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Gain of Chromosome 17

MedGen UID:
309191
•Concept ID:
C1517392
•
Cell or Molecular Dysfunction
Synonym: Chromosome 17 Amplification

Definition

A cytogenetic abnormality that refers to the allelic gain of all or part of chromosome 17. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGain of Chromosome 17

Professional guidelines

PubMed

Multilayered Omics-Based Analysis of a Head and Neck Cancer Model of Cisplatin Resistance Reveals Intratumoral Heterogeneity and Treatment-Induced Clonal Selection.
Niehr F, Eder T, Pilz T, Konschak R, Treue D, Klauschen F, Bockmayr M, Türkmen S, Jöhrens K, Budach V, Tinhofer I
Clin Cancer Res 2018 Jan 1;24(1):158-168. Epub 2017 Oct 23 doi: 10.1158/1078-0432.CCR-17-2410. PMID: 29061642
Baseline characteristics, chromosomal alterations, and treatment affecting prognosis of deletion 17p in newly diagnosed myeloma.
Merz M, Hielscher T, Seckinger A, Hose D, Mai EK, Raab MS, Goldschmidt H, Jauch A, Hillengass J
Am J Hematol 2016 Nov;91(11):E473-E477. Epub 2016 Sep 3 doi: 10.1002/ajh.24533. PMID: 27508939
Evaluation of genetic heterogeneity in neuroblastoma.
Tajiri T, Shono K, Tanaka S, Suita S
Surgery 2002 Jan;131(1 Suppl):S283-7. doi: 10.1067/msy.2002.119964. PMID: 11821825

Recent clinical studies

Etiology

Risk stratification of childhood medulloblastoma in the molecular era: the current consensus.
Ramaswamy V, Remke M, Bouffet E, Bailey S, Clifford SC, Doz F, Kool M, Dufour C, Vassal G, Milde T, Witt O, von Hoff K, Pietsch T, Northcott PA, Gajjar A, Robinson GW, Padovani L, André N, Massimino M, Pizer B, Packer R, Rutkowski S, Pfister SM, Taylor MD, Pomeroy SL
Acta Neuropathol 2016 Jun;131(6):821-31. Epub 2016 Apr 4 doi: 10.1007/s00401-016-1569-6. PMID: 27040285Free PMC Article
Chromosome 17/17q gain and unaltered profiles in high resolution array-CGH are prognostically informative in neuroblastoma.
Theissen J, Oberthuer A, Hombach A, Volland R, Hertwig F, Fischer M, Spitz R, Zapatka M, Brors B, Ortmann M, Simon T, Hero B, Berthold F
Genes Chromosomes Cancer 2014 Aug;53(8):639-49. Epub 2014 Apr 15 doi: 10.1002/gcc.22174. PMID: 24737690
Determination of 17q gain in patients with neuroblastoma by analysis of circulating DNA.
Combaret V, Bréjon S, Iacono I, Schleiermacher G, Pierron G, Ribeiro A, Bergeron C, Marabelle A, Puisieux A
Pediatr Blood Cancer 2011 May;56(5):757-61. Epub 2011 Jan 11 doi: 10.1002/pbc.22816. PMID: 21370407
Chromosome 17 alterations identify good-risk and poor-risk tumors independently of clinical factors in medulloblastoma.
McCabe MG, Bäcklund LM, Leong HS, Ichimura K, Collins VP
Neuro Oncol 2011 Apr;13(4):376-83. Epub 2011 Feb 2 doi: 10.1093/neuonc/noq192. PMID: 21292688Free PMC Article
Chromosome 17-linked dementias.
Wilhelmsen KC
Cell Mol Life Sci 1998 Sep;54(9):920-4. doi: 10.1007/s000180050221. PMID: 9791534

