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Gain of Chromosome 5q

MedGen UID:
309197
•Concept ID:
C1517413
•
Cell or Molecular Dysfunction

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGain of Chromosome 5q

Professional guidelines

PubMed

Copy number variations could predict the outcome of bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma.
Kim M, Lee SH, Kim J, Lee SE, Kim YJ, Min CK
Genes Chromosomes Cancer 2015 Jan;54(1):20-7. Epub 2014 Aug 21 doi: 10.1002/gcc.22213. PMID: 25145975
Cost effectiveness of lenalidomide in the treatment of transfusion-dependent myelodysplastic syndromes in the United States.
Goss TF, Szende A, Schaefer C, Totten PJ, Knight R, Jädersten M, Hellström-Lindberg E, List AF
Cancer Control 2006 Dec;13 Suppl:17-25. doi: 10.1177/107327480601304s04. PMID: 17242663
Molecular cytogenetic analysis of prostatic adenocarcinomas from screening studies : early cancers may contain aggressive genetic features.
Alers JC, Krijtenburg PJ, Vis AN, Hoedemaeker RF, Wildhagen MF, Hop WC, van Der Kwast TT, Schröder FH, Tanke HJ, van Dekken H
Am J Pathol 2001 Feb;158(2):399-406. doi: 10.1016/s0002-9440(10)63983-1. PMID: 11159178Free PMC Article

Recent clinical studies

Etiology

Loss of 5q in myeloid malignancies - A gain in understanding of biological and clinical consequences.
Venugopal S, Mascarenhas J, Steensma DP
Blood Rev 2021 Mar;46:100735. Epub 2020 Jul 23 doi: 10.1016/j.blre.2020.100735. PMID: 32736878
Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal.
Mitchell TJ, Turajlic S, Rowan A, Nicol D, Farmery JHR, O'Brien T, Martincorena I, Tarpey P, Angelopoulos N, Yates LR, Butler AP, Raine K, Stewart GD, Challacombe B, Fernando A, Lopez JI, Hazell S, Chandra A, Chowdhury S, Rudman S, Soultati A, Stamp G, Fotiadis N, Pickering L, Au L, Spain L, Lynch J, Stares M, Teague J, Maura F, Wedge DC, Horswell S, Chambers T, Litchfield K, Xu H, Stewart A, Elaidi R, Oudard S, McGranahan N, Csabai I, Gore M, Futreal PA, Larkin J, Lynch AG, Szallasi Z, Swanton C, Campbell PJ; TRACERx Renal Consortium
Cell 2018 Apr 19;173(3):611-623.e17. Epub 2018 Apr 12 doi: 10.1016/j.cell.2018.02.020. PMID: 29656891Free PMC Article
The chicken or the egg: PHEX, FGF23 and SIBLINGs unscrambled.
Rowe PS
Cell Biochem Funct 2012 Jul;30(5):355-75. Epub 2012 May 9 doi: 10.1002/cbf.2841. PMID: 22573484Free PMC Article
Genetic and epigenetic alterations during renal carcinogenesis.
Arai E, Kanai Y
Int J Clin Exp Pathol 2010 Dec 13;4(1):58-73. PMID: 21228928Free PMC Article
Gains, losses and complex karyotypes in myeloid disorders: a light at the end of the tunnel.
Alvarez S, Cigudosa JC
Hematol Oncol 2005 Mar;23(1):18-25. doi: 10.1002/hon.744. PMID: 16142824

Diagnosis

Loss of 5q in myeloid malignancies - A gain in understanding of biological and clinical consequences.
Venugopal S, Mascarenhas J, Steensma DP
Blood Rev 2021 Mar;46:100735. Epub 2020 Jul 23 doi: 10.1016/j.blre.2020.100735. PMID: 32736878
Strong Expression and Amplification of IGF1R in Pleuropulmonary Blastomas.
Vokuhl C, de Leon-Escapini L, Leuschner I
Pediatr Dev Pathol 2017 Nov-Dec;20(6):475-481. Epub 2017 Apr 6 doi: 10.1177/1093526617700945. PMID: 28382840
Genomic aberrations of myeloproliferative and myelodysplastic/myeloproliferative neoplasms in chronic phase and during disease progression.
Hahm C, Huh HJ, Mun YC, Seong CM, Chung WS, Huh J
Int J Lab Hematol 2015 Apr;37(2):181-9. Epub 2014 May 21 doi: 10.1111/ijlh.12257. PMID: 24845343
Genetic and epigenetic alterations during renal carcinogenesis.
Arai E, Kanai Y
Int J Clin Exp Pathol 2010 Dec 13;4(1):58-73. PMID: 21228928Free PMC Article
Cytogenetic studies in prostate cancer: are we making progress?
Brothman AR
Cancer Genet Cytogenet 1997 May;95(1):116-21. doi: 10.1016/s0165-4608(96)00302-0. PMID: 9140461

