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Gain of Chromosome 9p

MedGen UID:
309199
•Concept ID:
C1517425
•
Cell or Molecular Dysfunction

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGain of Chromosome 9p

Professional guidelines

PubMed

Clinical characteristics and treatment outcomes of newly diagnosed multiple myeloma with chromosome 1q abnormalities.
Abdallah N, Greipp P, Kapoor P, Gertz MA, Dispenzieri A, Baughn LB, Lacy MQ, Hayman SR, Buadi FK, Dingli D, Go RS, Hwa YL, Fonder A, Hobbs M, Lin Y, Leung N, Kourelis T, Warsame R, Siddiqui M, Lust J, Kyle RA, Bergsagel L, Ketterling R, Rajkumar SV, Kumar SK
Blood Adv 2020 Aug 11;4(15):3509-3519. doi: 10.1182/bloodadvances.2020002218. PMID: 32750129Free PMC Article
Assessing Genomic Copy Number Alterations as Best Practice for Renal Cell Neoplasia: An Evidence-Based Review from the Cancer Genomics Consortium Workgroup.
Liu YJ, Houldsworth J, Emmadi R, Dyer L, Wolff DJ
Cancer Genet 2020 Jun;244:40-54. Epub 2020 May 1 doi: 10.1016/j.cancergen.2020.04.004. PMID: 32434132
Copy number variations could predict the outcome of bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma.
Kim M, Lee SH, Kim J, Lee SE, Kim YJ, Min CK
Genes Chromosomes Cancer 2015 Jan;54(1):20-7. Epub 2014 Aug 21 doi: 10.1002/gcc.22213. PMID: 25145975

Recent clinical studies

Etiology

Impact of Aneuploidy and Chromosome 9p Loss on Tumor Immune Microenvironment and Immune Checkpoint Inhibitor Efficacy in NSCLC.
Alessi JV, Wang X, Elkrief A, Ricciuti B, Li YY, Gupta H, Spurr LF, Rizvi H, Luo J, Pecci F, Lamberti G, Recondo G, Venkatraman D, Di Federico A, Gandhi MM, Vaz VR, Nishino M, Sholl LM, Cherniack AD, Ladanyi M, Price A, Richards AL, Donoghue M, Lindsay J, Sharma B, Turner MM, Pfaff KL, Felt KD, Rodig SJ, Lin X, Meyerson ML, Johnson BE, Christiani DC, Schoenfeld AJ, Awad MM
J Thorac Oncol 2023 Nov;18(11):1524-1537. Epub 2023 May 27 doi: 10.1016/j.jtho.2023.05.019. PMID: 37247843Free PMC Article
Genomic profile of columnar cell variant of papillary thyroid carcinoma.
Janovitz T, Williamson DFK, Wong KS, Dong F, Barletta JA
Histopathology 2021 Oct;79(4):491-498. Epub 2021 Jun 15 doi: 10.1111/his.14374. PMID: 33783022
Clinical characteristics and treatment outcomes of newly diagnosed multiple myeloma with chromosome 1q abnormalities.
Abdallah N, Greipp P, Kapoor P, Gertz MA, Dispenzieri A, Baughn LB, Lacy MQ, Hayman SR, Buadi FK, Dingli D, Go RS, Hwa YL, Fonder A, Hobbs M, Lin Y, Leung N, Kourelis T, Warsame R, Siddiqui M, Lust J, Kyle RA, Bergsagel L, Ketterling R, Rajkumar SV, Kumar SK
Blood Adv 2020 Aug 11;4(15):3509-3519. doi: 10.1182/bloodadvances.2020002218. PMID: 32750129Free PMC Article
DNMT3A and TET2 dominate clonal hematopoiesis and demonstrate benign phenotypes and different genetic predispositions.
Buscarlet M, Provost S, Zada YF, Barhdadi A, Bourgoin V, Lépine G, Mollica L, Szuber N, Dubé MP, Busque L
Blood 2017 Aug 10;130(6):753-762. Epub 2017 Jun 27 doi: 10.1182/blood-2017-04-777029. PMID: 28655780
Genomic aberrations of myeloproliferative and myelodysplastic/myeloproliferative neoplasms in chronic phase and during disease progression.
Hahm C, Huh HJ, Mun YC, Seong CM, Chung WS, Huh J
Int J Lab Hematol 2015 Apr;37(2):181-9. Epub 2014 May 21 doi: 10.1111/ijlh.12257. PMID: 24845343