Diagnosis

Molecular Biomarkers of Response to Eribulin in Patients with Leiomyosarcoma.
Wozniak A, Boeckx B, Modave E, Weaver A, Lambrechts D, Littlefield BA, Schöffski P
Clin Cancer Res 2021 Jun 1;27(11):3106-3115. Epub 2021 Apr 1 doi: 10.1158/1078-0432.CCR-20-4315. PMID: 33795257
TRIM37 controls cancer-specific vulnerability to PLK4 inhibition.
Meitinger F, Ohta M, Lee KY, Watanabe S, Davis RL, Anzola JV, Kabeche R, Jenkins DA, Shiau AK, Desai A, Oegema K
Nature 2020 Sep;585(7825):440-446. Epub 2020 Sep 9 doi: 10.1038/s41586-020-2710-1. PMID: 32908304Free PMC Article
HER2, chromosome 17 polysomy and DNA ploidy status in breast cancer; a translational study.
Halilovic A, Verweij DI, Simons A, Stevens-Kroef MJPL, Vermeulen S, Elsink J, Tops BBJ, Otte-Höller I, van der Laak JAWM, van de Water C, Boelens OBA, Schlooz-Vries MS, Dijkstra JR, Nagtegaal ID, Tol J, van Cleef PHJ, Span PN, Bult P
Sci Rep 2019 Aug 12;9(1):11679. doi: 10.1038/s41598-019-48212-2. PMID: 31406196Free PMC Article
Chromosome 17/17q gain and unaltered profiles in high resolution array-CGH are prognostically informative in neuroblastoma.
Theissen J, Oberthuer A, Hombach A, Volland R, Hertwig F, Fischer M, Spitz R, Zapatka M, Brors B, Ortmann M, Simon T, Hero B, Berthold F
Genes Chromosomes Cancer 2014 Aug;53(8):639-49. Epub 2014 Apr 15 doi: 10.1002/gcc.22174. PMID: 24737690
Determination of 17q gain in patients with neuroblastoma by analysis of circulating DNA.
Combaret V, Bréjon S, Iacono I, Schleiermacher G, Pierron G, Ribeiro A, Bergeron C, Marabelle A, Puisieux A
Pediatr Blood Cancer 2011 May;56(5):757-61. Epub 2011 Jan 11 doi: 10.1002/pbc.22816. PMID: 21370407

Therapy

Molecular Biomarkers of Response to Eribulin in Patients with Leiomyosarcoma.
Wozniak A, Boeckx B, Modave E, Weaver A, Lambrechts D, Littlefield BA, Schöffski P
Clin Cancer Res 2021 Jun 1;27(11):3106-3115. Epub 2021 Apr 1 doi: 10.1158/1078-0432.CCR-20-4315. PMID: 33795257
TRIM37 controls cancer-specific vulnerability to PLK4 inhibition.
Meitinger F, Ohta M, Lee KY, Watanabe S, Davis RL, Anzola JV, Kabeche R, Jenkins DA, Shiau AK, Desai A, Oegema K
Nature 2020 Sep;585(7825):440-446. Epub 2020 Sep 9 doi: 10.1038/s41586-020-2710-1. PMID: 32908304Free PMC Article
Novel agents in chronic lymphocytic leukemia.
Lamanna N, O'Brien S
Hematology Am Soc Hematol Educ Program 2016 Dec 2;2016(1):137-145. doi: 10.1182/asheducation-2016.1.137. PMID: 27913472Free PMC Article
Concurrent gain of 17q and the MYC oncogene in a medullomyoblastoma.
Lindberg E, Persson A, Øra I, Mertens F, Englund E, Gisselsson D
Neuropathology 2007 Dec;27(6):556-60. doi: 10.1111/j.1440-1789.2007.00810.x. PMID: 18021376
Variety and complexity of chromosome 17 translocations in neuroblastoma.
Schleiermacher G, Raynal V, Janoueix-Lerosey I, Combaret V, Aurias A, Delattre O
Genes Chromosomes Cancer 2004 Feb;39(2):143-50. doi: 10.1002/gcc.10313. PMID: 14695994

