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Laryngeal Spindle Cell Squamous Carcinoma

MedGen UID:
310918
•Concept ID:
C1708656
•
Neoplastic Process
Synonyms: Laryngeal Carcinosarcoma; Laryngeal Sarcomatoid Carcinoma; Laryngeal Spindle Cell Carcinoma; Laryngeal Squamous Cell Carcinoma, Spindle Cell Variant

Definition

A squamous cell carcinoma that arises from the larynx. It is characterized by the presence of a malignant spindle cell cellular component. In some cases, there is a biphasic morphology due to the presence of a well-differentiated squamous cell carcinoma component. The latter is either in situ or invasive squamous cell carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLaryngeal Spindle Cell Squamous Carcinoma

Professional guidelines

PubMed

Elucidation of salvage laryngectomy pathologic and clinical variables to guide further treatment intensification investigation.
Scharpf J, Ward M, Adelstein D, Koyfman S, Li M
Laryngoscope 2018 Apr;128(4):823-830. Epub 2017 Sep 11 doi: 10.1002/lary.26782. PMID: 28891087
How phenotype guides management of non-conventional squamous cell carcinomas of the larynx?
López F, Williams MD, Cardesa A, Hunt JL, Strojan P, Rinaldo A, Nixon IJ, Rodrigo JP, Saba NF, Mendenhall WM, Quer M, Suárez C, Ferlito A
Eur Arch Otorhinolaryngol 2017 Jul;274(7):2709-2726. Epub 2017 Mar 31 doi: 10.1007/s00405-017-4533-8. PMID: 28364287

Recent clinical studies

Etiology

Non-Squamous Cell Malignancies of the Larynx.
Rotsides JM, Patel E, Oliver JR, Moses LE, Jacobson AS, Hu KS, Vaezi A, Tam M, Givi B
Laryngoscope 2022 Sep;132(9):1771-1777. Epub 2022 Jan 7 doi: 10.1002/lary.30007. PMID: 34994977
Clinical Analysis of Laryngeal Spindle Cell Carcinoma.
Chen L, Chen Q, Li C, Zhou L, Wang S, Zhang M
ORL J Otorhinolaryngol Relat Spec 2020;82(6):310-317. Epub 2020 Sep 2 doi: 10.1159/000508134. PMID: 32877904
Clinical outcome and comparison between squamous and non-squamous cell carcinoma of the larynx.
Chen L, Deng W, Li C, Lau H, Tao L, Wang S, Zhou L, Zhang M
Acta Otolaryngol 2020 Feb;140(2):195-201. Epub 2019 Dec 18 doi: 10.1080/00016489.2019.1700305. PMID: 31852360
Clinicopathologic Diagnostic and Prognostic Factors of Spindle Cell Carcinoma of Upper Airway.
de Araújo AB, Serrano TLI, Pedroso MCM, Mariano FV, Altemani A, Gripp FM, Crespo AN, Chone CT
Pathol Oncol Res 2020 Apr;26(2):1097-1104. Epub 2019 May 9 doi: 10.1007/s12253-019-00654-9. PMID: 31069711
How phenotype guides management of non-conventional squamous cell carcinomas of the larynx?
López F, Williams MD, Cardesa A, Hunt JL, Strojan P, Rinaldo A, Nixon IJ, Rodrigo JP, Saba NF, Mendenhall WM, Quer M, Suárez C, Ferlito A
Eur Arch Otorhinolaryngol 2017 Jul;274(7):2709-2726. Epub 2017 Mar 31 doi: 10.1007/s00405-017-4533-8. PMID: 28364287

Diagnosis

Clinical Analysis of Laryngeal Spindle Cell Carcinoma.
Chen L, Chen Q, Li C, Zhou L, Wang S, Zhang M
ORL J Otorhinolaryngol Relat Spec 2020;82(6):310-317. Epub 2020 Sep 2 doi: 10.1159/000508134. PMID: 32877904
Clinical outcome and comparison between squamous and non-squamous cell carcinoma of the larynx.
Chen L, Deng W, Li C, Lau H, Tao L, Wang S, Zhou L, Zhang M
Acta Otolaryngol 2020 Feb;140(2):195-201. Epub 2019 Dec 18 doi: 10.1080/00016489.2019.1700305. PMID: 31852360
Systemic therapy in non-conventional cancers of the larynx.
Tan E, Mody MD, Saba NF
Oral Oncol 2018 Jul;82:61-68. Epub 2018 May 26 doi: 10.1016/j.oraloncology.2018.05.005. PMID: 29909903
How phenotype guides management of non-conventional squamous cell carcinomas of the larynx?
López F, Williams MD, Cardesa A, Hunt JL, Strojan P, Rinaldo A, Nixon IJ, Rodrigo JP, Saba NF, Mendenhall WM, Quer M, Suárez C, Ferlito A
Eur Arch Otorhinolaryngol 2017 Jul;274(7):2709-2726. Epub 2017 Mar 31 doi: 10.1007/s00405-017-4533-8. PMID: 28364287
Laryngeal Dysplasia, Squamous Cell Carcinoma, and Variants.
Thompson LD
Surg Pathol Clin 2017 Mar;10(1):15-33. doi: 10.1016/j.path.2016.10.003. PMID: 28153131

