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Mediastinal Paraganglioma

MedGen UID:
310995
•Concept ID:
C1708957
•
Neoplastic Process

Definition

An extra-adrenal parasympathetic paraganglioma that arises from paraganglia in the mediastinum. Clinical signs and symptoms include chest pain, cough, hoarseness, and dysphagia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMediastinal Paraganglioma

Professional guidelines

PubMed

Diagnosis and management of multiple paragangliomas of the head and neck.
Szymańska A, Szymański M, Czekajska-Chehab E, Gołąbek W, Szczerbo-Trojanowska M
Eur Arch Otorhinolaryngol 2015 Aug;272(8):1991-9. Epub 2014 Jun 12 doi: 10.1007/s00405-014-3126-z. PMID: 24920325Free PMC Article
Primary neuroendocrine carcinomas of the mediastinum: review of current criteria for histopathologic diagnosis and classification.
Moran CA
Semin Diagn Pathol 2005 Aug;22(3):223-9. doi: 10.1053/j.semdp.2006.02.007. PMID: 16711403
Mediastinal tumors: diagnosis and treatment.
Wright CD, Mathisen DJ
World J Surg 2001 Feb;25(2):204-9. doi: 10.1007/s002680020020. PMID: 11338023

Recent clinical studies

Etiology

Mediastinal Paraganglioma: A retrospective analysis of 51 cases.
Kanj AN, Young WF, Ryu JH
Respir Med 2023 Sep;216:107296. Epub 2023 May 29 doi: 10.1016/j.rmed.2023.107296. PMID: 37257785
Rare and complicated functional posterior mediastinal paraganglioma.
SenthilKumar G, Rokkas CK, Sheinin YM, Linsky PL
BMJ Case Rep 2022 Jun 7;15(6) doi: 10.1136/bcr-2022-250500. PMID: 35672059Free PMC Article
Re-evaluating the prevalence and factors characteristic of catecholamine secreting head and neck paragangliomas.
Smith JD, Ellsperman SE, Basura GJ, Else T
Endocrinol Diabetes Metab 2021 Jul;4(3):e00256. Epub 2021 Jun 2 doi: 10.1002/edm2.256. PMID: 34277980Free PMC Article
Clinicopathological, immunophenotypic and genetic studies of mediastinal paragangliomas†.
Hsu YR, Torres-Mora J, Kipp BR, Sukov WR, Jenkins SM, Voss JS, Barr Fritcher EG, Schaff HV, Cassivi SD, Roden AC
Eur J Cardiothorac Surg 2019 Nov 1;56(5):867-875. doi: 10.1093/ejcts/ezz115. PMID: 31329844
Mediastinal paraganglioma: a surgical experience.
Herrera MF, van Heerden JA, Puga FJ, Hogan MJ, Carney JA
Ann Thorac Surg 1993 Nov;56(5):1096-100. doi: 10.1016/0003-4975(95)90022-5. PMID: 8239807

Diagnosis

Middle mediastinal paraganglioma: A case report and review of the literature.
Xu S, Hu G, Du J, Ma L, Zou L, Li Q
Medicine (Baltimore) 2023 Nov 24;102(47):e36327. doi: 10.1097/MD.0000000000036327. PMID: 38013330Free PMC Article
Mediastinal Paraganglioma: A retrospective analysis of 51 cases.
Kanj AN, Young WF, Ryu JH
Respir Med 2023 Sep;216:107296. Epub 2023 May 29 doi: 10.1016/j.rmed.2023.107296. PMID: 37257785
Mediastinal Paraganglioma.
Buchanan SN, Radecki KM, Chambers LW
Ann Thorac Surg 2017 May;103(5):e413-e414. doi: 10.1016/j.athoracsur.2016.10.031. PMID: 28431713
Ectopic acromegaly due to growth hormone releasing hormone.
Ghazi AA, Amirbaigloo A, Dezfooli AA, Saadat N, Ghazi S, Pourafkari M, Tirgari F, Dhall D, Bannykh S, Melmed S, Cooper O
Endocrine 2013 Apr;43(2):293-302. Epub 2012 Sep 15 doi: 10.1007/s12020-012-9790-0. PMID: 22983831Free PMC Article
Aorticopulmonary paraganglioma.
Hato T, Kaseda K, Harada M, Horio H
Gen Thorac Cardiovasc Surg 2011 Dec;59(12):812-4. Epub 2011 Dec 16 doi: 10.1007/s11748-010-0769-6. PMID: 22173680

