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Gain of Chromosome 17q

MedGen UID:
309192
Concept ID:
C1517394
Cell or Molecular Dysfunction
Synonym: add(17q)

Definition

A cytogenetic abnormality that refers to the duplication of all or part of the long arm of chromosome 17. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGain of Chromosome 17q

Professional guidelines

PubMed

Bate-Eya LT, Ebus ME, Koster J, den Hartog IJ, Zwijnenburg DA, Schild L, van der Ploeg I, Dolman ME, Caron HN, Versteeg R, Molenaar JJ
Eur J Cancer 2014 Feb;50(3):628-37. Epub 2013 Dec 6 doi: 10.1016/j.ejca.2013.11.015. PMID: 24321263

Recent clinical studies

Etiology

Hagemann S, Misiak D, Bell JL, Fuchs T, Lederer MI, Bley N, Hämmerle M, Ghazy E, Sippl W, Schulte JH, Hüttelmaier S
Mol Cancer 2023 May 29;22(1):88. doi: 10.1186/s12943-023-01792-0. PMID: 37246217Free PMC Article
Goddard J, Castle J, Southworth E, Fletcher A, Crosier S, Martin-Guerrero I, García-Ariza M, Navajas A, Masliah-Planchon J, Bourdeaut F, Dufour C, Ayrault O, Goschzik T, Pietsch T, Sill M, Pfister SM, Rutkowski S, Richardson S, Hill RM, Williamson D, Bailey S, Schwalbe EC, Clifford SC, Hicks D
Acta Neuropathol 2023 May;145(5):651-666. Epub 2023 Apr 4 doi: 10.1007/s00401-023-02566-0. PMID: 37014508Free PMC Article
Fellay CN, Frappaz D, Sunyach MP, Franceschi E, Brandes AA, Stupp R
Curr Opin Neurol 2011 Dec;24(6):626-32. doi: 10.1097/WCO.0b013e32834cd4b1. PMID: 22027544
Vasudevan SA, Nuchtern JG, Shohet JM
World J Surg 2005 Mar;29(3):317-24. doi: 10.1007/s00268-004-7820-7. PMID: 15706435
Bown N, Cotterill S, Lastowska M, O'Neill S, Pearson AD, Plantaz D, Meddeb M, Danglot G, Brinkschmidt C, Christiansen H, Laureys G, Speleman F, Nicholson J, Bernheim A, Betts DR, Vandesompele J, Van Roy N
N Engl J Med 1999 Jun 24;340(25):1954-61. doi: 10.1056/NEJM199906243402504. PMID: 10379019

Diagnosis

Meitinger F, Ohta M, Lee KY, Watanabe S, Davis RL, Anzola JV, Kabeche R, Jenkins DA, Shiau AK, Desai A, Oegema K
Nature 2020 Sep;585(7825):440-446. Epub 2020 Sep 9 doi: 10.1038/s41586-020-2710-1. PMID: 32908304Free PMC Article
Carless MA, Griffiths LR
Adv Exp Med Biol 2014;810:160-81. doi: 10.1007/978-1-4939-0437-2_9. PMID: 25207365
Combaret V, Bréjon S, Iacono I, Schleiermacher G, Pierron G, Ribeiro A, Bergeron C, Marabelle A, Puisieux A
Pediatr Blood Cancer 2011 May;56(5):757-61. Epub 2011 Jan 11 doi: 10.1002/pbc.22816. PMID: 21370407
Vandesompele J, Michels E, De Preter K, Menten B, Schramm A, Eggert A, Ambros PF, Combaret V, Francotte N, Antonacci F, De Paepe A, Laureys G, Speleman F, Van Roy N
Int J Cancer 2008 Mar 1;122(5):1177-82. doi: 10.1002/ijc.23156. PMID: 17973261
Bowcock AM, Barker JN
J Am Acad Dermatol 2003 Aug;49(2 Suppl):S51-6. doi: 10.1016/s0190-9622(03)01135-6. PMID: 12894126

