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Gain of Chromosome 17q

MedGen UID:
309192
•Concept ID:
C1517394
•
Cell or Molecular Dysfunction
Synonym: add(17q)

Definition

A cytogenetic abnormality that refers to the duplication of all or part of the long arm of chromosome 17. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGain of Chromosome 17q

Professional guidelines

PubMed

Newly-derived neuroblastoma cell lines propagated in serum-free media recapitulate the genotype and phenotype of primary neuroblastoma tumours.
Bate-Eya LT, Ebus ME, Koster J, den Hartog IJ, Zwijnenburg DA, Schild L, van der Ploeg I, Dolman ME, Caron HN, Versteeg R, Molenaar JJ
Eur J Cancer 2014 Feb;50(3):628-37. Epub 2013 Dec 6 doi: 10.1016/j.ejca.2013.11.015. PMID: 24321263

Recent clinical studies

Etiology

Chromosome 17/17q gain and unaltered profiles in high resolution array-CGH are prognostically informative in neuroblastoma.
Theissen J, Oberthuer A, Hombach A, Volland R, Hertwig F, Fischer M, Spitz R, Zapatka M, Brors B, Ortmann M, Simon T, Hero B, Berthold F
Genes Chromosomes Cancer 2014 Aug;53(8):639-49. Epub 2014 Apr 15 doi: 10.1002/gcc.22174. PMID: 24737690
Medulloblastomas in adults: prognostic factors and lessons from paediatrics.
Fellay CN, Frappaz D, Sunyach MP, Franceschi E, Brandes AA, Stupp R
Curr Opin Neurol 2011 Dec;24(6):626-32. doi: 10.1097/WCO.0b013e32834cd4b1. PMID: 22027544
Determination of 17q gain in patients with neuroblastoma by analysis of circulating DNA.
Combaret V, Bréjon S, Iacono I, Schleiermacher G, Pierron G, Ribeiro A, Bergeron C, Marabelle A, Puisieux A
Pediatr Blood Cancer 2011 May;56(5):757-61. Epub 2011 Jan 11 doi: 10.1002/pbc.22816. PMID: 21370407
Gain of distal chromosome arm 17q is not associated with poor prognosis in neuroblastoma.
Spitz R, Hero B, Ernestus K, Berthold F
Clin Cancer Res 2003 Oct 15;9(13):4835-40. PMID: 14581355
Gain of chromosome arm 17q and adverse outcome in patients with neuroblastoma.
Bown N, Cotterill S, Lastowska M, O'Neill S, Pearson AD, Plantaz D, Meddeb M, Danglot G, Brinkschmidt C, Christiansen H, Laureys G, Speleman F, Nicholson J, Bernheim A, Betts DR, Vandesompele J, Van Roy N
N Engl J Med 1999 Jun 24;340(25):1954-61. doi: 10.1056/NEJM199906243402504. PMID: 10379019

Diagnosis

TRIM37 controls cancer-specific vulnerability to PLK4 inhibition.
Meitinger F, Ohta M, Lee KY, Watanabe S, Davis RL, Anzola JV, Kabeche R, Jenkins DA, Shiau AK, Desai A, Oegema K
Nature 2020 Sep;585(7825):440-446. Epub 2020 Sep 9 doi: 10.1038/s41586-020-2710-1. PMID: 32908304Free PMC Article
Cytogenetics of melanoma and nonmelanoma skin cancer.
Carless MA, Griffiths LR
Adv Exp Med Biol 2014;810:160-81. doi: 10.1007/978-1-4939-0437-2_9. PMID: 25207365
Chromosome 17/17q gain and unaltered profiles in high resolution array-CGH are prognostically informative in neuroblastoma.
Theissen J, Oberthuer A, Hombach A, Volland R, Hertwig F, Fischer M, Spitz R, Zapatka M, Brors B, Ortmann M, Simon T, Hero B, Berthold F
Genes Chromosomes Cancer 2014 Aug;53(8):639-49. Epub 2014 Apr 15 doi: 10.1002/gcc.22174. PMID: 24737690
Determination of 17q gain in patients with neuroblastoma by analysis of circulating DNA.
Combaret V, Bréjon S, Iacono I, Schleiermacher G, Pierron G, Ribeiro A, Bergeron C, Marabelle A, Puisieux A
Pediatr Blood Cancer 2011 May;56(5):757-61. Epub 2011 Jan 11 doi: 10.1002/pbc.22816. PMID: 21370407
Gain of distal chromosome arm 17q is not associated with poor prognosis in neuroblastoma.
Spitz R, Hero B, Ernestus K, Berthold F
Clin Cancer Res 2003 Oct 15;9(13):4835-40. PMID: 14581355

