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MYCL Gene Amplification

MedGen UID:
309259
•Concept ID:
C1517684
•
Cell or Molecular Dysfunction
Synonyms: L-myc Gene Amplification; LMYC Gene Amplification; MYCL1 Gene Amplification; v-MYC Avian Myelocytomatosis Viral Oncogene Lung Carcinoma Derived Homolog Gene Amplification

Definition

A molecular genetic abnormality indicating the presence of multiple copies of the MYCL gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMYCL Gene Amplification

Recent clinical studies

Etiology

Case Series of Soft Tissue Sarcoma Patients with Brain Metastasis with Implications from Genomic and Transcriptomic Analysis.
Park C, Kim R, Choi J, Kim M, Kim TM, Han I, Kim JI, Kim HS
Cancer Res Treat 2024 Apr;56(2):665-674. Epub 2023 Sep 27 doi: 10.4143/crt.2023.864. PMID: 37752792Free PMC Article
Demystifying the Druggability of the MYC Family of Oncogenes.
Karadkhelkar NM, Lin M, Eubanks LM, Janda KD
J Am Chem Soc 2023 Feb 15;145(6):3259-3269. Epub 2023 Feb 3 doi: 10.1021/jacs.2c12732. PMID: 36734615Free PMC Article
MYCL1 Amplification and Expression of L-Myc and c-Myc in Surgically Resected Small-Cell Lung Carcinoma.
Qin J, Xie F, Li C, Han N, Lu H
Pathol Oncol Res 2021;27:1609775. Epub 2021 Jun 18 doi: 10.3389/pore.2021.1609775. PMID: 34257619Free PMC Article
Polyamine synthesis as a target of MYC oncogenes.
Bachmann AS, Geerts D
J Biol Chem 2018 Nov 30;293(48):18757-18769. Epub 2018 Nov 7 doi: 10.1074/jbc.TM118.003336. PMID: 30404920Free PMC Article
MYC family amplification and clinical risk-factors interact to predict an extremely poor prognosis in childhood medulloblastoma.
Ryan SL, Schwalbe EC, Cole M, Lu Y, Lusher ME, Megahed H, O'Toole K, Nicholson SL, Bognar L, Garami M, Hauser P, Korshunov A, Pfister SM, Williamson D, Taylor RE, Ellison DW, Bailey S, Clifford SC
Acta Neuropathol 2012 Apr;123(4):501-13. Epub 2011 Dec 3 doi: 10.1007/s00401-011-0923-y. PMID: 22139329

Diagnosis

Case Series of Soft Tissue Sarcoma Patients with Brain Metastasis with Implications from Genomic and Transcriptomic Analysis.
Park C, Kim R, Choi J, Kim M, Kim TM, Han I, Kim JI, Kim HS
Cancer Res Treat 2024 Apr;56(2):665-674. Epub 2023 Sep 27 doi: 10.4143/crt.2023.864. PMID: 37752792Free PMC Article
MYCL is a target of a BET bromodomain inhibitor, JQ1, on growth suppression efficacy in small cell lung cancer cells.
Kato F, Fiorentino FP, Alibés A, Perucho M, Sánchez-Céspedes M, Kohno T, Yokota J
Oncotarget 2016 Nov 22;7(47):77378-77388. doi: 10.18632/oncotarget.12671. PMID: 27764802Free PMC Article
Comprehensive serial molecular profiling of an "N of 1" exceptional non-responder with metastatic prostate cancer progressing to small cell carcinoma on treatment.
Kadakia KC, Tomlins SA, Sanghvi SK, Cani AK, Omata K, Hovelson DH, Liu CJ, Cooney KA
J Hematol Oncol 2015 Oct 6;8:109. doi: 10.1186/s13045-015-0204-7. PMID: 26444865Free PMC Article
MYC family amplification and clinical risk-factors interact to predict an extremely poor prognosis in childhood medulloblastoma.
Ryan SL, Schwalbe EC, Cole M, Lu Y, Lusher ME, Megahed H, O'Toole K, Nicholson SL, Bognar L, Garami M, Hauser P, Korshunov A, Pfister SM, Williamson D, Taylor RE, Ellison DW, Bailey S, Clifford SC
Acta Neuropathol 2012 Apr;123(4):501-13. Epub 2011 Dec 3 doi: 10.1007/s00401-011-0923-y. PMID: 22139329

