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Benign prostatic hyperplasia(BPH)

MedGen UID:
312369
Concept ID:
C1704272
Pathologic Function
Synonym: BPH
SNOMED CT: Nodular hyperplasia of prostate gland (266569009); BPH - benign prostatic hyperplasia (266569009); Benign prostatic hyperplasia (266569009); Benign enlargement of prostate (266569009); Benign prostatic hypertrophy (266569009); BEP - Benign enlargement of prostate (266569009)
 
HPO: HP:0008711
Monarch Initiative: MONDO:0010811
OMIM®: 600082

Definition

Benign prostatic hyperplasia (BPH) refers to the nonmalignant growth of the prostate gland, and is histologically defined as hyperplasia of the prostate gland. BPH is an age-related phenomenon in men beginning at about age 40 years. BPH may result in prostatic enlargement and clinical symptoms most commonly affecting the lower urinary tract. These symptoms may be obstructive, including hesitancy, weak flow, and urinary retention, or irritative, including increased frequency and urgency. However, not all men with histologic BPH will develop prostatic enlargement or urinary symptoms (review by Roehrborn, 2005). [from OMIM]

Clinical features

From HPO
Benign prostatic hyperplasia
MedGen UID:
312369
Concept ID:
C1704272
Pathologic Function
Benign prostatic hyperplasia (BPH) refers to the nonmalignant growth of the prostate gland, and is histologically defined as hyperplasia of the prostate gland. BPH is an age-related phenomenon in men beginning at about age 40 years. BPH may result in prostatic enlargement and clinical symptoms most commonly affecting the lower urinary tract. These symptoms may be obstructive, including hesitancy, weak flow, and urinary retention, or irritative, including increased frequency and urgency. However, not all men with histologic BPH will develop prostatic enlargement or urinary symptoms (review by Roehrborn, 2005).

Conditions with this feature

Benign prostatic hyperplasia
MedGen UID:
312369
Concept ID:
C1704272
Pathologic Function
Benign prostatic hyperplasia (BPH) refers to the nonmalignant growth of the prostate gland, and is histologically defined as hyperplasia of the prostate gland. BPH is an age-related phenomenon in men beginning at about age 40 years. BPH may result in prostatic enlargement and clinical symptoms most commonly affecting the lower urinary tract. These symptoms may be obstructive, including hesitancy, weak flow, and urinary retention, or irritative, including increased frequency and urgency. However, not all men with histologic BPH will develop prostatic enlargement or urinary symptoms (review by Roehrborn, 2005).

Professional guidelines

PubMed

Csikós E, Horváth A, Ács K, Papp N, Balázs VL, Dolenc MS, Kenda M, Kočevar Glavač N, Nagy M, Protti M, Mercolini L, Horváth G, Farkas Á, On Behalf Of The Oemonom
Molecules 2021 Nov 25;26(23) doi: 10.3390/molecules26237141. PMID: 34885733Free PMC Article
Miernik A, Gratzke C
Dtsch Arztebl Int 2020 Dec 4;117(49):843-854. doi: 10.3238/arztebl.2020.0843. PMID: 33593479Free PMC Article
Verhamme KM, Sturkenboom MC, Stricker BH, Bosch R
Drug Saf 2008;31(5):373-88. doi: 10.2165/00002018-200831050-00002. PMID: 18422378

Recent clinical studies

Etiology

Jia F, Wei Z, Kong X, Mao Y, Yang Y
J Gerontol A Biol Sci Med Sci 2024 Jan 1;79(1) doi: 10.1093/gerona/glad187. PMID: 37526403Free PMC Article
GBD 2019 Benign Prostatic Hyperplasia Collaborators
Lancet Healthy Longev 2022 Nov;3(11):e754-e776. Epub 2022 Oct 20 doi: 10.1016/S2666-7568(22)00213-6. PMID: 36273485Free PMC Article
Ottaiano N, Shelton T, Sanekommu G, Benson CR
Curr Urol Rep 2022 May;23(5):83-92. Epub 2022 Mar 9 doi: 10.1007/s11934-022-01091-z. PMID: 35262855
Miernik A, Gratzke C
Dtsch Arztebl Int 2020 Dec 4;117(49):843-854. doi: 10.3238/arztebl.2020.0843. PMID: 33593479Free PMC Article
McVary KT, Rogers T, Roehrborn CG
Urology 2019 Apr;126:171-179. Epub 2019 Jan 21 doi: 10.1016/j.urology.2018.12.041. PMID: 30677455

