U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Irritation

MedGen UID:
312795
Concept ID:
C1706307
Finding

Definition

A mild inflammatory tissue reaction; it can be caused by physical contact with an irritant or can be a local response to a systemic trigger. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIrritation

Professional guidelines

PubMed

Mohamed HB, Abd El-Hamid BN, Fathalla D, Fouad EA
Eur J Pharm Sci 2022 Aug 1;175:106206. Epub 2022 May 11 doi: 10.1016/j.ejps.2022.106206. PMID: 35568107
Sabeti S, Kheirkhah A, Yin J, Dana R
Surv Ophthalmol 2020 Mar-Apr;65(2):205-217. Epub 2019 Sep 5 doi: 10.1016/j.survophthal.2019.08.007. PMID: 31494111
Tella SH, Gallagher JC
J Steroid Biochem Mol Biol 2014 Jul;142:155-70. Epub 2013 Oct 29 doi: 10.1016/j.jsbmb.2013.09.008. PMID: 24176761Free PMC Article

Recent clinical studies

Etiology

Michanowicz DR, Leventhal OM, Domen JK, Williams SR, Lebel ED, Hill LAL, Buonocore JJ, Nordgaard CL, Bernstein AS, Shonkoff SBC
Curr Environ Health Rep 2023 Sep;10(3):337-352. Epub 2023 Jul 25 doi: 10.1007/s40572-023-00403-w. PMID: 37491689Free PMC Article
Akbari M
J Popul Ther Clin Pharmacol 2022;29(4):e30-e45. Epub 2022 Nov 9 doi: 10.47750/jptcp.2022.968. PMID: 36371649
Patel SS, Lovko VJ, Lockey RF
J Allergy Clin Immunol Pract 2020 Apr;8(4):1219-1223. Epub 2019 Nov 21 doi: 10.1016/j.jaip.2019.10.030. PMID: 31761688
Wolkoff P, Nielsen GD
Environ Int 2017 Apr;101:96-107. Epub 2017 Jan 23 doi: 10.1016/j.envint.2017.01.013. PMID: 28126407
Scognamiglio J, Jones L, Letizia CS, Api AM
Food Chem Toxicol 2012 Sep;50 Suppl 2:S244-55. Epub 2011 Oct 19 doi: 10.1016/j.fct.2011.10.030. PMID: 22036980

Diagnosis

Michanowicz DR, Leventhal OM, Domen JK, Williams SR, Lebel ED, Hill LAL, Buonocore JJ, Nordgaard CL, Bernstein AS, Shonkoff SBC
Curr Environ Health Rep 2023 Sep;10(3):337-352. Epub 2023 Jul 25 doi: 10.1007/s40572-023-00403-w. PMID: 37491689Free PMC Article
Salinas R, Puig M, Fry CL, Johnson DA, Kheirkhah A
Ocul Surf 2020 Jan;18(1):31-39. Epub 2019 Oct 5 doi: 10.1016/j.jtos.2019.10.002. PMID: 31593763
Hummel T, Frasnelli J
Handb Clin Neurol 2019;164:119-134. doi: 10.1016/B978-0-444-63855-7.00008-3. PMID: 31604542
Berardesca E, Farage M, Maibach H
Int J Cosmet Sci 2013 Feb;35(1):2-8. Epub 2012 Sep 21 doi: 10.1111/j.1468-2494.2012.00754.x. PMID: 22928591
Bent S, Nallamothu BK, Simel DL, Fihn SD, Saint S
JAMA 2002 May 22-29;287(20):2701-10. doi: 10.1001/jama.287.20.2701. PMID: 12020306

