U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Clonal T-Cell Receptor Gamma Chain Gene Rearrangement

MedGen UID:
309017
•Concept ID:
C1516679
•
Cell or Molecular Dysfunction
Synonym: Monoclonal T-Cell Receptor Gamma Chain Gene Rearrangement

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVClonal T-Cell Receptor Gamma Chain Gene Rearrangement

Professional guidelines

PubMed

Overlapping Features of Primary Cutaneous Marginal Zone Lymphoproliferative Disorder and Primary Cutaneous CD4 + Small/Medium T-Cell Lymphoproliferative Disorder : A Diagnostic Challenge Examined by Genomic Analysis.
Obiorah IE, Karrs J, Brown L, Wang HW, Karai LJ, Pham TH, Pham TA, Xi L, Pittaluga S, Raffeld M, Jaffe ES
Am J Surg Pathol 2023 Mar 1;47(3):344-353. Epub 2022 Oct 21 doi: 10.1097/PAS.0000000000001984. PMID: 36598455Free PMC Article
Resolving T-cell receptor clonality in two and genotype in four multiplex polymerase chain reactions.
Dictor M, Warenholt J, Isinger A
Haematologica 2005 Nov;90(11):1524-32. PMID: 16266900
IgH and TcR-gamma gene rearrangements identified in Hodgkin's disease by PCR demonstrate lack of correlation between genotype, phenotype, and Epstein-Barr virus status.
Al Saati T, Galoin S, Gravel S, Lamant L, Roda D, Chittal SM, Delsol G
J Pathol 1997 Apr;181(4):387-93. doi: 10.1002/(SICI)1096-9896(199704)181:4<387::AID-PATH781>3.0.CO;2-U. PMID: 9196435

Recent clinical studies

Etiology

Flow cytometric evaluation of TRBC1 expression in tissue specimens and body fluids is a novel and specific method for assessment of T-cell clonality and diagnosis of T-cell neoplasms.
Berg H, Otteson GE, Corley H, Shi M, Horna P, Jevremovic D, Olteanu H
Cytometry B Clin Cytom 2021 May;100(3):361-369. Epub 2020 Apr 25 doi: 10.1002/cyto.b.21881. PMID: 32333725
Clonal immunoglobulin heavy chain and T-cell receptor γ gene rearrangements in primary gastric lymphoma.
Shan GD, Hu FL, Yang M, Chen HT, Chen WG, Wang YG, Chen LH, Li YM, Xu GQ
World J Gastroenterol 2013 Sep 14;19(34):5727-31. doi: 10.3748/wjg.v19.i34.5727. PMID: 24039368Free PMC Article
Analysis of T-cell receptor-γ gene rearrangements using heteroduplex analysis by high-resolution microcapillary electrophoresis.
Beaufils N, Ben Lassoued A, Essaydi A, Dales JP, Formisano-Tréziny C, Bonnet N, Grob JJ, Gabert J
Leuk Res 2012 Sep;36(9):1119-23. Epub 2012 Jun 26 doi: 10.1016/j.leukres.2012.06.003. PMID: 22738890
Lymphoblastic lymphoma.
Cortelazzo S, Ponzoni M, Ferreri AJ, Hoelzer D
Crit Rev Oncol Hematol 2011 Sep;79(3):330-43. Epub 2011 Jan 26 doi: 10.1016/j.critrevonc.2010.12.003. PMID: 21273093
Clonal T cell receptor gamma-chain gene rearrangement by PCR-based GeneScan analysis in the skin and blood of patients with parapsoriasis and early-stage mycosis fungoides.
Klemke CD, Dippel E, Dembinski A, Pönitz N, Assaf C, Hummel M, Stein H, Goerdt S
J Pathol 2002 Jul;197(3):348-54. doi: 10.1002/path.1133. PMID: 12115881

