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Bronchial Glandular Papilloma

MedGen UID:
310948
•Concept ID:
C1708772
•
Neoplastic Process
Synonym: Lung Glandular Papilloma

Definition

A benign papillary neoplasm that arises endobronchially. It is characterized by the presence of fibrovascular cores lined by columnar, cuboidal, and goblet cells. Patients usually present with signs and symptoms of bronchial obstruction. Complete resection is curative. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBronchial Glandular Papilloma

Recent clinical studies

Etiology

Solitary pulmonary papillomas in adults: a clinicopathologic and in situ hybridization study of 14 cases combined with 27 cases in the literature.
Flieder DB, Koss MN, Nicholson A, Sesterhenn IA, Petras RE, Travis WD
Am J Surg Pathol 1998 Nov;22(11):1328-42. doi: 10.1097/00000478-199811000-00003. PMID: 9808125

Diagnosis

Mucous Gland Adenoma of the Lung: A Neoplastic Counterpart of Mucinous Bronchial Glands.
Sasaki E, Masago K, Kogure Y, Fujita S, Iwakoshi A, Kuroda H, Tsuzuki T, Tsuta K, Matsushita H, Oki M
Mod Pathol 2023 Jun;36(6):100182. Epub 2023 Apr 5 doi: 10.1016/j.modpat.2023.100182. PMID: 37028599
Sialadenoma Papilliferum of the Bronchus: An Unrecognized Bronchial Counterpart of the Salivary Gland Tumor With Frequent BRAF V600E Mutations.
Nakaguro M, Mino-Kenudson M, Urano M, Ogawa I, Honda Y, Hirai H, Tanigawa M, Sukeda A, Kajiwara N, Ohira T, Ikeda N, Mikami Y, Tada Y, Ikeda JI, Matsubayashi J, Faquin WC, Sadow PM, Nagao T
Am J Surg Pathol 2021 May 1;45(5):662-671. doi: 10.1097/PAS.0000000000001657. PMID: 33443864Free PMC Article
Pleomorphic (spindle and squamous cell) carcinoma arising in a peripheral mixed squamous and glandular papilloma in a 70-year-old man.
Lagana SM, Hanna RF, Borczuk AC
Arch Pathol Lab Med 2011 Oct;135(10):1353-6. doi: 10.5858/arpa.2010-0420-CR. PMID: 21970492
Cytological findings of mixed squamous cell and glandular papilloma in the lung.
Kadota K, Haba R, Katsuki N, Hayashi T, Miyai Y, Bando K, Shibuya S, Kushida Y
Diagn Cytopathol 2010 Dec;38(12):913-7. doi: 10.1002/dc.21334. PMID: 20301213
Solitary peripheral ciliated glandular papillomas of the lung: a report of 3 cases.
Aida S, Ohara I, Shimazaki H, Dai Y, Ogata S, Ozeki Y, Tamai S
Am J Surg Pathol 2008 Oct;32(10):1489-94. doi: 10.1097/PAS.0b013e31817a9061. PMID: 18708941

Prognosis

Sialadenoma Papilliferum of the Bronchus: An Unrecognized Bronchial Counterpart of the Salivary Gland Tumor With Frequent BRAF V600E Mutations.
Nakaguro M, Mino-Kenudson M, Urano M, Ogawa I, Honda Y, Hirai H, Tanigawa M, Sukeda A, Kajiwara N, Ohira T, Ikeda N, Mikami Y, Tada Y, Ikeda JI, Matsubayashi J, Faquin WC, Sadow PM, Nagao T
Am J Surg Pathol 2021 May 1;45(5):662-671. doi: 10.1097/PAS.0000000000001657. PMID: 33443864Free PMC Article
Cytological findings of mixed squamous cell and glandular papilloma in the lung.
Kadota K, Haba R, Katsuki N, Hayashi T, Miyai Y, Bando K, Shibuya S, Kushida Y
Diagn Cytopathol 2010 Dec;38(12):913-7. doi: 10.1002/dc.21334. PMID: 20301213
Solitary pulmonary papillomas in adults: a clinicopathologic and in situ hybridization study of 14 cases combined with 27 cases in the literature.
Flieder DB, Koss MN, Nicholson A, Sesterhenn IA, Petras RE, Travis WD
Am J Surg Pathol 1998 Nov;22(11):1328-42. doi: 10.1097/00000478-199811000-00003. PMID: 9808125

Clinical prediction guides

Sialadenoma Papilliferum of the Bronchus: An Unrecognized Bronchial Counterpart of the Salivary Gland Tumor With Frequent BRAF V600E Mutations.
Nakaguro M, Mino-Kenudson M, Urano M, Ogawa I, Honda Y, Hirai H, Tanigawa M, Sukeda A, Kajiwara N, Ohira T, Ikeda N, Mikami Y, Tada Y, Ikeda JI, Matsubayashi J, Faquin WC, Sadow PM, Nagao T
Am J Surg Pathol 2021 May 1;45(5):662-671. doi: 10.1097/PAS.0000000000001657. PMID: 33443864Free PMC Article
Solitary pulmonary papillomas in adults: a clinicopathologic and in situ hybridization study of 14 cases combined with 27 cases in the literature.
Flieder DB, Koss MN, Nicholson A, Sesterhenn IA, Petras RE, Travis WD
Am J Surg Pathol 1998 Nov;22(11):1328-42. doi: 10.1097/00000478-199811000-00003. PMID: 9808125

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