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Pleural Well Differentiated Papillary Mesothelial Tumor

MedGen UID:
311134
•Concept ID:
C1709580
•
Neoplastic Process
Synonyms: Pleural WDPM; Pleural WDPMT; Pleural Well Differentiated Papillary Mesothelioma; Pleural Well-Differentiated Papillary Mesothelial Tumor; Pleural Well-Differentiated Papillary Mesothelioma

Definition

A rare, non-invasive, localized or multifocal neoplasm that arises from the pleura. It is characterized by the presence of papillae with myxoid fibrovascular cores, lined by a single layer of mesothelial cells. The clinical course is usually indolent. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPleural Well Differentiated Papillary Mesothelial Tumor

Professional guidelines

PubMed

SOX6 Expression Is Sensitive for Peritoneal Epithelioid Malignant Mesothelioma, But Not Specific in the Differential Diagnosis With Tubo-ovarian Serous Neoplasia.
Chapel DB, Hirsch MS
Am J Surg Pathol 2022 Feb 1;46(2):213-219. doi: 10.1097/PAS.0000000000001792. PMID: 34411029
Adenomatoid Tumor: A Review of Pathology With Focus on Unusual Presentations and Sites, Histogenesis, Differential Diagnosis, and Molecular and Clinical Aspects With a Historic Overview of Its Description.
Karpathiou G, Hiroshima K, Peoc'h M
Adv Anat Pathol 2020 Nov;27(6):394-407. doi: 10.1097/PAP.0000000000000278. PMID: 32769378
Pathohistological diagnosis and differential diagnosis.
Tischoff I, Neid M, Neumann V, Tannapfel A
Recent Results Cancer Res 2011;189:57-78. doi: 10.1007/978-3-642-10862-4_5. PMID: 21479896

Recent clinical studies

Etiology

Pleural mesothelioma classification-update and challenges.
Dacic S
Mod Pathol 2022 Jan;35(Suppl 1):51-56. Epub 2021 Aug 31 doi: 10.1038/s41379-021-00895-7. PMID: 34465883
Clinical Features in Patients With Malignant Pleural Mesothelioma With 5-Year Survival and Evaluation of Original Diagnoses.
Paajanen J, Laaksonen S, Ilonen I, Vehmas T, Mäyränpää MI, Sutinen E, Kettunen E, Salo JA, Räsänen J, Wolff H, Myllärniemi M
Clin Lung Cancer 2020 Nov;21(6):e633-e639. Epub 2020 May 23 doi: 10.1016/j.cllc.2020.05.020. PMID: 32624414
Mesothelioma of the tunica vaginalis testis.
Butnor KJ, Pavlisko EN, Sporn TA, Roggli VL
Hum Pathol 2019 Oct;92:48-58. Epub 2019 Aug 1 doi: 10.1016/j.humpath.2019.07.009. PMID: 31376434
Pathohistological diagnosis and differential diagnosis.
Tischoff I, Neid M, Neumann V, Tannapfel A
Recent Results Cancer Res 2011;189:57-78. doi: 10.1007/978-3-642-10862-4_5. PMID: 21479896
Well-differentiated papillary mesothelioma of the pleura: a series of 24 cases.
Galateau-Sallé F, Vignaud JM, Burke L, Gibbs A, Brambilla E, Attanoos R, Goldberg M, Launoy G; Mesopath group
Am J Surg Pathol 2004 Apr;28(4):534-40. doi: 10.1097/00000478-200404000-00013. PMID: 15087673

Diagnosis

The 2021 WHO Classification of Tumors of the Pleura: Advances Since the 2015 Classification.
Sauter JL, Dacic S, Galateau-Salle F, Attanoos RL, Butnor KJ, Churg A, Husain AN, Kadota K, Khoor A, Nicholson AG, Roggli V, Schmitt F, Tsao MS, Travis WD
J Thorac Oncol 2022 May;17(5):608-622. Epub 2022 Jan 10 doi: 10.1016/j.jtho.2021.12.014. PMID: 35026477
Pleural mesothelioma classification-update and challenges.
Dacic S
Mod Pathol 2022 Jan;35(Suppl 1):51-56. Epub 2021 Aug 31 doi: 10.1038/s41379-021-00895-7. PMID: 34465883
Adenomatoid Tumor: A Review of Pathology With Focus on Unusual Presentations and Sites, Histogenesis, Differential Diagnosis, and Molecular and Clinical Aspects With a Historic Overview of Its Description.
Karpathiou G, Hiroshima K, Peoc'h M
Adv Anat Pathol 2020 Nov;27(6):394-407. doi: 10.1097/PAP.0000000000000278. PMID: 32769378
Pleural neoplastic pathology.
Karpathiou G, Stefanou D, Froudarakis ME
Respir Med 2015 Aug;109(8):931-43. Epub 2015 May 21 doi: 10.1016/j.rmed.2015.05.014. PMID: 26048082
Pathohistological diagnosis and differential diagnosis.
Tischoff I, Neid M, Neumann V, Tannapfel A
Recent Results Cancer Res 2011;189:57-78. doi: 10.1007/978-3-642-10862-4_5. PMID: 21479896

