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Densely Granulated Somatotroph Pituitary Neuroendocrine Tumor

MedGen UID:
310676
•Concept ID:
C1707675
•
Neoplastic Process
Synonyms: Densely Granulated Pituitary Gland Somatotroph Adenoma; Densely Granulated Somatotroph PitNET/Adenoma; Densely Granulated Somatotroph Pituitary Neuroendocrine Tumor/Adenoma

Definition

A growth hormone-producing pituitary neuroendocrine tumor composed of medium-sized acidophilic cells with granular cytoplasm and abundant secretory granules. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDensely Granulated Somatotroph Pituitary Neuroendocrine Tumor

Professional guidelines

PubMed

Clinical, hormonal and pathomorphological markers of somatotroph pituitary neuroendocrine tumors predicting the treatment outcome in acromegaly.
Tomasik A, Stelmachowska-Banaś M, Maksymowicz M, Czajka-Oraniec I, Raczkiewicz D, Zieliński G, Kunicki J, Zgliczyński W
Front Endocrinol (Lausanne) 2022;13:957301. Epub 2022 Sep 16 doi: 10.3389/fendo.2022.957301. PMID: 36187106Free PMC Article
MANAGEMENT OF ENDOCRINE DISEASE: Etiology and outcome of acromegaly in patients with a paradoxical GH response to glucose.
Hage M, Janot C, Salenave S, Chanson P, Kamenický P
Eur J Endocrinol 2021 May 10;184(6):R261-R268. doi: 10.1530/EJE-20-1448. PMID: 33830942
Pathological markers of somatotroph pituitary neuroendocrine tumors predicting the response to medical treatment.
Trouillas J, Vasiljevic A, Lapoirie M, Chinezu L, Jouanneau E, Raverot G
Minerva Endocrinol 2019 Jun;44(2):129-136. Epub 2018 Dec 7 doi: 10.23736/S0391-1977.18.02933-4. PMID: 30531694

Recent clinical studies

Etiology

Transcriptomic Classification of Pituitary Neuroendocrine Tumors Causing Acromegaly.
Rymuza J, Kober P, Rusetska N, Mossakowska BJ, Maksymowicz M, Nyc A, Baluszek S, Zieliński G, Kunicki J, Bujko M
Cells 2022 Nov 30;11(23) doi: 10.3390/cells11233846. PMID: 36497102Free PMC Article
Clinical, hormonal and pathomorphological markers of somatotroph pituitary neuroendocrine tumors predicting the treatment outcome in acromegaly.
Tomasik A, Stelmachowska-Banaś M, Maksymowicz M, Czajka-Oraniec I, Raczkiewicz D, Zieliński G, Kunicki J, Zgliczyński W
Front Endocrinol (Lausanne) 2022;13:957301. Epub 2022 Sep 16 doi: 10.3389/fendo.2022.957301. PMID: 36187106Free PMC Article
Predictive Factors of Somatostatin Receptor Ligand Response in Acromegaly-A Prospective Study.
Ilie MD, Tabarin A, Vasiljevic A, Bonneville JF, Moreau-Grangé L, Schillo F, Delemer B, Barlier A, Figarella-Branger D, Bisot-Locard S, Santos A, Chanson P, Raverot G
J Clin Endocrinol Metab 2022 Nov 23;107(11):2982-2991. doi: 10.1210/clinem/dgac512. PMID: 36136828
Oro-dental pathologies in acromegaly.
Kreitschmann-Andermahr I, Kohlmann J, Kleist B, Hirschfelder U, Buslei R, Buchfelder M, Siegel S
Endocrine 2018 May;60(2):323-328. Epub 2018 Mar 8 doi: 10.1007/s12020-018-1571-y. PMID: 29520625
Clinical implications of growth hormone-secreting tumor subtypes.
Kiseljak-Vassiliades K, Shafi S, Kerr JM, Phang TL, Kleinschmidt-DeMasters BK, Wierman ME
Endocrine 2012 Aug;42(1):18-28. Epub 2012 Mar 21 doi: 10.1007/s12020-012-9660-9. PMID: 22434413