Diagnosis

Clinical characteristics and treatment outcomes of newly diagnosed multiple myeloma with chromosome 1q abnormalities.
Abdallah N, Greipp P, Kapoor P, Gertz MA, Dispenzieri A, Baughn LB, Lacy MQ, Hayman SR, Buadi FK, Dingli D, Go RS, Hwa YL, Fonder A, Hobbs M, Lin Y, Leung N, Kourelis T, Warsame R, Siddiqui M, Lust J, Kyle RA, Bergsagel L, Ketterling R, Rajkumar SV, Kumar SK
Blood Adv 2020 Aug 11;4(15):3509-3519. doi: 10.1182/bloodadvances.2020002218. PMID: 32750129Free PMC Article
Assessing Genomic Copy Number Alterations as Best Practice for Renal Cell Neoplasia: An Evidence-Based Review from the Cancer Genomics Consortium Workgroup.
Liu YJ, Houldsworth J, Emmadi R, Dyer L, Wolff DJ
Cancer Genet 2020 Jun;244:40-54. Epub 2020 May 1 doi: 10.1016/j.cancergen.2020.04.004. PMID: 32434132
Choroid plexus hyperplasia and chromosome 9p gains.
Boxill M, Becher N, Sunde L, Thelle T
Am J Med Genet A 2018 Jun;176(6):1416-1422. Epub 2018 Apr 16 doi: 10.1002/ajmg.a.38697. PMID: 29663640
Genomic aberrations of myeloproliferative and myelodysplastic/myeloproliferative neoplasms in chronic phase and during disease progression.
Hahm C, Huh HJ, Mun YC, Seong CM, Chung WS, Huh J
Int J Lab Hematol 2015 Apr;37(2):181-9. Epub 2014 May 21 doi: 10.1111/ijlh.12257. PMID: 24845343
Cytogenetics of melanoma and nonmelanoma skin cancer.
Carless MA, Griffiths LR
Adv Exp Med Biol 2014;810:160-81. doi: 10.1007/978-1-4939-0437-2_9. PMID: 25207365

Therapy

Impact of Aneuploidy and Chromosome 9p Loss on Tumor Immune Microenvironment and Immune Checkpoint Inhibitor Efficacy in NSCLC.
Alessi JV, Wang X, Elkrief A, Ricciuti B, Li YY, Gupta H, Spurr LF, Rizvi H, Luo J, Pecci F, Lamberti G, Recondo G, Venkatraman D, Di Federico A, Gandhi MM, Vaz VR, Nishino M, Sholl LM, Cherniack AD, Ladanyi M, Price A, Richards AL, Donoghue M, Lindsay J, Sharma B, Turner MM, Pfaff KL, Felt KD, Rodig SJ, Lin X, Meyerson ML, Johnson BE, Christiani DC, Schoenfeld AJ, Awad MM
J Thorac Oncol 2023 Nov;18(11):1524-1537. Epub 2023 May 27 doi: 10.1016/j.jtho.2023.05.019. PMID: 37247843Free PMC Article
Genomic aberrations frequently alter chromatin regulatory genes in chordoma.
Wang L, Zehir A, Nafa K, Zhou N, Berger MF, Casanova J, Sadowska J, Lu C, Allis CD, Gounder M, Chandhanayingyong C, Ladanyi M, Boland PJ, Hameed M
Genes Chromosomes Cancer 2016 Jul;55(7):591-600. Epub 2016 May 9 doi: 10.1002/gcc.22362. PMID: 27072194Free PMC Article
Good response to long-term therapy with growth hormone in a patient with 9p trisomy syndrome: A case report and review of the literature.
Canton AP, Nishi MY, Furuya TK, Roela RA, Jorge AA
Am J Med Genet A 2016 Apr;170A(4):1046-9. Epub 2015 Dec 22 doi: 10.1002/ajmg.a.37521. PMID: 26689153
Heterogeneous cytogenetic subgroups and outcomes in childhood acute megakaryoblastic leukemia: a retrospective international study.
Inaba H, Zhou Y, Abla O, Adachi S, Auvrignon A, Beverloo HB, de Bont E, Chang TT, Creutzig U, Dworzak M, Elitzur S, Fynn A, Forestier E, Hasle H, Liang DC, Lee V, Locatelli F, Masetti R, De Moerloose B, Reinhardt D, Rodriguez L, Van Roy N, Shen S, Taga T, Tomizawa D, Yeoh AE, Zimmermann M, Raimondi SC
Blood 2015 Sep 24;126(13):1575-84. Epub 2015 Jul 27 doi: 10.1182/blood-2015-02-629204. PMID: 26215111Free PMC Article
Genome-wide analysis of Ollier disease: Is it all in the genes?
Pansuriya TC, Oosting J, Krenács T, Taminiau AH, Verdegaal SH, Sangiorgi L, Sciot R, Hogendoorn PC, Szuhai K, Bovée JV
Orphanet J Rare Dis 2011 Jan 14;6:2. doi: 10.1186/1750-1172-6-2. PMID: 21235737Free PMC Article