Therapy

Comprehensive serial molecular profiling of an "N of 1" exceptional non-responder with metastatic prostate cancer progressing to small cell carcinoma on treatment.
Kadakia KC, Tomlins SA, Sanghvi SK, Cani AK, Omata K, Hovelson DH, Liu CJ, Cooney KA
J Hematol Oncol 2015 Oct 6;8:109. doi: 10.1186/s13045-015-0204-7. PMID: 26444865Free PMC Article
Myc proteins as therapeutic targets.
Gustafson WC, Weiss WA
Oncogene 2010 Mar 4;29(9):1249-59. Epub 2010 Jan 25 doi: 10.1038/onc.2009.512. PMID: 20101214Free PMC Article

Prognosis

MYCL1 Amplification and Expression of L-Myc and c-Myc in Surgically Resected Small-Cell Lung Carcinoma.
Qin J, Xie F, Li C, Han N, Lu H
Pathol Oncol Res 2021;27:1609775. Epub 2021 Jun 18 doi: 10.3389/pore.2021.1609775. PMID: 34257619Free PMC Article
Molecular Pathogenesis of Merkel Cell Carcinoma.
DeCaprio JA
Annu Rev Pathol 2021 Jan 24;16:69-91. Epub 2020 Nov 23 doi: 10.1146/annurev-pathmechdis-012419-032817. PMID: 33228463
MYC, MYCL, and MYCN as therapeutic targets in lung cancer.
Massó-Vallés D, Beaulieu ME, Soucek L
Expert Opin Ther Targets 2020 Feb;24(2):101-114. Epub 2020 Feb 13 doi: 10.1080/14728222.2020.1723548. PMID: 32003251
Polyamine synthesis as a target of MYC oncogenes.
Bachmann AS, Geerts D
J Biol Chem 2018 Nov 30;293(48):18757-18769. Epub 2018 Nov 7 doi: 10.1074/jbc.TM118.003336. PMID: 30404920Free PMC Article
MYCL is a target of a BET bromodomain inhibitor, JQ1, on growth suppression efficacy in small cell lung cancer cells.
Kato F, Fiorentino FP, Alibés A, Perucho M, Sánchez-Céspedes M, Kohno T, Yokota J
Oncotarget 2016 Nov 22;7(47):77378-77388. doi: 10.18632/oncotarget.12671. PMID: 27764802Free PMC Article

Clinical prediction guides

MYC Activity Inference Captures Diverse Mechanisms of Aberrant MYC Pathway Activation in Human Cancers.
Schaafsma E, Zhao Y, Zhang L, Li Y, Cheng C
Mol Cancer Res 2021 Mar;19(3):414-428. Epub 2020 Nov 24 doi: 10.1158/1541-7786.MCR-20-0526. PMID: 33234576Free PMC Article
MYCL is a target of a BET bromodomain inhibitor, JQ1, on growth suppression efficacy in small cell lung cancer cells.
Kato F, Fiorentino FP, Alibés A, Perucho M, Sánchez-Céspedes M, Kohno T, Yokota J
Oncotarget 2016 Nov 22;7(47):77378-77388. doi: 10.18632/oncotarget.12671. PMID: 27764802Free PMC Article
MYC family amplification and clinical risk-factors interact to predict an extremely poor prognosis in childhood medulloblastoma.
Ryan SL, Schwalbe EC, Cole M, Lu Y, Lusher ME, Megahed H, O'Toole K, Nicholson SL, Bognar L, Garami M, Hauser P, Korshunov A, Pfister SM, Williamson D, Taylor RE, Ellison DW, Bailey S, Clifford SC
Acta Neuropathol 2012 Apr;123(4):501-13. Epub 2011 Dec 3 doi: 10.1007/s00401-011-0923-y. PMID: 22139329
Myc proteins as therapeutic targets.
Gustafson WC, Weiss WA
Oncogene 2010 Mar 4;29(9):1249-59. Epub 2010 Jan 25 doi: 10.1038/onc.2009.512. PMID: 20101214Free PMC Article
Gene amplification and gene dosage in cell lines derived from squamous cell carcinoma of the head and neck.
Yin XY, Donovan-Peluso M, Whiteside TL, Johnson JT, Day R, Herberman RB, Locker J
Genes Chromosomes Cancer 1991 Nov;3(6):443-54. doi: 10.1002/gcc.2870030606. PMID: 1777414

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