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Gain of Chromosome 5

MedGen UID:
309196
•Concept ID:
C1517411
•
Cell or Molecular Dysfunction

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGain of Chromosome 5

Professional guidelines

PubMed

Copy number genome alterations are associated with treatment response and outcome in relapsed childhood ETV6/RUNX1-positive acute lymphoblastic leukemia.
Bokemeyer A, Eckert C, Meyr F, Koerner G, von Stackelberg A, Ullmann R, Türkmen S, Henze G, Seeger K
Haematologica 2014 Apr;99(4):706-14. Epub 2013 Nov 15 doi: 10.3324/haematol.2012.072470. PMID: 24241490Free PMC Article
A mitotic recombination map proximal to the APC locus on chromosome 5q and assessment of influences on colorectal cancer risk.
Howarth K, Ranta S, Winter E, Teixeira A, Schaschl H, Harvey JJ, Rowan A, Jones A, Spain S, Clark S, Guenther T, Stewart A, Silver A, Tomlinson I
BMC Med Genet 2009 Jun 10;10:54. doi: 10.1186/1471-2350-10-54. PMID: 19515250Free PMC Article
Cost effectiveness of lenalidomide in the treatment of transfusion-dependent myelodysplastic syndromes in the United States.
Goss TF, Szende A, Schaefer C, Totten PJ, Knight R, Jädersten M, Hellström-Lindberg E, List AF
Cancer Control 2006 Dec;13 Suppl:17-25. doi: 10.1177/107327480601304s04. PMID: 17242663

Recent clinical studies

Therapy

Development and Validation of a Cytogenetic Prognostic Index Predicting Survival in Multiple Myeloma.
Perrot A, Lauwers-Cances V, Tournay E, Hulin C, Chretien ML, Royer B, Dib M, Decaux O, Jaccard A, Belhadj K, Brechignac S, Fontan J, Voillat L, Demarquette H, Collet P, Rodon P, Sohn C, Lifermann F, Orsini-Piocelle F, Richez V, Mohty M, Macro M, Minvielle S, Moreau P, Leleu X, Facon T, Attal M, Avet-Loiseau H, Corre J
J Clin Oncol 2019 Jul 1;37(19):1657-1665. Epub 2019 May 15 doi: 10.1200/JCO.18.00776. PMID: 31091136Free PMC Article
Loss of Chromosome 18q11.2-q12.1 Is Predictive for Survival in Patients With Metastatic Colorectal Cancer Treated With Bevacizumab.
van Dijk E, Biesma HD, Cordes M, Smeets D, Neerincx M, Das S, Eijk PP, Murphy V, Barat A, Bacon O, Prehn JHM, Betge J, Gaiser T, Fender B, Meijer GA, McNamara DA, Klinger R, Koopman M, Ebert MPA, Kay EW, Hennessey BT, Verheul HMW, Gallagher WM, O'Connor DP, Punt CJA, Loupakis F, Lambrechts D, Byrne AT, van Grieken NCT, Ylstra B
J Clin Oncol 2018 Jul 10;36(20):2052-2060. Epub 2018 May 24 doi: 10.1200/JCO.2017.77.1782. PMID: 29792754
Oncostatin M receptor is a novel therapeutic target in cervical squamous cell carcinoma.
Caffarel MM, Coleman N
J Pathol 2014 Mar;232(4):386-90. doi: 10.1002/path.4305. PMID: 24659184Free PMC Article
Cytogenetic and molecular predictors of response in patients with myeloid malignancies without del[5q] treated with lenalidomide.
Sugimoto Y, Sekeres MA, Makishima H, Traina F, Visconte V, Jankowska A, Jerez A, Szpurka H, O'Keefe CL, Guinta K, Afable M, Tiu R, McGraw KL, List AF, Maciejewski J
J Hematol Oncol 2012 Mar 5;5:4. doi: 10.1186/1756-8722-5-4. PMID: 22390313Free PMC Article
Regional cancer cytogenetics: a report on 1,143 diagnostic cases.
Perkins D, Brennan S, Carstairs K, Bailey D, Pantalony D, Poon A, Fernandes B, Dubé I
Cancer Genet Cytogenet 1997 Jul 1;96(1):64-80. doi: 10.1016/s0165-4608(96)00363-9. PMID: 9209473

