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Formation of Apurinic Site

MedGen UID:
309168
•Concept ID:
C1517296
•
Cell or Molecular Dysfunction

Definition

Formation of Apurinic Site involves the creation of an apurinic site as a result of the loss of a purine residue from DNA. Purine residues are especially vulnerable to cleavage of the N-glycosylic bond between the purine residue and sugar moiety of the nucleotide, leaving in DNA a nucleotide position with no base attached. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFormation of Apurinic Site

Professional guidelines

PubMed

Cytoplasmic APE1 promotes resistance response in osteosarcoma patients with cisplatin treatment.
Liu Y, Zhang Z, Zhang L, Zhong Z
Cell Biochem Funct 2020 Mar;38(2):195-203. Epub 2020 Jan 12 doi: 10.1002/cbf.3461. PMID: 31930546
Base excision repair: contribution to tumorigenesis and target in anticancer treatment paradigms.
Illuzzi JL, Wilson DM 3rd
Curr Med Chem 2012;19(23):3922-36. doi: 10.2174/092986712802002581. PMID: 22788768Free PMC Article
Anticancer clinical utility of the apurinic/apyrimidinic endonuclease/redox factor-1 (APE/Ref-1).
Zhang Y, Wang J
Chin J Cancer 2010 Mar;29(3):333-9. doi: 10.5732/cjc.009.10285. PMID: 20193121

Recent clinical studies

Etiology

Idiopathic sudden sensorineural hearing loss: A critique on corticosteroid therapy.
Murray DH, Fagan PA, Ryugo DK
Hear Res 2022 Sep 1;422:108565. Epub 2022 Jun 30 doi: 10.1016/j.heares.2022.108565. PMID: 35816890
Inhibition of APE1/Ref-1 for Neovascular Eye Diseases: From Biology to Therapy.
Hartman GD, Lambert-Cheatham NA, Kelley MR, Corson TW
Int J Mol Sci 2021 Sep 24;22(19) doi: 10.3390/ijms221910279. PMID: 34638620Free PMC Article
Inhibitors of nuclease and redox activity of apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1).
Laev SS, Salakhutdinov NF, Lavrik OI
Bioorg Med Chem 2017 May 1;25(9):2531-2544. Epub 2017 Jan 21 doi: 10.1016/j.bmc.2017.01.028. PMID: 28161249
Site-specific non-LTR retrotransposons.
Fujiwara H
Microbiol Spectr 2015 Apr;3(2):MDNA3-0001-2014. doi: 10.1128/microbiolspec.MDNA3-0001-2014. PMID: 26104700
Temozolomide: mechanisms of action, repair and resistance.
Zhang J, Stevens MF, Bradshaw TD
Curr Mol Pharmacol 2012 Jan;5(1):102-14. doi: 10.2174/1874467211205010102. PMID: 22122467

Diagnosis

Idiopathic sudden sensorineural hearing loss: A critique on corticosteroid therapy.
Murray DH, Fagan PA, Ryugo DK
Hear Res 2022 Sep 1;422:108565. Epub 2022 Jun 30 doi: 10.1016/j.heares.2022.108565. PMID: 35816890
APE1/Ref-1 Role in Inflammation and Immune Response.
Oliveira TT, Coutinho LG, de Oliveira LOA, Timoteo ARS, Farias GC, Agnez-Lima LF
Front Immunol 2022;13:793096. Epub 2022 Feb 28 doi: 10.3389/fimmu.2022.793096. PMID: 35296074Free PMC Article
A Dual Face of APE1 in the Maintenance of Genetic Stability in Monocytes: An Overview of the Current Status and Future Perspectives.
Betlej G, Bator E, Pyrkosz A, Kwiatkowska A
Genes (Basel) 2020 Jun 11;11(6) doi: 10.3390/genes11060643. PMID: 32545201Free PMC Article
Chromatin and other obstacles to base excision repair: potential roles in carcinogenesis.
Caffrey PJ, Delaney S
Mutagenesis 2020 Feb 13;35(1):39-50. doi: 10.1093/mutage/gez029. PMID: 31612219
Human apurinic/apyrimidinic endonuclease 1.
Li M, Wilson DM 3rd
Antioxid Redox Signal 2014 Feb 1;20(4):678-707. Epub 2013 Aug 20 doi: 10.1089/ars.2013.5492. PMID: 23834463Free PMC Article

