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Gain of Chromosome 5

MedGen UID:
309196
•Concept ID:
C1517411
•
Cell or Molecular Dysfunction

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGain of Chromosome 5

Professional guidelines

PubMed

Copy number genome alterations are associated with treatment response and outcome in relapsed childhood ETV6/RUNX1-positive acute lymphoblastic leukemia.
Bokemeyer A, Eckert C, Meyr F, Koerner G, von Stackelberg A, Ullmann R, Türkmen S, Henze G, Seeger K
Haematologica 2014 Apr;99(4):706-14. Epub 2013 Nov 15 doi: 10.3324/haematol.2012.072470. PMID: 24241490Free PMC Article
A mitotic recombination map proximal to the APC locus on chromosome 5q and assessment of influences on colorectal cancer risk.
Howarth K, Ranta S, Winter E, Teixeira A, Schaschl H, Harvey JJ, Rowan A, Jones A, Spain S, Clark S, Guenther T, Stewart A, Silver A, Tomlinson I
BMC Med Genet 2009 Jun 10;10:54. doi: 10.1186/1471-2350-10-54. PMID: 19515250Free PMC Article
Cost effectiveness of lenalidomide in the treatment of transfusion-dependent myelodysplastic syndromes in the United States.
Goss TF, Szende A, Schaefer C, Totten PJ, Knight R, Jädersten M, Hellström-Lindberg E, List AF
Cancer Control 2006 Dec;13 Suppl:17-25. doi: 10.1177/107327480601304s04. PMID: 17242663

Recent clinical studies

Etiology

Loss of 5q in myeloid malignancies - A gain in understanding of biological and clinical consequences.
Venugopal S, Mascarenhas J, Steensma DP
Blood Rev 2021 Mar;46:100735. Epub 2020 Jul 23 doi: 10.1016/j.blre.2020.100735. PMID: 32736878
Utility of copy number variants in the classification of intracranial ependymoma.
Evenson M, Cai C, Hucthagowder V, McNulty S, Neidich J, Kulkarni S, Dahiya S
Cancer Genet 2020 Jan;240:66-72. Epub 2019 Nov 18 doi: 10.1016/j.cancergen.2019.11.003. PMID: 31794935
Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal.
Mitchell TJ, Turajlic S, Rowan A, Nicol D, Farmery JHR, O'Brien T, Martincorena I, Tarpey P, Angelopoulos N, Yates LR, Butler AP, Raine K, Stewart GD, Challacombe B, Fernando A, Lopez JI, Hazell S, Chandra A, Chowdhury S, Rudman S, Soultati A, Stamp G, Fotiadis N, Pickering L, Au L, Spain L, Lynch J, Stares M, Teague J, Maura F, Wedge DC, Horswell S, Chambers T, Litchfield K, Xu H, Stewart A, Elaidi R, Oudard S, McGranahan N, Csabai I, Gore M, Futreal PA, Larkin J, Lynch AG, Szallasi Z, Swanton C, Campbell PJ; TRACERx Renal Consortium
Cell 2018 Apr 19;173(3):611-623.e17. Epub 2018 Apr 12 doi: 10.1016/j.cell.2018.02.020. PMID: 29656891Free PMC Article
NPM1 is overexpressed in hyperdiploid multiple myeloma due to a gain of chromosome 5 but is not delocalized to the cytoplasm.
Weinhold N, Moreaux J, Raab MS, Hose D, Hielscher T, Benner A, Meissner T, Ehrbrecht E, Brough M, Jauch A, Goldschmidt H, Klein B, Moos M
Genes Chromosomes Cancer 2010 Apr;49(4):333-41. doi: 10.1002/gcc.20745. PMID: 20073075
Gain of 5p15.33 is associated with progression of bladder cancer.
Yamamoto Y, Chochi Y, Matsuyama H, Eguchi S, Kawauchi S, Furuya T, Oga A, Kang JJ, Naito K, Sasaki K
Oncology 2007;72(1-2):132-8. Epub 2007 Nov 15 doi: 10.1159/000111132. PMID: 18025801