Therapy

Hartmann-Boyce J, Lindson N, Butler AR, McRobbie H, Bullen C, Begh R, Theodoulou A, Notley C, Rigotti NA, Turner T, Fanshawe TR, Hajek P
Cochrane Database Syst Rev 2022 Nov 17;11(11):CD010216. doi: 10.1002/14651858.CD010216.pub7. PMID: 36384212Free PMC Article
Zakarija-Grkovic I, Stewart F
Cochrane Database Syst Rev 2020 Sep 18;9(9):CD006946. doi: 10.1002/14651858.CD006946.pub4. PMID: 32944940Free PMC Article
Hartmann-Boyce J, Chepkin SC, Ye W, Bullen C, Lancaster T
Cochrane Database Syst Rev 2018 May 31;5(5):CD000146. doi: 10.1002/14651858.CD000146.pub5. PMID: 29852054Free PMC Article
Proksch E, de Bony R, Trapp S, Boudon S
J Dermatolog Treat 2017 Dec;28(8):766-773. Epub 2017 May 14 doi: 10.1080/09546634.2017.1325310. PMID: 28503966
King D, Mitchell B, Williams CP, Spurling GK
Cochrane Database Syst Rev 2015 Apr 20;2015(4):CD006821. doi: 10.1002/14651858.CD006821.pub3. PMID: 25892369Free PMC Article

Prognosis

Jalalzadeh H, Groenen H, Buis DR, Dreissen YE, Goosen JH, Ijpma FF, van der Laan MJ, Schaad RR, Segers P, van der Zwet WC, Griekspoor M, Harmsen WJ, Wolfhagen N, Boermeester MA
Lancet Microbe 2022 Oct;3(10):e762-e771. Epub 2022 Aug 16 doi: 10.1016/S2666-5247(22)00187-2. PMID: 35985350
Piapan L, Baldo J, Larese Filon F
Dermatitis 2019 Mar/Apr;30(2):142-149. doi: 10.1097/DER.0000000000000450. PMID: 30829804
Usatine RP, Riojas M
Am Fam Physician 2010 Aug 1;82(3):249-55. PMID: 20672788
Gautrin D, Desrosiers M, Castano R
Curr Opin Allergy Clin Immunol 2006 Apr;6(2):77-84. doi: 10.1097/01.all.0000216848.87699.38. PMID: 16520669
Rozenberg S, Fellemans C, Kroll M, Vandromme J
Int J Fertil Womens Med 2000 Mar-Apr;45(2):182-9. PMID: 10831188

Clinical prediction guides

Kordestani SS, Mohammadi FS, Noordadi M, Rezaee F, Fayyazbakhsh F
Adv Skin Wound Care 2023 Jan 1;36(1):35-40. doi: 10.1097/01.ASW.0000897448.59904.b0. PMID: 36537773
Yelehe-Okouma M, Czmil-Garon J, Pape E, Petitpain N, Gillet P
Fundam Clin Pharmacol 2018 Jun;32(3):252-260. Epub 2018 Mar 9 doi: 10.1111/fcp.12349. PMID: 29364542
Mckee RH, Adenuga MD, Carrillo JC
Crit Rev Toxicol 2015 Apr;45(4):273-365. doi: 10.3109/10408444.2015.1016216. PMID: 25868376
Birn J, Vedantham S
Vasc Med 2015 Feb;20(1):74-83. Epub 2014 Dec 10 doi: 10.1177/1358863X14560429. PMID: 25502563
Robinson MK, Perkins MA
Am J Contact Dermat 2002 Mar;13(1):21-9. doi: 10.1053/ajcd.2002.30471. PMID: 11887101

Recent systematic reviews

Hartmann-Boyce J, Lindson N, Butler AR, McRobbie H, Bullen C, Begh R, Theodoulou A, Notley C, Rigotti NA, Turner T, Fanshawe TR, Hajek P
Cochrane Database Syst Rev 2022 Nov 17;11(11):CD010216. doi: 10.1002/14651858.CD010216.pub7. PMID: 36384212Free PMC Article
Zakarija-Grkovic I, Stewart F
Cochrane Database Syst Rev 2020 Sep 18;9(9):CD006946. doi: 10.1002/14651858.CD006946.pub4. PMID: 32944940Free PMC Article
McKesey J, Tovar-Garza A, Pandya AG
Am J Clin Dermatol 2020 Apr;21(2):173-225. doi: 10.1007/s40257-019-00488-w. PMID: 31802394
Hartmann-Boyce J, Chepkin SC, Ye W, Bullen C, Lancaster T
Cochrane Database Syst Rev 2018 May 31;5(5):CD000146. doi: 10.1002/14651858.CD000146.pub5. PMID: 29852054Free PMC Article
King D, Mitchell B, Williams CP, Spurling GK
Cochrane Database Syst Rev 2015 Apr 20;2015(4):CD006821. doi: 10.1002/14651858.CD006821.pub3. PMID: 25892369Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...