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Sinonasal undifferentiated carcinoma(SNUC)

MedGen UID:
313704
Concept ID:
C1710096
Neoplastic Process
Synonyms: Highly aggressive undifferentiated carcinoma of the nasal cavity and paranasal sinuses; SNUC
SNOMED CT: SNUC - sinonasal undifferentiated carcinoma (697993003); Undifferentiated carcinoma of nasal sinus (697993003); Sinonasal undifferentiated carcinoma (697993003)
 
Monarch Initiative: MONDO:0006411

Definition

A rare, highly aggressive carcinoma that arises from the sinonasal tract. It is characterized by the presence of small to medium size malignant cells. The prognosis is poor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSinonasal undifferentiated carcinoma

Professional guidelines

PubMed

Thawani R, Kim MS, Arastu A, Feng Z, West MT, Taflin NF, Thein KZ, Li R, Geltzeiler M, Lee N, Fuller CD, Grandis JR, Floudas CS, Heinrich MC, Hanna E, Chandra RA
CA Cancer J Clin 2023 Jan;73(1):72-112. Epub 2022 Aug 2 doi: 10.3322/caac.21752. PMID: 35916666Free PMC Article
Amit M, Abdelmeguid AS, Watcherporn T, Takahashi H, Tam S, Bell D, Ferrarotto R, Glisson B, Kupferman ME, Roberts DB, Su SY, Raza SM, DeMonte F, Hanna EY
J Clin Oncol 2019 Feb 20;37(6):504-512. Epub 2019 Jan 7 doi: 10.1200/JCO.18.00353. PMID: 30615549Free PMC Article
Tyler MA, Holmes B, Patel ZM
Curr Opin Otolaryngol Head Neck Surg 2019 Feb;27(1):59-66. doi: 10.1097/MOO.0000000000000513. PMID: 30507692

Recent clinical studies

Etiology

Neo WL, Hanna EY, Kiong KL
Curr Opin Otolaryngol Head Neck Surg 2023 Apr 1;31(2):89-93. Epub 2023 Feb 7 doi: 10.1097/MOO.0000000000000877. PMID: 36912221
Vaziri Fard E, Zhang S, Cai Z, Ding J, Sun Q, Saluja K, Zhu H
Hum Pathol 2019 Jul;89:62-70. Epub 2019 May 3 doi: 10.1016/j.humpath.2019.04.008. PMID: 31054892
Amit M, Abdelmeguid AS, Watcherporn T, Takahashi H, Tam S, Bell D, Ferrarotto R, Glisson B, Kupferman ME, Roberts DB, Su SY, Raza SM, DeMonte F, Hanna EY
J Clin Oncol 2019 Feb 20;37(6):504-512. Epub 2019 Jan 7 doi: 10.1200/JCO.18.00353. PMID: 30615549Free PMC Article
Mourad WF, Hauerstock D, Shourbaji RA, Hu KS, Culliney B, Li Z, Jacobson A, Tran T, Manolidis S, Schantz S, Urken M, Persky M, Harrison LB
Am J Clin Oncol 2013 Dec;36(6):584-8. doi: 10.1097/COC.0b013e31825eb3a5. PMID: 22992621
Mendenhall WM, Mendenhall CM, Riggs CE Jr, Villaret DB, Mendenhall NP
Am J Clin Oncol 2006 Feb;29(1):27-31. doi: 10.1097/01.coc.0000189691.04140.02. PMID: 16462499