Prognosis

Proteogenomic characterization of skull-base chordoma.
Zhang Q, Xu Z, Han R, Wang Y, Ye Z, Zhu J, Cai Y, Zhang F, Zhao J, Yao B, Qin Z, Qiao N, Huang R, Feng J, Wang Y, Rui W, He F, Zhao Y, Ding C
Nat Commun 2024 Sep 27;15(1):8338. doi: 10.1038/s41467-024-52285-7. PMID: 39333076Free PMC Article
Somatic 9p24.1 alterations in HPV(-) head and neck squamous cancer dictate immune microenvironment and anti-PD-1 checkpoint inhibitor activity.
Zhao X, Cohen EEW, William WN Jr, Bianchi JJ, Abraham JP, Magee D, Spetzler DB, Gutkind JS, Alexandrov LB, Cavenee WK, Lippman SM, Davoli T
Proc Natl Acad Sci U S A 2022 Nov 22;119(47):e2213835119. Epub 2022 Nov 17 doi: 10.1073/pnas.2213835119. PMID: 36395141Free PMC Article
Genomic profile of columnar cell variant of papillary thyroid carcinoma.
Janovitz T, Williamson DFK, Wong KS, Dong F, Barletta JA
Histopathology 2021 Oct;79(4):491-498. Epub 2021 Jun 15 doi: 10.1111/his.14374. PMID: 33783022
Clinical characteristics and treatment outcomes of newly diagnosed multiple myeloma with chromosome 1q abnormalities.
Abdallah N, Greipp P, Kapoor P, Gertz MA, Dispenzieri A, Baughn LB, Lacy MQ, Hayman SR, Buadi FK, Dingli D, Go RS, Hwa YL, Fonder A, Hobbs M, Lin Y, Leung N, Kourelis T, Warsame R, Siddiqui M, Lust J, Kyle RA, Bergsagel L, Ketterling R, Rajkumar SV, Kumar SK
Blood Adv 2020 Aug 11;4(15):3509-3519. doi: 10.1182/bloodadvances.2020002218. PMID: 32750129Free PMC Article
Chromosomal aberrations in iris melanomas.
Mensink HW, Vaarwater J, de Keizer RJ, de Wolff-Rouendaal D, Mooy CM, de Klein A, Paridaens D
Br J Ophthalmol 2011 Mar;95(3):424-8. Epub 2010 Sep 29 doi: 10.1136/bjo.2010.181289. PMID: 20881029

Clinical prediction guides

Proteogenomic characterization of skull-base chordoma.
Zhang Q, Xu Z, Han R, Wang Y, Ye Z, Zhu J, Cai Y, Zhang F, Zhao J, Yao B, Qin Z, Qiao N, Huang R, Feng J, Wang Y, Rui W, He F, Zhao Y, Ding C
Nat Commun 2024 Sep 27;15(1):8338. doi: 10.1038/s41467-024-52285-7. PMID: 39333076Free PMC Article
Impact of Aneuploidy and Chromosome 9p Loss on Tumor Immune Microenvironment and Immune Checkpoint Inhibitor Efficacy in NSCLC.
Alessi JV, Wang X, Elkrief A, Ricciuti B, Li YY, Gupta H, Spurr LF, Rizvi H, Luo J, Pecci F, Lamberti G, Recondo G, Venkatraman D, Di Federico A, Gandhi MM, Vaz VR, Nishino M, Sholl LM, Cherniack AD, Ladanyi M, Price A, Richards AL, Donoghue M, Lindsay J, Sharma B, Turner MM, Pfaff KL, Felt KD, Rodig SJ, Lin X, Meyerson ML, Johnson BE, Christiani DC, Schoenfeld AJ, Awad MM
J Thorac Oncol 2023 Nov;18(11):1524-1537. Epub 2023 May 27 doi: 10.1016/j.jtho.2023.05.019. PMID: 37247843Free PMC Article
Somatic 9p24.1 alterations in HPV(-) head and neck squamous cancer dictate immune microenvironment and anti-PD-1 checkpoint inhibitor activity.
Zhao X, Cohen EEW, William WN Jr, Bianchi JJ, Abraham JP, Magee D, Spetzler DB, Gutkind JS, Alexandrov LB, Cavenee WK, Lippman SM, Davoli T
Proc Natl Acad Sci U S A 2022 Nov 22;119(47):e2213835119. Epub 2022 Nov 17 doi: 10.1073/pnas.2213835119. PMID: 36395141Free PMC Article
ALK gene copy number gain and its clinical significance in hepatocellular carcinoma.
Jia SW, Fu S, Wang F, Shao Q, Huang HB, Shao JY
World J Gastroenterol 2014 Jan 7;20(1):183-92. doi: 10.3748/wjg.v20.i1.183. PMID: 24415871Free PMC Article
Chromosomal aberrations in iris melanomas.
Mensink HW, Vaarwater J, de Keizer RJ, de Wolff-Rouendaal D, Mooy CM, de Klein A, Paridaens D
Br J Ophthalmol 2011 Mar;95(3):424-8. Epub 2010 Sep 29 doi: 10.1136/bjo.2010.181289. PMID: 20881029

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