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Malignant Central Nervous System Germ Cell Tumor

MedGen UID:
310971
Concept ID:
C1708864
Neoplastic Process
Synonym: Malignant Central Nervous System Germ Cell Neoplasm

Definition

A germ cell tumor that affects the central nervous system, characterized by the presence of malignant morphologic characteristics. Representative examples include choriocarcinoma, embryonal carcinoma, and germinoma. [from NCI]

Professional guidelines

PubMed

Weller M, van den Bent M, Preusser M, Le Rhun E, Tonn JC, Minniti G, Bendszus M, Balana C, Chinot O, Dirven L, French P, Hegi ME, Jakola AS, Platten M, Roth P, Rudà R, Short S, Smits M, Taphoorn MJB, von Deimling A, Westphal M, Soffietti R, Reifenberger G, Wick W
Nat Rev Clin Oncol 2021 Mar;18(3):170-186. Epub 2020 Dec 8 doi: 10.1038/s41571-020-00447-z. PMID: 33293629Free PMC Article
Tan AC, Ashley DM, López GY, Malinzak M, Friedman HS, Khasraw M
CA Cancer J Clin 2020 Jul;70(4):299-312. Epub 2020 Jun 1 doi: 10.3322/caac.21613. PMID: 32478924
Xu S, Tang L, Li X, Fan F, Liu Z
Cancer Lett 2020 Apr 28;476:1-12. Epub 2020 Feb 7 doi: 10.1016/j.canlet.2020.02.002. PMID: 32044356

Recent clinical studies

Etiology

Ogiwara H, Liao YM, Wong TT
Childs Nerv Syst 2023 Oct;39(10):2649-2665. Epub 2023 Oct 13 doi: 10.1007/s00381-023-06081-1. PMID: 37831207
Liu APY, Dhanda SK, Lin T, Sioson E, Vasilyeva A, Gudenas B, Tatevossian RG, Jia S, Neale G, Bowers DC, Hassall T, Partap S, Crawford JR, Chintagumpala M, Bouffet E, McCowage G, Broniscer A, Qaddoumi I, Armstrong G, Wright KD, Upadhyaya SA, Vinitsky A, Tinkle CL, Lucas J, Chiang J, Indelicato DJ, Sanders R, Klimo P Jr, Boop FA, Merchant TE, Ellison DW, Northcott PA, Orr BA, Zhou X, Onar-Thomas A, Gajjar A, Robinson GW
Acta Neuropathol 2022 Oct;144(4):733-746. Epub 2022 Aug 18 doi: 10.1007/s00401-022-02484-7. PMID: 35982322Free PMC Article
Cotter JA, Judkins AR
Pediatr Dev Pathol 2022 Jan-Feb;25(1):34-45. doi: 10.1177/10935266211018554. PMID: 35168419
Kristensen BW, Priesterbach-Ackley LP, Petersen JK, Wesseling P
Ann Oncol 2019 Aug 1;30(8):1265-1278. doi: 10.1093/annonc/mdz164. PMID: 31124566Free PMC Article
Lin NU, Lee EQ, Aoyama H, Barani IJ, Barboriak DP, Baumert BG, Bendszus M, Brown PD, Camidge DR, Chang SM, Dancey J, de Vries EG, Gaspar LE, Harris GJ, Hodi FS, Kalkanis SN, Linskey ME, Macdonald DR, Margolin K, Mehta MP, Schiff D, Soffietti R, Suh JH, van den Bent MJ, Vogelbaum MA, Wen PY; Response Assessment in Neuro-Oncology (RANO) group
Lancet Oncol 2015 Jun;16(6):e270-8. Epub 2015 May 27 doi: 10.1016/S1470-2045(15)70057-4. PMID: 26065612

