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Pancreatic mucinous-cystic neoplasm with an associated invasive carcinoma

MedGen UID:
309550
Concept ID:
C1518870
Neoplastic Process
Synonyms: pancreatic invasive mucinous cystadenocarcinoma; Pancreatic Mucinous Cystic Neoplasm with an Associated Invasive Carcinoma; pancreatic mucinous cystic neoplasm with an associated invasive carcinoma; Pancreatic Mucinous-Cystic Neoplasm with an Associated Invasive Carcinoma; pancreatic mucinous-cystic neoplasm with an associated invasive carcinoma
 
Monarch Initiative: MONDO:0004158

Definition

A cystic epithelial neoplasm characterized by the presence of columnar mucin-producing epithelial cells, ovarian-type stroma formation, and a focal or extensive invasive carcinomatous component. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPancreatic mucinous-cystic neoplasm with an associated invasive carcinoma

Professional guidelines

PubMed

Henn J, Wyzlic PK, Esposito I, Semaan A, Branchi V, Klinger C, Buhr HJ, Wellner UF, Keck T, Lingohr P, Glowka TR, Manekeller S, Kalff JC, Matthaei H; StuDoQ|Pancreas Study Group
Langenbecks Arch Surg 2023 Jan 14;408(1):28. doi: 10.1007/s00423-022-02740-0. PMID: 36640188Free PMC Article
Tanaka M, Fernández-Del Castillo C, Kamisawa T, Jang JY, Levy P, Ohtsuka T, Salvia R, Shimizu Y, Tada M, Wolfgang CL
Pancreatology 2017 Sep-Oct;17(5):738-753. Epub 2017 Jul 13 doi: 10.1016/j.pan.2017.07.007. PMID: 28735806
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article

Recent clinical studies

Etiology

Keane MG, Shamali A, Nilsson LN, Antila A, Millastre Bocos J, Marijinissen Van Zanten M, Verdejo Gil C, Maisonneuve P, Vaalavuo Y, Hoskins T, Robinson S, Ceyhan GO, Abu Hilal M, Pereira SP, Laukkarinen J, Del Chiaro M
Br J Surg 2018 Mar;105(4):439-446. doi: 10.1002/bjs.10787. PMID: 29488646
Tanaka M, Fernández-Del Castillo C, Kamisawa T, Jang JY, Levy P, Ohtsuka T, Salvia R, Shimizu Y, Tada M, Wolfgang CL
Pancreatology 2017 Sep-Oct;17(5):738-753. Epub 2017 Jul 13 doi: 10.1016/j.pan.2017.07.007. PMID: 28735806
Ngamruengphong S, Lennon AM
Surg Pathol Clin 2016 Dec;9(4):677-684. doi: 10.1016/j.path.2016.05.010. PMID: 27926366Free PMC Article
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article
Beger HG, Poch B, Vasilescu C
Int J Surg 2014;12(6):606-14. Epub 2014 Apr 15 doi: 10.1016/j.ijsu.2014.03.020. PMID: 24742543

Diagnosis

Tanaka M, Fernández-Del Castillo C, Kamisawa T, Jang JY, Levy P, Ohtsuka T, Salvia R, Shimizu Y, Tada M, Wolfgang CL
Pancreatology 2017 Sep-Oct;17(5):738-753. Epub 2017 Jul 13 doi: 10.1016/j.pan.2017.07.007. PMID: 28735806
Ngamruengphong S, Lennon AM
Surg Pathol Clin 2016 Dec;9(4):677-684. doi: 10.1016/j.path.2016.05.010. PMID: 27926366Free PMC Article
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article
Wilentz RE, Albores-Saavedra J, Hruban RH
Semin Diagn Pathol 2000 Feb;17(1):31-42. PMID: 10721805
Adsay NV, Longnecker DS, Klimstra DS
Semin Diagn Pathol 2000 Feb;17(1):16-30. PMID: 10721804