Prognosis

An ALYREF-MYCN coactivator complex drives neuroblastoma tumorigenesis through effects on USP3 and MYCN stability.
Nagy Z, Seneviratne JA, Kanikevich M, Chang W, Mayoh C, Venkat P, Du Y, Jiang C, Salib A, Koach J, Carter DR, Mittra R, Liu T, Parker MW, Cheung BB, Marshall GM
Nat Commun 2021 Mar 25;12(1):1881. doi: 10.1038/s41467-021-22143-x. PMID: 33767157Free PMC Article
HER2, chromosome 17 polysomy and DNA ploidy status in breast cancer; a translational study.
Halilovic A, Verweij DI, Simons A, Stevens-Kroef MJPL, Vermeulen S, Elsink J, Tops BBJ, Otte-Höller I, van der Laak JAWM, van de Water C, Boelens OBA, Schlooz-Vries MS, Dijkstra JR, Nagtegaal ID, Tol J, van Cleef PHJ, Span PN, Bult P
Sci Rep 2019 Aug 12;9(1):11679. doi: 10.1038/s41598-019-48212-2. PMID: 31406196Free PMC Article
Delineation of the frequency and boundary of chromosomal copy number variations in paediatric neuroblastoma.
Ho N, Peng H, Mayoh C, Liu PY, Atmadibrata B, Marshall GM, Li J, Liu T
Cell Cycle 2018;17(6):749-758. doi: 10.1080/15384101.2017.1421875. PMID: 29353549Free PMC Article
Risk stratification of childhood medulloblastoma in the molecular era: the current consensus.
Ramaswamy V, Remke M, Bouffet E, Bailey S, Clifford SC, Doz F, Kool M, Dufour C, Vassal G, Milde T, Witt O, von Hoff K, Pietsch T, Northcott PA, Gajjar A, Robinson GW, Padovani L, André N, Massimino M, Pizer B, Packer R, Rutkowski S, Pfister SM, Taylor MD, Pomeroy SL
Acta Neuropathol 2016 Jun;131(6):821-31. Epub 2016 Apr 4 doi: 10.1007/s00401-016-1569-6. PMID: 27040285Free PMC Article
Breast cancer and aneusomy 17: implications for carcinogenesis and therapeutic response.
Reinholz MM, Bruzek AK, Visscher DW, Lingle WL, Schroeder MJ, Perez EA, Jenkins RB
Lancet Oncol 2009 Mar;10(3):267-77. doi: 10.1016/S1470-2045(09)70063-4. PMID: 19261255Free PMC Article

Clinical prediction guides

Molecular Biomarkers of Response to Eribulin in Patients with Leiomyosarcoma.
Wozniak A, Boeckx B, Modave E, Weaver A, Lambrechts D, Littlefield BA, Schöffski P
Clin Cancer Res 2021 Jun 1;27(11):3106-3115. Epub 2021 Apr 1 doi: 10.1158/1078-0432.CCR-20-4315. PMID: 33795257
HER2, chromosome 17 polysomy and DNA ploidy status in breast cancer; a translational study.
Halilovic A, Verweij DI, Simons A, Stevens-Kroef MJPL, Vermeulen S, Elsink J, Tops BBJ, Otte-Höller I, van der Laak JAWM, van de Water C, Boelens OBA, Schlooz-Vries MS, Dijkstra JR, Nagtegaal ID, Tol J, van Cleef PHJ, Span PN, Bult P
Sci Rep 2019 Aug 12;9(1):11679. doi: 10.1038/s41598-019-48212-2. PMID: 31406196Free PMC Article
Risk stratification of childhood medulloblastoma in the molecular era: the current consensus.
Ramaswamy V, Remke M, Bouffet E, Bailey S, Clifford SC, Doz F, Kool M, Dufour C, Vassal G, Milde T, Witt O, von Hoff K, Pietsch T, Northcott PA, Gajjar A, Robinson GW, Padovani L, André N, Massimino M, Pizer B, Packer R, Rutkowski S, Pfister SM, Taylor MD, Pomeroy SL
Acta Neuropathol 2016 Jun;131(6):821-31. Epub 2016 Apr 4 doi: 10.1007/s00401-016-1569-6. PMID: 27040285Free PMC Article
Determination of 17q gain in patients with neuroblastoma by analysis of circulating DNA.
Combaret V, Bréjon S, Iacono I, Schleiermacher G, Pierron G, Ribeiro A, Bergeron C, Marabelle A, Puisieux A
Pediatr Blood Cancer 2011 May;56(5):757-61. Epub 2011 Jan 11 doi: 10.1002/pbc.22816. PMID: 21370407
Variety and complexity of chromosome 17 translocations in neuroblastoma.
Schleiermacher G, Raynal V, Janoueix-Lerosey I, Combaret V, Aurias A, Delattre O
Genes Chromosomes Cancer 2004 Feb;39(2):143-50. doi: 10.1002/gcc.10313. PMID: 14695994

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