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Breast Paget Disease without Invasive Carcinoma

MedGen UID:
311101
•Concept ID:
C1709447
•
Neoplastic Process
Synonyms: Paget Disease of the Breast without Invasive Carcinoma; Paget's Disease of the Breast without Invasive Carcinoma; Tis (Paget)

Definition

Paget disease involving the skin overlying the mammary gland, without accompanying invasive ductal or lobular breast carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast Paget Disease without Invasive Carcinoma

Professional guidelines

PubMed

Breast Cancer, Version 3.2022, NCCN Clinical Practice Guidelines in Oncology.
Gradishar WJ, Moran MS, Abraham J, Aft R, Agnese D, Allison KH, Anderson B, Burstein HJ, Chew H, Dang C, Elias AD, Giordano SH, Goetz MP, Goldstein LJ, Hurvitz SA, Isakoff SJ, Jankowitz RC, Javid SH, Krishnamurthy J, Leitch M, Lyons J, Mortimer J, Patel SA, Pierce LJ, Rosenberger LH, Rugo HS, Sitapati A, Smith KL, Smith ML, Soliman H, Stringer-Reasor EM, Telli ML, Ward JH, Wisinski KB, Young JS, Burns J, Kumar R
J Natl Compr Canc Netw 2022 Jun;20(6):691-722. doi: 10.6004/jnccn.2022.0030. PMID: 35714673
Interventions for the treatment of Paget's disease of the vulva.
Edey KA, Allan E, Murdoch JB, Cooper S, Bryant A
Cochrane Database Syst Rev 2013 Oct 26;(10):CD009245. doi: 10.1002/14651858.CD009245.pub2. PMID: 24163070
The management of Paget's disease of the breast.
Marcus E
Curr Treat Options Oncol 2004 Apr;5(2):153-60. doi: 10.1007/s11864-004-0047-x. PMID: 14990209

Recent clinical studies

Etiology

Treatment of Mammary Paget Disease: A systematic review and meta-analysis of real-world data.
Lin CW, Chiang MH, Tam KW
Int J Surg 2022 Nov;107:106964. Epub 2022 Oct 26 doi: 10.1016/j.ijsu.2022.106964. PMID: 36309195
Ten-Year Results of FAST: A Randomized Controlled Trial of 5-Fraction Whole-Breast Radiotherapy for Early Breast Cancer.
Brunt AM, Haviland JS, Sydenham M, Agrawal RK, Algurafi H, Alhasso A, Barrett-Lee P, Bliss P, Bloomfield D, Bowen J, Donovan E, Goodman A, Harnett A, Hogg M, Kumar S, Passant H, Quigley M, Sherwin L, Stewart A, Syndikus I, Tremlett J, Tsang Y, Venables K, Wheatley D, Bliss JM, Yarnold JR
J Clin Oncol 2020 Oct 1;38(28):3261-3272. Epub 2020 Jul 14 doi: 10.1200/JCO.19.02750. PMID: 32663119Free PMC Article
Paget's disease of the male breast in the 21st century: A systematic review.
Adams SJ, Kanthan R
Breast 2016 Oct;29:14-23. Epub 2016 Jul 6 doi: 10.1016/j.breast.2016.06.015. PMID: 27394005
Paget's disease of the breast.
Sakorafas GH, Blanchard K, Sarr MG, Farley DR
Cancer Treat Rev 2001 Feb;27(1):9-18. doi: 10.1053/ctrv.2000.0203. PMID: 11237774
Breast cancer.
Berg JW, Hutter RV
Cancer 1995 Jan 1;75(1 Suppl):257-69. doi: 10.1002/1097-0142(19950101)75:1+<257::aid-cncr2820751311>3.0.co;2-y. PMID: 8001000