Diagnosis

Flow cytometric evaluation of TRBC1 expression in tissue specimens and body fluids is a novel and specific method for assessment of T-cell clonality and diagnosis of T-cell neoplasms.
Berg H, Otteson GE, Corley H, Shi M, Horna P, Jevremovic D, Olteanu H
Cytometry B Clin Cytom 2021 May;100(3):361-369. Epub 2020 Apr 25 doi: 10.1002/cyto.b.21881. PMID: 32333725
CapTCR-seq: hybrid capture for T-cell receptor repertoire profiling.
Mulder DT, Mahé ER, Dowar M, Hanna Y, Li T, Nguyen LT, Butler MO, Hirano N, Delabie J, Ohashi PS, Pugh TJ
Blood Adv 2018 Dec 11;2(23):3506-3514. doi: 10.1182/bloodadvances.2017014639. PMID: 30530777Free PMC Article
Lymphoblastic lymphoma.
Cortelazzo S, Ponzoni M, Ferreri AJ, Hoelzer D
Crit Rev Oncol Hematol 2011 Sep;79(3):330-43. Epub 2011 Jan 26 doi: 10.1016/j.critrevonc.2010.12.003. PMID: 21273093
Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936.
van Dongen JJ, Langerak AW, Brüggemann M, Evans PA, Hummel M, Lavender FL, Delabesse E, Davi F, Schuuring E, García-Sanz R, van Krieken JH, Droese J, González D, Bastard C, White HE, Spaargaren M, González M, Parreira A, Smith JL, Morgan GJ, Kneba M, Macintyre EA
Leukemia 2003 Dec;17(12):2257-317. doi: 10.1038/sj.leu.2403202. PMID: 14671650
Immunophenotypic and antigen receptor gene rearrangement analysis in T cell neoplasia.
Knowles DM
Am J Pathol 1989 Apr;134(4):761-85. PMID: 2495724Free PMC Article

Therapy

Flow cytometric evaluation of TRBC1 expression in tissue specimens and body fluids is a novel and specific method for assessment of T-cell clonality and diagnosis of T-cell neoplasms.
Berg H, Otteson GE, Corley H, Shi M, Horna P, Jevremovic D, Olteanu H
Cytometry B Clin Cytom 2021 May;100(3):361-369. Epub 2020 Apr 25 doi: 10.1002/cyto.b.21881. PMID: 32333725
Open-Capsule Budesonide for Refractory Celiac Disease.
Mukewar SS, Sharma A, Rubio-Tapia A, Wu TT, Jabri B, Murray JA
Am J Gastroenterol 2017 Jun;112(6):959-967. Epub 2017 Mar 21 doi: 10.1038/ajg.2017.71. PMID: 28323276
Lymphoblastic lymphoma.
Cortelazzo S, Ponzoni M, Ferreri AJ, Hoelzer D
Crit Rev Oncol Hematol 2011 Sep;79(3):330-43. Epub 2011 Jan 26 doi: 10.1016/j.critrevonc.2010.12.003. PMID: 21273093
Characterization of T-cell repertoire in hairy cell leukemia patients before and after recombinant immunotoxin BL22 therapy.
Arons E, Sorbara L, Raffeld M, Stetler-Stevenson M, Steinberg SM, Liewehr DJ, Pastan I, Kreitman RJ
Cancer Immunol Immunother 2006 Sep;55(9):1100-10. Epub 2005 Nov 26 doi: 10.1007/s00262-005-0099-1. PMID: 16311729Free PMC Article
Molecular etiology of mature T-cell non-Hodgkin's lymphomas.
Evens AM, Gartenhaus RB
Front Biosci 2003 Jan 1;8:d156-75. doi: 10.2741/922. PMID: 12456315

