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Lung Pleomorphic Adenoma

MedGen UID:
313372
•Concept ID:
C1708780
•
Neoplastic Process

Definition

A very rare, well circumscribed, benign epithelial neoplasm that arises from the bronchus. It is characterized by the presence of epithelial cells, myoepithelial cells, and fibromyxoid stroma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLung Pleomorphic Adenoma

Professional guidelines

PubMed

Vinorelbine treatment of recurrent salivary gland carcinomas.
Airoldi M, Bumma C, Bertetto O, Gabriele P, Succo G, Pedani F
Bull Cancer 1998 Oct;85(10):892-4. PMID: 9835866

Recent clinical studies

Etiology

Cutaneous Myoepithelial Neoplasms on Acral Sites Show Distinctive and Reproducible Histopathologic and Immunohistochemical Features.
Mehta A, Davey J, Gharpuray-Pandit D, Plaza JA, Billings SD, Balogh P, Tchrakian N, Selvan S, Wiedemeyer K, Hornick JL, Brenn T
Am J Surg Pathol 2022 Sep 1;46(9):1241-1249. Epub 2022 Mar 31 doi: 10.1097/PAS.0000000000001896. PMID: 35354162
Auxiliary diagnostic value of D2-40 in early lung adenocarcinoma and precursor lesions.
Hongxia W, Qingqing Y, Chunfang Z, Jun C, Jing L, Guofeng L, Rong Y
J Clin Pathol 2022 Sep;75(9):632-635. Epub 2021 Jun 30 doi: 10.1136/jclinpath-2021-207574. PMID: 34193534
Sublingual gland neoplasms: clinicopathological study of 8 cases.
Gontarz M, Urbańska-Gąsiorowska M, Bargiel J, Gąsiorowski K, Marecik T, Szczurowski P, Zapała J, Wyszyńska-Pawelec G
Med Oral Patol Oral Cir Bucal 2021 Sep 1;26(5):e626-e631. doi: 10.4317/medoral.24634. PMID: 34415003Free PMC Article
Primary Pulmonary Salivary Gland-type Tumors: A Review and Update.
Falk N, Weissferdt A, Kalhor N, Moran CA
Adv Anat Pathol 2016 Jan;23(1):13-23. doi: 10.1097/PAP.0000000000000099. PMID: 26645458
Metastasizing pleomorphic adenoma of the salivary gland.
Manucha V, Ioffe OB
Arch Pathol Lab Med 2008 Sep;132(9):1445-7. doi: 10.5858/2008-132-1445-MPAOTS. PMID: 18788859

Diagnosis

Recent developments in the pathology of primary pulmonary salivary gland-type tumours.
Naso JR, Roden AC
Histopathology 2024 Jan;84(1):102-123. Epub 2023 Sep 11 doi: 10.1111/his.15039. PMID: 37694812
Malignant and Benign Tracheobronchial Neoplasms: Comprehensive Review with Radiologic, Bronchoscopic, and Pathologic Correlation.
Girvin F, Phan A, Steinberger S, Shostak E, Bessich J, Zhou F, Borczuk A, Brusca-Augello G, Goldberg M, Escalon J
Radiographics 2023 Sep;43(9):e230045. doi: 10.1148/rg.230045. PMID: 37561643
Right main bronchial pleomorphic adenoma: A case report and literature review.
Zhu Z, Lian X, Yang D
Medicine (Baltimore) 2018 Oct;97(42):e12648. doi: 10.1097/MD.0000000000012648. PMID: 30334948Free PMC Article
Metastasising pleomorphic adenoma: Systematic review.
Knight J, Ratnasingham K
Int J Surg 2015 Jul;19:137-45. Epub 2015 May 6 doi: 10.1016/j.ijsu.2015.04.084. PMID: 25958295
Metastasizing pleomorphic adenoma of the salivary gland.
Manucha V, Ioffe OB
Arch Pathol Lab Med 2008 Sep;132(9):1445-7. doi: 10.5858/2008-132-1445-MPAOTS. PMID: 18788859

Therapy

Challenges in diagnosis of pulmonary mucoepidermoid carcinoma: A case report.
Zhou X, Zhang M, Yan X, Zhong Y, Li S, Liu J, Peng L, Gan X
Medicine (Baltimore) 2019 Nov;98(44):e17684. doi: 10.1097/MD.0000000000017684. PMID: 31689789Free PMC Article
Mixed response to osimertinib and the beneficial effects of additional local therapy.
Shinno Y, Goto Y, Sato J, Morita R, Matsumoto Y, Murakami S, Kanda S, Horinouchi H, Fujiwara Y, Yamamoto N, Ohe Y
Thorac Cancer 2019 Apr;10(4):738-743. Epub 2019 Feb 8 doi: 10.1111/1759-7714.12991. PMID: 30735003Free PMC Article
Sialoblastoma of salivary glands in children: chemotherapy should be discussed as an alternative to mutilating surgery.
Prigent M, Teissier N, Peuchmaur M, El Maleh-Berges M, Philippe-Chomette P, Cardin P, Orbach D
Int J Pediatr Otorhinolaryngol 2010 Aug;74(8):942-5. doi: 10.1016/j.ijporl.2010.01.026. PMID: 20554035
Sustained response of carcinoma ex pleomorphic adenoma treated with trastuzumab and capecitabine.
Sharon E, Kelly RJ, Szabo E
Head Neck Oncol 2010 May 26;2:12. doi: 10.1186/1758-3284-2-12. PMID: 20504363Free PMC Article
Over-expression of glutathione S-transferases, DT-diaphorase and an apparently tumour-specific cytosolic class-3 aldehyde dehydrogenase by Warthin tumours and mucoepidermoid carcinomas of the human parotid gland.
Sreerama L, Sladek NE
Arch Oral Biol 1996 Jun;41(6):597-605. doi: 10.1016/0003-9969(96)00005-2. PMID: 8937651

