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Gain of Chromosome 21

MedGen UID:
309194
Concept ID:
C1517406
Cell or Molecular Dysfunction

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGain of Chromosome 21

Professional guidelines

PubMed

Klein K, Kaspers G, Harrison CJ, Beverloo HB, Reedijk A, Bongers M, Cloos J, Pession A, Reinhardt D, Zimmerman M, Creutzig U, Dworzak M, Alonzo T, Johnston D, Hirsch B, Zapotocky M, De Moerloose B, Fynn A, Lee V, Taga T, Tawa A, Auvrignon A, Zeller B, Forestier E, Salgado C, Balwierz W, Popa A, Rubnitz J, Raimondi S, Gibson B
J Clin Oncol 2015 Dec 20;33(36):4247-58. Epub 2015 Nov 16 doi: 10.1200/JCO.2015.61.1947. PMID: 26573082Free PMC Article

Recent clinical studies

Etiology

Hormann FM, Mooij EJ, van de Mheen M, Beverloo HB, den Boer ML, Boer JM
Genes Chromosomes Cancer 2024 Jan;63(1):e23217. Epub 2023 Dec 12 doi: 10.1002/gcc.23217. PMID: 38087879
Gialesaki S, Bräuer-Hartmann D, Issa H, Bhayadia R, Alejo-Valle O, Verboon L, Schmell AL, Laszig S, Regényi E, Schuschel K, Labuhn M, Ng M, Winkler R, Ihling C, Sinz A, Glaß M, Hüttelmaier S, Matzk S, Schmid L, Strüwe FJ, Kadel SK, Reinhardt D, Yaspo ML, Heckl D, Klusmann JH
Blood 2023 Mar 9;141(10):1105-1118. doi: 10.1182/blood.2022017619. PMID: 36493345Free PMC Article
Farley SJ, Grishok A, Zeldich E
Epigenetics Chromatin 2022 Dec 3;15(1):39. doi: 10.1186/s13072-022-00471-6. PMID: 36463299Free PMC Article
Laurent AP, Kotecha RS, Malinge S
Leukemia 2020 Aug;34(8):1984-1999. Epub 2020 May 20 doi: 10.1038/s41375-020-0854-5. PMID: 32433508Free PMC Article
Antonarakis SE
Nat Rev Genet 2017 Mar;18(3):147-163. Epub 2016 Dec 28 doi: 10.1038/nrg.2016.154. PMID: 28029161

Diagnosis

Hormann FM, Mooij EJ, van de Mheen M, Beverloo HB, den Boer ML, Boer JM
Genes Chromosomes Cancer 2024 Jan;63(1):e23217. Epub 2023 Dec 12 doi: 10.1002/gcc.23217. PMID: 38087879
Hirata K, Nambara T, Kawatani K, Nawa N, Yoshimatsu H, Kusakabe H, Banno K, Nishimura K, Ohtaka M, Nakanishi M, Taniguchi H, Arahori H, Wada K, Ozono K, Kitabatake Y
Sci Rep 2020 Aug 20;10(1):14047. doi: 10.1038/s41598-020-70362-x. PMID: 32820178Free PMC Article
Laurent AP, Kotecha RS, Malinge S
Leukemia 2020 Aug;34(8):1984-1999. Epub 2020 May 20 doi: 10.1038/s41375-020-0854-5. PMID: 32433508Free PMC Article
Passerini V, Ozeri-Galai E, de Pagter MS, Donnelly N, Schmalbrock S, Kloosterman WP, Kerem B, Storchová Z
Nat Commun 2016 Feb 15;7:10754. doi: 10.1038/ncomms10754. PMID: 26876972Free PMC Article
Harrison CJ, Moorman AV, Schwab C, Carroll AJ, Raetz EA, Devidas M, Strehl S, Nebral K, Harbott J, Teigler-Schlegel A, Zimmerman M, Dastuge N, Baruchel A, Soulier J, Auclerc MF, Attarbaschi A, Mann G, Stark B, Cazzaniga G, Chilton L, Vandenberghe P, Forestier E, Haltrich I, Raimondi SC, Parihar M, Bourquin JP, Tchinda J, Haferlach C, Vora A, Hunger SP, Heerema NA, Haas OA; Ponte di Legno International Workshop in Childhood Acute Lymphoblastic Leukemia
Leukemia 2014 May;28(5):1015-21. Epub 2013 Oct 29 doi: 10.1038/leu.2013.317. PMID: 24166298Free PMC Article

