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Gain of Chromosome 13

MedGen UID:
309189
•Concept ID:
C1517387
•
Cell or Molecular Dysfunction

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGain of Chromosome 13

Professional guidelines

PubMed

Clinical characteristics and treatment outcomes of newly diagnosed multiple myeloma with chromosome 1q abnormalities.
Abdallah N, Greipp P, Kapoor P, Gertz MA, Dispenzieri A, Baughn LB, Lacy MQ, Hayman SR, Buadi FK, Dingli D, Go RS, Hwa YL, Fonder A, Hobbs M, Lin Y, Leung N, Kourelis T, Warsame R, Siddiqui M, Lust J, Kyle RA, Bergsagel L, Ketterling R, Rajkumar SV, Kumar SK
Blood Adv 2020 Aug 11;4(15):3509-3519. doi: 10.1182/bloodadvances.2020002218. PMID: 32750129Free PMC Article
Multiple myeloma: an update on biology and treatment.
Ludwig H, Meran J, Zojer N
Ann Oncol 1999;10 Suppl 6:31-43. PMID: 10676551

Recent clinical studies

Etiology

Germline CHEK2 and ATM Variants in Myeloid and Other Hematopoietic Malignancies.
Stubbins RJ, Korotev S, Godley LA
Curr Hematol Malig Rep 2022 Aug;17(4):94-104. Epub 2022 Jun 8 doi: 10.1007/s11899-022-00663-7. PMID: 35674998
Parent-reported histories of adults with trisomy 13 syndrome.
Lebedoff AN, Carey JC
Am J Med Genet A 2021 Jun;185(6):1743-1756. Epub 2021 Mar 22 doi: 10.1002/ajmg.a.62165. PMID: 33750000
Clinical characteristics and treatment outcomes of newly diagnosed multiple myeloma with chromosome 1q abnormalities.
Abdallah N, Greipp P, Kapoor P, Gertz MA, Dispenzieri A, Baughn LB, Lacy MQ, Hayman SR, Buadi FK, Dingli D, Go RS, Hwa YL, Fonder A, Hobbs M, Lin Y, Leung N, Kourelis T, Warsame R, Siddiqui M, Lust J, Kyle RA, Bergsagel L, Ketterling R, Rajkumar SV, Kumar SK
Blood Adv 2020 Aug 11;4(15):3509-3519. doi: 10.1182/bloodadvances.2020002218. PMID: 32750129Free PMC Article
Pathogenesis of testicular germ cell tumours.
Looijenga LH, Oosterhuis JW
Rev Reprod 1999 May;4(2):90-100. doi: 10.1530/ror.0.0040090. PMID: 10357096
Biology and therapy of pediatric rhabdomyosarcoma.
Pappo AS, Shapiro DN, Crist WM, Maurer HM
J Clin Oncol 1995 Aug;13(8):2123-39. doi: 10.1200/JCO.1995.13.8.2123. PMID: 7636557

Diagnosis

Germline CHEK2 and ATM Variants in Myeloid and Other Hematopoietic Malignancies.
Stubbins RJ, Korotev S, Godley LA
Curr Hematol Malig Rep 2022 Aug;17(4):94-104. Epub 2022 Jun 8 doi: 10.1007/s11899-022-00663-7. PMID: 35674998
Parent-reported histories of adults with trisomy 13 syndrome.
Lebedoff AN, Carey JC
Am J Med Genet A 2021 Jun;185(6):1743-1756. Epub 2021 Mar 22 doi: 10.1002/ajmg.a.62165. PMID: 33750000
Clinical characteristics and treatment outcomes of newly diagnosed multiple myeloma with chromosome 1q abnormalities.
Abdallah N, Greipp P, Kapoor P, Gertz MA, Dispenzieri A, Baughn LB, Lacy MQ, Hayman SR, Buadi FK, Dingli D, Go RS, Hwa YL, Fonder A, Hobbs M, Lin Y, Leung N, Kourelis T, Warsame R, Siddiqui M, Lust J, Kyle RA, Bergsagel L, Ketterling R, Rajkumar SV, Kumar SK
Blood Adv 2020 Aug 11;4(15):3509-3519. doi: 10.1182/bloodadvances.2020002218. PMID: 32750129Free PMC Article
Biology and therapy of pediatric rhabdomyosarcoma.
Pappo AS, Shapiro DN, Crist WM, Maurer HM
J Clin Oncol 1995 Aug;13(8):2123-39. doi: 10.1200/JCO.1995.13.8.2123. PMID: 7636557
Cytogenetic analysis in the examination of solid tumors in children.
Mertens F, Mandahl N, Mitelman F, Heim S
Pediatr Hematol Oncol 1994 Jul-Aug;11(4):361-77. doi: 10.3109/08880019409140536. PMID: 7947009