Therapy

Meitinger F, Ohta M, Lee KY, Watanabe S, Davis RL, Anzola JV, Kabeche R, Jenkins DA, Shiau AK, Desai A, Oegema K
Nature 2020 Sep;585(7825):440-446. Epub 2020 Sep 9 doi: 10.1038/s41586-020-2710-1. PMID: 32908304Free PMC Article
Fellay CN, Frappaz D, Sunyach MP, Franceschi E, Brandes AA, Stupp R
Curr Opin Neurol 2011 Dec;24(6):626-32. doi: 10.1097/WCO.0b013e32834cd4b1. PMID: 22027544
Lindberg E, Persson A, Øra I, Mertens F, Englund E, Gisselsson D
Neuropathology 2007 Dec;27(6):556-60. doi: 10.1111/j.1440-1789.2007.00810.x. PMID: 18021376
Schleiermacher G, Raynal V, Janoueix-Lerosey I, Combaret V, Aurias A, Delattre O
Genes Chromosomes Cancer 2004 Feb;39(2):143-50. doi: 10.1002/gcc.10313. PMID: 14695994
Morowitz M, Shusterman S, Mosse Y, Hii G, Winter CL, Khazi D, Wang Q, King R, Maris JM
Mod Pathol 2003 Dec;16(12):1248-56. doi: 10.1097/01.MP.0000097364.64566.81. PMID: 14681326

Prognosis

Goddard J, Castle J, Southworth E, Fletcher A, Crosier S, Martin-Guerrero I, García-Ariza M, Navajas A, Masliah-Planchon J, Bourdeaut F, Dufour C, Ayrault O, Goschzik T, Pietsch T, Sill M, Pfister SM, Rutkowski S, Richardson S, Hill RM, Williamson D, Bailey S, Schwalbe EC, Clifford SC, Hicks D
Acta Neuropathol 2023 May;145(5):651-666. Epub 2023 Apr 4 doi: 10.1007/s00401-023-02566-0. PMID: 37014508Free PMC Article
Fellay CN, Frappaz D, Sunyach MP, Franceschi E, Brandes AA, Stupp R
Curr Opin Neurol 2011 Dec;24(6):626-32. doi: 10.1097/WCO.0b013e32834cd4b1. PMID: 22027544
Decock A, Ongenaert M, Vandesompele J, Speleman F
Epigenetics 2011 Aug;6(8):962-70. Epub 2011 Aug 1 doi: 10.4161/epi.6.8.16516. PMID: 21725203
Vandesompele J, Michels E, De Preter K, Menten B, Schramm A, Eggert A, Ambros PF, Combaret V, Francotte N, Antonacci F, De Paepe A, Laureys G, Speleman F, Van Roy N
Int J Cancer 2008 Mar 1;122(5):1177-82. doi: 10.1002/ijc.23156. PMID: 17973261
Vasudevan SA, Nuchtern JG, Shohet JM
World J Surg 2005 Mar;29(3):317-24. doi: 10.1007/s00268-004-7820-7. PMID: 15706435

Clinical prediction guides

Goddard J, Castle J, Southworth E, Fletcher A, Crosier S, Martin-Guerrero I, García-Ariza M, Navajas A, Masliah-Planchon J, Bourdeaut F, Dufour C, Ayrault O, Goschzik T, Pietsch T, Sill M, Pfister SM, Rutkowski S, Richardson S, Hill RM, Williamson D, Bailey S, Schwalbe EC, Clifford SC, Hicks D
Acta Neuropathol 2023 May;145(5):651-666. Epub 2023 Apr 4 doi: 10.1007/s00401-023-02566-0. PMID: 37014508Free PMC Article
Ohira M, Nakamura Y, Takimoto T, Nakazawa A, Hishiki T, Matsumoto K, Shichino H, Iehara T, Nagase H, Fukushima T, Yoneda A, Tajiri T, Nakagawara A, Kamijo T
Biomolecules 2021 Dec 23;12(1) doi: 10.3390/biom12010018. PMID: 35053166Free PMC Article
Combaret V, Bréjon S, Iacono I, Schleiermacher G, Pierron G, Ribeiro A, Bergeron C, Marabelle A, Puisieux A
Pediatr Blood Cancer 2011 May;56(5):757-61. Epub 2011 Jan 11 doi: 10.1002/pbc.22816. PMID: 21370407
Vandesompele J, Michels E, De Preter K, Menten B, Schramm A, Eggert A, Ambros PF, Combaret V, Francotte N, Antonacci F, De Paepe A, Laureys G, Speleman F, Van Roy N
Int J Cancer 2008 Mar 1;122(5):1177-82. doi: 10.1002/ijc.23156. PMID: 17973261
Bown N, Cotterill S, Lastowska M, O'Neill S, Pearson AD, Plantaz D, Meddeb M, Danglot G, Brinkschmidt C, Christiansen H, Laureys G, Speleman F, Nicholson J, Bernheim A, Betts DR, Vandesompele J, Van Roy N
N Engl J Med 1999 Jun 24;340(25):1954-61. doi: 10.1056/NEJM199906243402504. PMID: 10379019

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