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Appendix adenoma

MedGen UID:: 312900
•Concept ID:: C1706829
•: Neoplastic Process

Synonyms:	Appendix Adenoma; appendix adenoma; vermiform appendix adenoma

Monarch Initiative:	MONDO:0006088

Definition

A circumscribed neoplasm arising from the glandular epithelium of the appendix. Morphologically, it is characterized by a proliferation of neoplastic glandular cells and it is associated with dysplasia. According to the growth pattern, it may be classified as tubular, villous, or tubulovillous. The dysplasia is classified as mild, moderate, or severe. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAppendix adenoma

Disorder of gastrointestinal tract
- Intestinal disorder
  - Cecal disorder
    - Cecal neoplasm
      - Appendiceal neoplasm
        Benign neoplasm of appendix
        Appendix adenoma
        Appendix Mucinous Cystadenoma
        Appendix Serrated Lesions and Polyps
        Appendix Traditional Serrated Adenoma
        Appendix Tubular Adenoma
        Appendix Tubulovillous Adenoma
        Appendix villous adenoma

Professional guidelines

PubMed

Appendiceal tumors in patients undergoing primary surgery for mucinous ovarian tumors in a tertiary hospital, in Southern Thailand.

Nanthamongkolkul K, Wattanapaisal P, Boonyapipat S, Suphasynth Y, Pichatechaiyoot A, Geater AF, Kayasut K, Peeyananjarassri K
Taiwan J Obstet Gynecol 2022 Jul;61(4):657-662. doi: 10.1016/j.tjog.2022.03.042. PMID: 35779917

The histopathological classification, diagnosis and differential diagnosis of mucinous appendiceal neoplasms, appendiceal adenocarcinomas and pseudomyxoma peritonei.

Carr NJ, Bibeau F, Bradley RF, Dartigues P, Feakins RM, Geisinger KR, Gui X, Isaac S, Milione M, Misdraji J, Pai RK, Rodriguez-Justo M, Sobin LH, van Velthuysen MF, Yantiss RK
Histopathology 2017 Dec;71(6):847-858. Epub 2017 Sep 19 doi: 10.1111/his.13324. PMID: 28746986

Diagnosis and management of pediatric endocrine neoplasms.

Iqbal CW, Wahoff DC
Curr Opin Pediatr 2009 Jun;21(3):379-85. doi: 10.1097/MOP.0b013e32832b335e. PMID: 19421059

See all (6)

Recent clinical studies

Etiology

Neoplasms of the Appendix.

Köhler F, Matthes N, Rosenfeldt M, Kunzmann V, Germer CT, Wiegering A
Dtsch Arztebl Int 2023 Aug 7;120(31-32):519-525. doi: 10.3238/arztebl.m2023.0136. PMID: 37282595 Free PMC Article

Clinicopathological spectrums and prognosis of primary appendiceal adenocarcinoma, goblet cell adenocarcinoma, and low-grade appendiceal mucinous neoplasms.

Chen I, Liu X, Kovar-Peltz S, Conrad SJ, Chen HH, Liao X
Pathology 2023 Apr;55(3):375-382. Epub 2022 Oct 13 doi: 10.1016/j.pathol.2022.08.004. PMID: 36454563

Clinicopathological Features and Management of Appendiceal Mucoceles: A Systematic Review.

Morano WF, Gleeson EM, Sullivan SH, Padmanaban V, Mapow BL, Shewokis PA, Esquivel J, Bowne WB
Am Surg 2018 Feb 1;84(2):273-281. PMID: 29580358

The histopathological classification, diagnosis and differential diagnosis of mucinous appendiceal neoplasms, appendiceal adenocarcinomas and pseudomyxoma peritonei.

Pseudomyxoma peritonei.

Hinson FL, Ambrose NS
Br J Surg 1998 Oct;85(10):1332-9. doi: 10.1046/j.1365-2168.1998.00882.x. PMID: 9782010

See all (110)

Diagnosis

Ectopic insulinoma: a systematic review.

Guerrero-Pérez F, Vilarrasa N, Huánuco LV, Busquets J, Secanella L, Vercher-Conejero JL, Vidal N, Näf Cortés S, Villabona C
Rev Endocr Metab Disord 2023 Dec;24(6):1135-1146. Epub 2023 Jul 12 doi: 10.1007/s11154-023-09824-2. PMID: 37434098

Neoplasms of the Appendix.

Köhler F, Matthes N, Rosenfeldt M, Kunzmann V, Germer CT, Wiegering A
Dtsch Arztebl Int 2023 Aug 7;120(31-32):519-525. doi: 10.3238/arztebl.m2023.0136. PMID: 37282595 Free PMC Article

The histopathological classification, diagnosis and differential diagnosis of mucinous appendiceal neoplasms, appendiceal adenocarcinomas and pseudomyxoma peritonei.

Pseudomyxoma peritonei.

Hinson FL, Ambrose NS
Br J Surg 1998 Oct;85(10):1332-9. doi: 10.1046/j.1365-2168.1998.00882.x. PMID: 9782010

Pseudomyxoma peritonei.

Sugarbaker PH
Cancer Treat Res 1996;81:105-19. doi: 10.1007/978-1-4613-1245-1_10. PMID: 8834579

See all (223)

Therapy

Neoplasms of the Appendix.

