr;53(3):349-366. Epub 2021 Mar 5 doi: 10.1016/j.pathol.2021.01.002. PMID: 33685720
Novel markers in pediatric-type follicular lymphoma.
Agostinelli C, Akarca AU, Ramsay A, Rizvi H, Rodriguez-Justo M, Pomplun S, Proctor I, Sabattini E, Linch D, Daw S, Pittaluga S, Pileri SA, Jaffe ES, Quintanilla-Martinez L, Marafioti T
Virchows Arch 2019 Dec;475(6):771-779. Epub 2019 Nov 4 doi: 10.1007/s00428-019-02681-y. PMID: 31686194Free PMC Article
Anaplastic large cell lymphoma, ALK-negative.
Ferreri AJ, Govi S, Pileri SA, Savage KJ
Crit Rev Oncol Hematol 2013 Feb;85(2):206-15. Epub 2012 Jul 11 doi: 10.1016/j.critrevonc.2012.06.004. PMID: 22789917
Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936.
van Dongen JJ, Langerak AW, Brüggemann M, Evans PA, Hummel M, Lavender FL, Delabesse E, Davi F, Schuuring E, García-Sanz R, van Krieken JH, Droese J, González D, Bastard C, White HE, Spaargaren M, González M, Parreira A, Smith JL, Morgan GJ, Kneba M, Macintyre EA
Leukemia 2003 Dec;17(12):2257-317. doi: 10.1038/sj.leu.2403202. PMID: 14671650

Therapy

Morphologic and molecular analysis of Richter syndrome in chronic lymphocytic leukaemia patients treated with ibrutinib or venetoclax.
Gángó A, Kiss R, Farkas P, Hanna E, Demeter J, Deák B, Lévai D, Kotmayer L, Alpár D, Matolcsy A, Bödör C, Mátrai Z, Timár B
Pathology 2022 Feb;54(1):95-103. Epub 2021 Jul 28 doi: 10.1016/j.pathol.2021.04.008. PMID: 34332791
Classical Hodgkin Lymphoma Arising Adjacent to a Breast Implant.
Ryan C, Ged Y, Quinn F, Walker J, Kennedy J, Gillham C, Pittaluga S, McDermott R, Vandenberghe E, Grant C, Flavin R
Int J Surg Pathol 2016 Aug;24(5):448-55. Epub 2016 Feb 16 doi: 10.1177/1066896916632587. PMID: 26888955
Anaplastic large cell lymphoma, ALK-negative.
Ferreri AJ, Govi S, Pileri SA, Savage KJ
Crit Rev Oncol Hematol 2013 Feb;85(2):206-15. Epub 2012 Jul 11 doi: 10.1016/j.critrevonc.2012.06.004. PMID: 22789917
T-cell-rich B-cell lymphoma. A clinicopathologic study of eight cases.
Baddoura FK, Chan WC, Masih AS, Mitchell D, Sun NC, Weisenburger DD
Am J Clin Pathol 1995 Jan;103(1):65-75. doi: 10.1093/ajcp/103.1.65. PMID: 7817948
Recent results on the biology of Hodgkin and Reed-Sternberg cells. I. Biopsy material.
Drexler HG
Leuk Lymphoma 1992 Nov;8(4-5):283-313. doi: 10.3109/10428199209051008. PMID: 1337848

Prognosis

Morphologic and molecular analysis of Richter syndrome in chronic lymphocytic leukaemia patients treated with ibrutinib or venetoclax.
Gángó A, Kiss R, Farkas P, Hanna E, Demeter J, Deák B, Lévai D, Kotmayer L, Alpár D, Matolcsy A, Bödör C, Mátrai Z, Timár B
Pathology 2022 Feb;54(1):95-103. Epub 2021 Jul 28 doi: 10.1016/j.pathol.2021.04.008. PMID: 34332791
Anaplastic large cell lymphoma, ALK-negative.
Ferreri AJ, Govi S, Pileri SA, Savage KJ
Crit Rev Oncol Hematol 2013 Feb;85(2):206-15. Epub 2012 Jul 11 doi: 10.1016/j.critrevonc.2012.06.004. PMID: 22789917
Primary cutaneous marginal zone B-cell lymphoma.
Cho-Vega JH, Vega F, Rassidakis G, Medeiros LJ
Am J Clin Pathol 2006 Jun;125 Suppl:S38-49. doi: 10.1309/CVFYBQNMX1PKNAA7. PMID: 16830956
Reliable detection of clonal IgH/Bcl2 MBR rearrangement in follicular lymphoma: methodology and clinical significance.
Iqbal S, Jenner MJ, Summers KE, Davies AJ, Matthews J, Norton AJ, Calaminici M, Rohatiner AZ, Fitzgibbon J, Lister TA, Goff LK
Br J Haematol 2004 Feb;124(3):325-8. doi: 10.1046/j.1365-2141.2003.04796.x. PMID: 14717779
Molecular aspects of multiple myeloma.
Kastrinakis NG, Gorgoulis VG, Foukas PG, Dimopoulos MA, Kittas C
Ann Oncol 2000 Oct;11(10):1217-28. doi: 10.1023/a:1008331714186. PMID: 11106109

Clinical prediction guides

Clinicopathological and molecular genetic alterations in monomorphic-epitheliotropic intestinal T-cell lymphoma of the small intestine.
Zhou B, Guo M, Li X, Duan T, Peng L, Hao H
Eur J Med Res 2024 Mar 23;29(1):191. doi: 10.1186/s40001-024-01797-5. PMID: 38520011Free PMC Article
Tracing Founder Mutations in Circulating and Tissue-Resident Follicular Lymphoma Precursors.
Schroers-Martin JG, Soo J, Brisou G, Scherer F, Kurtz DM, Sworder BJ, Khodadoust MS, Jin MC, Bru A, Liu CL, Stehr H, Vineis P; EPIC Consortium, Natkunam Y, Teras LR, Song JY, Nadel B, Diehn M, Roulland S, Alizadeh AA
Cancer Discov 2023 Jun 2;13(6):1310-1323. doi: 10.1158/2159-8290.CD-23-0111. PMID: 36939219Free PMC Article
Characterization of molecular genetics and clinicopathology in thymic MALT lymphoma.
Wang X, Miao Y, Cao Z, Zheng S, Xue X, Feng X
Ann Hematol 2022 Jan;101(1):91-97. Epub 2021 Oct 4 doi: 10.1007/s00277-021-04671-0. PMID: 34605949
Novel markers in pediatric-type follicular lymphoma.
Agostinelli C, Akarca AU, Ramsay A, Rizvi H, Rodriguez-Justo M, Pomplun S, Proctor I, Sabattini E, Linch D, Daw S, Pittaluga S, Pileri SA, Jaffe ES, Quintanilla-Martinez L, Marafioti T
Virchows Arch 2019 Dec;475(6):771-779. Epub 2019 Nov 4 doi: 10.1007/s00428-019-02681-y. PMID: 31686194Free PMC Article
Molecular aspects of multiple myeloma.
Kastrinakis NG, Gorgoulis VG, Foukas PG, Dimopoulos MA, Kittas C
Ann Oncol 2000 Oct;11(10):1217-28. doi: 10.1023/a:1008331714186. PMID: 11106109

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