U.S. flag

An official website of the United States government


Send to:

Choose Destination

Malignant Proliferating Pilar Tumor

MedGen UID:
Concept ID:
Neoplastic Process
Synonyms: Malignant Pilar Tumor; Malignant Proliferating Trichilemmal Cyst; Malignant Proliferating Trichilemmal Tumor


A rare malignant neoplasm that arises from the outer root sheath of the hair follicle. It usually occurs in the scalp, face and trunk. Histopathology shows cords of malignant squamous cells infiltrating into the dermis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Proliferating Pilar Tumor

Professional guidelines


Nemeh MN, Curtiss P, Nijhawan RI
J Am Acad Dermatol 2024 Jan;90(1):122-124. Epub 2023 Jun 24 doi: 10.1016/j.jaad.2023.05.097. PMID: 37364614
Martínez-Bosch N, Cristóbal H, Iglesias M, Gironella M, Barranco L, Visa L, Calafato D, Jiménez-Parrado S, Earl J, Carrato A, Manero-Rupérez N, Moreno M, Morales A, Guerra C, Navarro P, García de Frutos P
EBioMedicine 2022 Jan;75:103797. Epub 2021 Dec 29 doi: 10.1016/j.ebiom.2021.103797. PMID: 34973624Free PMC Article
LeBoit PE, Sexton M
J Am Acad Dermatol 1993 Oct;29(4):609-18. doi: 10.1016/0190-9622(93)70228-l. PMID: 7691906

Recent clinical studies


Moran JMT, DeSimone MS, Mariño-Enríquez A, Russell-Goldman EE, Fletcher CDM, Mochel MC, Hoang MP
Am J Surg Pathol 2023 Oct 1;47(10):1151-1159. Epub 2023 Jul 31 doi: 10.1097/PAS.0000000000002105. PMID: 37515420

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...