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Loss of Chromosome 3q

MedGen UID:
310940
•Concept ID:
C1708742
•
Cell or Molecular Dysfunction
Synonyms: 3q Deletion; del(3q)

Definition

A cytogenetic abnormality that refers to the loss of all or part of the long arm of chromosome 3 (3q). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLoss of Chromosome 3q

Professional guidelines

PubMed

Clinical Utility of Fluorescence In Situ Hybridization (FISH) for Deletion of Chromosome 3p in the Work-up of Renal Masses.
Perrino CM, Orien JA, Tretter JG, Zhao W, Zynger DL
Appl Immunohistochem Mol Morphol 2019 Aug;27(7):549-557. doi: 10.1097/PAI.0000000000000676. PMID: 29912766
Genetic gains and losses in oral squamous cell carcinoma: impact on clinical management.
Ribeiro IP, Marques F, Caramelo F, Pereira J, Patrício M, Prazeres H, Ferrão J, Julião MJ, Castelo-Branco M, de Melo JB, Baptista IP, Carreira IM
Cell Oncol (Dordr) 2014 Feb;37(1):29-39. Epub 2013 Dec 19 doi: 10.1007/s13402-013-0161-5. PMID: 24353162
Opportunities to improve the prevention and treatment of cervical cancer.
Roden RB, Monie A, Wu TC
Curr Mol Med 2007 Aug;7(5):490-503. doi: 10.2174/156652407781387127. PMID: 17691964

Recent clinical studies

Etiology

Loss of Chromosome 3q Is a Prognostic Marker in Fusion-Negative Rhabdomyosarcoma.
Dehner CA, Bell RC, Cao Y, He K, Chrisinger JSA, Armstrong AE, Yohe M, Shern J, Hirbe AC
JCO Precis Oncol 2023 Sep;7:e2300037. doi: 10.1200/PO.23.00037. PMID: 37738543Free PMC Article
Evolutionary characterization of lung adenocarcinoma morphology in TRACERx.
Karasaki T, Moore DA, Veeriah S, Naceur-Lombardelli C, Toncheva A, Magno N, Ward S, Bakir MA, Watkins TBK, Grigoriadis K, Huebner A, Hill MS, Frankell AM, Abbosh C, Puttick C, Zhai H, Gimeno-Valiente F, Saghafinia S, Kanu N, Dietzen M, Pich O, Lim EL, Martínez-Ruiz C, Black JRM, Biswas D, Campbell BB, Lee C, Colliver E, Enfield KSS, Hessey S, Hiley CT, Zaccaria S, Litchfield K, Birkbak NJ, Cadieux EL, Demeulemeester J, Van Loo P, Adusumilli PS, Tan KS, Cheema W, Sanchez-Vega F, Jones DR, Rekhtman N, Travis WD, Hackshaw A, Marafioti T, Salgado R, Le Quesne J, Nicholson AG; TRACERx Consortium, McGranahan N, Swanton C, Jamal-Hanjani M
Nat Med 2023 Apr;29(4):833-845. Epub 2023 Apr 12 doi: 10.1038/s41591-023-02230-w. PMID: 37045996Free PMC Article
Impact of chromosome alterations, genetic mutations and clonal hematopoiesis of indeterminate potential (CHIP) on the classification and risk stratification of MDS.
Ganguly BB, Banerjee D, Agarwal MB
Blood Cells Mol Dis 2018 Mar;69:90-100. Epub 2017 Oct 16 doi: 10.1016/j.bcmd.2017.10.001. PMID: 29079134
The complex landscape of genetic alterations in mantle cell lymphoma.
Royo C, Salaverria I, Hartmann EM, Rosenwald A, Campo E, Beà S
Semin Cancer Biol 2011 Nov;21(5):322-34. Epub 2011 Sep 18 doi: 10.1016/j.semcancer.2011.09.007. PMID: 21945515
Opportunities to improve the prevention and treatment of cervical cancer.
Roden RB, Monie A, Wu TC
Curr Mol Med 2007 Aug;7(5):490-503. doi: 10.2174/156652407781387127. PMID: 17691964

Diagnosis

Loss of Chromosome 3q Is a Prognostic Marker in Fusion-Negative Rhabdomyosarcoma.
Dehner CA, Bell RC, Cao Y, He K, Chrisinger JSA, Armstrong AE, Yohe M, Shern J, Hirbe AC
JCO Precis Oncol 2023 Sep;7:e2300037. doi: 10.1200/PO.23.00037. PMID: 37738543Free PMC Article
Impact of chromosome alterations, genetic mutations and clonal hematopoiesis of indeterminate potential (CHIP) on the classification and risk stratification of MDS.
Ganguly BB, Banerjee D, Agarwal MB
Blood Cells Mol Dis 2018 Mar;69:90-100. Epub 2017 Oct 16 doi: 10.1016/j.bcmd.2017.10.001. PMID: 29079134
Cytogenetics of melanoma and nonmelanoma skin cancer.
Carless MA, Griffiths LR
Adv Exp Med Biol 2014;810:160-81. doi: 10.1007/978-1-4939-0437-2_9. PMID: 25207365
Review of papillary renal cell carcinoma with focus on clinical and pathobiological aspects.
Kuroda N, Toi M, Hiroi M, Enzan H
Histol Histopathol 2003 Apr;18(2):487-94. doi: 10.14670/HH-18.487. PMID: 12647800
The value of molecular genetic analysis in the diagnosis and prognosis of renal cell tumours.
Kovacs G
World J Urol 1994;12(2):64-8. doi: 10.1007/BF00184238. PMID: 8087142

