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Tumor Angiogenesis

MedGen UID:
311378
•Concept ID:
C1519670
•
Neoplastic Process

Definition

Proliferation of blood vessels in a tumor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTumor Angiogenesis

Professional guidelines

PubMed

Regorafenib for the Treatment of Sarcoma.
Blay JY, Duffaud F, George S, Maki RG, Penel N
Curr Treat Options Oncol 2022 Nov;23(11):1477-1502. Epub 2022 Sep 30 doi: 10.1007/s11864-022-00990-0. PMID: 36178573
Novel Peptide Therapeutic Approaches for Cancer Treatment.
Li CM, Haratipour P, Lingeman RG, Perry JJP, Gu L, Hickey RJ, Malkas LH
Cells 2021 Oct 27;10(11) doi: 10.3390/cells10112908. PMID: 34831131Free PMC Article
Bleeding in cancer patients and its treatment: a review.
Johnstone C, Rich SE
Ann Palliat Med 2018 Apr;7(2):265-273. Epub 2017 Dec 18 doi: 10.21037/apm.2017.11.01. PMID: 29307210

Recent clinical studies

Etiology

Regorafenib for the Treatment of Sarcoma.
Blay JY, Duffaud F, George S, Maki RG, Penel N
Curr Treat Options Oncol 2022 Nov;23(11):1477-1502. Epub 2022 Sep 30 doi: 10.1007/s11864-022-00990-0. PMID: 36178573
The Role of Respiratory Microbiota in Lung Cancer.
Wang D, Cheng J, Zhang J, Zhou F, He X, Shi Y, Tao Y
Int J Biol Sci 2021;17(13):3646-3658. Epub 2021 Aug 25 doi: 10.7150/ijbs.51376. PMID: 34512172Free PMC Article
Multi-omics analysis of tumor angiogenesis characteristics and potential epigenetic regulation mechanisms in renal clear cell carcinoma.
Zheng W, Zhang S, Guo H, Chen X, Huang Z, Jiang S, Li M
Cell Commun Signal 2021 Mar 24;19(1):39. doi: 10.1186/s12964-021-00728-9. PMID: 33761933Free PMC Article
Endothelial Cells in the Tumor Microenvironment.
Sobierajska K, Ciszewski WM, Sacewicz-Hofman I, Niewiarowska J
Adv Exp Med Biol 2020;1234:71-86. doi: 10.1007/978-3-030-37184-5_6. PMID: 32040856
NF-κB and STAT3 signaling pathways collaboratively link inflammation to cancer.
Fan Y, Mao R, Yang J
Protein Cell 2013 Mar;4(3):176-85. Epub 2013 Mar 13 doi: 10.1007/s13238-013-2084-3. PMID: 23483479Free PMC Article

Diagnosis

Hypoxic pancreatic cancer derived exosomal miR-30b-5p promotes tumor angiogenesis by inhibiting GJA1 expression.
Chen K, Wang Q, Liu X, Wang F, Yang Y, Tian X
Int J Biol Sci 2022;18(3):1220-1237. Epub 2022 Jan 1 doi: 10.7150/ijbs.67675. PMID: 35173549Free PMC Article
Exosomes in gastric cancer: roles, mechanisms, and applications.
Fu M, Gu J, Jiang P, Qian H, Xu W, Zhang X
Mol Cancer 2019 Mar 15;18(1):41. doi: 10.1186/s12943-019-1001-7. PMID: 30876419Free PMC Article
Advances in the techniques and methodologies of cancer gene therapy.
Sun W, Shi Q, Zhang H, Yang K, Ke Y, Wang Y, Qiao L
Discov Med 2019 Jan;27(146):45-55. PMID: 30721651
Imaging with ultrasound contrast agents: current status and future.
Chong WK, Papadopoulou V, Dayton PA
Abdom Radiol (NY) 2018 Apr;43(4):762-772. doi: 10.1007/s00261-018-1516-1. PMID: 29508011
The role of tumor-associated macrophage in breast cancer biology.
Choi J, Gyamfi J, Jang H, Koo JS
Histol Histopathol 2018 Feb;33(2):133-145. Epub 2017 Jul 6 doi: 10.14670/HH-11-916. PMID: 28681373