Prognosis

Single-Chromosomal Gains Can Function as Metastasis Suppressors and Promoters in Colon Cancer.
Vasudevan A, Baruah PS, Smith JC, Wang Z, Sayles NM, Andrews P, Kendall J, Leu J, Chunduri NK, Levy D, Wigler M, Storchová Z, Sheltzer JM
Dev Cell 2020 Feb 24;52(4):413-428.e6. doi: 10.1016/j.devcel.2020.01.034. PMID: 32097652Free PMC Article
Utility of copy number variants in the classification of intracranial ependymoma.
Evenson M, Cai C, Hucthagowder V, McNulty S, Neidich J, Kulkarni S, Dahiya S
Cancer Genet 2020 Jan;240:66-72. Epub 2019 Nov 18 doi: 10.1016/j.cancergen.2019.11.003. PMID: 31794935
Development and Validation of a Cytogenetic Prognostic Index Predicting Survival in Multiple Myeloma.
Perrot A, Lauwers-Cances V, Tournay E, Hulin C, Chretien ML, Royer B, Dib M, Decaux O, Jaccard A, Belhadj K, Brechignac S, Fontan J, Voillat L, Demarquette H, Collet P, Rodon P, Sohn C, Lifermann F, Orsini-Piocelle F, Richez V, Mohty M, Macro M, Minvielle S, Moreau P, Leleu X, Facon T, Attal M, Avet-Loiseau H, Corre J
J Clin Oncol 2019 Jul 1;37(19):1657-1665. Epub 2019 May 15 doi: 10.1200/JCO.18.00776. PMID: 31091136Free PMC Article
Landscape of chromosomal copy number aberrations in gangliogliomas and dysembryoplastic neuroepithelial tumours.
Prabowo AS, van Thuijl HF, Scheinin I, Sie D, van Essen HF, Iyer AM, Spliet WG, Ferrier CH, van Rijen PC, Veersema TJ, Thom M, Schouten-van Meeteren AY, Reijneveld JC, Ylstra B, Wesseling P, Aronica E
Neuropathol Appl Neurobiol 2015 Oct;41(6):743-55. Epub 2015 May 19 doi: 10.1111/nan.12235. PMID: 25764012
Gain of 5p15.33 is associated with progression of bladder cancer.
Yamamoto Y, Chochi Y, Matsuyama H, Eguchi S, Kawauchi S, Furuya T, Oga A, Kang JJ, Naito K, Sasaki K
Oncology 2007;72(1-2):132-8. Epub 2007 Nov 15 doi: 10.1159/000111132. PMID: 18025801

Clinical prediction guides

Genomic analyses of the metastasis-derived prostate cancer cell lines LNCaP, VCaP, and PC3-AR.
Sienkiewicz K, Yang C, Paschal BM, Ratan A
Prostate 2022 Mar;82(4):442-451. Epub 2021 Dec 24 doi: 10.1002/pros.24290. PMID: 34951700Free PMC Article
Development and Validation of a Cytogenetic Prognostic Index Predicting Survival in Multiple Myeloma.
Perrot A, Lauwers-Cances V, Tournay E, Hulin C, Chretien ML, Royer B, Dib M, Decaux O, Jaccard A, Belhadj K, Brechignac S, Fontan J, Voillat L, Demarquette H, Collet P, Rodon P, Sohn C, Lifermann F, Orsini-Piocelle F, Richez V, Mohty M, Macro M, Minvielle S, Moreau P, Leleu X, Facon T, Attal M, Avet-Loiseau H, Corre J
J Clin Oncol 2019 Jul 1;37(19):1657-1665. Epub 2019 May 15 doi: 10.1200/JCO.18.00776. PMID: 31091136Free PMC Article
Landscape of chromosomal copy number aberrations in gangliogliomas and dysembryoplastic neuroepithelial tumours.
Prabowo AS, van Thuijl HF, Scheinin I, Sie D, van Essen HF, Iyer AM, Spliet WG, Ferrier CH, van Rijen PC, Veersema TJ, Thom M, Schouten-van Meeteren AY, Reijneveld JC, Ylstra B, Wesseling P, Aronica E
Neuropathol Appl Neurobiol 2015 Oct;41(6):743-55. Epub 2015 May 19 doi: 10.1111/nan.12235. PMID: 25764012
Gain of 5p15.33 is associated with progression of bladder cancer.
Yamamoto Y, Chochi Y, Matsuyama H, Eguchi S, Kawauchi S, Furuya T, Oga A, Kang JJ, Naito K, Sasaki K
Oncology 2007;72(1-2):132-8. Epub 2007 Nov 15 doi: 10.1159/000111132. PMID: 18025801
Amplification of chromosome 5p correlates with increased expression of Skp2 in HPV-immortalized keratinocytes.
Dowen SE, Neutze DM, Pett MR, Cottage A, Stern P, Coleman N, Stanley MA
Oncogene 2003 Apr 24;22(16):2531-40. doi: 10.1038/sj.onc.1206296. PMID: 12717429

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