Diagnosis

Loss of 5q in myeloid malignancies - A gain in understanding of biological and clinical consequences.
Venugopal S, Mascarenhas J, Steensma DP
Blood Rev 2021 Mar;46:100735. Epub 2020 Jul 23 doi: 10.1016/j.blre.2020.100735. PMID: 32736878
Utility of copy number variants in the classification of intracranial ependymoma.
Evenson M, Cai C, Hucthagowder V, McNulty S, Neidich J, Kulkarni S, Dahiya S
Cancer Genet 2020 Jan;240:66-72. Epub 2019 Nov 18 doi: 10.1016/j.cancergen.2019.11.003. PMID: 31794935
Development and Validation of a Cytogenetic Prognostic Index Predicting Survival in Multiple Myeloma.
Perrot A, Lauwers-Cances V, Tournay E, Hulin C, Chretien ML, Royer B, Dib M, Decaux O, Jaccard A, Belhadj K, Brechignac S, Fontan J, Voillat L, Demarquette H, Collet P, Rodon P, Sohn C, Lifermann F, Orsini-Piocelle F, Richez V, Mohty M, Macro M, Minvielle S, Moreau P, Leleu X, Facon T, Attal M, Avet-Loiseau H, Corre J
J Clin Oncol 2019 Jul 1;37(19):1657-1665. Epub 2019 May 15 doi: 10.1200/JCO.18.00776. PMID: 31091136Free PMC Article
The presence of extra chromosomes leads to genomic instability.
Passerini V, Ozeri-Galai E, de Pagter MS, Donnelly N, Schmalbrock S, Kloosterman WP, Kerem B, Storchová Z
Nat Commun 2016 Feb 15;7:10754. doi: 10.1038/ncomms10754. PMID: 26876972Free PMC Article
Landscape of chromosomal copy number aberrations in gangliogliomas and dysembryoplastic neuroepithelial tumours.
Prabowo AS, van Thuijl HF, Scheinin I, Sie D, van Essen HF, Iyer AM, Spliet WG, Ferrier CH, van Rijen PC, Veersema TJ, Thom M, Schouten-van Meeteren AY, Reijneveld JC, Ylstra B, Wesseling P, Aronica E
Neuropathol Appl Neurobiol 2015 Oct;41(6):743-55. Epub 2015 May 19 doi: 10.1111/nan.12235. PMID: 25764012

Therapy

Development and Validation of a Cytogenetic Prognostic Index Predicting Survival in Multiple Myeloma.
Perrot A, Lauwers-Cances V, Tournay E, Hulin C, Chretien ML, Royer B, Dib M, Decaux O, Jaccard A, Belhadj K, Brechignac S, Fontan J, Voillat L, Demarquette H, Collet P, Rodon P, Sohn C, Lifermann F, Orsini-Piocelle F, Richez V, Mohty M, Macro M, Minvielle S, Moreau P, Leleu X, Facon T, Attal M, Avet-Loiseau H, Corre J
J Clin Oncol 2019 Jul 1;37(19):1657-1665. Epub 2019 May 15 doi: 10.1200/JCO.18.00776. PMID: 31091136Free PMC Article
Loss of Chromosome 18q11.2-q12.1 Is Predictive for Survival in Patients With Metastatic Colorectal Cancer Treated With Bevacizumab.
van Dijk E, Biesma HD, Cordes M, Smeets D, Neerincx M, Das S, Eijk PP, Murphy V, Barat A, Bacon O, Prehn JHM, Betge J, Gaiser T, Fender B, Meijer GA, McNamara DA, Klinger R, Koopman M, Ebert MPA, Kay EW, Hennessey BT, Verheul HMW, Gallagher WM, O'Connor DP, Punt CJA, Loupakis F, Lambrechts D, Byrne AT, van Grieken NCT, Ylstra B
J Clin Oncol 2018 Jul 10;36(20):2052-2060. Epub 2018 May 24 doi: 10.1200/JCO.2017.77.1782. PMID: 29792754
Oncostatin M receptor is a novel therapeutic target in cervical squamous cell carcinoma.
Caffarel MM, Coleman N
J Pathol 2014 Mar;232(4):386-90. doi: 10.1002/path.4305. PMID: 24659184Free PMC Article
Cytogenetic and molecular predictors of response in patients with myeloid malignancies without del[5q] treated with lenalidomide.
Sugimoto Y, Sekeres MA, Makishima H, Traina F, Visconte V, Jankowska A, Jerez A, Szpurka H, O'Keefe CL, Guinta K, Afable M, Tiu R, McGraw KL, List AF, Maciejewski J
J Hematol Oncol 2012 Mar 5;5:4. doi: 10.1186/1756-8722-5-4. PMID: 22390313Free PMC Article
Non-random trisomies of chromosomes 5, 8 and 12 in the prolactinoma sub-type of pituitary adenomas: conventional cytogenetics and interphase FISH study.
Finelli P, Giardino D, Rizzi N, Buiatiotis S, Virduci T, Franzin A, Losa M, Larizza L
Int J Cancer 2000 May 1;86(3):344-50. doi: 10.1002/(sici)1097-0215(20000501)86:3<344::aid-ijc7>3.0.co;2-8. PMID: 10760821