Therapy

Cell-free DNA analysis reveals POLR1D-mediated resistance to bevacizumab in colorectal cancer.
Zhou Q, Perakis SO, Ulz P, Mohan S, Riedl JM, Talakic E, Lax S, Tötsch M, Hoefler G, Bauernhofer T, Pichler M, Gerger A, Geigl JB, Heitzer E, Speicher MR
Genome Med 2020 Feb 22;12(1):20. doi: 10.1186/s13073-020-0719-6. PMID: 32087735Free PMC Article
An increased frequency of 13q deletions detected by fluorescence in situ hybridization and its impact on survival in children and adolescents with Burkitt lymphoma: results from the Children's Oncology Group study CCG-5961.
Nelson M, Perkins SL, Dave BJ, Coccia PF, Bridge JA, Lyden ER, Heerema NA, Lones MA, Harrison L, Cairo MS, Sanger WG
Br J Haematol 2010 Feb;148(4):600-10. Epub 2009 Nov 4 doi: 10.1111/j.1365-2141.2009.07967.x. PMID: 19895612Free PMC Article
Abnormalities of chromosome bands 13q12 to 13q14 in childhood acute lymphoblastic leukemia.
Heerema NA, Sather HN, Sensel MG, Lee MK, Hutchinson RJ, Nachman JB, Reaman GH, Lange BJ, Steinherz PG, Bostrom BC, Gaynon PS, Uckun FM
J Clin Oncol 2000 Nov 15;18(22):3837-44. doi: 10.1200/JCO.2000.18.22.3837. PMID: 11078497
Biology and therapy of pediatric rhabdomyosarcoma.
Pappo AS, Shapiro DN, Crist WM, Maurer HM
J Clin Oncol 1995 Aug;13(8):2123-39. doi: 10.1200/JCO.1995.13.8.2123. PMID: 7636557
Different genetic pathways in leukemogenesis for patients presenting with therapy-related myelodysplasia and therapy-related acute myeloid leukemia.
Pedersen-Bjergaard J, Pedersen M, Roulston D, Philip P
Blood 1995 Nov 1;86(9):3542-52. PMID: 7579462

Prognosis

Parent-reported histories of adults with trisomy 13 syndrome.
Lebedoff AN, Carey JC
Am J Med Genet A 2021 Jun;185(6):1743-1756. Epub 2021 Mar 22 doi: 10.1002/ajmg.a.62165. PMID: 33750000
Clinical characteristics and treatment outcomes of newly diagnosed multiple myeloma with chromosome 1q abnormalities.
Abdallah N, Greipp P, Kapoor P, Gertz MA, Dispenzieri A, Baughn LB, Lacy MQ, Hayman SR, Buadi FK, Dingli D, Go RS, Hwa YL, Fonder A, Hobbs M, Lin Y, Leung N, Kourelis T, Warsame R, Siddiqui M, Lust J, Kyle RA, Bergsagel L, Ketterling R, Rajkumar SV, Kumar SK
Blood Adv 2020 Aug 11;4(15):3509-3519. doi: 10.1182/bloodadvances.2020002218. PMID: 32750129Free PMC Article
Biology and therapy of pediatric rhabdomyosarcoma.
Pappo AS, Shapiro DN, Crist WM, Maurer HM
J Clin Oncol 1995 Aug;13(8):2123-39. doi: 10.1200/JCO.1995.13.8.2123. PMID: 7636557
Cytogenetic analysis in the examination of solid tumors in children.
Mertens F, Mandahl N, Mitelman F, Heim S
Pediatr Hematol Oncol 1994 Jul-Aug;11(4):361-77. doi: 10.3109/08880019409140536. PMID: 7947009
Activated oncogenes and putative tumor suppressor genes involved in human breast cancers.
Tripathy D, Benz CC
Cancer Treat Res 1992;63:15-60. doi: 10.1007/978-1-4615-3088-6_2. PMID: 1363356

Clinical prediction guides

Cell-free DNA analysis reveals POLR1D-mediated resistance to bevacizumab in colorectal cancer.
Zhou Q, Perakis SO, Ulz P, Mohan S, Riedl JM, Talakic E, Lax S, Tötsch M, Hoefler G, Bauernhofer T, Pichler M, Gerger A, Geigl JB, Heitzer E, Speicher MR
Genome Med 2020 Feb 22;12(1):20. doi: 10.1186/s13073-020-0719-6. PMID: 32087735Free PMC Article
Induced Chromosomal Aneuploidy Results in Global and Consistent Deregulation of the Transcriptome of Cancer Cells.
Wangsa D, Braun R, Stuelten CH, Brown M, Bauer KM, Emons G, Weston LA, Hu Y, Yang HH, Vila-Casadesús M, Lee MP, Brauer P, Warner L, Upender M, Hummon AB, Camps J, Ried T
Neoplasia 2019 Jul;21(7):721-729. Epub 2019 Jun 4 doi: 10.1016/j.neo.2019.04.009. PMID: 31174021Free PMC Article
High resolution analysis of DNA copy-number aberrations of chromosomes 8, 13, and 20 in gastric cancers.
Buffart TE, van Grieken NC, Tijssen M, Coffa J, Ylstra B, Grabsch HI, van de Velde CJ, Carvalho B, Meijer GA
Virchows Arch 2009 Sep;455(3):213-23. Epub 2009 Aug 21 doi: 10.1007/s00428-009-0814-y. PMID: 19697059Free PMC Article
Losses of chromosome arms 4q, 8p, 13q and gain of 8q are correlated with increasing chromosomal instability in hepatocellular carcinoma.
Hertz S, Rothämel T, Skawran B, Giere C, Steinemann D, Flemming P, Becker T, Flik J, Wiese B, Soudah B, Kreipe H, Schlegelberger B, Wilkens L
Pathobiology 2008;75(5):312-22. Epub 2008 Oct 15 doi: 10.1159/000151712. PMID: 18931534
Cytogenetic analysis in the examination of solid tumors in children.
Mertens F, Mandahl N, Mitelman F, Heim S
Pediatr Hematol Oncol 1994 Jul-Aug;11(4):361-77. doi: 10.3109/08880019409140536. PMID: 7947009

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