Diagnosis

A current perspective of pituitary adenoma MRI characteristics: a review.
Gruppetta M
Expert Rev Endocrinol Metab 2022 Nov;17(6):499-511. Epub 2022 Nov 13 doi: 10.1080/17446651.2022.2144230. PMID: 36373167
Clinical, hormonal and pathomorphological markers of somatotroph pituitary neuroendocrine tumors predicting the treatment outcome in acromegaly.
Tomasik A, Stelmachowska-Banaś M, Maksymowicz M, Czajka-Oraniec I, Raczkiewicz D, Zieliński G, Kunicki J, Zgliczyński W
Front Endocrinol (Lausanne) 2022;13:957301. Epub 2022 Sep 16 doi: 10.3389/fendo.2022.957301. PMID: 36187106Free PMC Article
Pathological markers of somatotroph pituitary neuroendocrine tumors predicting the response to medical treatment.
Trouillas J, Vasiljevic A, Lapoirie M, Chinezu L, Jouanneau E, Raverot G
Minerva Endocrinol 2019 Jun;44(2):129-136. Epub 2018 Dec 7 doi: 10.23736/S0391-1977.18.02933-4. PMID: 30531694
Oro-dental pathologies in acromegaly.
Kreitschmann-Andermahr I, Kohlmann J, Kleist B, Hirschfelder U, Buslei R, Buchfelder M, Siegel S
Endocrine 2018 May;60(2):323-328. Epub 2018 Mar 8 doi: 10.1007/s12020-018-1571-y. PMID: 29520625
Clinical implications of growth hormone-secreting tumor subtypes.
Kiseljak-Vassiliades K, Shafi S, Kerr JM, Phang TL, Kleinschmidt-DeMasters BK, Wierman ME
Endocrine 2012 Aug;42(1):18-28. Epub 2012 Mar 21 doi: 10.1007/s12020-012-9660-9. PMID: 22434413

Therapy

Clinical and prognostic significance of granulation patterns in somatotroph adenomas/tumors of the pituitary: a meta-analysis.
Vuong HG, Dunn IF
Pituitary 2023 Dec;26(6):653-659. Epub 2023 Sep 21 doi: 10.1007/s11102-023-01353-0. PMID: 37735314
Clinical, hormonal and pathomorphological markers of somatotroph pituitary neuroendocrine tumors predicting the treatment outcome in acromegaly.
Tomasik A, Stelmachowska-Banaś M, Maksymowicz M, Czajka-Oraniec I, Raczkiewicz D, Zieliński G, Kunicki J, Zgliczyński W
Front Endocrinol (Lausanne) 2022;13:957301. Epub 2022 Sep 16 doi: 10.3389/fendo.2022.957301. PMID: 36187106Free PMC Article
Predictive Factors of Somatostatin Receptor Ligand Response in Acromegaly-A Prospective Study.
Ilie MD, Tabarin A, Vasiljevic A, Bonneville JF, Moreau-Grangé L, Schillo F, Delemer B, Barlier A, Figarella-Branger D, Bisot-Locard S, Santos A, Chanson P, Raverot G
J Clin Endocrinol Metab 2022 Nov 23;107(11):2982-2991. doi: 10.1210/clinem/dgac512. PMID: 36136828
Growth hormone tumor histological subtypes predict response to surgical and medical therapy.
Kiseljak-Vassiliades K, Carlson NE, Borges MT, Kleinschmidt-DeMasters BK, Lillehei KO, Kerr JM, Wierman ME
Endocrine 2015 May;49(1):231-41. Epub 2014 Aug 17 doi: 10.1007/s12020-014-0383-y. PMID: 25129651Free PMC Article
Stereotactic radiosurgery for acromegaly: outcomes by adenoma subtype.
Lee CC, Vance ML, Lopes MB, Xu Z, Chen CJ, Sheehan J
Pituitary 2015 Jun;18(3):326-34. doi: 10.1007/s11102-014-0578-5. PMID: 24925503