Therapy

A concise review of VEGF, PDGF, FGF, Notch, angiopoietin, and HGF signalling in tumor angiogenesis with a focus on alternative approaches and future directions.
Vimalraj S
Int J Biol Macromol 2022 Nov 30;221:1428-1438. Epub 2022 Sep 17 doi: 10.1016/j.ijbiomac.2022.09.129. PMID: 36122781
Exosomes in Angiogenesis and Anti-angiogenic Therapy in Cancers.
Olejarz W, Kubiak-Tomaszewska G, Chrzanowska A, Lorenc T
Int J Mol Sci 2020 Aug 14;21(16) doi: 10.3390/ijms21165840. PMID: 32823989Free PMC Article
Tumor angiogenesis: causes, consequences, challenges and opportunities.
Lugano R, Ramachandran M, Dimberg A
Cell Mol Life Sci 2020 May;77(9):1745-1770. Epub 2019 Nov 6 doi: 10.1007/s00018-019-03351-7. PMID: 31690961Free PMC Article
The Intersection between Tumor Angiogenesis and Immune Suppression.
Rahma OE, Hodi FS
Clin Cancer Res 2019 Sep 15;25(18):5449-5457. Epub 2019 Apr 3 doi: 10.1158/1078-0432.CCR-18-1543. PMID: 30944124
Tumor angiogenesis and vascular normalization: alternative therapeutic targets.
Viallard C, Larrivée B
Angiogenesis 2017 Nov;20(4):409-426. Epub 2017 Jun 28 doi: 10.1007/s10456-017-9562-9. PMID: 28660302

Prognosis

ARL13B promotes angiogenesis and glioma growth by activating VEGFA-VEGFR2 signaling.
Chen L, Xie X, Wang T, Xu L, Zhai Z, Wu H, Deng L, Lu Q, Chen Z, Yang X, Lu H, Chen YG, Luo S
Neuro Oncol 2023 May 4;25(5):871-885. doi: 10.1093/neuonc/noac245. PMID: 36322624Free PMC Article
Tie2 Receptor in Tumor-Infiltrating Macrophages Is Dispensable for Tumor Angiogenesis and Tumor Relapse after Chemotherapy.
Jakab M, Rostalski T, Lee KH, Mogler C, Augustin HG
Cancer Res 2022 Apr 1;82(7):1353-1364. doi: 10.1158/0008-5472.CAN-21-3181. PMID: 35373291Free PMC Article
Hypoxic pancreatic cancer derived exosomal miR-30b-5p promotes tumor angiogenesis by inhibiting GJA1 expression.
Chen K, Wang Q, Liu X, Wang F, Yang Y, Tian X
Int J Biol Sci 2022;18(3):1220-1237. Epub 2022 Jan 1 doi: 10.7150/ijbs.67675. PMID: 35173549Free PMC Article
Effect of Anlotinib as a Third-Line or Further Treatment on Overall Survival of Patients With Advanced Non-Small Cell Lung Cancer: The ALTER 0303 Phase 3 Randomized Clinical Trial.
Han B, Li K, Wang Q, Zhang L, Shi J, Wang Z, Cheng Y, He J, Shi Y, Zhao Y, Yu H, Zhao Y, Chen W, Luo Y, Wu L, Wang X, Pirker R, Nan K, Jin F, Dong J, Li B, Sun Y
JAMA Oncol 2018 Nov 1;4(11):1569-1575. doi: 10.1001/jamaoncol.2018.3039. PMID: 30098152Free PMC Article
Lenvatinib: A Promising Molecular Targeted Agent for Multiple Cancers.
Suyama K, Iwase H
Cancer Control 2018 Jan-Dec;25(1):1073274818789361. doi: 10.1177/1073274818789361. PMID: 30032643Free PMC Article

