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Colon Intramucosal Adenocarcinoma

MedGen UID:
310620
•Concept ID:
C1707434
•
Neoplastic Process
Synonym: Colon Intramucosal Neoplasia

Definition

An adenocarcinoma that arises from the colonic glandular epithelium and invades the lamina propria or muscularis mucosa but not the submucosa. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColon Intramucosal Adenocarcinoma

Professional guidelines

PubMed

Warning for unprincipled colorectal endoscopic submucosal dissection: accurate diagnosis and reasonable treatment strategy.
Tanaka S, Terasaki M, Hayashi N, Oka S, Chayama K
Dig Endosc 2013 Mar;25(2):107-16. Epub 2012 Dec 20 doi: 10.1111/den.12016. PMID: 23368854Free PMC Article
Utility of MMP-1, p53, E-cadherin, and collagen IV immunohistochemical stains in the differential diagnosis of adenomas with misplaced epithelium versus adenomas with invasive adenocarcinoma.
Yantiss RK, Bosenberg MW, Antonioli DA, Odze RD
Am J Surg Pathol 2002 Feb;26(2):206-15. doi: 10.1097/00000478-200202000-00007. PMID: 11812942

Recent clinical studies

Etiology

EMR/ESD: Techniques, Complications, and Evidence.
Ahmed Y, Othman M
Curr Gastroenterol Rep 2020 Jun 15;22(8):39. doi: 10.1007/s11894-020-00777-z. PMID: 32542462
Histopathological Analysis of 173 Consecutive Patients with Colorectal Carcinoma: A Pathologist's View.
Canbey Göret C, Göret NE
Med Sci Monit 2018 Sep 26;24:6809-6815. doi: 10.12659/MSM.911012. PMID: 30255856Free PMC Article
Gastrointestinal Polyposis in Cowden Syndrome.
Shaco-Levy R, Jasperson KW, Martin K, Samadder NJ, Burt RW, Ying J, Bronner MP
J Clin Gastroenterol 2017 Aug;51(7):e60-e67. doi: 10.1097/MCG.0000000000000703. PMID: 27661969
Development and progression of colorectal cancer based on follow-up analysis.
Hisabe T, Hirai F, Matsui T
Dig Endosc 2014 Apr;26 Suppl 2:73-7. doi: 10.1111/den.12276. PMID: 24750153
Barrett's oesophagus: an ideal model to study cancer genetics.
di Pietro M, Fitzgerald RC
Hum Genet 2009 Aug;126(2):233-46. Epub 2009 Apr 14 doi: 10.1007/s00439-009-0665-2. PMID: 19365640

Diagnosis

Invasive carcinoma versus pseudoinvasion: interobserver variability in the assessment of left-sided colorectal polypectomies.
Lee M, Kudose S, Del Portillo A, Ko HM, Lee H, Pittman ME, Salomao MA, Sepulveda AR, Lagana SM
J Clin Pathol 2022 Sep;75(9):593-597. Epub 2021 Apr 12 doi: 10.1136/jclinpath-2021-207406. PMID: 33846218
Colonic Adenomatous Polyps Involving Submucosal Lymphoglandular Complexes: A Diagnostic Pitfall.
Lee HE, Wu TT, Chandan VS, Torbenson MS, Mounajjed T
Am J Surg Pathol 2018 Aug;42(8):1083-1089. doi: 10.1097/PAS.0000000000001081. PMID: 29738362
Intramucosal colorectal carcinoma with invasion of the lamina propria: a study by the Japanese Society for Cancer of the Colon and Rectum.
Kojima M, Shimazaki H, Iwaya K, Nakamura T, Kawachi H, Ichikawa K, Sekine S, Ishiguro S, Shimoda T, Kushima R, Yao T, Fujimori T, Hase K, Watanabe T, Sugihara K, Lauwers GY, Ochiai A
Hum Pathol 2017 Aug;66:230-237. Epub 2017 Jul 13 doi: 10.1016/j.humpath.2017.04.031. PMID: 28711649
Gastrointestinal Polyposis in Cowden Syndrome.
Shaco-Levy R, Jasperson KW, Martin K, Samadder NJ, Burt RW, Ying J, Bronner MP
J Clin Gastroenterol 2017 Aug;51(7):e60-e67. doi: 10.1097/MCG.0000000000000703. PMID: 27661969
Barrett's oesophagus: an ideal model to study cancer genetics.
di Pietro M, Fitzgerald RC
Hum Genet 2009 Aug;126(2):233-46. Epub 2009 Apr 14 doi: 10.1007/s00439-009-0665-2. PMID: 19365640

