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Gain of Chromosome 2p

MedGen UID:
309195
•Concept ID:
C1517408
•
Cell or Molecular Dysfunction

Definition

A cytogenetic abnormality that refers to the duplication of all or part of the short arm of chromosome 2. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGain of Chromosome 2p

Professional guidelines

PubMed

Cytogenetics in the management of chronic lymphocytic leukemia: Guidelines from the Groupe Francophone de Cytogénétique Hématologique (GFCH).
Nguyen-Khac F, Balogh Z, Chauzeix J, Veronese L, Chapiro E
Curr Res Transl Med 2023 Oct-Dec;71(4):103410. Epub 2023 Sep 17 doi: 10.1016/j.retram.2023.103410. PMID: 38039634
Primary Intestinal Diffuse Large B-cell Lymphoma in Taiwan Showed a Relative Higher Rate of Perforation and EBV Association.
Lu YH, Chang ST, Yang SF, Weng SF, Huang WT, Hsieh PP, Hsu JD, Tsou MH, Chuang SS
Appl Immunohistochem Mol Morphol 2016 Sep;24(8):541-9. doi: 10.1097/PAI.0000000000000226. PMID: 26258754
Genome-wide copy number analysis of Hodgkin Reed-Sternberg cells identifies recurrent imbalances with correlations to treatment outcome.
Steidl C, Telenius A, Shah SP, Farinha P, Barclay L, Boyle M, Connors JM, Horsman DE, Gascoyne RD
Blood 2010 Jul 22;116(3):418-27. Epub 2010 Mar 25 doi: 10.1182/blood-2009-12-257345. PMID: 20339089

Recent clinical studies

Etiology

IGF2BP1 induces neuroblastoma via a druggable feedforward loop with MYCN promoting 17q oncogene expression.
Hagemann S, Misiak D, Bell JL, Fuchs T, Lederer MI, Bley N, Hämmerle M, Ghazy E, Sippl W, Schulte JH, Hüttelmaier S
Mol Cancer 2023 May 29;22(1):88. doi: 10.1186/s12943-023-01792-0. PMID: 37246217Free PMC Article
Significance of chromosome 2p gain in ibrutinib-treated chronic lymphocytic leukemia patients.
Miller CR, Huang Y, Ruppert AS, Labanowska J, Jaglowski SM, Maddocks KJ, Rogers KA, Bhat S, Kittai AS, Grever M, Lapalombella R, Abruzzo LV, Heerema NA, Byrd JC, Hertlein EK, Woyach JA
Leukemia 2021 Nov;35(11):3287-3290. Epub 2021 Apr 5 doi: 10.1038/s41375-021-01237-x. PMID: 33820961Free PMC Article
ALK ligand ALKAL2 potentiates MYCN-driven neuroblastoma in the absence of ALK mutation.
Borenäs M, Umapathy G, Lai WY, Lind DE, Witek B, Guan J, Mendoza-Garcia P, Masudi T, Claeys A, Chuang TP, El Wakil A, Arefin B, Fransson S, Koster J, Johansson M, Gaarder J, Van den Eynden J, Hallberg B, Palmer RH
EMBO J 2021 Feb 1;40(3):e105784. Epub 2021 Jan 7 doi: 10.15252/embj.2020105784. PMID: 33411331Free PMC Article
Clinicopathological and molecular features of hereditary leiomyomatosis and renal cell cancer-associated renal cell carcinomas.
Furuya M, Iribe Y, Nagashima Y, Kambe N, Ohe C, Kinoshita H, Sato C, Kishida T, Okubo Y, Numakura K, Nanjo H, Nakaigawa N, Makiyama K, Hasumi H, Iwashita H, Ohta J, Kitamura H, Nakajima T, Yoshida T, Nakagawa M, Tanaka R, Yao M
J Clin Pathol 2020 Dec;73(12):819-825. Epub 2020 May 6 doi: 10.1136/jclinpath-2020-206548. PMID: 32376712
Gain of the short arm of chromosome 2 (2p gain) has a significant role in drug-resistant chronic lymphocytic leukemia.
Kostopoulou F, Gabillaud C, Chapiro E, Grange B, Tran J, Bouzy S, Degaud M, Ghamlouch H, Le Garff-Tavernier M, Maloum K, Choquet S, Leblond V, Gabarre J, Lavaud A, Morel V, Roos-Weil D, Uzunov M, Guieze R, Bernard OA, Susin SA, Tournilhac O, Nguyen-Khac F; French Innovative Leukemia Organization (FILO) group
Cancer Med 2019 Jun;8(6):3131-3141. Epub 2019 May 7 doi: 10.1002/cam4.2123. PMID: 31066214Free PMC Article

