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Secondary Osteosarcoma

MedGen UID:
313693
•Concept ID:
C1710042
•
Neoplastic Process
Synonym: Secondary Bone Osteosarcoma

Definition

An osteosarcoma arising from a pre-existing lesion of the bone, usually Paget disease, or due to radiation therapy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSecondary Osteosarcoma

Professional guidelines

PubMed

Current Status and Prospects of Clinical Treatment of Osteosarcoma.
Jiang ZY, Liu JB, Wang XF, Ma YS, Fu D
Technol Cancer Res Treat 2022 Jan-Dec;21:15330338221124696. doi: 10.1177/15330338221124696. PMID: 36128851Free PMC Article
Treatment of secondary osteosarcoma in a pediatric Hodgkin lymphoma survivor: Overcoming toxicity challenges.
Aquino-López A, Wang LL, Flores RJ
Pediatr Blood Cancer 2021 Dec;68(12):e29269. Epub 2021 Aug 12 doi: 10.1002/pbc.29269. PMID: 34383364
Problems and controversies in the management of childhood sarcomas.
Womer RB
Br Med Bull 1996 Oct;52(4):826-43. doi: 10.1093/oxfordjournals.bmb.a011586. PMID: 9039735

Recent clinical studies

Etiology

Treating secondary malignant neoplasms: A burden of childhood cancer survivors.
Podda MG, Meazza C, Gattuso G, Sironi G, Nigro O, Bergamaschi L, Biassoni V, Casanova M, Chiaravalli S, Ferrari A, Luksch R, Puma N, Schiavello E, Spreafico F, Grampa P, Manoukian S, Vennarini S, Collini P, Daolio PA, Gennaro M, Guzzo M, Morosi C, Biasoni D, Massimino M, Terenziani M
Tumori 2023 Oct;109(5):436-441. Epub 2023 Mar 24 doi: 10.1177/03008916231160824. PMID: 36964667Free PMC Article
Secondary osteosarcoma: a challenge indeed.
Meazza C, Giovanna S, Nigro O, Gattuso G, Francesco B, Podda M, Luksch R, Biassoni V, Schiavello E, Ferrari A, Spreafico F, Casanova M, Chiaravalli S, Puma N, Bergamaschi L, Livellara V, Carlo M, Parafioriti A, Daolio P, Bastoni S, Vennarini S, Pecori E, Alessandro O, Collini P, Massimino M, Terenziani M
Int J Clin Oncol 2023 Jan;28(1):184-190. Epub 2022 Nov 19 doi: 10.1007/s10147-022-02267-w. PMID: 36401730
Bone Infarcts and Tumorigenesis-Is There a Connection? A Mini-Mapping Review.
Konarski W, Poboży T, Hordowicz M, Śliwczyński A, Kotela I, Krakowiak J, Kotela A
Int J Environ Res Public Health 2022 Jul 29;19(15) doi: 10.3390/ijerph19159282. PMID: 35954639Free PMC Article
Secondary osteosarcoma: is there a predilection for the chondroblastic subtype?
Barker JP, Monument MJ, Jones KB, Putnam AR, Randall RL
Orthopedics 2015 May;38(5):e359-66. doi: 10.3928/01477447-20150504-51. PMID: 25970361
Pediatric and adult osteosarcoma: comparisons and contrasts in presentation and therapy.
Benjamin RS, Patel SR
Cancer Treat Res 2009;152:355-63. doi: 10.1007/978-1-4419-0284-9_19. PMID: 20213401

