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Pancreatic mucinous-cystic neoplasm with an associated invasive carcinoma

MedGen UID:
309550
•Concept ID:
C1518870
•
Neoplastic Process
Synonyms: pancreatic invasive mucinous cystadenocarcinoma; Pancreatic Mucinous Cystic Neoplasm with an Associated Invasive Carcinoma; pancreatic mucinous cystic neoplasm with an associated invasive carcinoma; Pancreatic Mucinous-Cystic Neoplasm with an Associated Invasive Carcinoma; pancreatic mucinous-cystic neoplasm with an associated invasive carcinoma
 
Monarch Initiative: MONDO:0004158

Definition

A cystic epithelial neoplasm characterized by the presence of columnar mucin-producing epithelial cells, ovarian-type stroma formation, and a focal or extensive invasive carcinomatous component. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPancreatic mucinous-cystic neoplasm with an associated invasive carcinoma

Professional guidelines

PubMed

Surgical treatment for pancreatic cystic lesions-implications from the multi-center and prospective German StuDoQ|Pancreas registry.
Henn J, Wyzlic PK, Esposito I, Semaan A, Branchi V, Klinger C, Buhr HJ, Wellner UF, Keck T, Lingohr P, Glowka TR, Manekeller S, Kalff JC, Matthaei H; StuDoQ|Pancreas Study Group
Langenbecks Arch Surg 2023 Jan 14;408(1):28. doi: 10.1007/s00423-022-02740-0. PMID: 36640188Free PMC Article
Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas.
Tanaka M, Fernández-Del Castillo C, Kamisawa T, Jang JY, Levy P, Ohtsuka T, Salvia R, Shimizu Y, Tada M, Wolfgang CL
Pancreatology 2017 Sep-Oct;17(5):738-753. Epub 2017 Jul 13 doi: 10.1016/j.pan.2017.07.007. PMID: 28735806
A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article

Recent clinical studies

Etiology

Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project.
Semaan A, Bernard V, Wong J, Makino Y, Swartzlander DB, Rajapakshe KI, Lee JJ, Officer A, Schmidt CM, Wu HH, Scaife CL, Affolter KE, Nachmanson D, Firpo MA, Yip-Schneider M, Lowy AM, Harismendy O, Sen S, Maitra A, Jakubek YA, Guerrero PA
Cancer Res Commun 2023 Oct 10;3(10):2062-2073. doi: 10.1158/2767-9764.CRC-22-0419. PMID: 37721516Free PMC Article
Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas.
Tanaka M, Fernández-Del Castillo C, Kamisawa T, Jang JY, Levy P, Ohtsuka T, Salvia R, Shimizu Y, Tada M, Wolfgang CL
Pancreatology 2017 Sep-Oct;17(5):738-753. Epub 2017 Jul 13 doi: 10.1016/j.pan.2017.07.007. PMID: 28735806
Analysis of Pancreatic Cyst Fluid.
Ngamruengphong S, Lennon AM
Surg Pathol Clin 2016 Dec;9(4):677-684. doi: 10.1016/j.path.2016.05.010. PMID: 27926366Free PMC Article
A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article
Benign cystic neoplasm and endocrine tumours of the pancreas--when and how to operate--an overview.
Beger HG, Poch B, Vasilescu C
Int J Surg 2014;12(6):606-14. Epub 2014 Apr 15 doi: 10.1016/j.ijsu.2014.03.020. PMID: 24742543

Diagnosis

Surgical treatment for pancreatic cystic lesions-implications from the multi-center and prospective German StuDoQ|Pancreas registry.
Henn J, Wyzlic PK, Esposito I, Semaan A, Branchi V, Klinger C, Buhr HJ, Wellner UF, Keck T, Lingohr P, Glowka TR, Manekeller S, Kalff JC, Matthaei H; StuDoQ|Pancreas Study Group
Langenbecks Arch Surg 2023 Jan 14;408(1):28. doi: 10.1007/s00423-022-02740-0. PMID: 36640188Free PMC Article
Mucin-producing Cystic Hepatobiliary Neoplasms: Updated Nomenclature and Clinical, Pathologic, and Imaging Features.
Lee MH, Katabathina VS, Lubner MG, Shah HU, Prasad SR, Matkowskyj KA, Pickhardt PJ
Radiographics 2021 Oct;41(6):1592-1610. doi: 10.1148/rg.2021210011. PMID: 34597230Free PMC Article
Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas.
Tanaka M, Fernández-Del Castillo C, Kamisawa T, Jang JY, Levy P, Ohtsuka T, Salvia R, Shimizu Y, Tada M, Wolfgang CL
Pancreatology 2017 Sep-Oct;17(5):738-753. Epub 2017 Jul 13 doi: 10.1016/j.pan.2017.07.007. PMID: 28735806
Analysis of Pancreatic Cyst Fluid.
Ngamruengphong S, Lennon AM
Surg Pathol Clin 2016 Dec;9(4):677-684. doi: 10.1016/j.path.2016.05.010. PMID: 27926366Free PMC Article
A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article