Therapy

Evaluation of recurrence and surgical complementation rates after endoscopic resection of large colorectal non-pedunculated lesions.
Azevedo AAS, Ribeiro MCDPN, Mota FL, Correa PAFP, Loureiro JFM
Rev Esp Enferm Dig 2020 Dec;112(12):898-902. doi: 10.17235/reed.2020.6695/2019. PMID: 33054283
Mesenteric phlebosclerosis complicating colonic cancer treated by endoscopic submucosal dissection.
Kawasaki K, Eizuka M, Kudara N, Yanai S, Toya Y, Torisu T, Umeno J, Nakamura S, Sugai T, Matsumoto T
Clin J Gastroenterol 2020 Dec;13(6):1183-1188. Epub 2020 Aug 16 doi: 10.1007/s12328-020-01205-5. PMID: 32803642
EMR/ESD: Techniques, Complications, and Evidence.
Ahmed Y, Othman M
Curr Gastroenterol Rep 2020 Jun 15;22(8):39. doi: 10.1007/s11894-020-00777-z. PMID: 32542462
Endoscopic mucosal imaging of gastrointestinal neoplasia in 2013.
Urquhart P, DaCosta R, Marcon N
Curr Gastroenterol Rep 2013 Jul;15(7):330. doi: 10.1007/s11894-013-0330-8. PMID: 23771504
A case of more abundant and dysplastic adenomas in the interposed colon than in the native colon.
Hwang HJ, Song KH, Youn YH, Kwon JE, Kim H, Chung JB, Lee YC
Yonsei Med J 2007 Dec 31;48(6):1075-8. doi: 10.3349/ymj.2007.48.6.1075. PMID: 18159607Free PMC Article

Prognosis

Colonic Adenomatous Polyps Involving Submucosal Lymphoglandular Complexes: A Diagnostic Pitfall.
Lee HE, Wu TT, Chandan VS, Torbenson MS, Mounajjed T
Am J Surg Pathol 2018 Aug;42(8):1083-1089. doi: 10.1097/PAS.0000000000001081. PMID: 29738362
Gastrointestinal Polyposis in Cowden Syndrome.
Shaco-Levy R, Jasperson KW, Martin K, Samadder NJ, Burt RW, Ying J, Bronner MP
J Clin Gastroenterol 2017 Aug;51(7):e60-e67. doi: 10.1097/MCG.0000000000000703. PMID: 27661969
Development and progression of colorectal cancer based on follow-up analysis.
Hisabe T, Hirai F, Matsui T
Dig Endosc 2014 Apr;26 Suppl 2:73-7. doi: 10.1111/den.12276. PMID: 24750153
Barrett's oesophagus: an ideal model to study cancer genetics.
di Pietro M, Fitzgerald RC
Hum Genet 2009 Aug;126(2):233-46. Epub 2009 Apr 14 doi: 10.1007/s00439-009-0665-2. PMID: 19365640
Pathology of colorectal cancer.
Ponz de Leon M, Di Gregorio C
Dig Liver Dis 2001 May;33(4):372-88. doi: 10.1016/s1590-8658(01)80095-5. PMID: 11432519

Clinical prediction guides

Invasive carcinoma versus pseudoinvasion: interobserver variability in the assessment of left-sided colorectal polypectomies.
Lee M, Kudose S, Del Portillo A, Ko HM, Lee H, Pittman ME, Salomao MA, Sepulveda AR, Lagana SM
J Clin Pathol 2022 Sep;75(9):593-597. Epub 2021 Apr 12 doi: 10.1136/jclinpath-2021-207406. PMID: 33846218
Colonic Adenomatous Polyps Involving Submucosal Lymphoglandular Complexes: A Diagnostic Pitfall.
Lee HE, Wu TT, Chandan VS, Torbenson MS, Mounajjed T
Am J Surg Pathol 2018 Aug;42(8):1083-1089. doi: 10.1097/PAS.0000000000001081. PMID: 29738362
Intramucosal colorectal carcinoma with invasion of the lamina propria: a study by the Japanese Society for Cancer of the Colon and Rectum.
Kojima M, Shimazaki H, Iwaya K, Nakamura T, Kawachi H, Ichikawa K, Sekine S, Ishiguro S, Shimoda T, Kushima R, Yao T, Fujimori T, Hase K, Watanabe T, Sugihara K, Lauwers GY, Ochiai A
Hum Pathol 2017 Aug;66:230-237. Epub 2017 Jul 13 doi: 10.1016/j.humpath.2017.04.031. PMID: 28711649
NOD2 induces autophagy to control AIEC bacteria infectiveness in intestinal epithelial cells.
Negroni A, Colantoni E, Vitali R, Palone F, Pierdomenico M, Costanzo M, Cesi V, Cucchiara S, Stronati L
Inflamm Res 2016 Oct;65(10):803-13. Epub 2016 Jun 22 doi: 10.1007/s00011-016-0964-8. PMID: 27335178
Development and progression of colorectal cancer based on follow-up analysis.
Hisabe T, Hirai F, Matsui T
Dig Endosc 2014 Apr;26 Suppl 2:73-7. doi: 10.1111/den.12276. PMID: 24750153

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