Diagnosis

Ogiwara H, Liao YM, Wong TT
Childs Nerv Syst 2023 Oct;39(10):2649-2665. Epub 2023 Oct 13 doi: 10.1007/s00381-023-06081-1. PMID: 37831207
Liu APY, Dhanda SK, Lin T, Sioson E, Vasilyeva A, Gudenas B, Tatevossian RG, Jia S, Neale G, Bowers DC, Hassall T, Partap S, Crawford JR, Chintagumpala M, Bouffet E, McCowage G, Broniscer A, Qaddoumi I, Armstrong G, Wright KD, Upadhyaya SA, Vinitsky A, Tinkle CL, Lucas J, Chiang J, Indelicato DJ, Sanders R, Klimo P Jr, Boop FA, Merchant TE, Ellison DW, Northcott PA, Orr BA, Zhou X, Onar-Thomas A, Gajjar A, Robinson GW
Acta Neuropathol 2022 Oct;144(4):733-746. Epub 2022 Aug 18 doi: 10.1007/s00401-022-02484-7. PMID: 35982322Free PMC Article
Cotter JA, Judkins AR
Pediatr Dev Pathol 2022 Jan-Feb;25(1):34-45. doi: 10.1177/10935266211018554. PMID: 35168419
Kristensen BW, Priesterbach-Ackley LP, Petersen JK, Wesseling P
Ann Oncol 2019 Aug 1;30(8):1265-1278. doi: 10.1093/annonc/mdz164. PMID: 31124566Free PMC Article
Kong Z, Wang Y, Dai C, Yao Y, Ma W, Wang Y
J Child Neurol 2018 Aug;33(9):610-620. Epub 2018 May 30 doi: 10.1177/0883073818772470. PMID: 29848146

Therapy

Schaff LR, Mellinghoff IK
JAMA 2023 Feb 21;329(7):574-587. doi: 10.1001/jama.2023.0023. PMID: 36809318
Liu APY, Dhanda SK, Lin T, Sioson E, Vasilyeva A, Gudenas B, Tatevossian RG, Jia S, Neale G, Bowers DC, Hassall T, Partap S, Crawford JR, Chintagumpala M, Bouffet E, McCowage G, Broniscer A, Qaddoumi I, Armstrong G, Wright KD, Upadhyaya SA, Vinitsky A, Tinkle CL, Lucas J, Chiang J, Indelicato DJ, Sanders R, Klimo P Jr, Boop FA, Merchant TE, Ellison DW, Northcott PA, Orr BA, Zhou X, Onar-Thomas A, Gajjar A, Robinson GW
Acta Neuropathol 2022 Oct;144(4):733-746. Epub 2022 Aug 18 doi: 10.1007/s00401-022-02484-7. PMID: 35982322Free PMC Article
Kristensen BW, Priesterbach-Ackley LP, Petersen JK, Wesseling P
Ann Oncol 2019 Aug 1;30(8):1265-1278. doi: 10.1093/annonc/mdz164. PMID: 31124566Free PMC Article
Mehta AM, Sonabend AM, Bruce JN
Neurotherapeutics 2017 Apr;14(2):358-371. doi: 10.1007/s13311-017-0520-4. PMID: 28299724Free PMC Article
Lin NU, Lee EQ, Aoyama H, Barani IJ, Barboriak DP, Baumert BG, Bendszus M, Brown PD, Camidge DR, Chang SM, Dancey J, de Vries EG, Gaspar LE, Harris GJ, Hodi FS, Kalkanis SN, Linskey ME, Macdonald DR, Margolin K, Mehta MP, Schiff D, Soffietti R, Suh JH, van den Bent MJ, Vogelbaum MA, Wen PY; Response Assessment in Neuro-Oncology (RANO) group
Lancet Oncol 2015 Jun;16(6):e270-8. Epub 2015 May 27 doi: 10.1016/S1470-2045(15)70057-4. PMID: 26065612