Therapy

Surveillance after resection of non-invasive intraductal papillary mucinous neoplasms (IPMN). A systematic review.
Correa-Gallego C, Miyasaka Y, Hozaka Y, Nishino H, Kawamoto M, Vieira DL, Ohtsuka T, Wolfgang C
Pancreatology 2023 Apr;23(3):258-265. Epub 2023 Feb 27 doi: 10.1016/j.pan.2023.02.008. PMID: 36906508
Age-related risks of complications after distal pancreatectomy for neuroendocrine and cystic neoplasms.
Ramanathan R, Al Abbas AI, Mason T, Wolfe LG, Kaplan BJ
HPB (Oxford) 2019 Jul;21(7):810-817. Epub 2018 Dec 7 doi: 10.1016/j.hpb.2018.09.015. PMID: 30528554
Systemic Chemotherapy for Advanced Rare Pancreatic Histotype Tumors: A Retrospective Multicenter Analysis.
Brunetti O, Aprile G, Marchetti P, Vasile E, Casadei Gardini A, Scartozzi M, Barni S, Delfanti S, De Vita F, Di Costanzo F, Milella M, Cella CA, Berardi R, Cataldo I, Scarpa A, Basile D, Mazzuca F, Graziano G, Argentiero A, Santini D, Reni M, Cascinu S, Silvestris N
Pancreas 2018 Jul;47(6):759-771. doi: 10.1097/MPA.0000000000001063. PMID: 29771769
Successful pregnancy after mucinous cystic neoplasm with invasive carcinoma of the pancreas in a patient with polycystic ovarian syndrome: a case report.
Holloman C, Carlan SJ, Sundharkrishnan L, Guzman A, Madruga M
J Med Case Rep 2017 Jul 11;11(1):188. doi: 10.1186/s13256-017-1343-y. PMID: 28693619Free PMC Article
Benign cystic neoplasm and endocrine tumours of the pancreas--when and how to operate--an overview.
Beger HG, Poch B, Vasilescu C
Int J Surg 2014;12(6):606-14. Epub 2014 Apr 15 doi: 10.1016/j.ijsu.2014.03.020. PMID: 24742543

Prognosis

Malignancy risk factors and prognostic variables of pancreatic mucinous cystic neoplasms in Chinese patients.
Xia Q, Li F, Min R, Sun S, Han YX, Feng ZZ, Li N
World J Gastroenterol 2023 May 28;29(20):3119-3132. doi: 10.3748/wjg.v29.i20.3119. PMID: 37346158Free PMC Article
Mucin-producing Cystic Hepatobiliary Neoplasms: Updated Nomenclature and Clinical, Pathologic, and Imaging Features.
Lee MH, Katabathina VS, Lubner MG, Shah HU, Prasad SR, Matkowskyj KA, Pickhardt PJ
Radiographics 2021 Oct;41(6):1592-1610. doi: 10.1148/rg.2021210011. PMID: 34597230Free PMC Article
Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas.
Tanaka M, Fernández-Del Castillo C, Kamisawa T, Jang JY, Levy P, Ohtsuka T, Salvia R, Shimizu Y, Tada M, Wolfgang CL
Pancreatology 2017 Sep-Oct;17(5):738-753. Epub 2017 Jul 13 doi: 10.1016/j.pan.2017.07.007. PMID: 28735806
A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article
Mucinous cystic neoplasms of the pancreas: update on the surgical pathology and molecular genetics.
Fukushima N, Zamboni G
Semin Diagn Pathol 2014 Nov;31(6):467-474. Epub 2014 Sep 2 doi: 10.1053/j.semdp.2014.08.007. PMID: 25441310

Clinical prediction guides

Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project.
Semaan A, Bernard V, Wong J, Makino Y, Swartzlander DB, Rajapakshe KI, Lee JJ, Officer A, Schmidt CM, Wu HH, Scaife CL, Affolter KE, Nachmanson D, Firpo MA, Yip-Schneider M, Lowy AM, Harismendy O, Sen S, Maitra A, Jakubek YA, Guerrero PA
Cancer Res Commun 2023 Oct 10;3(10):2062-2073. doi: 10.1158/2767-9764.CRC-22-0419. PMID: 37721516Free PMC Article
Clinical characteristics and survival prediction of surgical patients with invasive pancreatic cystic neoplasm: a large retrospective study over two decades.
Song Y, Li Z, Cui H, Xu J, Song J
World J Surg Oncol 2023 Aug 23;21(1):261. doi: 10.1186/s12957-023-03145-z. PMID: 37612715Free PMC Article
Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas.
Tanaka M, Fernández-Del Castillo C, Kamisawa T, Jang JY, Levy P, Ohtsuka T, Salvia R, Shimizu Y, Tada M, Wolfgang CL
Pancreatology 2017 Sep-Oct;17(5):738-753. Epub 2017 Jul 13 doi: 10.1016/j.pan.2017.07.007. PMID: 28735806
A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article
Benign cystic neoplasm and endocrine tumours of the pancreas--when and how to operate--an overview.
Beger HG, Poch B, Vasilescu C
Int J Surg 2014;12(6):606-14. Epub 2014 Apr 15 doi: 10.1016/j.ijsu.2014.03.020. PMID: 24742543

Recent systematic reviews

Association of high-risk stigmata and worrisome features with advanced neoplasia in intraductal papillary mucinous neoplasms (IPMN): A systematic review.
Ohno E, Balduzzi A, Hijioka S, De Pastena M, Marchegiani G, Kato H, Takenaka M, Haba S, Salvia R
Pancreatology 2024 Feb;24(1):48-61. Epub 2023 Dec 7 doi: 10.1016/j.pan.2023.12.002. PMID: 38161091
Surveillance after resection of non-invasive intraductal papillary mucinous neoplasms (IPMN). A systematic review.
Correa-Gallego C, Miyasaka Y, Hozaka Y, Nishino H, Kawamoto M, Vieira DL, Ohtsuka T, Wolfgang C
Pancreatology 2023 Apr;23(3):258-265. Epub 2023 Feb 27 doi: 10.1016/j.pan.2023.02.008. PMID: 36906508

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