Therapy

Selective autophagy.
Faruk MO, Ichimura Y, Komatsu M
Cancer Sci 2021 Oct;112(10):3972-3978. Epub 2021 Aug 25 doi: 10.1111/cas.15112. PMID: 34407274Free PMC Article
sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance.
Kaur A, Webster MR, Marchbank K, Behera R, Ndoye A, Kugel CH 3rd, Dang VM, Appleton J, O'Connell MP, Cheng P, Valiga AA, Morissette R, McDonnell NB, Ferrucci L, Kossenkov AV, Meeth K, Tang HY, Yin X, Wood WH 3rd, Lehrmann E, Becker KG, Flaherty KT, Frederick DT, Wargo JA, Cooper ZA, Tetzlaff MT, Hudgens C, Aird KM, Zhang R, Xu X, Liu Q, Bartlett E, Karakousis G, Eroglu Z, Lo RS, Chan M, Menzies AM, Long GV, Johnson DB, Sosman J, Schilling B, Schadendorf D, Speicher DW, Bosenberg M, Ribas A, Weeraratna AT
Nature 2016 Apr 14;532(7598):250-4. Epub 2016 Apr 4 doi: 10.1038/nature17392. PMID: 27042933Free PMC Article
Site-specific non-LTR retrotransposons.
Fujiwara H
Microbiol Spectr 2015 Apr;3(2):MDNA3-0001-2014. doi: 10.1128/microbiolspec.MDNA3-0001-2014. PMID: 26104700
Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA.
Lucifora J, Xia Y, Reisinger F, Zhang K, Stadler D, Cheng X, Sprinzl MF, Koppensteiner H, Makowska Z, Volz T, Remouchamps C, Chou WM, Thasler WE, Hüser N, Durantel D, Liang TJ, Münk C, Heim MH, Browning JL, Dejardin E, Dandri M, Schindler M, Heikenwalder M, Protzer U
Science 2014 Mar 14;343(6176):1221-8. Epub 2014 Feb 20 doi: 10.1126/science.1243462. PMID: 24557838Free PMC Article
Temozolomide: mechanisms of action, repair and resistance.
Zhang J, Stevens MF, Bradshaw TD
Curr Mol Pharmacol 2012 Jan;5(1):102-14. doi: 10.2174/1874467211205010102. PMID: 22122467

Prognosis

Idiopathic sudden sensorineural hearing loss: A critique on corticosteroid therapy.
Murray DH, Fagan PA, Ryugo DK
Hear Res 2022 Sep 1;422:108565. Epub 2022 Jun 30 doi: 10.1016/j.heares.2022.108565. PMID: 35816890
Small-molecule inhibition of APE1 induces apoptosis, pyroptosis, and necroptosis in non-small cell lung cancer.
Long K, Gu L, Li L, Zhang Z, Li E, Zhang Y, He L, Pan F, Guo Z, Hu Z
Cell Death Dis 2021 May 18;12(6):503. doi: 10.1038/s41419-021-03804-7. PMID: 34006852Free PMC Article
PARPs' impact on base excision DNA repair.
Lavrik OI
DNA Repair (Amst) 2020 Sep;93:102911. doi: 10.1016/j.dnarep.2020.102911. PMID: 33087277
Chromatin and other obstacles to base excision repair: potential roles in carcinogenesis.
Caffrey PJ, Delaney S
Mutagenesis 2020 Feb 13;35(1):39-50. doi: 10.1093/mutage/gez029. PMID: 31612219
sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance.
Kaur A, Webster MR, Marchbank K, Behera R, Ndoye A, Kugel CH 3rd, Dang VM, Appleton J, O'Connell MP, Cheng P, Valiga AA, Morissette R, McDonnell NB, Ferrucci L, Kossenkov AV, Meeth K, Tang HY, Yin X, Wood WH 3rd, Lehrmann E, Becker KG, Flaherty KT, Frederick DT, Wargo JA, Cooper ZA, Tetzlaff MT, Hudgens C, Aird KM, Zhang R, Xu X, Liu Q, Bartlett E, Karakousis G, Eroglu Z, Lo RS, Chan M, Menzies AM, Long GV, Johnson DB, Sosman J, Schilling B, Schadendorf D, Speicher DW, Bosenberg M, Ribas A, Weeraratna AT
Nature 2016 Apr 14;532(7598):250-4. Epub 2016 Apr 4 doi: 10.1038/nature17392. PMID: 27042933Free PMC Article

Clinical prediction guides

Conformational Rearrangements Regulating the DNA Repair Protein APE1.
Komaniecka N, Porras M, Cairn L, Santas JA, Ferreiro N, Penedo JC, Bañuelos S
Int J Mol Sci 2022 Jul 20;23(14) doi: 10.3390/ijms23148015. PMID: 35887361Free PMC Article
Structural dissection of sequence recognition and catalytic mechanism of human LINE-1 endonuclease.
Miller I, Totrov M, Korotchkina L, Kazyulkin DN, Gudkov AV, Korolev S
Nucleic Acids Res 2021 Nov 8;49(19):11350-11366. doi: 10.1093/nar/gkab826. PMID: 34554261Free PMC Article
Bioinformatic Prediction of Signaling Pathways for Apurinic/Apyrimidinic Endodeoxyribonuclease 1 (APEX1) and Its Role in Cholangiocarcinoma Cells.
Tummanatsakun D, Proungvitaya T, Roytrakul S, Proungvitaya S
Molecules 2021 Apr 29;26(9) doi: 10.3390/molecules26092587. PMID: 33946672Free PMC Article
New perspectives in cancer biology from a study of canonical and non-canonical functions of base excision repair proteins with a focus on early steps.
Malfatti MC, Antoniali G, Codrich M, Burra S, Mangiapane G, Dalla E, Tell G
Mutagenesis 2020 Feb 13;35(1):129-149. doi: 10.1093/mutage/gez051. PMID: 31858150
Evaluation and Clinical Significance of Jagged-1-activated Notch Signaling by APEX1 in Colorectal Cancer.
Kim HB, Lim HJ, Lee HJ, Park JH, Park SG
Anticancer Res 2019 Nov;39(11):6097-6105. doi: 10.21873/anticanres.13817. PMID: 31704837

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