Prognosis

Overlapping Features of Primary Cutaneous Marginal Zone Lymphoproliferative Disorder and Primary Cutaneous CD4 + Small/Medium T-Cell Lymphoproliferative Disorder : A Diagnostic Challenge Examined by Genomic Analysis.
Obiorah IE, Karrs J, Brown L, Wang HW, Karai LJ, Pham TH, Pham TA, Xi L, Pittaluga S, Raffeld M, Jaffe ES
Am J Surg Pathol 2023 Mar 1;47(3):344-353. Epub 2022 Oct 21 doi: 10.1097/PAS.0000000000001984. PMID: 36598455Free PMC Article
Anaplastic Large T-Cell Lymphoma in the Intestine of Dogs.
Stranahan LW, Whitley D, Thaiwong T, Kiupel M, Oliveira F
Vet Pathol 2019 Nov;56(6):878-884. Epub 2019 Jun 6 doi: 10.1177/0300985819852132. PMID: 31170900Free PMC Article
Lymphoblastic lymphoma.
Cortelazzo S, Ponzoni M, Ferreri AJ, Hoelzer D
Crit Rev Oncol Hematol 2011 Sep;79(3):330-43. Epub 2011 Jan 26 doi: 10.1016/j.critrevonc.2010.12.003. PMID: 21273093
Characterization of T-cell repertoire in hairy cell leukemia patients before and after recombinant immunotoxin BL22 therapy.
Arons E, Sorbara L, Raffeld M, Stetler-Stevenson M, Steinberg SM, Liewehr DJ, Pastan I, Kreitman RJ
Cancer Immunol Immunother 2006 Sep;55(9):1100-10. Epub 2005 Nov 26 doi: 10.1007/s00262-005-0099-1. PMID: 16311729Free PMC Article
gamma delta T-cell lymphoma of the skin: a clinical, microscopic, and molecular study.
Toro JR, Beaty M, Sorbara L, Turner ML, White J, Kingma DW, Raffeld M, Jaffe ES
Arch Dermatol 2000 Aug;136(8):1024-32. doi: 10.1001/archderm.136.8.1024. PMID: 10926739

Clinical prediction guides

Assessment of T-cell receptor repertoire and clonal expansion in peripheral T-cell lymphoma using RNA-seq data.
Gong Q, Wang C, Zhang W, Iqbal J, Hu Y, Greiner TC, Cornish A, Kim JH, Rabadan R, Abate F, Wang X, Inghirami GG, McKeithan TW, Chan WC
Sci Rep 2017 Sep 12;7(1):11301. doi: 10.1038/s41598-017-11310-0. PMID: 28900149Free PMC Article
Pattern of immunoglobulin and T-cell receptor-δ/γ gene rearrangements in Iranian children with B-precursor acute lymphoblastic leukemia.
Poopak B, Saki N, Purfatholah AA, Najmabadi H, Mortazavi Y, Arzanian MT, Khosravipour G, Haghnejad F, Salari F, Shahjahani M
Hematology 2014 Jul;19(5):259-66. Epub 2014 Jan 3 doi: 10.1179/1607845413Y.0000000126. PMID: 24620952
Immunosuppressive treatments for myelodysplastic syndromes.
Shimamoto T, Ohyashiki K
Leuk Lymphoma 2003 Apr;44(4):593-604. doi: 10.1080/1042819021000055345. PMID: 12769335
Improved polymerase chain reaction detection of clonal T-cell lymphoid neoplasms.
Benhattar J, Delacretaz F, Martin P, Chaubert P, Costa J
Diagn Mol Pathol 1995 Jun;4(2):108-12. doi: 10.1097/00019606-199506000-00006. PMID: 7551290
The structure of the T cell antigen receptor genes in normal and malignant T cells.
Minden MD, Mak TW
Blood 1986 Aug;68(2):327-36. PMID: 3089348

Recent systematic reviews

Composite EBV negative peripheral T-cell lymphoma and diffuse large B-cell lymphoma involving the ileum: a case report and a systematic review of the literature.
Abou-Elella AA, Nifong TP
Leuk Lymphoma 2006 Oct;47(10):2208-17. doi: 10.1080/10428190600763348. PMID: 17071497

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...