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Colorectal signet ring cell carcinoma

MedGen UID:
313040
Concept ID:
C1707440
Neoplastic Process
Synonyms: Colorectal Signet Ring Cell Carcinoma; colorectal signet ring cell carcinoma; colorectal signet Ring cell carcinoma; Colorectal Signet-Ring Cell Carcinoma
 
Monarch Initiative: MONDO:0044336

Definition

An invasive colorectal adenocarcinoma characterized by the presence of malignant glandular epithelial cells with prominent intracytoplasmic mucin resulting in the displacement of the nuclei. The malignant glandular cells with intracytoplasmic mucin constitute more than 50% of the malignant cellular infiltrate. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Ooi BS, Ho YH, Eu KW, Seow Choen F
ANZ J Surg 2001 Dec;71(12):703-6. doi: 10.1046/j.1445-1433.2001.02269.x. PMID: 11906382
Psathakis D, Schiedeck TH, Krug F, Oevermann E, Kujath P, Bruch HP
Dis Colon Rectum 1999 Dec;42(12):1618-25. doi: 10.1007/BF02236218. PMID: 10613484

Recent clinical studies

Etiology

Feng L, Yang YJ, Du J, Yu YJ, Diao JD
Sci Rep 2020 Oct 21;10(1):17881. doi: 10.1038/s41598-020-74720-7. PMID: 33087758Free PMC Article
Yang LL, Wang M, He P
Sci Rep 2020 Jun 26;10(1):10460. doi: 10.1038/s41598-020-67388-6. PMID: 32591589Free PMC Article
Liang Z, Yan D, Li G, Cheng H
Clin Colorectal Cancer 2018 Mar;17(1):e39-e44. Epub 2017 Jul 8 doi: 10.1016/j.clcc.2017.06.010. PMID: 28789931
Hugen N, Verhoeven RH, Lemmens VE, van Aart CJ, Elferink MA, Radema SA, Nagtegaal ID, de Wilt JH
Int J Cancer 2015 Jan 15;136(2):333-9. Epub 2014 May 28 doi: 10.1002/ijc.28981. PMID: 24841868
Céspedes MV, Larriba MJ, Pavón MA, Alamo P, Casanova I, Parreño M, Feliu A, Sancho FJ, Muñoz A, Mangues R
Am J Pathol 2010 Oct;177(4):2067-79. Epub 2010 Sep 2 doi: 10.2353/ajpath.2010.100079. PMID: 20813963Free PMC Article

Diagnosis

Matsushima S, Kobayashi R, Sano H, Hori D, Yanagi M, Goto J, Kobayashi K
Pediatr Int 2022 Jan;64(1):e15374. doi: 10.1111/ped.15374. PMID: 36169041
Aitchison A, Hakkaart C, Whitehead M, Khan S, Siddique S, Ahmed R, Frizelle FA, Keenan JI
Pathol Res Pract 2020 May;216(5):152912. Epub 2020 Feb 29 doi: 10.1016/j.prp.2020.152912. PMID: 32147272
Liang Z, Yan D, Li G, Cheng H
Clin Colorectal Cancer 2018 Mar;17(1):e39-e44. Epub 2017 Jul 8 doi: 10.1016/j.clcc.2017.06.010. PMID: 28789931
Céspedes MV, Larriba MJ, Pavón MA, Alamo P, Casanova I, Parreño M, Feliu A, Sancho FJ, Muñoz A, Mangues R
Am J Pathol 2010 Oct;177(4):2067-79. Epub 2010 Sep 2 doi: 10.2353/ajpath.2010.100079. PMID: 20813963Free PMC Article
Mizushima T, Nomura M, Fujii M, Akamatsu H, Mizuno H, Tominaga H, Hasegawa J, Nakajima K, Yasumasa K, Yoshikawa M, Nishida T
Surg Today 2010 Mar;40(3):234-8. Epub 2010 Feb 24 doi: 10.1007/s00595-009-4057-y. PMID: 20180076

Therapy

Matsushima S, Kobayashi R, Sano H, Hori D, Yanagi M, Goto J, Kobayashi K
Pediatr Int 2022 Jan;64(1):e15374. doi: 10.1111/ped.15374. PMID: 36169041
Shi T, Huang M, Han D, Tang X, Chen Y, Li Z, Liu C, Xiang D, Wang T, Chen Y, Wang R, Lei Z, Chu X
Cancer Med 2019 Apr;8(4):1930-1940. Epub 2019 Mar 12 doi: 10.1002/cam4.2054. PMID: 30864303Free PMC Article
Hugen N, Verhoeven RH, Lemmens VE, van Aart CJ, Elferink MA, Radema SA, Nagtegaal ID, de Wilt JH
Int J Cancer 2015 Jan 15;136(2):333-9. Epub 2014 May 28 doi: 10.1002/ijc.28981. PMID: 24841868

Prognosis

Li F, Liu L, Feng Q, Wang X, Liu F, Yang L, Miao L, Wang W, Ji G, Yu C
World J Surg Oncol 2024 Apr 22;22(1):107. doi: 10.1186/s12957-024-03362-0. PMID: 38644507Free PMC Article
An Y, Zhou J, Lin G, Wu H, Cong L, Li Y, Qiu X, Shi W
Pathol Oncol Res 2021;27:1609859. Epub 2021 Jul 26 doi: 10.3389/pore.2021.1609859. PMID: 34381313Free PMC Article
Yang LL, Wang M, He P
Sci Rep 2020 Jun 26;10(1):10460. doi: 10.1038/s41598-020-67388-6. PMID: 32591589Free PMC Article
Liang Z, Yan D, Li G, Cheng H
Clin Colorectal Cancer 2018 Mar;17(1):e39-e44. Epub 2017 Jul 8 doi: 10.1016/j.clcc.2017.06.010. PMID: 28789931
Tajiri K, Sudou T, Fujita F, Hisaka T, Kinugasa T, Akagi Y
Anticancer Res 2017 Jul;37(7):3817-3823. doi: 10.21873/anticanres.11760. PMID: 28668881

Clinical prediction guides

Zhou D, Yang YJ, Han L, Yu YJ, Diao JD
Medicine (Baltimore) 2023 Dec 1;102(48):e36453. doi: 10.1097/MD.0000000000036453. PMID: 38050222Free PMC Article
Zhang F, Xu B, Peng Y, Mao Z
J Cancer Res Clin Oncol 2023 Sep;149(12):9747-9756. Epub 2023 May 28 doi: 10.1007/s00432-023-04880-2. PMID: 37245170Free PMC Article
Chen W, Cai H, Chen K, Liu X, Jiang W, Li S, Zhang Y, Chen Z, Guan G
Bosn J Basic Med Sci 2022 Feb 1;22(1):124-130. doi: 10.17305/bjbms.2021.5856. PMID: 34247568Free PMC Article
An Y, Zhou J, Lin G, Wu H, Cong L, Li Y, Qiu X, Shi W
Pathol Oncol Res 2021;27:1609859. Epub 2021 Jul 26 doi: 10.3389/pore.2021.1609859. PMID: 34381313Free PMC Article
Mizushima T, Nomura M, Fujii M, Akamatsu H, Mizuno H, Tominaga H, Hasegawa J, Nakajima K, Yasumasa K, Yoshikawa M, Nishida T
Surg Today 2010 Mar;40(3):234-8. Epub 2010 Feb 24 doi: 10.1007/s00595-009-4057-y. PMID: 20180076

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