Prognosis

Gajjar A, Mahajan A, Abdelbaki M, Anderson C, Antony R, Bale T, Bindra R, Bowers DC, Cohen K, Cole B, Dorris K, Ermoian R, Franson A, Helgager J, Landi D, Lin C, Metrock L, Nanda R, Palmer J, Partap S, Plant A, Pruthi S, Reynolds R, Ruggieri P, Stearns D, Storm P, Wang A, Warren K, Whipple N, Zaky W, McMillian NR, Pluchino LA
J Natl Compr Canc Netw 2022 Dec;20(12):1339-1362. doi: 10.6004/jnccn.2022.0062. PMID: 36509072
Ostrom QT, Price M, Neff C, Cioffi G, Waite KA, Kruchko C, Barnholtz-Sloan JS
Neuro Oncol 2022 Oct 5;24(Suppl 5):v1-v95. doi: 10.1093/neuonc/noac202. PMID: 36196752Free PMC Article
Cotter JA, Judkins AR
Pediatr Dev Pathol 2022 Jan-Feb;25(1):34-45. doi: 10.1177/10935266211018554. PMID: 35168419
Blessing MM, Alexandrescu S
Surg Pathol Clin 2020 Jun;13(2):235-247. Epub 2020 Apr 7 doi: 10.1016/j.path.2020.01.003. PMID: 32389264
Kristensen BW, Priesterbach-Ackley LP, Petersen JK, Wesseling P
Ann Oncol 2019 Aug 1;30(8):1265-1278. doi: 10.1093/annonc/mdz164. PMID: 31124566Free PMC Article

Clinical prediction guides

Zhao S, Chi H, Yang Q, Chen S, Wu C, Lai G, Xu K, Su K, Luo H, Peng G, Xia Z, Cheng C, Lu P
Front Immunol 2023;14:1090040. Epub 2023 Feb 7 doi: 10.3389/fimmu.2023.1090040. PMID: 36825022Free PMC Article
Schaff LR, Mellinghoff IK
JAMA 2023 Feb 21;329(7):574-587. doi: 10.1001/jama.2023.0023. PMID: 36809318
Wang J, Wu N, Feng X, Liang Y, Huang M, Li W, Hou L, Yin C
Front Immunol 2022;13:1052692. Epub 2023 Jan 4 doi: 10.3389/fimmu.2022.1052692. PMID: 36685506Free PMC Article
Fangusaro J, Witt O, Hernáiz Driever P, Bag AK, de Blank P, Kadom N, Kilburn L, Lober RM, Robison NJ, Fisher MJ, Packer RJ, Young Poussaint T, Papusha L, Avula S, Brandes AA, Bouffet E, Bowers D, Artemov A, Chintagumpala M, Zurakowski D, van den Bent M, Bison B, Yeom KW, Taal W, Warren KE
Lancet Oncol 2020 Jun;21(6):e305-e316. doi: 10.1016/S1470-2045(20)30064-4. PMID: 32502457
Reifenberger G, Wirsching HG, Knobbe-Thomsen CB, Weller M
Nat Rev Clin Oncol 2017 Jul;14(7):434-452. Epub 2016 Dec 29 doi: 10.1038/nrclinonc.2016.204. PMID: 28031556

Recent systematic reviews

D'Alessandris QG, Battistelli M, Pennisi G, Offi M, Martini M, Cenci T, Falchetti ML, Lauretti L, Olivi A, Pallini R, Montano N
Expert Rev Mol Med 2023 Mar 15;25:e10. doi: 10.1017/erm.2023.6. PMID: 36919343
Kweh BTS, Rosenfeld JV, Hunn M, Tee JW
J Neurosurg 2022 Mar 1;136(3):736-748. Epub 2021 Aug 20 doi: 10.3171/2021.2.JNS204052. PMID: 34416731
Harvengt J, Gernay C, Mastouri M, Farhat N, Lebrethon MC, Seghaye MC, Bours V
J Clin Endocrinol Metab 2020 Jul 1;105(7) doi: 10.1210/clinem/dgaa247. PMID: 32407531
Brown TJ, Brennan MC, Li M, Church EW, Brandmeir NJ, Rakszawski KL, Patel AS, Rizk EB, Suki D, Sawaya R, Glantz M
JAMA Oncol 2016 Nov 1;2(11):1460-1469. doi: 10.1001/jamaoncol.2016.1373. PMID: 27310651Free PMC Article
Pilarski R, Burt R, Kohlman W, Pho L, Shannon KM, Swisher E
J Natl Cancer Inst 2013 Nov 6;105(21):1607-16. Epub 2013 Oct 17 doi: 10.1093/jnci/djt277. PMID: 24136893

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