Therapy

Ramanathan R, Al Abbas AI, Mason T, Wolfe LG, Kaplan BJ
HPB (Oxford) 2019 Jul;21(7):810-817. Epub 2018 Dec 7 doi: 10.1016/j.hpb.2018.09.015. PMID: 30528554
Brunetti O, Aprile G, Marchetti P, Vasile E, Casadei Gardini A, Scartozzi M, Barni S, Delfanti S, De Vita F, Di Costanzo F, Milella M, Cella CA, Berardi R, Cataldo I, Scarpa A, Basile D, Mazzuca F, Graziano G, Argentiero A, Santini D, Reni M, Cascinu S, Silvestris N
Pancreas 2018 Jul;47(6):759-771. doi: 10.1097/MPA.0000000000001063. PMID: 29771769
Holloman C, Carlan SJ, Sundharkrishnan L, Guzman A, Madruga M
J Med Case Rep 2017 Jul 11;11(1):188. doi: 10.1186/s13256-017-1343-y. PMID: 28693619Free PMC Article
Beger HG, Poch B, Vasilescu C
Int J Surg 2014;12(6):606-14. Epub 2014 Apr 15 doi: 10.1016/j.ijsu.2014.03.020. PMID: 24742543
Frankel TL, LaFemina J, Bamboat ZM, D'Angelica MI, DeMatteo RP, Fong Y, Kingham TP, Jarnagin WR, Allen PJ
HPB (Oxford) 2013 Oct;15(10):814-21. Epub 2013 Jun 19 doi: 10.1111/hpb.12137. PMID: 23782351Free PMC Article

Prognosis

Keane MG, Shamali A, Nilsson LN, Antila A, Millastre Bocos J, Marijinissen Van Zanten M, Verdejo Gil C, Maisonneuve P, Vaalavuo Y, Hoskins T, Robinson S, Ceyhan GO, Abu Hilal M, Pereira SP, Laukkarinen J, Del Chiaro M
Br J Surg 2018 Mar;105(4):439-446. doi: 10.1002/bjs.10787. PMID: 29488646
Tanaka M, Fernández-Del Castillo C, Kamisawa T, Jang JY, Levy P, Ohtsuka T, Salvia R, Shimizu Y, Tada M, Wolfgang CL
Pancreatology 2017 Sep-Oct;17(5):738-753. Epub 2017 Jul 13 doi: 10.1016/j.pan.2017.07.007. PMID: 28735806
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article
Fukushima N, Zamboni G
Semin Diagn Pathol 2014 Nov;31(6):467-474. Epub 2014 Sep 2 doi: 10.1053/j.semdp.2014.08.007. PMID: 25441310
Adsay NV, Longnecker DS, Klimstra DS
Semin Diagn Pathol 2000 Feb;17(1):16-30. PMID: 10721804

Clinical prediction guides

Keane MG, Shamali A, Nilsson LN, Antila A, Millastre Bocos J, Marijinissen Van Zanten M, Verdejo Gil C, Maisonneuve P, Vaalavuo Y, Hoskins T, Robinson S, Ceyhan GO, Abu Hilal M, Pereira SP, Laukkarinen J, Del Chiaro M
Br J Surg 2018 Mar;105(4):439-446. doi: 10.1002/bjs.10787. PMID: 29488646
Tanaka M, Fernández-Del Castillo C, Kamisawa T, Jang JY, Levy P, Ohtsuka T, Salvia R, Shimizu Y, Tada M, Wolfgang CL
Pancreatology 2017 Sep-Oct;17(5):738-753. Epub 2017 Jul 13 doi: 10.1016/j.pan.2017.07.007. PMID: 28735806
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article
Beger HG, Poch B, Vasilescu C
Int J Surg 2014;12(6):606-14. Epub 2014 Apr 15 doi: 10.1016/j.ijsu.2014.03.020. PMID: 24742543
Wilentz RE, Albores-Saavedra J, Hruban RH
Semin Diagn Pathol 2000 Feb;17(1):31-42. PMID: 10721805

Recent systematic reviews

Correa-Gallego C, Miyasaka Y, Hozaka Y, Nishino H, Kawamoto M, Vieira DL, Ohtsuka T, Wolfgang C
Pancreatology 2023 Apr;23(3):258-265. Epub 2023 Feb 27 doi: 10.1016/j.pan.2023.02.008. PMID: 36906508

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