Therapy

Imaging-Guided Use of Combined (177)Lu-DOTATATE and Capecitabine Therapy in Metastatic Mediastinal Paraganglioma.
Ashwathanarayana AG, Biswal CK, Sood A, Parihar AS, Kapoor R, Mittal BR
J Nucl Med Technol 2017 Dec;45(4):314-316. Epub 2017 Aug 10 doi: 10.2967/jnmt.117.197400. PMID: 28798226
Ectopic acromegaly due to growth hormone releasing hormone.
Ghazi AA, Amirbaigloo A, Dezfooli AA, Saadat N, Ghazi S, Pourafkari M, Tirgari F, Dhall D, Bannykh S, Melmed S, Cooper O
Endocrine 2013 Apr;43(2):293-302. Epub 2012 Sep 15 doi: 10.1007/s12020-012-9790-0. PMID: 22983831Free PMC Article
Peptide receptor radionuclide therapy (PRRT) with 177Lu-DOTATATE in individuals with neck or mediastinal paraganglioma (PGL).
Zovato S, Kumanova A, Demattè S, Sansovini M, Bodei L, Di Sarra D, Casagranda E, Severi S, Ambrosetti A, Schiavi F, Opocher G, Paganelli G
Horm Metab Res 2012 May;44(5):411-4. Epub 2012 May 7 doi: 10.1055/s-0032-1311637. PMID: 22566197
Clinical, radiological, and pathological findings in four children with gastrointestinal stromal tumors of the stomach.
Sauseng W, Benesch M, Lackner H, Urban C, Kronberger M, Gadner H, Höllwarth M, Spuller E, Aschauer M, Horcher E
Pediatr Hematol Oncol 2007 Apr-May;24(3):209-19. doi: 10.1080/08880010601104687. PMID: 17454792
Metastatic paraganglioma and paraneoplastic-induced anemia in an adolescent: treatment with hepatic arterial chemoembolization.
Mutabagani KH, Klopfenstein KJ, Hogan MJ, Caniano DA
J Pediatr Hematol Oncol 1999 Nov-Dec;21(6):544-7. PMID: 10598670

Prognosis

Primary mediastinal paraganglioma associated with a familial variant in the succinate dehydrogenase B subunit gene.
Samuel N, Ejaz R, Silver J, Ezzat S, Cusimano RJ, Kim RH
J Surg Oncol 2018 Feb;117(2):160-162. Epub 2017 Sep 10 doi: 10.1002/jso.24818. PMID: 28891197
Asymptomatic but functional paraganglioma of the posterior mediastinum.
Suzawa K, Yamamoto H, Ichimura K, Toyooka S, Miyoshi S
Ann Thorac Surg 2014 Mar;97(3):1077-80. doi: 10.1016/j.athoracsur.2013.06.100. PMID: 24580932
Resection of an intrapericardial paraganglioma under cardiopulmonary bypass.
Matsumoto J, Tanaka N, Yoshida Y, Yamamoto T
Asian Cardiovasc Thorac Ann 2013 Aug;21(4):476-8. Epub 2013 Jul 9 doi: 10.1177/0218492312459641. PMID: 24570537
Anterior mediastinal paraganglioma mimicking thymoma.
Lee HM, Jeong DS, Park PW, Kim WS, Sung K, Lee YT
Heart Surg Forum 2012 Jun;15(3):E170-1. doi: 10.1532/HSF98.20111173. PMID: 22698609
Mediastinal paraganglioma: a surgical experience.
Herrera MF, van Heerden JA, Puga FJ, Hogan MJ, Carney JA
Ann Thorac Surg 1993 Nov;56(5):1096-100. doi: 10.1016/0003-4975(95)90022-5. PMID: 8239807

Clinical prediction guides

Resection of an intrapericardial paraganglioma under cardiopulmonary bypass.
Matsumoto J, Tanaka N, Yoshida Y, Yamamoto T
Asian Cardiovasc Thorac Ann 2013 Aug;21(4):476-8. Epub 2013 Jul 9 doi: 10.1177/0218492312459641. PMID: 24570537
A new observation of the Carney's triad with long follow-Up period and additional tumors.
Scopsi L, Collini P, Muscolino G
Cancer Detect Prev 1999;23(5):435-43. doi: 10.1046/j.1525-1500.1999.99047.x. PMID: 10468897

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