U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Gain of Chromosome 12q

MedGen UID:
309188
Concept ID:
C1517384
Cell or Molecular Dysfunction

Definition

A chromosomal aberration where there are 3 copies of the long arm of chromosome 12. This aberration is associated with 12q duplication syndrome. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGain of Chromosome 12q

Professional guidelines

PubMed

Skotheim RI, Kraggerud SM, Fosså SD, Stenwig AE, Gedde-Dahl T Jr, Danielsen HE, Jakobsen KS, Lothe RA
Neoplasia 2001 May-Jun;3(3):196-203. doi: 10.1038/sj.neo.7900153. PMID: 11494113Free PMC Article

Recent clinical studies

Etiology

Novara F, Arcaini L, Merli M, Passamonti F, Zibellini S, Rizzi S, Rattotti S, Rumi E, Pascutto C, Vetro A, Astori C, Boveri E, Lucioni M, Paulli M, Zuffardi O, Lazzarino M
Hum Pathol 2009 Nov;40(11):1628-37. Epub 2009 Aug 3 doi: 10.1016/j.humpath.2009.01.025. PMID: 19647853
Hough RE, Goepel JR, Alcock HE, Hancock BW, Lorigan PC, Hammond DW
Br J Cancer 2001 Feb;84(4):499-503. doi: 10.1054/bjoc.2000.1638. PMID: 11207045Free PMC Article
Zondervan PE, Wink J, Alers JC, IJzermans JN, Schalm SW, de Man RA, van Dekken H
J Pathol 2000 Oct;192(2):207-15. doi: 10.1002/1096-9896(2000)9999:9999<::AID-PATH690>3.0.CO;2-#. PMID: 11004697
Larramendy ML, Mandahl N, Mertens F, Blomqvist C, Kivioja AH, Karaharju E, Valle J, Böhling T, Tarkkanen M, Rydholm A, Akerman M, Bauer HC, Anttila JP, Elomaa I, Knuutila S
Hum Pathol 1999 Oct;30(10):1247-53. doi: 10.1016/s0046-8177(99)90045-x. PMID: 10534175
van Dekken H, Geelen E, Dinjens WN, Wijnhoven BP, Tilanus HW, Tanke HJ, Rosenberg C
Cancer Res 1999 Feb 1;59(3):748-52. PMID: 9973227

Diagnosis

Park AK, Lee JY, Cheong H, Ramaswamy V, Park SH, Kool M, Phi JH, Choi SA, Cavalli F, Taylor MD, Kim SK
BMC Cancer 2019 Jun 11;19(1):571. doi: 10.1186/s12885-019-5742-x. PMID: 31185958Free PMC Article
Geckinli BB, Aydin H, Karaman A, Delil K, Simsek H, Gokmeydan E, Turkdogan D
Genet Couns 2015;26(4):393-400. PMID: 26852509
Kuroda N, Toi M, Hiroi M, Enzan H
Histol Histopathol 2003 Apr;18(2):487-94. doi: 10.14670/HH-18.487. PMID: 12647800
Schick B, Brunner C, Praetorius M, Plinkert PK, Urbschat S
Laryngoscope 2002 Feb;112(2):397-401. doi: 10.1097/00005537-200202000-00035. PMID: 11889404
van Dekken H, Geelen E, Dinjens WN, Wijnhoven BP, Tilanus HW, Tanke HJ, Rosenberg C
Cancer Res 1999 Feb 1;59(3):748-52. PMID: 9973227

Therapy

Chen QR, Bilke S, Wei JS, Whiteford CC, Cenacchi N, Krasnoselsky AL, Greer BT, Son CG, Westermann F, Berthold F, Schwab M, Catchpoole D, Khan J
BMC Genomics 2004 Sep 20;5:70. doi: 10.1186/1471-2164-5-70. PMID: 15380028Free PMC Article
Wong MP, Fung LF, Wang E, Chow WS, Chiu SW, Lam WK, Ho KK, Ma ES, Wan TS, Chung LP
Cancer 2003 Mar 1;97(5):1263-70. doi: 10.1002/cncr.11183. PMID: 12599234

Prognosis

Loncarevic IF, Hering A, Posorski N, Linden T, Hoyer H, Bucsky P
Pediatr Blood Cancer 2008 Sep;51(3):356-62. doi: 10.1002/pbc.21603. PMID: 18478573
Hough RE, Goepel JR, Alcock HE, Hancock BW, Lorigan PC, Hammond DW
Br J Cancer 2001 Feb;84(4):499-503. doi: 10.1054/bjoc.2000.1638. PMID: 11207045Free PMC Article
Zondervan PE, Wink J, Alers JC, IJzermans JN, Schalm SW, de Man RA, van Dekken H
J Pathol 2000 Oct;192(2):207-15. doi: 10.1002/1096-9896(2000)9999:9999<::AID-PATH690>3.0.CO;2-#. PMID: 11004697
Larramendy ML, Mandahl N, Mertens F, Blomqvist C, Kivioja AH, Karaharju E, Valle J, Böhling T, Tarkkanen M, Rydholm A, Akerman M, Bauer HC, Anttila JP, Elomaa I, Knuutila S
Hum Pathol 1999 Oct;30(10):1247-53. doi: 10.1016/s0046-8177(99)90045-x. PMID: 10534175
van Dekken H, Geelen E, Dinjens WN, Wijnhoven BP, Tilanus HW, Tanke HJ, Rosenberg C
Cancer Res 1999 Feb 1;59(3):748-52. PMID: 9973227

Clinical prediction guides

Stary S, Vinatzer U, Müllauer L, Raderer M, Birner P, Streubel B
Genes Chromosomes Cancer 2013 Jan;52(1):33-43. Epub 2012 Sep 11 doi: 10.1002/gcc.22004. PMID: 22965301
Novara F, Arcaini L, Merli M, Passamonti F, Zibellini S, Rizzi S, Rattotti S, Rumi E, Pascutto C, Vetro A, Astori C, Boveri E, Lucioni M, Paulli M, Zuffardi O, Lazzarino M
Hum Pathol 2009 Nov;40(11):1628-37. Epub 2009 Aug 3 doi: 10.1016/j.humpath.2009.01.025. PMID: 19647853
Micci F, Teixeira MR, Haugom L, Kristensen G, Abeler VM, Heim S
Genes Chromosomes Cancer 2004 Jul;40(3):229-46. doi: 10.1002/gcc.20038. PMID: 15139002
Zondervan PE, Wink J, Alers JC, IJzermans JN, Schalm SW, de Man RA, van Dekken H
J Pathol 2000 Oct;192(2):207-15. doi: 10.1002/1096-9896(2000)9999:9999<::AID-PATH690>3.0.CO;2-#. PMID: 11004697
Sehgal A
Semin Surg Oncol 1998 Jan-Feb;14(1):3-12. doi: 10.1002/(sici)1098-2388(199801/02)14:1<3::aid-ssu2>3.0.co;2-f. PMID: 9407626

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...