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Gain of Chromosome 13

MedGen UID:
309189
•Concept ID:
C1517387
•
Cell or Molecular Dysfunction

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGain of Chromosome 13

Professional guidelines

PubMed

Clinical characteristics and treatment outcomes of newly diagnosed multiple myeloma with chromosome 1q abnormalities.
Abdallah N, Greipp P, Kapoor P, Gertz MA, Dispenzieri A, Baughn LB, Lacy MQ, Hayman SR, Buadi FK, Dingli D, Go RS, Hwa YL, Fonder A, Hobbs M, Lin Y, Leung N, Kourelis T, Warsame R, Siddiqui M, Lust J, Kyle RA, Bergsagel L, Ketterling R, Rajkumar SV, Kumar SK
Blood Adv 2020 Aug 11;4(15):3509-3519. doi: 10.1182/bloodadvances.2020002218. PMID: 32750129Free PMC Article
Multiple myeloma: an update on biology and treatment.
Ludwig H, Meran J, Zojer N
Ann Oncol 1999;10 Suppl 6:31-43. PMID: 10676551

Recent clinical studies

Etiology

Germline CHEK2 and ATM Variants in Myeloid and Other Hematopoietic Malignancies.
Stubbins RJ, Korotev S, Godley LA
Curr Hematol Malig Rep 2022 Aug;17(4):94-104. Epub 2022 Jun 8 doi: 10.1007/s11899-022-00663-7. PMID: 35674998
Parent-reported histories of adults with trisomy 13 syndrome.
Lebedoff AN, Carey JC
Am J Med Genet A 2021 Jun;185(6):1743-1756. Epub 2021 Mar 22 doi: 10.1002/ajmg.a.62165. PMID: 33750000
Clinical characteristics and treatment outcomes of newly diagnosed multiple myeloma with chromosome 1q abnormalities.
Abdallah N, Greipp P, Kapoor P, Gertz MA, Dispenzieri A, Baughn LB, Lacy MQ, Hayman SR, Buadi FK, Dingli D, Go RS, Hwa YL, Fonder A, Hobbs M, Lin Y, Leung N, Kourelis T, Warsame R, Siddiqui M, Lust J, Kyle RA, Bergsagel L, Ketterling R, Rajkumar SV, Kumar SK
Blood Adv 2020 Aug 11;4(15):3509-3519. doi: 10.1182/bloodadvances.2020002218. PMID: 32750129Free PMC Article
Pathogenesis of testicular germ cell tumours.
Looijenga LH, Oosterhuis JW
Rev Reprod 1999 May;4(2):90-100. doi: 10.1530/ror.0.0040090. PMID: 10357096
Biology and therapy of pediatric rhabdomyosarcoma.
Pappo AS, Shapiro DN, Crist WM, Maurer HM
J Clin Oncol 1995 Aug;13(8):2123-39. doi: 10.1200/JCO.1995.13.8.2123. PMID: 7636557

Diagnosis

Germline CHEK2 and ATM Variants in Myeloid and Other Hematopoietic Malignancies.
Stubbins RJ, Korotev S, Godley LA
Curr Hematol Malig Rep 2022 Aug;17(4):94-104. Epub 2022 Jun 8 doi: 10.1007/s11899-022-00663-7. PMID: 35674998
Parent-reported histories of adults with trisomy 13 syndrome.
Lebedoff AN, Carey JC
Am J Med Genet A 2021 Jun;185(6):1743-1756. Epub 2021 Mar 22 doi: 10.1002/ajmg.a.62165. PMID: 33750000
Clinical characteristics and treatment outcomes of newly diagnosed multiple myeloma with chromosome 1q abnormalities.
Abdallah N, Greipp P, Kapoor P, Gertz MA, Dispenzieri A, Baughn LB, Lacy MQ, Hayman SR, Buadi FK, Dingli D, Go RS, Hwa YL, Fonder A, Hobbs M, Lin Y, Leung N, Kourelis T, Warsame R, Siddiqui M, Lust J, Kyle RA, Bergsagel L, Ketterling R, Rajkumar SV, Kumar SK
Blood Adv 2020 Aug 11;4(15):3509-3519. doi: 10.1182/bloodadvances.2020002218. PMID: 32750129Free PMC Article
Biology and therapy of pediatric rhabdomyosarcoma.
Pappo AS, Shapiro DN, Crist WM, Maurer HM
J Clin Oncol 1995 Aug;13(8):2123-39. doi: 10.1200/JCO.1995.13.8.2123. PMID: 7636557
Cytogenetic analysis in the examination of solid tumors in children.
Mertens F, Mandahl N, Mitelman F, Heim S
Pediatr Hematol Oncol 1994 Jul-Aug;11(4):361-77. doi: 10.3109/08880019409140536. PMID: 7947009