Diagnosis

Does the Clinical Presentation of Secondary Osteosarcoma in Patients Who Survive Retinoblastoma Differ From That of Conventional Osteosarcoma and How Do We Detect Them?
Kim Y, Park JW, Cho HS, Jang WY, Han I, Kim HS
Clin Orthop Relat Res 2023 Nov 1;481(11):2154-2163. Epub 2023 May 5 doi: 10.1097/CORR.0000000000002667. PMID: 37145140Free PMC Article
Treating secondary malignant neoplasms: A burden of childhood cancer survivors.
Podda MG, Meazza C, Gattuso G, Sironi G, Nigro O, Bergamaschi L, Biassoni V, Casanova M, Chiaravalli S, Ferrari A, Luksch R, Puma N, Schiavello E, Spreafico F, Grampa P, Manoukian S, Vennarini S, Collini P, Daolio PA, Gennaro M, Guzzo M, Morosi C, Biasoni D, Massimino M, Terenziani M
Tumori 2023 Oct;109(5):436-441. Epub 2023 Mar 24 doi: 10.1177/03008916231160824. PMID: 36964667Free PMC Article
Secondary osteosarcoma: a challenge indeed.
Meazza C, Giovanna S, Nigro O, Gattuso G, Francesco B, Podda M, Luksch R, Biassoni V, Schiavello E, Ferrari A, Spreafico F, Casanova M, Chiaravalli S, Puma N, Bergamaschi L, Livellara V, Carlo M, Parafioriti A, Daolio P, Bastoni S, Vennarini S, Pecori E, Alessandro O, Collini P, Massimino M, Terenziani M
Int J Clin Oncol 2023 Jan;28(1):184-190. Epub 2022 Nov 19 doi: 10.1007/s10147-022-02267-w. PMID: 36401730
Current Status and Prospects of Clinical Treatment of Osteosarcoma.
Jiang ZY, Liu JB, Wang XF, Ma YS, Fu D
Technol Cancer Res Treat 2022 Jan-Dec;21:15330338221124696. doi: 10.1177/15330338221124696. PMID: 36128851Free PMC Article
Bone Infarcts and Tumorigenesis-Is There a Connection? A Mini-Mapping Review.
Konarski W, Poboży T, Hordowicz M, Śliwczyński A, Kotela I, Krakowiak J, Kotela A
Int J Environ Res Public Health 2022 Jul 29;19(15) doi: 10.3390/ijerph19159282. PMID: 35954639Free PMC Article

Therapy

Secondary osteosarcoma: a challenge indeed.
Meazza C, Giovanna S, Nigro O, Gattuso G, Francesco B, Podda M, Luksch R, Biassoni V, Schiavello E, Ferrari A, Spreafico F, Casanova M, Chiaravalli S, Puma N, Bergamaschi L, Livellara V, Carlo M, Parafioriti A, Daolio P, Bastoni S, Vennarini S, Pecori E, Alessandro O, Collini P, Massimino M, Terenziani M
Int J Clin Oncol 2023 Jan;28(1):184-190. Epub 2022 Nov 19 doi: 10.1007/s10147-022-02267-w. PMID: 36401730
Individualized combination therapies based on whole-exome sequencing displayed significant clinical benefits in a glioblastoma patient with secondary osteosarcoma: case report and genetic characterization.
Yi GZ, Zhu TC, Que TS, Li ZY, Huang GL
BMC Neurol 2022 Oct 21;22(1):390. doi: 10.1186/s12883-022-02920-x. PMID: 36271359Free PMC Article
Current Status and Prospects of Clinical Treatment of Osteosarcoma.
Jiang ZY, Liu JB, Wang XF, Ma YS, Fu D
Technol Cancer Res Treat 2022 Jan-Dec;21:15330338221124696. doi: 10.1177/15330338221124696. PMID: 36128851Free PMC Article
Osteosarcoma After Hematopoietic Stem Cell Transplantation in Children and Adolescents: Case Report and Review of the Literature.
Kebudi R, Ozger H, Kızılocak H, Bay SB, Bilgiç B
Pediatr Blood Cancer 2016 Sep;63(9):1664-6. Epub 2016 May 17 doi: 10.1002/pbc.26067. PMID: 27187839
Problems and controversies in the management of childhood sarcomas.
Womer RB
Br Med Bull 1996 Oct;52(4):826-43. doi: 10.1093/oxfordjournals.bmb.a011586. PMID: 9039735