Therapy

Laryngeal Squamous Cell Carcinoma with Osteosarcomatous Differentiation and Involvement of Thyroid Cartilage Mimicking Sarcoma Arising from Thyroid Cartilage.
Escher P, Bu L, Cayci Z, Yueh B, Li F
Head Neck Pathol 2020 Sep;14(3):771-777. Epub 2019 Dec 23 doi: 10.1007/s12105-019-01119-w. PMID: 31873935Free PMC Article
Systemic therapy in non-conventional cancers of the larynx.
Tan E, Mody MD, Saba NF
Oral Oncol 2018 Jul;82:61-68. Epub 2018 May 26 doi: 10.1016/j.oraloncology.2018.05.005. PMID: 29909903
Spindle cell carcinoma of the larynx with a verrucous carcinoma component: combined carcinoma of larynx.
Karahatay S, Yilmaz YF, Gunhan O, Birkent H, Yetiser S
Auris Nasus Larynx 2007 Dec;34(4):557-9. Epub 2007 May 7 doi: 10.1016/j.anl.2007.02.006. PMID: 17485187
Diagnostically challenging lesions in head and neck pathology.
Thompson LD
Eur Arch Otorhinolaryngol 1997;254(8):357-66. doi: 10.1007/BF01642550. PMID: 9332890
Laryngeal pseudosarcoma.
Giordano AM, Ewing S, Adams G, Maisel R
Laryngoscope 1983 Jun;93(6):735-40. doi: 10.1288/00005537-198306000-00007. PMID: 6855396

Prognosis

Prognostic significance of head and neck spindle cell carcinoma.
Patel AM, Choudhry HS, Desai AD, Shah VP, Patel P, Eloy JA, Roden DF, Fang CH
Head Neck 2023 Mar;45(3):685-696. Epub 2022 Dec 30 doi: 10.1002/hed.27285. PMID: 36584171
Clinical Analysis of Laryngeal Spindle Cell Carcinoma.
Chen L, Chen Q, Li C, Zhou L, Wang S, Zhang M
ORL J Otorhinolaryngol Relat Spec 2020;82(6):310-317. Epub 2020 Sep 2 doi: 10.1159/000508134. PMID: 32877904
Clinical outcome and comparison between squamous and non-squamous cell carcinoma of the larynx.
Chen L, Deng W, Li C, Lau H, Tao L, Wang S, Zhou L, Zhang M
Acta Otolaryngol 2020 Feb;140(2):195-201. Epub 2019 Dec 18 doi: 10.1080/00016489.2019.1700305. PMID: 31852360
Clinicopathologic Diagnostic and Prognostic Factors of Spindle Cell Carcinoma of Upper Airway.
de Araújo AB, Serrano TLI, Pedroso MCM, Mariano FV, Altemani A, Gripp FM, Crespo AN, Chone CT
Pathol Oncol Res 2020 Apr;26(2):1097-1104. Epub 2019 May 9 doi: 10.1007/s12253-019-00654-9. PMID: 31069711
Laryngeal spindle cell carcinoma: A population-based analysis of incidence and survival.
Dubal PM, Marchiano E, Kam D, Dutta R, Kalyoussef E, Baredes S, Eloy JA
Laryngoscope 2015 Dec;125(12):2709-14. Epub 2015 May 21 doi: 10.1002/lary.25383. PMID: 25994520

Clinical prediction guides

Non-Squamous Cell Malignancies of the Larynx.
Rotsides JM, Patel E, Oliver JR, Moses LE, Jacobson AS, Hu KS, Vaezi A, Tam M, Givi B
Laryngoscope 2022 Sep;132(9):1771-1777. Epub 2022 Jan 7 doi: 10.1002/lary.30007. PMID: 34994977
Clinicopathologic features and outcome of head and neck mucosal spindle cell squamous cell carcinoma.
Prieto-Granada CN, Xu B, Alzumaili B, Al Rasheed MRH, Eskander A, Enepekides D, Patel SG, Stevens TM, Dogan S, Ghossein R, Katabi N
Virchows Arch 2021 Oct;479(4):729-739. Epub 2021 May 12 doi: 10.1007/s00428-021-03117-2. PMID: 33982148Free PMC Article
Clinical Analysis of Laryngeal Spindle Cell Carcinoma.
Chen L, Chen Q, Li C, Zhou L, Wang S, Zhang M
ORL J Otorhinolaryngol Relat Spec 2020;82(6):310-317. Epub 2020 Sep 2 doi: 10.1159/000508134. PMID: 32877904
Clinical outcome and comparison between squamous and non-squamous cell carcinoma of the larynx.
Chen L, Deng W, Li C, Lau H, Tao L, Wang S, Zhou L, Zhang M
Acta Otolaryngol 2020 Feb;140(2):195-201. Epub 2019 Dec 18 doi: 10.1080/00016489.2019.1700305. PMID: 31852360
Clinicopathologic Diagnostic and Prognostic Factors of Spindle Cell Carcinoma of Upper Airway.
de Araújo AB, Serrano TLI, Pedroso MCM, Mariano FV, Altemani A, Gripp FM, Crespo AN, Chone CT
Pathol Oncol Res 2020 Apr;26(2):1097-1104. Epub 2019 May 9 doi: 10.1007/s12253-019-00654-9. PMID: 31069711

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