Clinical prediction guides

Identify the immune characteristics and immunotherapy value of CD93 in the pan-cancer based on the public data sets.
Guo A, Zhang J, Tian Y, Peng Y, Luo P, Zhang J, Liu Z, Wu W, Zhang H, Cheng Q
Front Immunol 2022;13:907182. Epub 2022 Oct 27 doi: 10.3389/fimmu.2022.907182. PMID: 36389798Free PMC Article
Interleukin-8: A chemokine at the intersection of cancer plasticity, angiogenesis, and immune suppression.
Fousek K, Horn LA, Palena C
Pharmacol Ther 2021 Mar;219:107692. Epub 2020 Sep 24 doi: 10.1016/j.pharmthera.2020.107692. PMID: 32980444Free PMC Article
Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis.
Rohlenova K, Goveia J, García-Caballero M, Subramanian A, Kalucka J, Treps L, Falkenberg KD, de Rooij LPMH, Zheng Y, Lin L, Sokol L, Teuwen LA, Geldhof V, Taverna F, Pircher A, Conradi LC, Khan S, Stegen S, Panovska D, De Smet F, Staal FJT, Mclaughlin RJ, Vinckier S, Van Bergen T, Ectors N, De Haes P, Wang J, Bolund L, Schoonjans L, Karakach TK, Yang H, Carmeliet G, Liu Y, Thienpont B, Dewerchin M, Eelen G, Li X, Luo Y, Carmeliet P
Cell Metab 2020 Apr 7;31(4):862-877.e14. doi: 10.1016/j.cmet.2020.03.009. PMID: 32268117
Interleukin-22 promotes tumor angiogenesis.
Protopsaltis NJ, Liang W, Nudleman E, Ferrara N
Angiogenesis 2019 May;22(2):311-323. Epub 2018 Dec 11 doi: 10.1007/s10456-018-9658-x. PMID: 30539314
Lenvatinib: A Promising Molecular Targeted Agent for Multiple Cancers.
Suyama K, Iwase H
Cancer Control 2018 Jan-Dec;25(1):1073274818789361. doi: 10.1177/1073274818789361. PMID: 30032643Free PMC Article

Recent systematic reviews

MicroRNAs in Tumor Endothelial Cells: Regulation, Function and Therapeutic Applications.
Gu Y, Becker MA, Müller L, Reuss K, Umlauf F, Tang T, Menger MD, Laschke MW
Cells 2023 Jun 22;12(13) doi: 10.3390/cells12131692. PMID: 37443725Free PMC Article
Phytochemicals in Inhibition of Prostate Cancer: Evidence from Molecular Mechanisms Studies.
Hao Q, Wu Y, Vadgama JV, Wang P
Biomolecules 2022 Sep 16;12(9) doi: 10.3390/biom12091306. PMID: 36139145Free PMC Article
Increased circulating vascular endothelial growth factor in acute myeloid leukemia patients: a systematic review and meta-analysis.
Song M, Wang H, Ye Q
Syst Rev 2020 May 6;9(1):103. doi: 10.1186/s13643-020-01368-9. PMID: 32375879Free PMC Article
β-Blockers Reduce Breast Cancer Recurrence and Breast Cancer Death: A Meta-Analysis.
Childers WK, Hollenbeak CS, Cheriyath P
Clin Breast Cancer 2015 Dec;15(6):426-31. Epub 2015 Jul 10 doi: 10.1016/j.clbc.2015.07.001. PMID: 26516037
A systematic review of vascular endothelial growth factor expression as a biomarker of prognosis in patients with osteosarcoma.
Chen D, Zhang YJ, Zhu KW, Wang WC
Tumour Biol 2013 Jun;34(3):1895-9. Epub 2013 Apr 16 doi: 10.1007/s13277-013-0733-z. PMID: 23589053

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