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Vaginal Keratinizing Squamous Cell Carcinoma

MedGen UID:
311445
•Concept ID:
C1519922
•
Neoplastic Process

Definition

A squamous cell carcinoma that arises from the vagina and is characterized by the presence of keratin pearls. Intercellular bridges and cytoplasmic keratinization are usually present. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVaginal Keratinizing Squamous Cell Carcinoma

Professional guidelines

PubMed

AgNOR technique could be useful for differential diagnosis of squamous carcinomatous cells and atypical cells related to human papillomavirus in cervical smears.
Palaoro L, Rocher A
Biotech Histochem 2009 Jun;84(3):73-8. Epub 2009 Mar 28 doi: 10.1080/10520290902853412. PMID: 19333799
The applicability of a keratin 7 monoclonal antibody in routinely Papanicolaou-stained cytologic specimens for the differential diagnosis of carcinomas.
Baars JH, De Ruijter JL, Smedts F, Van Niekerk CC, Poels LG, Seldenrijk CA, Ramaekers FC
Am J Clin Pathol 1994 Mar;101(3):257-61. doi: 10.1093/ajcp/101.3.257. PMID: 7510926
Carcinoma of the cervix stage IB: results of treatment with radiation therapy.
Montana GS, Fowler WC Jr, Varia MA, Walton LA, Kirsch M, Halle JS, McCafferty BB
Int J Radiat Oncol Biol Phys 1983 Jan;9(1):45-9. doi: 10.1016/0360-3016(83)90207-9. PMID: 6841175

Recent clinical studies

Etiology

Differentiated cervical intraepithelial neoplasia-associated invasive cervical squamous cell carcinoma as a source of major cytopathological and surgical pathological discrepancy in Papanicolaou smear screening tests.
Mai KT
Cytopathology 2018 Apr;29(2):143-149. doi: 10.1111/cyt.12523. PMID: 29575422
Does Differentiated Squamous Intraepithelial Neoplasia Occur in the Cervix?
Mai KT
Appl Immunohistochem Mol Morphol 2018 Apr;26(4):e52-e60. doi: 10.1097/PAI.0000000000000577. PMID: 28877072
The role of steroid contraceptive hormones in the pathogenesis of invasive cervical cancer: a review.
Moodley M, Moodley J, Chetty R, Herrington CS
Int J Gynecol Cancer 2003 Mar-Apr;13(2):103-10. doi: 10.1046/j.1525-1438.2003.13030.x. PMID: 12657108
False-positive squamous cell carcinoma in cervical smears: cytologic-histologic correlation in 19 cases.
Levine PH, Elgert PA, Mittal K
Diagn Cytopathol 2003 Jan;28(1):23-7. doi: 10.1002/dc.10220. PMID: 12508178
Basaloid and warty carcinomas of the vulva. Distinctive types of squamous cell carcinoma frequently associated with human papillomaviruses.
Kurman RJ, Toki T, Schiffman MH
Am J Surg Pathol 1993 Feb;17(2):133-45. doi: 10.1097/00000478-199302000-00005. PMID: 8380681

Diagnosis

Epidermoid carcinoma in the neovagina of a patient with Mayer-Rokitansky-Küster-Hauser syndrome. Case report and literature review.
Fernández-Ruiz M, Pantoja-Garrido M, Frías-Sánchez Z, Rodríguez-Jiménez I, Aguilar-Martín MDV
Rev Colomb Obstet Ginecol 2019 Dec;70(4):266-276. doi: 10.18597/rcog.3328. PMID: 32142241
Primary squamous cell carcinoma of the vagina: human papillomavirus detection, p16(INK4A) overexpression and clinicopathological correlations.
Fuste V, del Pino M, Perez A, Garcia A, Torne A, Pahisa J, Ordi J
Histopathology 2010 Dec;57(6):907-16. doi: 10.1111/j.1365-2559.2010.03727.x. PMID: 21166704
False-positive squamous cell carcinoma in cervical smears: cytologic-histologic correlation in 19 cases.
Levine PH, Elgert PA, Mittal K
Diagn Cytopathol 2003 Jan;28(1):23-7. doi: 10.1002/dc.10220. PMID: 12508178
Invasive squamous-cell carcinoma in ThinPrep specimens: diagnostic clues in the cellular pattern.
Clark SB, Dawson AE
Diagn Cytopathol 2002 Jan;26(1):1-4. doi: 10.1002/dc.10033. PMID: 11782077
Chemoprevention trials in the cervix: design, feasibility, and recruitment.
Mitchell MF, Hittelman WN, Lotan R, Nishioka K, Tortolero-Luna G, Richards-Kortum R, Hong WK
J Cell Biochem Suppl 1995;23:104-12. PMID: 8747384