Diagnosis

Miernik A, Gratzke C
Dtsch Arztebl Int 2020 Dec 4;117(49):843-854. doi: 10.3238/arztebl.2020.0843. PMID: 33593479Free PMC Article
Billet M, Windsor TA
Emerg Med Clin North Am 2019 Nov;37(4):649-660. Epub 2019 Aug 16 doi: 10.1016/j.emc.2019.07.005. PMID: 31563200
Langan RC
Prim Care 2019 Jun;46(2):223-232. Epub 2019 Apr 1 doi: 10.1016/j.pop.2019.02.003. PMID: 31030823
Foo KT
World J Urol 2019 Jul;37(7):1293-1296. Epub 2019 Feb 25 doi: 10.1007/s00345-019-02691-0. PMID: 30805683Free PMC Article
Egan KB
Urol Clin North Am 2016 Aug;43(3):289-97. doi: 10.1016/j.ucl.2016.04.001. PMID: 27476122

Therapy

Sebastianelli A, Spatafora P, Morselli S, Vignozzi L, Serni S, McVary KT, Kaplan S, Gravas S, Chapple C, Gacci M
Curr Urol Rep 2020 Oct 27;21(12):56. doi: 10.1007/s11934-020-01009-7. PMID: 33108544Free PMC Article
Traish AM
Fertil Steril 2020 Jan;113(1):21-50. doi: 10.1016/j.fertnstert.2019.11.030. PMID: 32033719
Solomon ZJ, Mirabal JR, Mazur DJ, Kohn TP, Lipshultz LI, Pastuszak AW
Sex Med Rev 2019 Jan;7(1):84-94. Epub 2018 Nov 30 doi: 10.1016/j.sxmr.2018.09.006. PMID: 30503797Free PMC Article
Pathak P, Helo S, McVary KT
Eur Urol Focus 2018 Jan;4(1):32-35. Epub 2018 Mar 9 doi: 10.1016/j.euf.2018.02.011. PMID: 29530631
Evans HC, Goa KL
Drugs Aging 2003;20(12):905-16; discussion 917-8. doi: 10.2165/00002512-200320120-00005. PMID: 14565784

Prognosis

Liu D, Li C, Li Y, Zhou L, Li J, Wang Y, Wan X, Zhou L, Wang L
World J Urol 2023 Dec;41(12):3629-3634. Epub 2023 Oct 13 doi: 10.1007/s00345-023-04658-8. PMID: 37831157
Egan KB
Urol Clin North Am 2016 Aug;43(3):289-97. doi: 10.1016/j.ucl.2016.04.001. PMID: 27476122
Zou C, Gong D, Fang N, Fan Y
World J Urol 2016 Feb;34(2):281-9. Epub 2015 Jun 29 doi: 10.1007/s00345-015-1626-0. PMID: 26119349
Keehn A, Lowe FC
Can J Urol 2015 Oct;22 Suppl 1:18-23. PMID: 26497340
Djavan B, Waldert M, Ghawidel C, Marberger M
Curr Opin Urol 2004 Jan;14(1):45-50. doi: 10.1097/00042307-200401000-00010. PMID: 15091050

Clinical prediction guides

Ma K, Dong Q
BMC Public Health 2023 Jun 14;23(1):1147. doi: 10.1186/s12889-023-15972-6. PMID: 37316942Free PMC Article
Li S, Sun Y, Liu J, Han F, Liu B, Liu W
Comput Math Methods Med 2022;2022:9855770. Epub 2022 Jul 4 doi: 10.1155/2022/9855770. PMID: 35832128Free PMC Article
Powell T, Kellner D, Ayyagari R
Tech Vasc Interv Radiol 2020 Sep;23(3):100688. Epub 2020 Oct 6 doi: 10.1016/j.tvir.2020.100688. PMID: 33308530
Bilhim T, Tinto HR, Fernandes L, Martins Pisco J
Tech Vasc Interv Radiol 2012 Dec;15(4):276-85. doi: 10.1053/j.tvir.2012.09.006. PMID: 23244724
Santos Dias J
Tech Vasc Interv Radiol 2012 Dec;15(4):265-9. doi: 10.1053/j.tvir.2012.09.007. PMID: 23244722

Recent systematic reviews

Cornu JN, Zantek P, Burtt G, Martin C, Martin A, Springate C, Chughtai B
Eur Urol 2023 Jun;83(6):534-547. Epub 2023 Mar 22 doi: 10.1016/j.eururo.2023.02.028. PMID: 36964042
Sciacqua LV, Vanzulli A, Di Meo R, Pellegrino G, Lavorato R, Vitale G, Carrafiello G
Technol Cancer Res Treat 2023 Jan-Dec;22:15330338231155000. doi: 10.1177/15330338231155000. PMID: 36794408Free PMC Article
Xu Z, Hall TL, Vlaisavljevich E, Lee FT Jr
Int J Hyperthermia 2021;38(1):561-575. doi: 10.1080/02656736.2021.1905189. PMID: 33827375Free PMC Article
Das K, Buchholz N
Clin Nutr ESPEN 2019 Oct;33:5-11. Epub 2019 Aug 12 doi: 10.1016/j.clnesp.2019.07.015. PMID: 31451276
Vuichoud C, Loughlin KR
Can J Urol 2015 Oct;22 Suppl 1:1-6. PMID: 26497338

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