Therapy

TRIM37 controls cancer-specific vulnerability to PLK4 inhibition.
Meitinger F, Ohta M, Lee KY, Watanabe S, Davis RL, Anzola JV, Kabeche R, Jenkins DA, Shiau AK, Desai A, Oegema K
Nature 2020 Sep;585(7825):440-446. Epub 2020 Sep 9 doi: 10.1038/s41586-020-2710-1. PMID: 32908304Free PMC Article
Medulloblastomas in adults: prognostic factors and lessons from paediatrics.
Fellay CN, Frappaz D, Sunyach MP, Franceschi E, Brandes AA, Stupp R
Curr Opin Neurol 2011 Dec;24(6):626-32. doi: 10.1097/WCO.0b013e32834cd4b1. PMID: 22027544
Concurrent gain of 17q and the MYC oncogene in a medullomyoblastoma.
Lindberg E, Persson A, Øra I, Mertens F, Englund E, Gisselsson D
Neuropathology 2007 Dec;27(6):556-60. doi: 10.1111/j.1440-1789.2007.00810.x. PMID: 18021376
Variety and complexity of chromosome 17 translocations in neuroblastoma.
Schleiermacher G, Raynal V, Janoueix-Lerosey I, Combaret V, Aurias A, Delattre O
Genes Chromosomes Cancer 2004 Feb;39(2):143-50. doi: 10.1002/gcc.10313. PMID: 14695994
Cytogenetic studies in prostate cancer: are we making progress?
Brothman AR
Cancer Genet Cytogenet 1997 May;95(1):116-21. doi: 10.1016/s0165-4608(96)00302-0. PMID: 9140461

Prognosis

Delineation of the frequency and boundary of chromosomal copy number variations in paediatric neuroblastoma.
Ho N, Peng H, Mayoh C, Liu PY, Atmadibrata B, Marshall GM, Li J, Liu T
Cell Cycle 2018;17(6):749-758. doi: 10.1080/15384101.2017.1421875. PMID: 29353549Free PMC Article
Neuroblastoma epigenetics: from candidate gene approaches to genome-wide screenings.
Decock A, Ongenaert M, Vandesompele J, Speleman F
Epigenetics 2011 Aug;6(8):962-70. Epub 2011 Aug 1 doi: 10.4161/epi.6.8.16516. PMID: 21725203
Determination of 17q gain in patients with neuroblastoma by analysis of circulating DNA.
Combaret V, Bréjon S, Iacono I, Schleiermacher G, Pierron G, Ribeiro A, Bergeron C, Marabelle A, Puisieux A
Pediatr Blood Cancer 2011 May;56(5):757-61. Epub 2011 Jan 11 doi: 10.1002/pbc.22816. PMID: 21370407
Concurrent gain of 17q and the MYC oncogene in a medullomyoblastoma.
Lindberg E, Persson A, Øra I, Mertens F, Englund E, Gisselsson D
Neuropathology 2007 Dec;27(6):556-60. doi: 10.1111/j.1440-1789.2007.00810.x. PMID: 18021376
Gain of 1q and loss of 9q21.3-q32 are associated with a less favorable prognosis in papillary thyroid carcinoma.
Kjellman P, Lagercrantz S, Höög A, Wallin G, Larsson C, Zedenius J
Genes Chromosomes Cancer 2001 Sep;32(1):43-9. doi: 10.1002/gcc.1165. PMID: 11477660

Clinical prediction guides

Determination of 17q gain in patients with neuroblastoma by analysis of circulating DNA.
Combaret V, Bréjon S, Iacono I, Schleiermacher G, Pierron G, Ribeiro A, Bergeron C, Marabelle A, Puisieux A
Pediatr Blood Cancer 2011 May;56(5):757-61. Epub 2011 Jan 11 doi: 10.1002/pbc.22816. PMID: 21370407
Gain of distal chromosome arm 17q is not associated with poor prognosis in neuroblastoma.
Spitz R, Hero B, Ernestus K, Berthold F
Clin Cancer Res 2003 Oct 15;9(13):4835-40. PMID: 14581355
Molecular analysis of chromosome arm 17q gain in neuroblastoma.
Janoueix-Lerosey I, Penther D, Thioux M, de Crémoux P, Derré J, Ambros P, Vielh P, Bénard J, Aurias A, Delattre O
Genes Chromosomes Cancer 2000 Jul;28(3):276-84. doi: 10.1002/1098-2264(200007)28:3<276::aid-gcc5>3.0.co;2-p. PMID: 10862033
Gain of chromosome arm 17q and adverse outcome in patients with neuroblastoma.
Bown N, Cotterill S, Lastowska M, O'Neill S, Pearson AD, Plantaz D, Meddeb M, Danglot G, Brinkschmidt C, Christiansen H, Laureys G, Speleman F, Nicholson J, Bernheim A, Betts DR, Vandesompele J, Van Roy N
N Engl J Med 1999 Jun 24;340(25):1954-61. doi: 10.1056/NEJM199906243402504. PMID: 10379019
Cytogenetic analysis in the examination of solid tumors in children.
Mertens F, Mandahl N, Mitelman F, Heim S
Pediatr Hematol Oncol 1994 Jul-Aug;11(4):361-77. doi: 10.3109/08880019409140536. PMID: 7947009

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