Diagnosis

Cytogenetics in the management of chronic lymphocytic leukemia: Guidelines from the Groupe Francophone de Cytogénétique Hématologique (GFCH).
Nguyen-Khac F, Balogh Z, Chauzeix J, Veronese L, Chapiro E
Curr Res Transl Med 2023 Oct-Dec;71(4):103410. Epub 2023 Sep 17 doi: 10.1016/j.retram.2023.103410. PMID: 38039634
ALK ligand ALKAL2 potentiates MYCN-driven neuroblastoma in the absence of ALK mutation.
Borenäs M, Umapathy G, Lai WY, Lind DE, Witek B, Guan J, Mendoza-Garcia P, Masudi T, Claeys A, Chuang TP, El Wakil A, Arefin B, Fransson S, Koster J, Johansson M, Gaarder J, Van den Eynden J, Hallberg B, Palmer RH
EMBO J 2021 Feb 1;40(3):e105784. Epub 2021 Jan 7 doi: 10.15252/embj.2020105784. PMID: 33411331Free PMC Article
Clinicopathological and molecular features of hereditary leiomyomatosis and renal cell cancer-associated renal cell carcinomas.
Furuya M, Iribe Y, Nagashima Y, Kambe N, Ohe C, Kinoshita H, Sato C, Kishida T, Okubo Y, Numakura K, Nanjo H, Nakaigawa N, Makiyama K, Hasumi H, Iwashita H, Ohta J, Kitamura H, Nakajima T, Yoshida T, Nakagawa M, Tanaka R, Yao M
J Clin Pathol 2020 Dec;73(12):819-825. Epub 2020 May 6 doi: 10.1136/jclinpath-2020-206548. PMID: 32376712
Gain of the short arm of chromosome 2 (2p gain) has a significant role in drug-resistant chronic lymphocytic leukemia.
Kostopoulou F, Gabillaud C, Chapiro E, Grange B, Tran J, Bouzy S, Degaud M, Ghamlouch H, Le Garff-Tavernier M, Maloum K, Choquet S, Leblond V, Gabarre J, Lavaud A, Morel V, Roos-Weil D, Uzunov M, Guieze R, Bernard OA, Susin SA, Tournilhac O, Nguyen-Khac F; French Innovative Leukemia Organization (FILO) group
Cancer Med 2019 Jun;8(6):3131-3141. Epub 2019 May 7 doi: 10.1002/cam4.2123. PMID: 31066214Free PMC Article
Chromosome 2p gain in monoclonal B-cell lymphocytosis and in early stage chronic lymphocytic leukemia.
Fabris S, Mosca L, Cutrona G, Lionetti M, Agnelli L, Ciceri G, Barbieri M, Maura F, Matis S, Colombo M, Gentile M, Recchia AG, Anna Pesce E, Di Raimondo F, Musolino C, Gobbi M, Di Renzo N, Mauro FR, Brugiatelli M, Ilariucci F, Lipari MG, Angrilli F, Consoli U, Fragasso A, Molica S, Festini G, Vincelli I, Cortelezzi A, Federico M, Morabito F, Ferrarini M, Neri A
Am J Hematol 2013 Jan;88(1):24-31. Epub 2012 Oct 9 doi: 10.1002/ajh.23340. PMID: 23044996