Therapy

Cell-free DNA analysis reveals POLR1D-mediated resistance to bevacizumab in colorectal cancer.
Zhou Q, Perakis SO, Ulz P, Mohan S, Riedl JM, Talakic E, Lax S, Tötsch M, Hoefler G, Bauernhofer T, Pichler M, Gerger A, Geigl JB, Heitzer E, Speicher MR
Genome Med 2020 Feb 22;12(1):20. doi: 10.1186/s13073-020-0719-6. PMID: 32087735Free PMC Article
Sporadic aneuploidy in PHA-stimulated lymphocytes of trisomies 21, 18, and 13.
Reish O, Regev M, Kanesky A, Girafi S, Mashevich M
Cytogenet Genome Res 2011;133(2-4):184-9. Epub 2011 Jan 19 doi: 10.1159/000323504. PMID: 21252489
An increased frequency of 13q deletions detected by fluorescence in situ hybridization and its impact on survival in children and adolescents with Burkitt lymphoma: results from the Children's Oncology Group study CCG-5961.
Nelson M, Perkins SL, Dave BJ, Coccia PF, Bridge JA, Lyden ER, Heerema NA, Lones MA, Harrison L, Cairo MS, Sanger WG
Br J Haematol 2010 Feb;148(4):600-10. Epub 2009 Nov 4 doi: 10.1111/j.1365-2141.2009.07967.x. PMID: 19895612Free PMC Article
Biology and therapy of pediatric rhabdomyosarcoma.
Pappo AS, Shapiro DN, Crist WM, Maurer HM
J Clin Oncol 1995 Aug;13(8):2123-39. doi: 10.1200/JCO.1995.13.8.2123. PMID: 7636557
Different genetic pathways in leukemogenesis for patients presenting with therapy-related myelodysplasia and therapy-related acute myeloid leukemia.
Pedersen-Bjergaard J, Pedersen M, Roulston D, Philip P
Blood 1995 Nov 1;86(9):3542-52. PMID: 7579462

Prognosis

Parent-reported histories of adults with trisomy 13 syndrome.
Lebedoff AN, Carey JC
Am J Med Genet A 2021 Jun;185(6):1743-1756. Epub 2021 Mar 22 doi: 10.1002/ajmg.a.62165. PMID: 33750000
Clinical characteristics and treatment outcomes of newly diagnosed multiple myeloma with chromosome 1q abnormalities.
Abdallah N, Greipp P, Kapoor P, Gertz MA, Dispenzieri A, Baughn LB, Lacy MQ, Hayman SR, Buadi FK, Dingli D, Go RS, Hwa YL, Fonder A, Hobbs M, Lin Y, Leung N, Kourelis T, Warsame R, Siddiqui M, Lust J, Kyle RA, Bergsagel L, Ketterling R, Rajkumar SV, Kumar SK
Blood Adv 2020 Aug 11;4(15):3509-3519. doi: 10.1182/bloodadvances.2020002218. PMID: 32750129Free PMC Article
Cell-free DNA analysis reveals POLR1D-mediated resistance to bevacizumab in colorectal cancer.
Zhou Q, Perakis SO, Ulz P, Mohan S, Riedl JM, Talakic E, Lax S, Tötsch M, Hoefler G, Bauernhofer T, Pichler M, Gerger A, Geigl JB, Heitzer E, Speicher MR
Genome Med 2020 Feb 22;12(1):20. doi: 10.1186/s13073-020-0719-6. PMID: 32087735Free PMC Article
Biology and therapy of pediatric rhabdomyosarcoma.
Pappo AS, Shapiro DN, Crist WM, Maurer HM
J Clin Oncol 1995 Aug;13(8):2123-39. doi: 10.1200/JCO.1995.13.8.2123. PMID: 7636557
Cytogenetic analysis in the examination of solid tumors in children.
Mertens F, Mandahl N, Mitelman F, Heim S
Pediatr Hematol Oncol 1994 Jul-Aug;11(4):361-77. doi: 10.3109/08880019409140536. PMID: 7947009

Clinical prediction guides

Cell-free DNA analysis reveals POLR1D-mediated resistance to bevacizumab in colorectal cancer.
Zhou Q, Perakis SO, Ulz P, Mohan S, Riedl JM, Talakic E, Lax S, Tötsch M, Hoefler G, Bauernhofer T, Pichler M, Gerger A, Geigl JB, Heitzer E, Speicher MR
Genome Med 2020 Feb 22;12(1):20. doi: 10.1186/s13073-020-0719-6. PMID: 32087735Free PMC Article
Induced Chromosomal Aneuploidy Results in Global and Consistent Deregulation of the Transcriptome of Cancer Cells.
Wangsa D, Braun R, Stuelten CH, Brown M, Bauer KM, Emons G, Weston LA, Hu Y, Yang HH, Vila-Casadesús M, Lee MP, Brauer P, Warner L, Upender M, Hummon AB, Camps J, Ried T
Neoplasia 2019 Jul;21(7):721-729. Epub 2019 Jun 4 doi: 10.1016/j.neo.2019.04.009. PMID: 31174021Free PMC Article
Oncogenic Role of miR-15a-3p in 13q Amplicon-Driven Colorectal Adenoma-to-Carcinoma Progression.
de Groen FL, Timmer LM, Menezes RX, Diosdado B, Hooijberg E, Meijer GA, Steenbergen RD, Carvalho B
PLoS One 2015;10(7):e0132495. Epub 2015 Jul 6 doi: 10.1371/journal.pone.0132495. PMID: 26148070Free PMC Article
Translocations of 14q32 and deletions of 13q14 are common chromosomal abnormalities in systemic amyloidosis.
Harrison CJ, Mazzullo H, Ross FM, Cheung KL, Gerrard G, Harewood L, Mehta A, Lachmann HJ, Hawkins PN, Orchard KH
Br J Haematol 2002 May;117(2):427-35. doi: 10.1046/j.1365-2141.2002.03438.x. PMID: 11972529
Cytogenetic analysis in the examination of solid tumors in children.
Mertens F, Mandahl N, Mitelman F, Heim S
Pediatr Hematol Oncol 1994 Jul-Aug;11(4):361-77. doi: 10.3109/08880019409140536. PMID: 7947009

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