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Nodular ganglioneuroblastoma

MedGen UID:
309203
•Concept ID:
C1517445
•
Neoplastic Process
Synonyms: Ganglioneuroblastoma, nodular; Ganglioneuroblastoma, Nodular; ganglioneuroblastoma, nodular; nodular ganglioneuroblastoma
SNOMED CT: Nodular ganglioneuroblastoma (822950002); Ganglioneuroblastoma, nodular (822950002)
 
Monarch Initiative: MONDO:0003325

Definition

A ganglioneuroblastoma characterized by the presence of neuroblastic cells in a Schwannian stroma, and the formation of hemorrhagic neuroblastic nodules. [from NCI]

Professional guidelines

PubMed

Treatment and outcome of Ganglioneuroma and Ganglioneuroblastoma intermixed.
Decarolis B, Simon T, Krug B, Leuschner I, Vokuhl C, Kaatsch P, von Schweinitz D, Klingebiel T, Mueller I, Schweigerer L, Berthold F, Hero B
BMC Cancer 2016 Jul 27;16:542. doi: 10.1186/s12885-016-2513-9. PMID: 27465021Free PMC Article
Terminology and morphologic criteria of neuroblastic tumors: recommendations by the International Neuroblastoma Pathology Committee.
Shimada H, Ambros IM, Dehner LP, Hata J, Joshi VV, Roald B
Cancer 1999 Jul 15;86(2):349-63. PMID: 10421272

Recent clinical studies

Etiology

Mediastinal neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: Pathology review and diagnostic approach.
Choi JH, Ro JY
Semin Diagn Pathol 2022 Mar;39(2):120-130. Epub 2021 Jun 15 doi: 10.1053/j.semdp.2021.06.007. PMID: 34167847
Importance of Magnetic Resonance Imaging With Diffusion-weighted Imaging in Guiding Biopsy of Nodular Ganglioneuroblastoma: A Case Report.
Jain N, Halbert J, Patel PA, Biassoni L, Anderson J, Sebire N, McHugh K, Barone G
J Pediatr Hematol Oncol 2021 Jan;43(1):e130-e135. doi: 10.1097/MPH.0000000000001686. PMID: 31815883
High Oct4 expression: implications in the pathogenesis of neuroblastic tumours.
Monferrer E, Burgos-Panadero R, Blanquer-Maceiras M, Cañete A, Navarro S, Noguera R
BMC Cancer 2019 Jan 3;19(1):1. doi: 10.1186/s12885-018-5219-3. PMID: 30606139Free PMC Article
Update on Adrenal Tumours in 2017 World Health Organization (WHO) of Endocrine Tumours.
Lam AK
Endocr Pathol 2017 Sep;28(3):213-227. doi: 10.1007/s12022-017-9484-5. PMID: 28477311
Genetic abnormalities in adolescents and young adults with neuroblastoma: A report from the Italian Neuroblastoma group.
Mazzocco K, Defferrari R, Sementa AR, Garaventa A, Longo L, De Mariano M, Esposito MR, Negri F, Ircolò D, Viscardi E, Luksch R, D'Angelo P, Prete A, Castellano A, Massirio P, Erminio G, Gigliotti AR, Tonini GP, Conte M
Pediatr Blood Cancer 2015 Oct;62(10):1725-32. Epub 2015 Apr 29 doi: 10.1002/pbc.25552. PMID: 25925003

Diagnosis

Mediastinal neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: Pathology review and diagnostic approach.
Choi JH, Ro JY
Semin Diagn Pathol 2022 Mar;39(2):120-130. Epub 2021 Jun 15 doi: 10.1053/j.semdp.2021.06.007. PMID: 34167847
Composite Neuroblastoma Metastatic to a Lymph Node: The Novel Histopathologic Diagnosis of a Unique Multiclonal Neoplasm.
Kurtz JL, Shimada H, Hazard FK
Ann Clin Lab Sci 2021 Jul;51(4):573-579. PMID: 34452899
Importance of Magnetic Resonance Imaging With Diffusion-weighted Imaging in Guiding Biopsy of Nodular Ganglioneuroblastoma: A Case Report.
Jain N, Halbert J, Patel PA, Biassoni L, Anderson J, Sebire N, McHugh K, Barone G
J Pediatr Hematol Oncol 2021 Jan;43(1):e130-e135. doi: 10.1097/MPH.0000000000001686. PMID: 31815883
High incidence of MYCN amplification in a Moroccan series of neuroblastic tumors: comparison to current biological data.
Tabyaoui I, Tahiri-Jouti N, Serhier Z, El Maani K, Cherkaoui S, Al Zemmouri M, Othmani MB, Zamiati S
Diagn Mol Pathol 2013 Jun;22(2):112-8. doi: 10.1097/PDM.0b013e318277448e. PMID: 23628823

Prognosis

Composite Neuroblastoma Metastatic to a Lymph Node: The Novel Histopathologic Diagnosis of a Unique Multiclonal Neoplasm.
Kurtz JL, Shimada H, Hazard FK
Ann Clin Lab Sci 2021 Jul;51(4):573-579. PMID: 34452899
Importance of Magnetic Resonance Imaging With Diffusion-weighted Imaging in Guiding Biopsy of Nodular Ganglioneuroblastoma: A Case Report.
Jain N, Halbert J, Patel PA, Biassoni L, Anderson J, Sebire N, McHugh K, Barone G
J Pediatr Hematol Oncol 2021 Jan;43(1):e130-e135. doi: 10.1097/MPH.0000000000001686. PMID: 31815883
Update on Adrenal Tumours in 2017 World Health Organization (WHO) of Endocrine Tumours.
Lam AK
Endocr Pathol 2017 Sep;28(3):213-227. doi: 10.1007/s12022-017-9484-5. PMID: 28477311
Genetic abnormalities in adolescents and young adults with neuroblastoma: A report from the Italian Neuroblastoma group.
Mazzocco K, Defferrari R, Sementa AR, Garaventa A, Longo L, De Mariano M, Esposito MR, Negri F, Ircolò D, Viscardi E, Luksch R, D'Angelo P, Prete A, Castellano A, Massirio P, Erminio G, Gigliotti AR, Tonini GP, Conte M
Pediatr Blood Cancer 2015 Oct;62(10):1725-32. Epub 2015 Apr 29 doi: 10.1002/pbc.25552. PMID: 25925003
Large mediastinal nodular ganglioneuroblastoma in a child from Africa.
Guarino S, Astini C, Howard JP, Colombelli V
Ann Ital Chir 2012 Nov-Dec;83(6):543-6. PMID: 23080230

Clinical prediction guides

Update on Adrenal Tumours in 2017 World Health Organization (WHO) of Endocrine Tumours.
Lam AK
Endocr Pathol 2017 Sep;28(3):213-227. doi: 10.1007/s12022-017-9484-5. PMID: 28477311
Genetic abnormalities in adolescents and young adults with neuroblastoma: A report from the Italian Neuroblastoma group.
Mazzocco K, Defferrari R, Sementa AR, Garaventa A, Longo L, De Mariano M, Esposito MR, Negri F, Ircolò D, Viscardi E, Luksch R, D'Angelo P, Prete A, Castellano A, Massirio P, Erminio G, Gigliotti AR, Tonini GP, Conte M
Pediatr Blood Cancer 2015 Oct;62(10):1725-32. Epub 2015 Apr 29 doi: 10.1002/pbc.25552. PMID: 25925003

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