Therapy

The Importance of FISH Signal Cut-off Value and Copy Number Variation for 1q21 in Newly Diagnosed Multiple Myeloma: Is it Underestimated?
Gao L, Liu Y, Li Y, Feng L, Wang Z, Wen L, Wang F, Huang X, Lu J, Lai Y
Clin Lymphoma Myeloma Leuk 2022 Jul;22(7):535-544. Epub 2022 Jan 31 doi: 10.1016/j.clml.2022.01.013. PMID: 35292207
Significance of chromosome 2p gain in ibrutinib-treated chronic lymphocytic leukemia patients.
Miller CR, Huang Y, Ruppert AS, Labanowska J, Jaglowski SM, Maddocks KJ, Rogers KA, Bhat S, Kittai AS, Grever M, Lapalombella R, Abruzzo LV, Heerema NA, Byrd JC, Hertlein EK, Woyach JA
Leukemia 2021 Nov;35(11):3287-3290. Epub 2021 Apr 5 doi: 10.1038/s41375-021-01237-x. PMID: 33820961Free PMC Article
Gain of the short arm of chromosome 2 (2p gain) has a significant role in drug-resistant chronic lymphocytic leukemia.
Kostopoulou F, Gabillaud C, Chapiro E, Grange B, Tran J, Bouzy S, Degaud M, Ghamlouch H, Le Garff-Tavernier M, Maloum K, Choquet S, Leblond V, Gabarre J, Lavaud A, Morel V, Roos-Weil D, Uzunov M, Guieze R, Bernard OA, Susin SA, Tournilhac O, Nguyen-Khac F; French Innovative Leukemia Organization (FILO) group
Cancer Med 2019 Jun;8(6):3131-3141. Epub 2019 May 7 doi: 10.1002/cam4.2123. PMID: 31066214Free PMC Article
Chromosome 2p gain in monoclonal B-cell lymphocytosis and in early stage chronic lymphocytic leukemia.
Fabris S, Mosca L, Cutrona G, Lionetti M, Agnelli L, Ciceri G, Barbieri M, Maura F, Matis S, Colombo M, Gentile M, Recchia AG, Anna Pesce E, Di Raimondo F, Musolino C, Gobbi M, Di Renzo N, Mauro FR, Brugiatelli M, Ilariucci F, Lipari MG, Angrilli F, Consoli U, Fragasso A, Molica S, Festini G, Vincelli I, Cortelezzi A, Federico M, Morabito F, Ferrarini M, Neri A
Am J Hematol 2013 Jan;88(1):24-31. Epub 2012 Oct 9 doi: 10.1002/ajh.23340. PMID: 23044996
Cytogenetic studies in prostate cancer: are we making progress?
Brothman AR
Cancer Genet Cytogenet 1997 May;95(1):116-21. doi: 10.1016/s0165-4608(96)00302-0. PMID: 9140461