Diagnosis

A peculiar case of Paget's disease of the breast.
Plutino FM, Del Medico P, Vescio G, Fava MG
Ann Ital Chir 2022 May 5;11 PMID: 35588206
The nipple-areolar complex: comprehensive imaging review.
Lyons D, Wahab RA, Vijapura C, Mahoney MC
Clin Radiol 2021 Mar;76(3):172-184. Epub 2020 Oct 17 doi: 10.1016/j.crad.2020.09.013. PMID: 33077158
Paget Disease of the Breast in Pregnancy and Lactation.
Gilmore R, Prasath V, Habibi M
Adv Exp Med Biol 2020;1252:133-136. doi: 10.1007/978-3-030-41596-9_18. PMID: 32816273
Nipple Ultrasound: A Pictorial Essay.
Chiorean A, Pintican RM, Szep M, Feier D, Rogojan L, Fetica B, Dindelegan G, Vlad B, Duma M
Korean J Radiol 2020 Aug;21(8):955-966. doi: 10.3348/kjr.2019.0831. PMID: 32677380Free PMC Article
Paget's disease of the breast.
Marques-Costa JC, Cuzzi T, Carneiro S, Parish LC, Ramos-e-Silva M
Skinmed 2012 May-Jun;10(3):160-5; quiz 165. PMID: 22779098

Therapy

The Paget Trial: topical 5% imiquimod cream for noninvasive vulvar Paget disease.
van der Linden M, van Hees CL, van Beurden M, Bulten J, van Dorst EB, Esajas MD, Meeuwis KA, Boll D, van Poelgeest MI, de Hullu JA
Am J Obstet Gynecol 2022 Aug;227(2):250.e1-250.e8. Epub 2022 Apr 18 doi: 10.1016/j.ajog.2022.04.012. PMID: 35447145
Ten-Year Results of FAST: A Randomized Controlled Trial of 5-Fraction Whole-Breast Radiotherapy for Early Breast Cancer.
Brunt AM, Haviland JS, Sydenham M, Agrawal RK, Algurafi H, Alhasso A, Barrett-Lee P, Bliss P, Bloomfield D, Bowen J, Donovan E, Goodman A, Harnett A, Hogg M, Kumar S, Passant H, Quigley M, Sherwin L, Stewart A, Syndikus I, Tremlett J, Tsang Y, Venables K, Wheatley D, Bliss JM, Yarnold JR
J Clin Oncol 2020 Oct 1;38(28):3261-3272. Epub 2020 Jul 14 doi: 10.1200/JCO.19.02750. PMID: 32663119Free PMC Article
Paget's disease of the male breast: case report and a point of view from actual literature.
Vergine M, Musella A, Gulotta E, Frusone F, De Luca A, Maceli F, Libia A, Benedetti Panici P, Monti M
G Chir 2018 Mar-Apr;39(2):114-117. PMID: 29694313
Interventions for the treatment of Paget's disease of the vulva.
Edey KA, Allan E, Murdoch JB, Cooper S, Bryant A
Cochrane Database Syst Rev 2013 Oct 26;(10):CD009245. doi: 10.1002/14651858.CD009245.pub2. PMID: 24163070
Effectiveness of photodynamic therapy for mammary and extra-mammary Paget's disease: a state of the science review.
Nardelli AA, Stafinski T, Menon D
BMC Dermatol 2011 Jun 15;11:13. doi: 10.1186/1471-5945-11-13. PMID: 21676258Free PMC Article