Prognosis

Current Status and Prospects of Clinical Treatment of Osteosarcoma.
Jiang ZY, Liu JB, Wang XF, Ma YS, Fu D
Technol Cancer Res Treat 2022 Jan-Dec;21:15330338221124696. doi: 10.1177/15330338221124696. PMID: 36128851Free PMC Article
Bone Infarcts and Tumorigenesis-Is There a Connection? A Mini-Mapping Review.
Konarski W, Poboży T, Hordowicz M, Śliwczyński A, Kotela I, Krakowiak J, Kotela A
Int J Environ Res Public Health 2022 Jul 29;19(15) doi: 10.3390/ijerph19159282. PMID: 35954639Free PMC Article
Bone Infarct-Associated Osteosarcoma: Epidemiologic and Survival Trends.
Laranga R, Focaccia M, Evangelista A, Lucarelli E, Donati DM, Spazzoli B
Oncol Res Treat 2022;45(6):326-335. Epub 2022 Jan 14 doi: 10.1159/000521986. PMID: 35034028
Clinical and histopathological profile of primary or secondary osteosarcoma of the jaws.
Angiero F, Moltrasio F, Cattoretti G, Valente MG
Anticancer Res 2011 Dec;31(12):4485-9. PMID: 22199320
Pediatric and adult osteosarcoma: comparisons and contrasts in presentation and therapy.
Benjamin RS, Patel SR
Cancer Treat Res 2009;152:355-63. doi: 10.1007/978-1-4419-0284-9_19. PMID: 20213401

Clinical prediction guides

Does the Clinical Presentation of Secondary Osteosarcoma in Patients Who Survive Retinoblastoma Differ From That of Conventional Osteosarcoma and How Do We Detect Them?
Kim Y, Park JW, Cho HS, Jang WY, Han I, Kim HS
Clin Orthop Relat Res 2023 Nov 1;481(11):2154-2163. Epub 2023 May 5 doi: 10.1097/CORR.0000000000002667. PMID: 37145140Free PMC Article
A nomogram for predicting cancer-specific survival in patients with osteosarcoma as secondary malignancy.
He Y, Liu H, Wang S, Zhang J
Sci Rep 2020 Jul 30;10(1):12817. doi: 10.1038/s41598-020-69740-2. PMID: 32732990Free PMC Article
Osteoblastic osteosarcoma in monostotic Paget's disease.
Calabrò T, Mavrogenis AF, Ruggieri P
Musculoskelet Surg 2011 Apr;95(1):37-40. Epub 2011 Mar 16 doi: 10.1007/s12306-011-0100-4. PMID: 21409504
Osteosarcoma as a second malignant neoplasm.
Hamre MR, Severson RK, Chuba P, Lucas DR, Thomas RL, Mott MP
Radiother Oncol 2002 Dec;65(3):153-7. doi: 10.1016/s0167-8140(02)00150-0. PMID: 12464443
Effective adjuvant chemotherapy for advanced nasopharyngeal carcinoma in children: a final update of a long-term prospective study in a single institution.
Ghim TT, Briones M, Mason P, Crocker I, Davis P, Bell B, Vega R, Corden B, Meacham L, Alvarado CS
J Pediatr Hematol Oncol 1998 Mar-Apr;20(2):131-5. doi: 10.1097/00043426-199803000-00008. PMID: 9544163

Recent systematic reviews

Bone Infarcts and Tumorigenesis-Is There a Connection? A Mini-Mapping Review.
Konarski W, Poboży T, Hordowicz M, Śliwczyński A, Kotela I, Krakowiak J, Kotela A
Int J Environ Res Public Health 2022 Jul 29;19(15) doi: 10.3390/ijerph19159282. PMID: 35954639Free PMC Article

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