Prognosis

Cytogenetics in the management of chronic lymphocytic leukemia: Guidelines from the Groupe Francophone de Cytogénétique Hématologique (GFCH).
Nguyen-Khac F, Balogh Z, Chauzeix J, Veronese L, Chapiro E
Curr Res Transl Med 2023 Oct-Dec;71(4):103410. Epub 2023 Sep 17 doi: 10.1016/j.retram.2023.103410. PMID: 38039634
Significance of chromosome 2p gain in ibrutinib-treated chronic lymphocytic leukemia patients.
Miller CR, Huang Y, Ruppert AS, Labanowska J, Jaglowski SM, Maddocks KJ, Rogers KA, Bhat S, Kittai AS, Grever M, Lapalombella R, Abruzzo LV, Heerema NA, Byrd JC, Hertlein EK, Woyach JA
Leukemia 2021 Nov;35(11):3287-3290. Epub 2021 Apr 5 doi: 10.1038/s41375-021-01237-x. PMID: 33820961Free PMC Article
Gain of the short arm of chromosome 2 (2p gain) has a significant role in drug-resistant chronic lymphocytic leukemia.
Kostopoulou F, Gabillaud C, Chapiro E, Grange B, Tran J, Bouzy S, Degaud M, Ghamlouch H, Le Garff-Tavernier M, Maloum K, Choquet S, Leblond V, Gabarre J, Lavaud A, Morel V, Roos-Weil D, Uzunov M, Guieze R, Bernard OA, Susin SA, Tournilhac O, Nguyen-Khac F; French Innovative Leukemia Organization (FILO) group
Cancer Med 2019 Jun;8(6):3131-3141. Epub 2019 May 7 doi: 10.1002/cam4.2123. PMID: 31066214Free PMC Article
Delineation of the frequency and boundary of chromosomal copy number variations in paediatric neuroblastoma.
Ho N, Peng H, Mayoh C, Liu PY, Atmadibrata B, Marshall GM, Li J, Liu T
Cell Cycle 2018;17(6):749-758. doi: 10.1080/15384101.2017.1421875. PMID: 29353549Free PMC Article
The genetic and clinical significance of MYCN gain as detected by FISH in neuroblastoma.
Souzaki R, Tajiri T, Teshiba R, Higashi M, Kinoshita Y, Tanaka S, Taguchi T
Pediatr Surg Int 2011 Mar;27(3):231-6. doi: 10.1007/s00383-010-2781-4. PMID: 21046119

Clinical prediction guides

Genomic and Transcriptomic Tumor Heterogeneity in Bilateral Retinoblastoma.
Winter U, Ganiewich D, Ottaviani D, Zugbi S, Aschero R, Sendoya JM, Cafferata EG, Mena M, Sgroi M, Sampor C, Lubieniecki F, Fandiño A, Abba MC, Doz F, Podhjacer O, Carcaboso AM, Letouzé E, Radvanyi F, Chantada GL, Llera AS, Schaiquevich P
JAMA Ophthalmol 2020 May 1;138(5):569-574. doi: 10.1001/jamaophthalmol.2020.0427. PMID: 32191268Free PMC Article
Chromosome 20q Amplification Defines a Subtype of Microsatellite Stable, Left-Sided Colon Cancers with Wild-type RAS/RAF and Better Overall Survival.
Ptashkin RN, Pagan C, Yaeger R, Middha S, Shia J, O'Rourke KP, Berger MF, Wang L, Cimera R, Wang J, Klimstra DS, Saltz L, Ladanyi M, Zehir A, Hechtman JF
Mol Cancer Res 2017 Jun;15(6):708-713. Epub 2017 Feb 9 doi: 10.1158/1541-7786.MCR-16-0352. PMID: 28184012Free PMC Article
Genome instability model of metastatic neuroblastoma tumorigenesis by a dictionary learning algorithm.
Masecchia S, Coco S, Barla A, Verri A, Tonini GP
BMC Med Genomics 2015 Sep 10;8:57. doi: 10.1186/s12920-015-0132-y. PMID: 26358114Free PMC Article
Identification of frequent BRAF copy number gain and alterations of RAF genes in Chinese prostate cancer.
Ren G, Liu X, Mao X, Zhang Y, Stankiewicz E, Hylands L, Song R, Berney DM, Clark J, Cooper C, Lu YJ
Genes Chromosomes Cancer 2012 Nov;51(11):1014-23. Epub 2012 Jul 25 doi: 10.1002/gcc.21984. PMID: 22833462
Clinical relevance of chromosome abnormalities in non-small cell lung cancer.
Feder M, Siegfried JM, Balshem A, Litwin S, Keller SM, Liu Z, Testa JR
Cancer Genet Cytogenet 1998 Apr 1;102(1):25-31. doi: 10.1016/s0165-4608(97)00274-4. PMID: 9530336

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