Köhler F, Matthes N, Rosenfeldt M, Kunzmann V, Germer CT, Wiegering A
Dtsch Arztebl Int 2023 Aug 7;120(31-32):519-525. doi: 10.3238/arztebl.m2023.0136. PMID: 37282595 Free PMC Article

Postoperative Complications Independently Predict Cancer-Related Survival in Peritoneal Malignancies.

Choudry MHA, Shuai Y, Jones HL, Pai RK, Pingpank JF, Ahrendt SS, Holtzman MP, Zeh HJ, Bartlett DL
Ann Surg Oncol 2018 Dec;25(13):3950-3959. Epub 2018 Oct 9 doi: 10.1245/s10434-018-6823-9. PMID: 30302637

Serrated lesions of the appendix: a morphologic and immunohistochemical appraisal.

Bellizzi AM, Rock J, Marsh WL, Frankel WL
Am J Clin Pathol 2010 Apr;133(4):623-32. doi: 10.1309/AJCP1UJPX6UURLCH. PMID: 20231616

Pseudomyxoma peritonei syndrome of appendiceal origin: an overview.

Brueggen C, Baird G, Meisheid A
Clin J Oncol Nurs 2007 Aug;11(4):525-32. doi: 10.1188/07.CJON.525-532. PMID: 17723965

Pseudomyxoma peritonei.

Hinson FL, Ambrose NS
Br J Surg 1998 Oct;85(10):1332-9. doi: 10.1046/j.1365-2168.1998.00882.x. PMID: 9782010

See all (24)

Prognosis

Clinicopathological spectrums and prognosis of primary appendiceal adenocarcinoma, goblet cell adenocarcinoma, and low-grade appendiceal mucinous neoplasms.

Chen I, Liu X, Kovar-Peltz S, Conrad SJ, Chen HH, Liao X
Pathology 2023 Apr;55(3):375-382. Epub 2022 Oct 13 doi: 10.1016/j.pathol.2022.08.004. PMID: 36454563

SATB2 Expression in Human Tumors: A Tissue Microarray Study on More Than 15 000 Tumors.

Dum D, Kromm D, Lennartz M, De Wispelaere N, Büscheck F, Luebke AM, Burandt E, Menz A, Kluth M, Hube-Magg C, Hinsch A, Höflmayer D, Weidemann S, Fraune C, Möller K, Lebok P, Sauter G, Simon R, Uhlig R, Wilczak W, Minner S, Krech R, Bernreuther C, Marx A, Steurer S, Jacobsen F, Clauditz T, Krech T
Arch Pathol Lab Med 2023 Apr 1;147(4):451-464. doi: 10.5858/arpa.2021-0317-OA. PMID: 35917493

Mucocoele and mucinous tumours of the appendix: A review of the literature.

Rymer B, Forsythe RO, Husada G
Int J Surg 2015 Jun;18:132-5. Epub 2015 Apr 24 doi: 10.1016/j.ijsu.2015.04.052. PMID: 25917270

Pseudomyxoma peritonei.

Hinson FL, Ambrose NS
Br J Surg 1998 Oct;85(10):1332-9. doi: 10.1046/j.1365-2168.1998.00882.x. PMID: 9782010

Pseudomyxoma peritonei.

Sugarbaker PH
Cancer Treat Res 1996;81:105-19. doi: 10.1007/978-1-4613-1245-1_10. PMID: 8834579

See all (82)

Clinical prediction guides

Endoscopic features of lymphoid follicles in the colonic mucosa using the image enhanced endoscopy and its association with colorectal adenoma.

Tahara T, Takahama K, Tahara S, Horiguchi N, Funasaka K, Nakagawa Y, Shibata T, Tsukamoto T, Ieda HO, Fukui T, Naganuma M, Ohmiya N
PLoS One 2023;18(5):e0286300. Epub 2023 May 30 doi: 10.1371/journal.pone.0286300. PMID: 37253036 Free PMC Article

FABP1 expression in human tumors: a tissue microarray study on 17,071 tumors.

Dum D, Ocokoljic A, Lennartz M, Hube-Magg C, Reiswich V, Höflmayer D, Jacobsen F, Bernreuther C, Lebok P, Sauter G, Luebke AM, Burandt E, Marx AH, Simon R, Clauditz TS, Minner S, Menz A, Büscheck F, Gorbokon N, Steurer S, Blessin NC, Krech T
Virchows Arch 2022 Dec;481(6):945-961. Epub 2022 Aug 11 doi: 10.1007/s00428-022-03394-5. PMID: 35951102 Free PMC Article

Clinical characteristics of appendiceal diverticular disease.

Çakar E, Bayrak S, Çolak Ş, Dal F, Gürbulak B, Bektaş H, Yarıkkaya E, Ferlengez AG
Int J Colorectal Dis 2019 Dec;34(12):2035-2041. Epub 2019 Nov 4 doi: 10.1007/s00384-019-03410-2. PMID: 31686198

Serrated lesions of the appendix: do they differ from their colorectal counterparts?

Yuyucu Karabulut Y, Savaş B, Kurşun N, Ensar A
Turk J Gastroenterol 2014 Feb;25(1):29-34. doi: 10.5152/tjg.2014.4056. PMID: 24918127

If not appendicitis, then what else can it be? A retrospective review of 1492 appendectomies.

Ma KW, Chia NH, Yeung HW, Cheung MT
Hong Kong Med J 2010 Feb;16(1):12-7. PMID: 20124568

See all (39)