Prognosis

Recent developments in the pathology of primary pulmonary salivary gland-type tumours.
Naso JR, Roden AC
Histopathology 2024 Jan;84(1):102-123. Epub 2023 Sep 11 doi: 10.1111/his.15039. PMID: 37694812
Parotid incidentalomas: a systematic review.
Thompson C, Nolli T, Bannister M
J Laryngol Otol 2021 Sep;135(9):765-769. Epub 2021 Jul 26 doi: 10.1017/S0022215121002036. PMID: 34308809
The PLAG1-GDH1 Axis Promotes Anoikis Resistance and Tumor Metastasis through CamKK2-AMPK Signaling in LKB1-Deficient Lung Cancer.
Jin L, Chun J, Pan C, Kumar A, Zhang G, Ha Y, Li D, Alesi GN, Kang Y, Zhou L, Yu WM, Magliocca KR, Khuri FR, Qu CK, Metallo C, Owonikoko TK, Kang S
Mol Cell 2018 Jan 4;69(1):87-99.e7. Epub 2017 Dec 14 doi: 10.1016/j.molcel.2017.11.025. PMID: 29249655Free PMC Article
Metastasising pleomorphic adenoma: Systematic review.
Knight J, Ratnasingham K
Int J Surg 2015 Jul;19:137-45. Epub 2015 May 6 doi: 10.1016/j.ijsu.2015.04.084. PMID: 25958295
Metastasizing pleomorphic adenoma of the salivary gland.
Manucha V, Ioffe OB
Arch Pathol Lab Med 2008 Sep;132(9):1445-7. doi: 10.5858/2008-132-1445-MPAOTS. PMID: 18788859

Clinical prediction guides

A rare case of canalicular adenoma in the parotid gland: Highlighting diagnostic limitations of fine-needle aspiration.
Su V, Chen H, Khorsandi A, Chai RL
Am J Otolaryngol 2023 Mar-Apr;44(2):103792. Epub 2023 Jan 20 doi: 10.1016/j.amjoto.2023.103792. PMID: 36706718
Cutaneous Myoepithelial Neoplasms on Acral Sites Show Distinctive and Reproducible Histopathologic and Immunohistochemical Features.
Mehta A, Davey J, Gharpuray-Pandit D, Plaza JA, Billings SD, Balogh P, Tchrakian N, Selvan S, Wiedemeyer K, Hornick JL, Brenn T
Am J Surg Pathol 2022 Sep 1;46(9):1241-1249. Epub 2022 Mar 31 doi: 10.1097/PAS.0000000000001896. PMID: 35354162
Prognostic factors in myoepithelial carcinoma of salivary glands: a clinicopathologic study of 48 cases.
Kong M, Drill EN, Morris L, West L, Klimstra D, Gonen M, Ghossein R, Katabi N
Am J Surg Pathol 2015 Jul;39(7):931-8. doi: 10.1097/PAS.0000000000000452. PMID: 25970687Free PMC Article
Metastasizing pleomorphic adenoma of the salivary gland.
Manucha V, Ioffe OB
Arch Pathol Lab Med 2008 Sep;132(9):1445-7. doi: 10.5858/2008-132-1445-MPAOTS. PMID: 18788859
Metastasizing pleomorphic salivary adenoma.
Nouraei SA, Ferguson MS, Clarke PM, Sandison A, Sandhu GS, Michaels L, Rhys-Evans P
Arch Otolaryngol Head Neck Surg 2006 Jul;132(7):788-93. doi: 10.1001/archotol.132.7.788. PMID: 16847191

Recent systematic reviews

Parotid incidentalomas: a systematic review.
Thompson C, Nolli T, Bannister M
J Laryngol Otol 2021 Sep;135(9):765-769. Epub 2021 Jul 26 doi: 10.1017/S0022215121002036. PMID: 34308809
Metastasising pleomorphic adenoma: Systematic review.
Knight J, Ratnasingham K
Int J Surg 2015 Jul;19:137-45. Epub 2015 May 6 doi: 10.1016/j.ijsu.2015.04.084. PMID: 25958295

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