Prognosis

Utility of copy number variants in the classification of intracranial ependymoma.
Evenson M, Cai C, Hucthagowder V, McNulty S, Neidich J, Kulkarni S, Dahiya S
Cancer Genet 2020 Jan;240:66-72. Epub 2019 Nov 18 doi: 10.1016/j.cancergen.2019.11.003. PMID: 31794935
Development and Validation of a Cytogenetic Prognostic Index Predicting Survival in Multiple Myeloma.
Perrot A, Lauwers-Cances V, Tournay E, Hulin C, Chretien ML, Royer B, Dib M, Decaux O, Jaccard A, Belhadj K, Brechignac S, Fontan J, Voillat L, Demarquette H, Collet P, Rodon P, Sohn C, Lifermann F, Orsini-Piocelle F, Richez V, Mohty M, Macro M, Minvielle S, Moreau P, Leleu X, Facon T, Attal M, Avet-Loiseau H, Corre J
J Clin Oncol 2019 Jul 1;37(19):1657-1665. Epub 2019 May 15 doi: 10.1200/JCO.18.00776. PMID: 31091136Free PMC Article
Landscape of chromosomal copy number aberrations in gangliogliomas and dysembryoplastic neuroepithelial tumours.
Prabowo AS, van Thuijl HF, Scheinin I, Sie D, van Essen HF, Iyer AM, Spliet WG, Ferrier CH, van Rijen PC, Veersema TJ, Thom M, Schouten-van Meeteren AY, Reijneveld JC, Ylstra B, Wesseling P, Aronica E
Neuropathol Appl Neurobiol 2015 Oct;41(6):743-55. Epub 2015 May 19 doi: 10.1111/nan.12235. PMID: 25764012
Gain of 5p15.33 is associated with progression of bladder cancer.
Yamamoto Y, Chochi Y, Matsuyama H, Eguchi S, Kawauchi S, Furuya T, Oga A, Kang JJ, Naito K, Sasaki K
Oncology 2007;72(1-2):132-8. Epub 2007 Nov 15 doi: 10.1159/000111132. PMID: 18025801
Gain of 5p15 detected by comparative genomic hybridization as an independent marker of poor prognosis in patients with esophageal squamous cell carcinoma.
Ueno T, Tangoku A, Yoshino S, Abe T, Toshimitsu H, Furuya T, Kawauchi S, Oga A, Oka M, Sasaki K
Clin Cancer Res 2002 Feb;8(2):526-33. PMID: 11839673

Clinical prediction guides

Genomic analyses of the metastasis-derived prostate cancer cell lines LNCaP, VCaP, and PC3-AR.
Sienkiewicz K, Yang C, Paschal BM, Ratan A
Prostate 2022 Mar;82(4):442-451. Epub 2021 Dec 24 doi: 10.1002/pros.24290. PMID: 34951700Free PMC Article
Development and Validation of a Cytogenetic Prognostic Index Predicting Survival in Multiple Myeloma.
Perrot A, Lauwers-Cances V, Tournay E, Hulin C, Chretien ML, Royer B, Dib M, Decaux O, Jaccard A, Belhadj K, Brechignac S, Fontan J, Voillat L, Demarquette H, Collet P, Rodon P, Sohn C, Lifermann F, Orsini-Piocelle F, Richez V, Mohty M, Macro M, Minvielle S, Moreau P, Leleu X, Facon T, Attal M, Avet-Loiseau H, Corre J
J Clin Oncol 2019 Jul 1;37(19):1657-1665. Epub 2019 May 15 doi: 10.1200/JCO.18.00776. PMID: 31091136Free PMC Article
Gain of 5p15.33 is associated with progression of bladder cancer.
Yamamoto Y, Chochi Y, Matsuyama H, Eguchi S, Kawauchi S, Furuya T, Oga A, Kang JJ, Naito K, Sasaki K
Oncology 2007;72(1-2):132-8. Epub 2007 Nov 15 doi: 10.1159/000111132. PMID: 18025801
Amplification of chromosome 5p correlates with increased expression of Skp2 in HPV-immortalized keratinocytes.
Dowen SE, Neutze DM, Pett MR, Cottage A, Stern P, Coleman N, Stanley MA
Oncogene 2003 Apr 24;22(16):2531-40. doi: 10.1038/sj.onc.1206296. PMID: 12717429
Structural alterations of chromosome 5 in twelve human prostate cancer cell lines.
Ozen M, Navone NM, Multani AS, Troncoso P, Logothetis CJ, Chung LW, von Eschenbach AC, Pathak S
Cancer Genet Cytogenet 1998 Oct 15;106(2):105-9. doi: 10.1016/s0165-4608(98)00051-x. PMID: 9797773

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