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Reactive C-Cell Hyperplasia

MedGen UID:
313653
•Concept ID:
C1709844
•
Pathologic Function

Definition

A non-neoplastic proliferation of C-cells in the thyroid gland caused by external stimuli such as hypercalcemia and chronic lymphocytic thyroiditis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReactive C-Cell Hyperplasia

Recent clinical studies

Etiology

Reactive C cell hyperplasia as an incidental finding after thyroidectomy for papillary carcinoma.
Manatakis DK, Bakavos A, Soulou VN, Dimakis C, Tseleni-Balafouta S
Hormones (Athens) 2019 Sep;18(3):289-295. Epub 2019 Jul 10 doi: 10.1007/s42000-019-00119-3. PMID: 31292912

Diagnosis

Reactive C cell hyperplasia as an incidental finding after thyroidectomy for papillary carcinoma.
Manatakis DK, Bakavos A, Soulou VN, Dimakis C, Tseleni-Balafouta S
Hormones (Athens) 2019 Sep;18(3):289-295. Epub 2019 Jul 10 doi: 10.1007/s42000-019-00119-3. PMID: 31292912
C Cell and Follicular Epithelial Cell Precursor Lesions of the Thyroid.
Scognamiglio T
Arch Pathol Lab Med 2017 Dec;141(12):1646-1652. Epub 2017 Jun 23 doi: 10.5858/arpa.2016-0399-RA. PMID: 28644684
C-cell hyperplasia and medullary thyroid microcarcinoma.
Albores-Saavedra JA, Krueger JE
Endocr Pathol 2001 Winter;12(4):365-77. doi: 10.1385/ep:12:4:365. PMID: 11914470
Polysialic acid of the neural cell adhesion molecule in the human thyroid: a marker for medullary thyroid carcinoma and primary C-cell hyperplasia. An immunohistochemical study on 79 thyroid lesions.
Komminoth P, Roth J, Saremaslani P, Matias-Guiu X, Wolfe HJ, Heitz PU
Am J Surg Pathol 1994 Apr;18(4):399-411. doi: 10.1097/00000478-199404000-00008. PMID: 8141431

Therapy

Circulating miR-375 as a novel prognostic marker for metastatic medullary thyroid cancer patients.
Romeo P, Colombo C, Granata R, Calareso G, Gualeni AV, Dugo M, De Cecco L, Rizzetti MG, Zanframundo A, Aiello A, Carcangiu ML, Gloghini A, Ferrero S, Licitra L, Greco A, Fugazzola L, Locati LD, Borrello MG
Endocr Relat Cancer 2018 Mar;25(3):217-231. Epub 2018 Jan 3 doi: 10.1530/ERC-17-0389. PMID: 29298817

Prognosis

Circulating miR-375 as a novel prognostic marker for metastatic medullary thyroid cancer patients.
Romeo P, Colombo C, Granata R, Calareso G, Gualeni AV, Dugo M, De Cecco L, Rizzetti MG, Zanframundo A, Aiello A, Carcangiu ML, Gloghini A, Ferrero S, Licitra L, Greco A, Fugazzola L, Locati LD, Borrello MG
Endocr Relat Cancer 2018 Mar;25(3):217-231. Epub 2018 Jan 3 doi: 10.1530/ERC-17-0389. PMID: 29298817

Clinical prediction guides

Reactive C cell hyperplasia as an incidental finding after thyroidectomy for papillary carcinoma.
Manatakis DK, Bakavos A, Soulou VN, Dimakis C, Tseleni-Balafouta S
Hormones (Athens) 2019 Sep;18(3):289-295. Epub 2019 Jul 10 doi: 10.1007/s42000-019-00119-3. PMID: 31292912
Circulating miR-375 as a novel prognostic marker for metastatic medullary thyroid cancer patients.
Romeo P, Colombo C, Granata R, Calareso G, Gualeni AV, Dugo M, De Cecco L, Rizzetti MG, Zanframundo A, Aiello A, Carcangiu ML, Gloghini A, Ferrero S, Licitra L, Greco A, Fugazzola L, Locati LD, Borrello MG
Endocr Relat Cancer 2018 Mar;25(3):217-231. Epub 2018 Jan 3 doi: 10.1530/ERC-17-0389. PMID: 29298817
Possible association of CEA expression with oxyphilic change but not with C-cell hyperplasia in Hashimoto's thyroiditis.
Gakiopoulou H, Litsiou E, Valaris K, Balafoutas D, Patsouris E, Tseleni-Balafouta S
Endocr J 2010;57(8):693-9. Epub 2010 Jul 3 doi: 10.1507/endocrj.k10e-071. PMID: 20616436

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