Therapy

Akutsu SN, Miyamoto T, Oba D, Tomioka K, Ochiai H, Ohashi H, Matsuura S
PLoS One 2022;17(3):e0264965. Epub 2022 Mar 10 doi: 10.1371/journal.pone.0264965. PMID: 35271616Free PMC Article
Perrot A, Lauwers-Cances V, Tournay E, Hulin C, Chretien ML, Royer B, Dib M, Decaux O, Jaccard A, Belhadj K, Brechignac S, Fontan J, Voillat L, Demarquette H, Collet P, Rodon P, Sohn C, Lifermann F, Orsini-Piocelle F, Richez V, Mohty M, Macro M, Minvielle S, Moreau P, Leleu X, Facon T, Attal M, Avet-Loiseau H, Corre J
J Clin Oncol 2019 Jul 1;37(19):1657-1665. Epub 2019 May 15 doi: 10.1200/JCO.18.00776. PMID: 31091136Free PMC Article
Ivanov Öfverholm I, Tran AN, Olsson L, Zachariadis V, Heyman M, Rudd E, Syk Lundberg E, Nordenskjöld M, Johansson B, Nordgren A, Barbany G
Leuk Lymphoma 2016 Sep;57(9):2161-70. Epub 2016 Apr 19 doi: 10.3109/10428194.2015.1136740. PMID: 27090575
Klein K, Kaspers G, Harrison CJ, Beverloo HB, Reedijk A, Bongers M, Cloos J, Pession A, Reinhardt D, Zimmerman M, Creutzig U, Dworzak M, Alonzo T, Johnston D, Hirsch B, Zapotocky M, De Moerloose B, Fynn A, Lee V, Taga T, Tawa A, Auvrignon A, Zeller B, Forestier E, Salgado C, Balwierz W, Popa A, Rubnitz J, Raimondi S, Gibson B
J Clin Oncol 2015 Dec 20;33(36):4247-58. Epub 2015 Nov 16 doi: 10.1200/JCO.2015.61.1947. PMID: 26573082Free PMC Article
Ji Z, Weldon RH, Marchetti F, Chen H, Li G, Xing C, Kurtovich E, Young S, Schmid TE, Waidyanatha S, Rappaport S, Zhang L, Eskenazi B
Environ Mol Mutagen 2012 Apr;53(3):218-26. Epub 2012 Feb 20 doi: 10.1002/em.21683. PMID: 22351378

Prognosis

Magatha LS, Scott JX, Subramaniam G, Chandrasekaran T, Paul SFD, Koshy T
Med Princ Pract 2021;30(6):563-570. Epub 2021 Jul 7 doi: 10.1159/000518280. PMID: 34348305Free PMC Article
Perrot A, Lauwers-Cances V, Tournay E, Hulin C, Chretien ML, Royer B, Dib M, Decaux O, Jaccard A, Belhadj K, Brechignac S, Fontan J, Voillat L, Demarquette H, Collet P, Rodon P, Sohn C, Lifermann F, Orsini-Piocelle F, Richez V, Mohty M, Macro M, Minvielle S, Moreau P, Leleu X, Facon T, Attal M, Avet-Loiseau H, Corre J
J Clin Oncol 2019 Jul 1;37(19):1657-1665. Epub 2019 May 15 doi: 10.1200/JCO.18.00776. PMID: 31091136Free PMC Article
Carlson ML, Smadbeck JB, Link MJ, Klee EW, Vasmatzis G, Schimmenti LA
Otol Neurotol 2018 Oct;39(9):e860-e871. doi: 10.1097/MAO.0000000000001932. PMID: 30106846
Weber S, Haferlach C, Jeromin S, Nadarajah N, Dicker F, Noël L, Zenger M, Alpermann T, Kern W, Haferlach T, Schnittger S
Genes Chromosomes Cancer 2016 Feb;55(2):148-57. Epub 2015 Nov 6 doi: 10.1002/gcc.22321. PMID: 26542308
Li Z, Chen P, Su R, Li Y, Hu C, Wang Y, Arnovitz S, He M, Gurbuxani S, Zuo Z, Elkahloun AG, Li S, Weng H, Huang H, Neilly MB, Wang S, Olson EN, Larson RA, Le Beau MM, Zhang J, Jiang X, Wei M, Jin J, Liu PP, Chen J
Blood 2015 Oct 22;126(17):2005-15. Epub 2015 Sep 11 doi: 10.1182/blood-2015-04-639062. PMID: 26361793Free PMC Article

Clinical prediction guides

Tuna M, Mills GB, Amos CI
Neoplasia 2023 Nov;45:100932. Epub 2023 Oct 4 doi: 10.1016/j.neo.2023.100932. PMID: 37801862Free PMC Article
Hazra A, O'Hara A, Polyak K, Nakhlis F, Harrison BT, Giordano A, Overmoyer B, Lynce F
Cells 2023 Apr 4;12(7) doi: 10.3390/cells12071086. PMID: 37048158Free PMC Article
Krivega M, Stiefel CM, Storchova Z
Am J Hum Genet 2022 Dec 1;109(12):2126-2140. doi: 10.1016/j.ajhg.2022.10.014. PMID: 36459979Free PMC Article
Li Z, Chen P, Su R, Li Y, Hu C, Wang Y, Arnovitz S, He M, Gurbuxani S, Zuo Z, Elkahloun AG, Li S, Weng H, Huang H, Neilly MB, Wang S, Olson EN, Larson RA, Le Beau MM, Zhang J, Jiang X, Wei M, Jin J, Liu PP, Chen J
Blood 2015 Oct 22;126(17):2005-15. Epub 2015 Sep 11 doi: 10.1182/blood-2015-04-639062. PMID: 26361793Free PMC Article
Siddique T, Hentati A
Clin Neurosci 1995-1996;3(6):338-47. PMID: 9021255

Supplemental Content

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