Therapy

Cytogenetic and molecular predictors of response in patients with myeloid malignancies without del[5q] treated with lenalidomide.
Sugimoto Y, Sekeres MA, Makishima H, Traina F, Visconte V, Jankowska A, Jerez A, Szpurka H, O'Keefe CL, Guinta K, Afable M, Tiu R, McGraw KL, List AF, Maciejewski J
J Hematol Oncol 2012 Mar 5;5:4. doi: 10.1186/1756-8722-5-4. PMID: 22390313Free PMC Article
Genome-wide analysis of Ollier disease: Is it all in the genes?
Pansuriya TC, Oosting J, Krenács T, Taminiau AH, Verdegaal SH, Sangiorgi L, Sciot R, Hogendoorn PC, Szuhai K, Bovée JV
Orphanet J Rare Dis 2011 Jan 14;6:2. doi: 10.1186/1750-1172-6-2. PMID: 21235737Free PMC Article
Gains, losses and complex karyotypes in myeloid disorders: a light at the end of the tunnel.
Alvarez S, Cigudosa JC
Hematol Oncol 2005 Mar;23(1):18-25. doi: 10.1002/hon.744. PMID: 16142824
Establishment of OC3 oral carcinoma cell line and identification of NF-kappa B activation responses to areca nut extract.
Lin SC, Liu CJ, Chiu CP, Chang SM, Lu SY, Chen YJ
J Oral Pathol Med 2004 Feb;33(2):79-86. doi: 10.1111/j.1600-0714.2004.00034.x. PMID: 14720193
Cytogenetic studies in prostate cancer: are we making progress?
Brothman AR
Cancer Genet Cytogenet 1997 May;95(1):116-21. doi: 10.1016/s0165-4608(96)00302-0. PMID: 9140461

Prognosis

Strong Expression and Amplification of IGF1R in Pleuropulmonary Blastomas.
Vokuhl C, de Leon-Escapini L, Leuschner I
Pediatr Dev Pathol 2017 Nov-Dec;20(6):475-481. Epub 2017 Apr 6 doi: 10.1177/1093526617700945. PMID: 28382840
Genomic aberrations of myeloproliferative and myelodysplastic/myeloproliferative neoplasms in chronic phase and during disease progression.
Hahm C, Huh HJ, Mun YC, Seong CM, Chung WS, Huh J
Int J Lab Hematol 2015 Apr;37(2):181-9. Epub 2014 May 21 doi: 10.1111/ijlh.12257. PMID: 24845343
Cytogenetic and molecular predictors of response in patients with myeloid malignancies without del[5q] treated with lenalidomide.
Sugimoto Y, Sekeres MA, Makishima H, Traina F, Visconte V, Jankowska A, Jerez A, Szpurka H, O'Keefe CL, Guinta K, Afable M, Tiu R, McGraw KL, List AF, Maciejewski J
J Hematol Oncol 2012 Mar 5;5:4. doi: 10.1186/1756-8722-5-4. PMID: 22390313Free PMC Article
Genetic and epigenetic alterations during renal carcinogenesis.
Arai E, Kanai Y
Int J Clin Exp Pathol 2010 Dec 13;4(1):58-73. PMID: 21228928Free PMC Article
Gains, losses and complex karyotypes in myeloid disorders: a light at the end of the tunnel.
Alvarez S, Cigudosa JC
Hematol Oncol 2005 Mar;23(1):18-25. doi: 10.1002/hon.744. PMID: 16142824

Clinical prediction guides

Tumor-derived CK1α mutations enhance MDMX inhibition of p53.
Liu X, Huang Q, Chen L, Zhang H, Schonbrunn E, Chen J
Oncogene 2020 Jan;39(1):176-186. Epub 2019 Aug 28 doi: 10.1038/s41388-019-0979-z. PMID: 31462704Free PMC Article
Strong Expression and Amplification of IGF1R in Pleuropulmonary Blastomas.
Vokuhl C, de Leon-Escapini L, Leuschner I
Pediatr Dev Pathol 2017 Nov-Dec;20(6):475-481. Epub 2017 Apr 6 doi: 10.1177/1093526617700945. PMID: 28382840
Cytogenetic and molecular predictors of response in patients with myeloid malignancies without del[5q] treated with lenalidomide.
Sugimoto Y, Sekeres MA, Makishima H, Traina F, Visconte V, Jankowska A, Jerez A, Szpurka H, O'Keefe CL, Guinta K, Afable M, Tiu R, McGraw KL, List AF, Maciejewski J
J Hematol Oncol 2012 Mar 5;5:4. doi: 10.1186/1756-8722-5-4. PMID: 22390313Free PMC Article
Genome-wide analysis of Ollier disease: Is it all in the genes?
Pansuriya TC, Oosting J, Krenács T, Taminiau AH, Verdegaal SH, Sangiorgi L, Sciot R, Hogendoorn PC, Szuhai K, Bovée JV
Orphanet J Rare Dis 2011 Jan 14;6:2. doi: 10.1186/1750-1172-6-2. PMID: 21235737Free PMC Article
Gains, losses and complex karyotypes in myeloid disorders: a light at the end of the tunnel.
Alvarez S, Cigudosa JC
Hematol Oncol 2005 Mar;23(1):18-25. doi: 10.1002/hon.744. PMID: 16142824

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