Prognosis

Clinical and prognostic significance of granulation patterns in somatotroph adenomas/tumors of the pituitary: a meta-analysis.
Vuong HG, Dunn IF
Pituitary 2023 Dec;26(6):653-659. Epub 2023 Sep 21 doi: 10.1007/s11102-023-01353-0. PMID: 37735314
A current perspective of pituitary adenoma MRI characteristics: a review.
Gruppetta M
Expert Rev Endocrinol Metab 2022 Nov;17(6):499-511. Epub 2022 Nov 13 doi: 10.1080/17446651.2022.2144230. PMID: 36373167
Clinical, hormonal and pathomorphological markers of somatotroph pituitary neuroendocrine tumors predicting the treatment outcome in acromegaly.
Tomasik A, Stelmachowska-Banaś M, Maksymowicz M, Czajka-Oraniec I, Raczkiewicz D, Zieliński G, Kunicki J, Zgliczyński W
Front Endocrinol (Lausanne) 2022;13:957301. Epub 2022 Sep 16 doi: 10.3389/fendo.2022.957301. PMID: 36187106Free PMC Article
Pathological markers of somatotroph pituitary neuroendocrine tumors predicting the response to medical treatment.
Trouillas J, Vasiljevic A, Lapoirie M, Chinezu L, Jouanneau E, Raverot G
Minerva Endocrinol 2019 Jun;44(2):129-136. Epub 2018 Dec 7 doi: 10.23736/S0391-1977.18.02933-4. PMID: 30531694
Oro-dental pathologies in acromegaly.
Kreitschmann-Andermahr I, Kohlmann J, Kleist B, Hirschfelder U, Buslei R, Buchfelder M, Siegel S
Endocrine 2018 May;60(2):323-328. Epub 2018 Mar 8 doi: 10.1007/s12020-018-1571-y. PMID: 29520625

Clinical prediction guides

A current perspective of pituitary adenoma MRI characteristics: a review.
Gruppetta M
Expert Rev Endocrinol Metab 2022 Nov;17(6):499-511. Epub 2022 Nov 13 doi: 10.1080/17446651.2022.2144230. PMID: 36373167
Clinical, hormonal and pathomorphological markers of somatotroph pituitary neuroendocrine tumors predicting the treatment outcome in acromegaly.
Tomasik A, Stelmachowska-Banaś M, Maksymowicz M, Czajka-Oraniec I, Raczkiewicz D, Zieliński G, Kunicki J, Zgliczyński W
Front Endocrinol (Lausanne) 2022;13:957301. Epub 2022 Sep 16 doi: 10.3389/fendo.2022.957301. PMID: 36187106Free PMC Article
Clinical, biological, radiological, and pathological comparison of sparsely and densely granulated somatotroph adenomas: a single center experience from a cohort of 131 patients with acromegaly.
Swanson AA, Erickson D, Donegan DM, Jenkins SM, Van Gompel JJ, Atkinson JLD, Erickson BJ, Giannini C
Pituitary 2021 Apr;24(2):192-206. Epub 2020 Oct 19 doi: 10.1007/s11102-020-01096-2. PMID: 33074402
Pathological markers of somatotroph pituitary neuroendocrine tumors predicting the response to medical treatment.
Trouillas J, Vasiljevic A, Lapoirie M, Chinezu L, Jouanneau E, Raverot G
Minerva Endocrinol 2019 Jun;44(2):129-136. Epub 2018 Dec 7 doi: 10.23736/S0391-1977.18.02933-4. PMID: 30531694
Clinical implications of growth hormone-secreting tumor subtypes.
Kiseljak-Vassiliades K, Shafi S, Kerr JM, Phang TL, Kleinschmidt-DeMasters BK, Wierman ME
Endocrine 2012 Aug;42(1):18-28. Epub 2012 Mar 21 doi: 10.1007/s12020-012-9660-9. PMID: 22434413

Recent systematic reviews

Metabolomics in acromegaly: a systematic review.
Pînzariu O, Georgescu CE
J Investig Med 2023 Aug;71(6):634-645. Epub 2023 May 4 doi: 10.1177/10815589231169452. PMID: 37139720

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