Prognosis

Treatment of Mammary Paget Disease: A systematic review and meta-analysis of real-world data.
Lin CW, Chiang MH, Tam KW
Int J Surg 2022 Nov;107:106964. Epub 2022 Oct 26 doi: 10.1016/j.ijsu.2022.106964. PMID: 36309195
A peculiar case of Paget's disease of the breast.
Plutino FM, Del Medico P, Vescio G, Fava MG
Ann Ital Chir 2022 May 5;11 PMID: 35588206
Ten-Year Results of FAST: A Randomized Controlled Trial of 5-Fraction Whole-Breast Radiotherapy for Early Breast Cancer.
Brunt AM, Haviland JS, Sydenham M, Agrawal RK, Algurafi H, Alhasso A, Barrett-Lee P, Bliss P, Bloomfield D, Bowen J, Donovan E, Goodman A, Harnett A, Hogg M, Kumar S, Passant H, Quigley M, Sherwin L, Stewart A, Syndikus I, Tremlett J, Tsang Y, Venables K, Wheatley D, Bliss JM, Yarnold JR
J Clin Oncol 2020 Oct 1;38(28):3261-3272. Epub 2020 Jul 14 doi: 10.1200/JCO.19.02750. PMID: 32663119Free PMC Article
Paget's disease of the male breast in the 21st century: A systematic review.
Adams SJ, Kanthan R
Breast 2016 Oct;29:14-23. Epub 2016 Jul 6 doi: 10.1016/j.breast.2016.06.015. PMID: 27394005
Breast cancer.
Berg JW, Hutter RV
Cancer 1995 Jan 1;75(1 Suppl):257-69. doi: 10.1002/1097-0142(19950101)75:1+<257::aid-cncr2820751311>3.0.co;2-y. PMID: 8001000

Clinical prediction guides

Treatment of Mammary Paget Disease: A systematic review and meta-analysis of real-world data.
Lin CW, Chiang MH, Tam KW
Int J Surg 2022 Nov;107:106964. Epub 2022 Oct 26 doi: 10.1016/j.ijsu.2022.106964. PMID: 36309195
Invasive vulvar extramammary Paget's disease in the United States.
Kilts TP, Long B, Glasgow AE, Bakkum-Gamez JN, Habermann EB, Cliby WA
Gynecol Oncol 2020 Jun;157(3):649-655. Epub 2020 Apr 5 doi: 10.1016/j.ygyno.2020.03.018. PMID: 32268952
Invasive Paget disease of the breast: 20 years of experience at a single institution.
Lee HW, Kim TE, Cho SY, Kim SW, Kil WH, Lee JE, Nam SJ, Cho EY
Hum Pathol 2014 Dec;45(12):2480-7. Epub 2014 Sep 7 doi: 10.1016/j.humpath.2014.08.015. PMID: 25288235
The neu-protein and breast cancer.
De Potter CR, Schelfhout AM
Virchows Arch 1995;426(2):107-15. doi: 10.1007/BF00192631. PMID: 7757280
Cadherins in cutaneous biology.
Furukawa F, Takigawa M, Matsuyoshi N, Shirahama S, Wakita H, Fujita M, Horiguchi Y, Imamura S
J Dermatol 1994 Nov;21(11):802-13. doi: 10.1111/j.1346-8138.1994.tb03294.x. PMID: 7852640

Recent systematic reviews

Treatment of Mammary Paget Disease: A systematic review and meta-analysis of real-world data.
Lin CW, Chiang MH, Tam KW
Int J Surg 2022 Nov;107:106964. Epub 2022 Oct 26 doi: 10.1016/j.ijsu.2022.106964. PMID: 36309195
Paget's disease of the male breast in the 21st century: A systematic review.
Adams SJ, Kanthan R
Breast 2016 Oct;29:14-23. Epub 2016 Jul 6 doi: 10.1016/j.breast.2016.06.015. PMID: 27394005
Interventions for the treatment of Paget's disease of the vulva.
Edey KA, Allan E, Murdoch JB, Cooper S, Bryant A
Cochrane Database Syst Rev 2013 Oct 26;(10):CD009245. doi: 10.1002/14651858.CD009245.pub2. PMID: 24163070
Effectiveness of photodynamic therapy for mammary and extra-mammary Paget's disease: a state of the science review.
Nardelli AA, Stafinski T, Menon D
BMC Dermatol 2011 Jun 15;11:13. doi: 10.1186/1471-5945-11-13. PMID: 21676258Free PMC Article

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