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Pancreatic mucinous-cystic neoplasm with an associated invasive carcinoma

MedGen UID:
309550
Concept ID:
C1518870
Neoplastic Process
Synonyms: pancreatic invasive mucinous cystadenocarcinoma; Pancreatic Mucinous Cystic Neoplasm with an Associated Invasive Carcinoma; pancreatic mucinous cystic neoplasm with an associated invasive carcinoma; Pancreatic Mucinous-Cystic Neoplasm with an Associated Invasive Carcinoma; pancreatic mucinous-cystic neoplasm with an associated invasive carcinoma
 
Monarch Initiative: MONDO:0004158

Definition

A cystic epithelial neoplasm characterized by the presence of columnar mucin-producing epithelial cells, ovarian-type stroma formation, and a focal or extensive invasive carcinomatous component. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPancreatic mucinous-cystic neoplasm with an associated invasive carcinoma

Professional guidelines

PubMed

Henn J, Wyzlic PK, Esposito I, Semaan A, Branchi V, Klinger C, Buhr HJ, Wellner UF, Keck T, Lingohr P, Glowka TR, Manekeller S, Kalff JC, Matthaei H; StuDoQ|Pancreas Study Group
Langenbecks Arch Surg 2023 Jan 14;408(1):28. doi: 10.1007/s00423-022-02740-0. PMID: 36640188Free PMC Article
Tanaka M, Fernández-Del Castillo C, Kamisawa T, Jang JY, Levy P, Ohtsuka T, Salvia R, Shimizu Y, Tada M, Wolfgang CL
Pancreatology 2017 Sep-Oct;17(5):738-753. Epub 2017 Jul 13 doi: 10.1016/j.pan.2017.07.007. PMID: 28735806
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article

Recent clinical studies

Etiology

Ohno E, Balduzzi A, Hijioka S, De Pastena M, Marchegiani G, Kato H, Takenaka M, Haba S, Salvia R
Pancreatology 2024 Feb;24(1):48-61. Epub 2023 Dec 7 doi: 10.1016/j.pan.2023.12.002. PMID: 38161091
Tanaka M, Fernández-Del Castillo C, Kamisawa T, Jang JY, Levy P, Ohtsuka T, Salvia R, Shimizu Y, Tada M, Wolfgang CL
Pancreatology 2017 Sep-Oct;17(5):738-753. Epub 2017 Jul 13 doi: 10.1016/j.pan.2017.07.007. PMID: 28735806
Ngamruengphong S, Lennon AM
Surg Pathol Clin 2016 Dec;9(4):677-684. doi: 10.1016/j.path.2016.05.010. PMID: 27926366Free PMC Article
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article
Adsay NV
J Gastrointest Surg 2008 Mar;12(3):401-4. Epub 2007 Oct 24 doi: 10.1007/s11605-007-0348-z. PMID: 17957438

Diagnosis

Park MA, Zaw T, Yoder SJ, Gomez M, Genilo-Delgado M, Basinski T, Katende E, Dam A, Mok SRS, Monteiro A, Mohammadi A, Jeong DK, Jiang K, Centeno BA, Hodul P, Malafa M, Fleming J, Chen DT, Mo Q, Teer JK, Permuth JB
G3 (Bethesda) 2023 Feb 9;13(2) doi: 10.1093/g3journal/jkac314. PMID: 36454217Free PMC Article
Tanaka M, Fernández-Del Castillo C, Kamisawa T, Jang JY, Levy P, Ohtsuka T, Salvia R, Shimizu Y, Tada M, Wolfgang CL
Pancreatology 2017 Sep-Oct;17(5):738-753. Epub 2017 Jul 13 doi: 10.1016/j.pan.2017.07.007. PMID: 28735806
Ngamruengphong S, Lennon AM
Surg Pathol Clin 2016 Dec;9(4):677-684. doi: 10.1016/j.path.2016.05.010. PMID: 27926366Free PMC Article
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article
Adsay NV
J Gastrointest Surg 2008 Mar;12(3):401-4. Epub 2007 Oct 24 doi: 10.1007/s11605-007-0348-z. PMID: 17957438