Therapy

The role of steroid contraceptive hormones in the pathogenesis of invasive cervical cancer: a review.
Moodley M, Moodley J, Chetty R, Herrington CS
Int J Gynecol Cancer 2003 Mar-Apr;13(2):103-10. doi: 10.1046/j.1525-1438.2003.13030.x. PMID: 12657108
Chronic estrogen-induced cervical and vaginal squamous carcinogenesis in human papillomavirus type 16 transgenic mice.
Arbeit JM, Howley PM, Hanahan D
Proc Natl Acad Sci U S A 1996 Apr 2;93(7):2930-5. doi: 10.1073/pnas.93.7.2930. PMID: 8610145Free PMC Article
Chemoprevention trials in the cervix: design, feasibility, and recruitment.
Mitchell MF, Hittelman WN, Lotan R, Nishioka K, Tortolero-Luna G, Richards-Kortum R, Hong WK
J Cell Biochem Suppl 1995;23:104-12. PMID: 8747384
Carcinoma of the cervix stage IB: results of treatment with radiation therapy.
Montana GS, Fowler WC Jr, Varia MA, Walton LA, Kirsch M, Halle JS, McCafferty BB
Int J Radiat Oncol Biol Phys 1983 Jan;9(1):45-9. doi: 10.1016/0360-3016(83)90207-9. PMID: 6841175
Radiation therapy of primary vaginal carcinoma.
Nori D, Hilaris BS, Stanimir G, Lewis JL Jr
Int J Radiat Oncol Biol Phys 1983 Oct;9(10):1471-5. doi: 10.1016/0360-3016(83)90320-6. PMID: 6629889

Prognosis

Epidermoid carcinoma in the neovagina of a patient with Mayer-Rokitansky-Küster-Hauser syndrome. Case report and literature review.
Fernández-Ruiz M, Pantoja-Garrido M, Frías-Sánchez Z, Rodríguez-Jiménez I, Aguilar-Martín MDV
Rev Colomb Obstet Ginecol 2019 Dec;70(4):266-276. doi: 10.18597/rcog.3328. PMID: 32142241
Does Differentiated Squamous Intraepithelial Neoplasia Occur in the Cervix?
Mai KT
Appl Immunohistochem Mol Morphol 2018 Apr;26(4):e52-e60. doi: 10.1097/PAI.0000000000000577. PMID: 28877072
Primary squamous cell carcinoma of endometrium: clinicopathologic analysis of two cases with review of the literature.
Li Y, Lu HJ, Yang Y
Eur J Gynaecol Oncol 2013;34(4):355-7. PMID: 24020148
Invasive squamous-cell carcinoma in ThinPrep specimens: diagnostic clues in the cellular pattern.
Clark SB, Dawson AE
Diagn Cytopathol 2002 Jan;26(1):1-4. doi: 10.1002/dc.10033. PMID: 11782077
Basaloid and warty carcinomas of the vulva. Distinctive types of squamous cell carcinoma frequently associated with human papillomaviruses.
Kurman RJ, Toki T, Schiffman MH
Am J Surg Pathol 1993 Feb;17(2):133-45. doi: 10.1097/00000478-199302000-00005. PMID: 8380681

Clinical prediction guides

Epidermoid carcinoma in the neovagina of a patient with Mayer-Rokitansky-Küster-Hauser syndrome. Case report and literature review.
Fernández-Ruiz M, Pantoja-Garrido M, Frías-Sánchez Z, Rodríguez-Jiménez I, Aguilar-Martín MDV
Rev Colomb Obstet Ginecol 2019 Dec;70(4):266-276. doi: 10.18597/rcog.3328. PMID: 32142241
Urothelial carcinoma involving vaginal specimens from patients with neobladder: a potential pitfall in diagnostic cytopathology.
Sigel CS, Park KJ, Fine SW, Lin O
Diagn Cytopathol 2012 Feb;40(2):168-72. Epub 2010 Dec 31 doi: 10.1002/dc.21600. PMID: 22246935
The role of steroid contraceptive hormones in the pathogenesis of invasive cervical cancer: a review.
Moodley M, Moodley J, Chetty R, Herrington CS
Int J Gynecol Cancer 2003 Mar-Apr;13(2):103-10. doi: 10.1046/j.1525-1438.2003.13030.x. PMID: 12657108
Invasive squamous-cell carcinoma in ThinPrep specimens: diagnostic clues in the cellular pattern.
Clark SB, Dawson AE
Diagn Cytopathol 2002 Jan;26(1):1-4. doi: 10.1002/dc.10033. PMID: 11782077
Cytokeratins of normal epithelia and some neoplasms of the female genital tract.
Moll R, Levy R, Czernobilsky B, Hohlweg-Majert P, Dallenbach-Hellweg G, Franke WW
Lab Invest 1983 Nov;49(5):599-610. PMID: 6195450

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