U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Formation of Apurinic Site

MedGen UID:
309168
Concept ID:
C1517296
Cell or Molecular Dysfunction

Definition

Formation of Apurinic Site involves the creation of an apurinic site as a result of the loss of a purine residue from DNA. Purine residues are especially vulnerable to cleavage of the N-glycosylic bond between the purine residue and sugar moiety of the nucleotide, leaving in DNA a nucleotide position with no base attached. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFormation of Apurinic Site

Professional guidelines

PubMed

Manoel-Caetano FS, Rossi AFT, Ribeiro ML, Prates J, Oliani SM, Silva AE
DNA Repair (Amst) 2020 Dec;96:102976. Epub 2020 Sep 28 doi: 10.1016/j.dnarep.2020.102976. PMID: 33065487
Illuzzi JL, Wilson DM 3rd
Curr Med Chem 2012;19(23):3922-36. doi: 10.2174/092986712802002581. PMID: 22788768Free PMC Article
Zhang Y, Wang J
Chin J Cancer 2010 Mar;29(3):333-9. doi: 10.5732/cjc.009.10285. PMID: 20193121

Recent clinical studies

Etiology

Murray DH, Fagan PA, Ryugo DK
Hear Res 2022 Sep 1;422:108565. Epub 2022 Jun 30 doi: 10.1016/j.heares.2022.108565. PMID: 35816890
Hartman GD, Lambert-Cheatham NA, Kelley MR, Corson TW
Int J Mol Sci 2021 Sep 24;22(19) doi: 10.3390/ijms221910279. PMID: 34638620Free PMC Article
Laev SS, Salakhutdinov NF, Lavrik OI
Bioorg Med Chem 2017 May 1;25(9):2531-2544. Epub 2017 Jan 21 doi: 10.1016/j.bmc.2017.01.028. PMID: 28161249
Fujiwara H
Microbiol Spectr 2015 Apr;3(2):MDNA3-0001-2014. doi: 10.1128/microbiolspec.MDNA3-0001-2014. PMID: 26104700
Zhang J, Stevens MF, Bradshaw TD
Curr Mol Pharmacol 2012 Jan;5(1):102-14. doi: 10.2174/1874467211205010102. PMID: 22122467

Diagnosis

Wang H, Zhang L, Sun H, Xu S, Li K, Su X
Int J Biol Macromol 2023 Jul 1;242(Pt 3):124918. Epub 2023 May 25 doi: 10.1016/j.ijbiomac.2023.124918. PMID: 37244341
Komaniecka N, Porras M, Cairn L, Santas JA, Ferreiro N, Penedo JC, Bañuelos S
Int J Mol Sci 2022 Jul 20;23(14) doi: 10.3390/ijms23148015. PMID: 35887361Free PMC Article
Murray DH, Fagan PA, Ryugo DK
Hear Res 2022 Sep 1;422:108565. Epub 2022 Jun 30 doi: 10.1016/j.heares.2022.108565. PMID: 35816890
Oliveira TT, Coutinho LG, de Oliveira LOA, Timoteo ARS, Farias GC, Agnez-Lima LF
Front Immunol 2022;13:793096. Epub 2022 Feb 28 doi: 10.3389/fimmu.2022.793096. PMID: 35296074Free PMC Article
Li M, Wilson DM 3rd
Antioxid Redox Signal 2014 Feb 1;20(4):678-707. Epub 2013 Aug 20 doi: 10.1089/ars.2013.5492. PMID: 23834463Free PMC Article

Therapy

Faruk MO, Ichimura Y, Komatsu M
Cancer Sci 2021 Oct;112(10):3972-3978. Epub 2021 Aug 25 doi: 10.1111/cas.15112. PMID: 34407274Free PMC Article
Kaur A, Webster MR, Marchbank K, Behera R, Ndoye A, Kugel CH 3rd, Dang VM, Appleton J, O'Connell MP, Cheng P, Valiga AA, Morissette R, McDonnell NB, Ferrucci L, Kossenkov AV, Meeth K, Tang HY, Yin X, Wood WH 3rd, Lehrmann E, Becker KG, Flaherty KT, Frederick DT, Wargo JA, Cooper ZA, Tetzlaff MT, Hudgens C, Aird KM, Zhang R, Xu X, Liu Q, Bartlett E, Karakousis G, Eroglu Z, Lo RS, Chan M, Menzies AM, Long GV, Johnson DB, Sosman J, Schilling B, Schadendorf D, Speicher DW, Bosenberg M, Ribas A, Weeraratna AT
Nature 2016 Apr 14;532(7598):250-4. Epub 2016 Apr 4 doi: 10.1038/nature17392. PMID: 27042933Free PMC Article
Fujiwara H
Microbiol Spectr 2015 Apr;3(2):MDNA3-0001-2014. doi: 10.1128/microbiolspec.MDNA3-0001-2014. PMID: 26104700
Lucifora J, Xia Y, Reisinger F, Zhang K, Stadler D, Cheng X, Sprinzl MF, Koppensteiner H, Makowska Z, Volz T, Remouchamps C, Chou WM, Thasler WE, Hüser N, Durantel D, Liang TJ, Münk C, Heim MH, Browning JL, Dejardin E, Dandri M, Schindler M, Heikenwalder M, Protzer U
Science 2014 Mar 14;343(6176):1221-8. Epub 2014 Feb 20 doi: 10.1126/science.1243462. PMID: 24557838Free PMC Article
Zhang J, Stevens MF, Bradshaw TD
Curr Mol Pharmacol 2012 Jan;5(1):102-14. doi: 10.2174/1874467211205010102. PMID: 22122467