Therapy

Concordant chromosome 3 results in paired choroidal melanoma biopsies and subsequent tumour resection specimens.
Coupland SE, Kalirai H, Ho V, Thornton S, Damato BE, Heimann H
Br J Ophthalmol 2015 Oct;99(10):1444-50. Epub 2015 Jul 23 doi: 10.1136/bjophthalmol-2015-307057. PMID: 26206786
Genomic microarray analysis on formalin-fixed paraffin-embedded material for uveal melanoma prognostication.
Minca EC, Tubbs RR, Portier BP, Wang Z, Lanigan C, Aronow ME, Triozzi PL, Singh A, Cook JR, Saunthararajah Y, Plesec TP, Schoenfield L, Cawich V, Sulpizio S, Schultz RA
Cancer Genet 2014 Jul-Aug;207(7-8):306-15. Epub 2014 Aug 29 doi: 10.1016/j.cancergen.2014.08.005. PMID: 25442074
Comparative genome-wide profiling of post-transplant lymphoproliferative disorders and diffuse large B-cell lymphomas.
Rinaldi A, Kwee I, Poretti G, Mensah A, Pruneri G, Capello D, Rossi D, Zucca E, Ponzoni M, Catapano C, Tibiletti MG, Paulli M, Gaidano G, Bertoni F
Br J Haematol 2006 Jul;134(1):27-36. doi: 10.1111/j.1365-2141.2006.06114.x. PMID: 16803564
Biology of HPV in HIV infection.
Palefsky J
Adv Dent Res 2006 Apr 1;19(1):99-105. doi: 10.1177/154407370601900120. PMID: 16672559
Chromosome abnormalities in adult T-cell leukemia/lymphoma: a karyotype review committee report.
Kamada N, Sakurai M, Miyamoto K, Sanada I, Sadamori N, Fukuhara S, Abe S, Shiraishi Y, Abe T, Kaneko Y
Cancer Res 1992 Mar 15;52(6):1481-93. PMID: 1540956

Prognosis

Loss of Chromosome 3q Is a Prognostic Marker in Fusion-Negative Rhabdomyosarcoma.
Dehner CA, Bell RC, Cao Y, He K, Chrisinger JSA, Armstrong AE, Yohe M, Shern J, Hirbe AC
JCO Precis Oncol 2023 Sep;7:e2300037. doi: 10.1200/PO.23.00037. PMID: 37738543Free PMC Article
Loss of heterozygosity and copy number alterations in flow-sorted bulky cervical cancer.
van den Tillaart SA, Corver WE, Ruano Neto D, ter Haar NT, Goeman JJ, Trimbos JB, Fleuren GJ, Oosting J
PLoS One 2013;8(7):e67414. Epub 2013 Jul 9 doi: 10.1371/journal.pone.0067414. PMID: 23874418Free PMC Article
The complex landscape of genetic alterations in mantle cell lymphoma.
Royo C, Salaverria I, Hartmann EM, Rosenwald A, Campo E, Beà S
Semin Cancer Biol 2011 Nov;21(5):322-34. Epub 2011 Sep 18 doi: 10.1016/j.semcancer.2011.09.007. PMID: 21945515
Frequent loss of chromosome arm 1p DNA in parathyroid adenomas.
Cryns VL, Yi SM, Tahara H, Gaz RD, Arnold A
Genes Chromosomes Cancer 1995 May;13(1):9-17. doi: 10.1002/gcc.2870130103. PMID: 7541648
The value of molecular genetic analysis in the diagnosis and prognosis of renal cell tumours.
Kovacs G
World J Urol 1994;12(2):64-8. doi: 10.1007/BF00184238. PMID: 8087142

Clinical prediction guides

Atypical 3q26/MECOM rearrangements genocopy inv(3)/t(3;3) in acute myeloid leukemia.
Ottema S, Mulet-Lazaro R, Beverloo HB, Erpelinck C, van Herk S, van der Helm R, Havermans M, Grob T, Valk PJM, Bindels E, Haferlach T, Haferlach C, Smeenk L, Delwel R
Blood 2020 Jul 9;136(2):224-234. doi: 10.1182/blood.2019003701. PMID: 32219447
Impact of chromosome alterations, genetic mutations and clonal hematopoiesis of indeterminate potential (CHIP) on the classification and risk stratification of MDS.
Ganguly BB, Banerjee D, Agarwal MB
Blood Cells Mol Dis 2018 Mar;69:90-100. Epub 2017 Oct 16 doi: 10.1016/j.bcmd.2017.10.001. PMID: 29079134
The complex landscape of genetic alterations in mantle cell lymphoma.
Royo C, Salaverria I, Hartmann EM, Rosenwald A, Campo E, Beà S
Semin Cancer Biol 2011 Nov;21(5):322-34. Epub 2011 Sep 18 doi: 10.1016/j.semcancer.2011.09.007. PMID: 21945515
Frequent loss of chromosome arm 1p DNA in parathyroid adenomas.
Cryns VL, Yi SM, Tahara H, Gaz RD, Arnold A
Genes Chromosomes Cancer 1995 May;13(1):9-17. doi: 10.1002/gcc.2870130103. PMID: 7541648
The value of molecular genetic analysis in the diagnosis and prognosis of renal cell tumours.
Kovacs G
World J Urol 1994;12(2):64-8. doi: 10.1007/BF00184238. PMID: 8087142

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