Therapy

Correa-Gallego C, Miyasaka Y, Hozaka Y, Nishino H, Kawamoto M, Vieira DL, Ohtsuka T, Wolfgang C
Pancreatology 2023 Apr;23(3):258-265. Epub 2023 Feb 27 doi: 10.1016/j.pan.2023.02.008. PMID: 36906508
Ramanathan R, Al Abbas AI, Mason T, Wolfe LG, Kaplan BJ
HPB (Oxford) 2019 Jul;21(7):810-817. Epub 2018 Dec 7 doi: 10.1016/j.hpb.2018.09.015. PMID: 30528554
Brunetti O, Aprile G, Marchetti P, Vasile E, Casadei Gardini A, Scartozzi M, Barni S, Delfanti S, De Vita F, Di Costanzo F, Milella M, Cella CA, Berardi R, Cataldo I, Scarpa A, Basile D, Mazzuca F, Graziano G, Argentiero A, Santini D, Reni M, Cascinu S, Silvestris N
Pancreas 2018 Jul;47(6):759-771. doi: 10.1097/MPA.0000000000001063. PMID: 29771769
Holloman C, Carlan SJ, Sundharkrishnan L, Guzman A, Madruga M
J Med Case Rep 2017 Jul 11;11(1):188. doi: 10.1186/s13256-017-1343-y. PMID: 28693619Free PMC Article
Beger HG, Poch B, Vasilescu C
Int J Surg 2014;12(6):606-14. Epub 2014 Apr 15 doi: 10.1016/j.ijsu.2014.03.020. PMID: 24742543

Prognosis

Ohno E, Balduzzi A, Hijioka S, De Pastena M, Marchegiani G, Kato H, Takenaka M, Haba S, Salvia R
Pancreatology 2024 Feb;24(1):48-61. Epub 2023 Dec 7 doi: 10.1016/j.pan.2023.12.002. PMID: 38161091
Lupinacci RM, Goloudina A, Buhard O, Bachet JB, Maréchal R, Demetter P, Cros J, Bardier-Dupas A, Collura A, Cervera P, Scriva A, Dumont S, Hammel P, Sauvanet A, Louvet C, Delpéro JR, Paye F, Vaillant JC, André T, Closset J, Emile JF, Van Laethem JL, Jonchère V, Abd Alsamad I, Antoine M, Rodenas A, Fléjou JF, Dusetti N, Iovanna J, Duval A, Svrcek M
Gastroenterology 2018 Mar;154(4):1061-1065. Epub 2017 Nov 20 doi: 10.1053/j.gastro.2017.11.009. PMID: 29158190
Tanaka M, Fernández-Del Castillo C, Kamisawa T, Jang JY, Levy P, Ohtsuka T, Salvia R, Shimizu Y, Tada M, Wolfgang CL
Pancreatology 2017 Sep-Oct;17(5):738-753. Epub 2017 Jul 13 doi: 10.1016/j.pan.2017.07.007. PMID: 28735806
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article
Adsay NV
J Gastrointest Surg 2008 Mar;12(3):401-4. Epub 2007 Oct 24 doi: 10.1007/s11605-007-0348-z. PMID: 17957438

Clinical prediction guides

Song Y, Li Z, Cui H, Xu J, Song J
World J Surg Oncol 2023 Aug 23;21(1):261. doi: 10.1186/s12957-023-03145-z. PMID: 37612715Free PMC Article
Park MA, Zaw T, Yoder SJ, Gomez M, Genilo-Delgado M, Basinski T, Katende E, Dam A, Mok SRS, Monteiro A, Mohammadi A, Jeong DK, Jiang K, Centeno BA, Hodul P, Malafa M, Fleming J, Chen DT, Mo Q, Teer JK, Permuth JB
G3 (Bethesda) 2023 Feb 9;13(2) doi: 10.1093/g3journal/jkac314. PMID: 36454217Free PMC Article
Tanaka M, Fernández-Del Castillo C, Kamisawa T, Jang JY, Levy P, Ohtsuka T, Salvia R, Shimizu Y, Tada M, Wolfgang CL
Pancreatology 2017 Sep-Oct;17(5):738-753. Epub 2017 Jul 13 doi: 10.1016/j.pan.2017.07.007. PMID: 28735806
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article
Beger HG, Poch B, Vasilescu C
Int J Surg 2014;12(6):606-14. Epub 2014 Apr 15 doi: 10.1016/j.ijsu.2014.03.020. PMID: 24742543

Recent systematic reviews

Ohno E, Balduzzi A, Hijioka S, De Pastena M, Marchegiani G, Kato H, Takenaka M, Haba S, Salvia R
Pancreatology 2024 Feb;24(1):48-61. Epub 2023 Dec 7 doi: 10.1016/j.pan.2023.12.002. PMID: 38161091
Correa-Gallego C, Miyasaka Y, Hozaka Y, Nishino H, Kawamoto M, Vieira DL, Ohtsuka T, Wolfgang C
Pancreatology 2023 Apr;23(3):258-265. Epub 2023 Feb 27 doi: 10.1016/j.pan.2023.02.008. PMID: 36906508

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