Prognosis

Murray DH, Fagan PA, Ryugo DK
Hear Res 2022 Sep 1;422:108565. Epub 2022 Jun 30 doi: 10.1016/j.heares.2022.108565. PMID: 35816890
Zhao CR, Yang FF, Cui Q, Wang D, Zhou Y, Li YS, Zhang YP, Tang RZ, Yao WJ, Wang X, Pang W, Zhao JN, Jiang ZT, Zhu JJ, Chien S, Zhou J
Proc Natl Acad Sci U S A 2021 Nov 30;118(48) doi: 10.1073/pnas.2115158118. PMID: 34810252Free PMC Article
Long K, Gu L, Li L, Zhang Z, Li E, Zhang Y, He L, Pan F, Guo Z, Hu Z
Cell Death Dis 2021 May 18;12(6):503. doi: 10.1038/s41419-021-03804-7. PMID: 34006852Free PMC Article
Lavrik OI
DNA Repair (Amst) 2020 Sep;93:102911. doi: 10.1016/j.dnarep.2020.102911. PMID: 33087277
Kaur A, Webster MR, Marchbank K, Behera R, Ndoye A, Kugel CH 3rd, Dang VM, Appleton J, O'Connell MP, Cheng P, Valiga AA, Morissette R, McDonnell NB, Ferrucci L, Kossenkov AV, Meeth K, Tang HY, Yin X, Wood WH 3rd, Lehrmann E, Becker KG, Flaherty KT, Frederick DT, Wargo JA, Cooper ZA, Tetzlaff MT, Hudgens C, Aird KM, Zhang R, Xu X, Liu Q, Bartlett E, Karakousis G, Eroglu Z, Lo RS, Chan M, Menzies AM, Long GV, Johnson DB, Sosman J, Schilling B, Schadendorf D, Speicher DW, Bosenberg M, Ribas A, Weeraratna AT
Nature 2016 Apr 14;532(7598):250-4. Epub 2016 Apr 4 doi: 10.1038/nature17392. PMID: 27042933Free PMC Article

Clinical prediction guides

Tapryal N, Chakraborty A, Saha K, Islam A, Pan L, Hosoki K, Sayed IM, Duran JM, Alcantara J, Castillo V, Tindle C, Sarker AH, Wakamiya M, Cardenas VJ, Sharma G, Crotty Alexander LE, Sur S, Sahoo D, Ghosh G, Das S, Ghosh P, Boldogh I, Hazra TK
Nat Commun 2023 Dec 9;14(1):8169. doi: 10.1038/s41467-023-43938-0. PMID: 38071370Free PMC Article
Komaniecka N, Porras M, Cairn L, Santas JA, Ferreiro N, Penedo JC, Bañuelos S
Int J Mol Sci 2022 Jul 20;23(14) doi: 10.3390/ijms23148015. PMID: 35887361Free PMC Article
Zhao CR, Yang FF, Cui Q, Wang D, Zhou Y, Li YS, Zhang YP, Tang RZ, Yao WJ, Wang X, Pang W, Zhao JN, Jiang ZT, Zhu JJ, Chien S, Zhou J
Proc Natl Acad Sci U S A 2021 Nov 30;118(48) doi: 10.1073/pnas.2115158118. PMID: 34810252Free PMC Article
Miller I, Totrov M, Korotchkina L, Kazyulkin DN, Gudkov AV, Korolev S
Nucleic Acids Res 2021 Nov 8;49(19):11350-11366. doi: 10.1093/nar/gkab826. PMID: 34554261Free PMC Article
Tummanatsakun D, Proungvitaya T, Roytrakul S, Proungvitaya S
Molecules 2021 Apr 29;26(9) doi: 10.3390/molecules26092587. PMID: 33946672Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...