Therapy

Peritoneal mesothelioma: the site of origin matters.
Kindler HL
Am Soc Clin Oncol Educ Book 2013:182-8. doi: 10.14694/EdBook_AM.2013.33.182. PMID: 23714495
Well-differentiated papillary mesothelioma: clustering in a Portuguese family with a germline BAP1 mutation.
Ribeiro C, Campelos S, Moura CS, Machado JC, Justino A, Parente B
Ann Oncol 2013 Aug;24(8):2147-50. Epub 2013 Apr 12 doi: 10.1093/annonc/mdt135. PMID: 23585512
Fine-needle aspiration of a well-differentiated papillary mesothelioma in the inguinal hernia sac: A case report and review of literature.
Wheeler YY, Burroughs F, Li QK
Diagn Cytopathol 2009 Oct;37(10):748-54. doi: 10.1002/dc.21084. PMID: 19373910
Well-differentiated papillary mesothelioma of the pleura: a series of 24 cases.
Galateau-Sallé F, Vignaud JM, Burke L, Gibbs A, Brambilla E, Attanoos R, Goldberg M, Launoy G; Mesopath group
Am J Surg Pathol 2004 Apr;28(4):534-40. doi: 10.1097/00000478-200404000-00013. PMID: 15087673
Pathology of malignant mesothelioma.
Attanoos RL, Gibbs AR
Histopathology 1997 May;30(5):403-18. doi: 10.1046/j.1365-2559.1997.5460776.x. PMID: 9181361

Prognosis

The 2021 WHO Classification of Tumors of the Pleura: Advances Since the 2015 Classification.
Sauter JL, Dacic S, Galateau-Salle F, Attanoos RL, Butnor KJ, Churg A, Husain AN, Kadota K, Khoor A, Nicholson AG, Roggli V, Schmitt F, Tsao MS, Travis WD
J Thorac Oncol 2022 May;17(5):608-622. Epub 2022 Jan 10 doi: 10.1016/j.jtho.2021.12.014. PMID: 35026477
Pleural mesothelioma classification-update and challenges.
Dacic S
Mod Pathol 2022 Jan;35(Suppl 1):51-56. Epub 2021 Aug 31 doi: 10.1038/s41379-021-00895-7. PMID: 34465883
Pleural neoplastic pathology.
Karpathiou G, Stefanou D, Froudarakis ME
Respir Med 2015 Aug;109(8):931-43. Epub 2015 May 21 doi: 10.1016/j.rmed.2015.05.014. PMID: 26048082
Pathohistological diagnosis and differential diagnosis.
Tischoff I, Neid M, Neumann V, Tannapfel A
Recent Results Cancer Res 2011;189:57-78. doi: 10.1007/978-3-642-10862-4_5. PMID: 21479896
Well-differentiated papillary mesothelioma.
Butnor KJ, Sporn TA, Hammar SP, Roggli VL
Am J Surg Pathol 2001 Oct;25(10):1304-9. doi: 10.1097/00000478-200110000-00012. PMID: 11688466

Clinical prediction guides

SOX6 Expression Is Sensitive for Peritoneal Epithelioid Malignant Mesothelioma, But Not Specific in the Differential Diagnosis With Tubo-ovarian Serous Neoplasia.
Chapel DB, Hirsch MS
Am J Surg Pathol 2022 Feb 1;46(2):213-219. doi: 10.1097/PAS.0000000000001792. PMID: 34411029
Clinicopathological Characteristics of Well-differentiated Papillary Mesothelioma of The Peritoneum: A Single-institutional Experience of 12 Cases.
Kim M, Kim HS
In Vivo 2019 Mar-Apr;33(2):633-642. doi: 10.21873/invivo.11521. PMID: 30804152Free PMC Article
The 2015 World Health Organization Classification of Tumors of the Pleura: Advances since the 2004 Classification.
Galateau-Salle F, Churg A, Roggli V, Travis WD; World Health Organization Committee for Tumors of the Pleura
J Thorac Oncol 2016 Feb;11(2):142-54. doi: 10.1016/j.jtho.2015.11.005. PMID: 26811225
Well-differentiated papillary mesothelioma with invasive foci.
Churg A, Allen T, Borczuk AC, Cagle PT, Galateau-Sallé F, Hwang H, Murer B, Murty VV, Ordonez N, Tazelaar HD, Wick M
Am J Surg Pathol 2014 Jul;38(7):990-8. doi: 10.1097/PAS.0000000000000200. PMID: 24618613
Well-differentiated papillary mesothelioma: a clinicopathological and immunohistochemical study of 18 cases with additional observation.
Chen X, Sheng W, Wang J
Histopathology 2013 Apr;62(5):805-13. doi: 10.1111/his.12089. PMID: 23530588

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