Diagnosis

Thawani R, Kim MS, Arastu A, Feng Z, West MT, Taflin NF, Thein KZ, Li R, Geltzeiler M, Lee N, Fuller CD, Grandis JR, Floudas CS, Heinrich MC, Hanna E, Chandra RA
CA Cancer J Clin 2023 Jan;73(1):72-112. Epub 2022 Aug 2 doi: 10.3322/caac.21752. PMID: 35916666Free PMC Article
Jurmeister P, Glöß S, Roller R, Leitheiser M, Schmid S, Mochmann LH, Payá Capilla E, Fritz R, Dittmayer C, Friedrich C, Thieme A, Keyl P, Jarosch A, Schallenberg S, Bläker H, Hoffmann I, Vollbrecht C, Lehmann A, Hummel M, Heim D, Haji M, Harter P, Englert B, Frank S, Hench J, Paulus W, Hasselblatt M, Hartmann W, Dohmen H, Keber U, Jank P, Denkert C, Stadelmann C, Bremmer F, Richter A, Wefers A, Ribbat-Idel J, Perner S, Idel C, Chiariotti L, Della Monica R, Marinelli A, Schüller U, Bockmayr M, Liu J, Lund VJ, Forster M, Lechner M, Lorenzo-Guerra SL, Hermsen M, Johann PD, Agaimy A, Seegerer P, Koch A, Heppner F, Pfister SM, Jones DTW, Sill M, von Deimling A, Snuderl M, Müller KR, Forgó E, Howitt BE, Mertins P, Klauschen F, Capper D
Nat Commun 2022 Nov 28;13(1):7148. doi: 10.1038/s41467-022-34815-3. PMID: 36443295Free PMC Article
Kakkar A, Ashraf SF, Rathor A, Adhya AK, Mani S, Sikka K, Jain D
Arch Pathol Lab Med 2022 Sep 1;146(9):1122-1130. doi: 10.5858/arpa.2021-0001-OA. PMID: 34871352
Abdelmeguid AS, Bell D, Hanna EY
Adv Otorhinolaryngol 2020;84:168-184. Epub 2020 Jul 30 doi: 10.1159/000457936. PMID: 32731236
Abdelmeguid AS, Bell D, Hanna EY
Curr Oncol Rep 2019 Feb 26;21(3):26. doi: 10.1007/s11912-019-0776-4. PMID: 30806835

Therapy

Neo WL, Hanna EY, Kiong KL
Curr Opin Otolaryngol Head Neck Surg 2023 Apr 1;31(2):89-93. Epub 2023 Feb 7 doi: 10.1097/MOO.0000000000000877. PMID: 36912221
Amit M, Abdelmeguid AS, Watcherporn T, Takahashi H, Tam S, Bell D, Ferrarotto R, Glisson B, Kupferman ME, Roberts DB, Su SY, Raza SM, DeMonte F, Hanna EY
J Clin Oncol 2019 Feb 20;37(6):504-512. Epub 2019 Jan 7 doi: 10.1200/JCO.18.00353. PMID: 30615549Free PMC Article
Morand GB, Anderegg N, Vital D, Ikenberg K, Huber GF, Soyka MB, Egger M, Holzmann D
Oral Oncol 2017 Dec;75:28-34. Epub 2017 Oct 22 doi: 10.1016/j.oraloncology.2017.10.008. PMID: 29224819
Mourad WF, Hauerstock D, Shourbaji RA, Hu KS, Culliney B, Li Z, Jacobson A, Tran T, Manolidis S, Schantz S, Urken M, Persky M, Harrison LB
Am J Clin Oncol 2013 Dec;36(6):584-8. doi: 10.1097/COC.0b013e31825eb3a5. PMID: 22992621
Newman SA
Surv Ophthalmol 1993 Nov-Dec;38(3):303-9. doi: 10.1016/0039-6257(93)90079-m. PMID: 8310398

Prognosis

Jurmeister P, Glöß S, Roller R, Leitheiser M, Schmid S, Mochmann LH, Payá Capilla E, Fritz R, Dittmayer C, Friedrich C, Thieme A, Keyl P, Jarosch A, Schallenberg S, Bläker H, Hoffmann I, Vollbrecht C, Lehmann A, Hummel M, Heim D, Haji M, Harter P, Englert B, Frank S, Hench J, Paulus W, Hasselblatt M, Hartmann W, Dohmen H, Keber U, Jank P, Denkert C, Stadelmann C, Bremmer F, Richter A, Wefers A, Ribbat-Idel J, Perner S, Idel C, Chiariotti L, Della Monica R, Marinelli A, Schüller U, Bockmayr M, Liu J, Lund VJ, Forster M, Lechner M, Lorenzo-Guerra SL, Hermsen M, Johann PD, Agaimy A, Seegerer P, Koch A, Heppner F, Pfister SM, Jones DTW, Sill M, von Deimling A, Snuderl M, Müller KR, Forgó E, Howitt BE, Mertins P, Klauschen F, Capper D
Nat Commun 2022 Nov 28;13(1):7148. doi: 10.1038/s41467-022-34815-3. PMID: 36443295Free PMC Article
Abdelmeguid AS, Bell D, Hanna EY
Adv Otorhinolaryngol 2020;84:168-184. Epub 2020 Jul 30 doi: 10.1159/000457936. PMID: 32731236
Contrera KJ, Woody NM, Rahman M, Sindwani R, Burkey BB
Head Neck 2020 Aug;42(8):2202-2212. Epub 2020 Mar 25 doi: 10.1002/hed.26150. PMID: 32212360
Abdelmeguid AS, Bell D, Hanna EY
Curr Oncol Rep 2019 Feb 26;21(3):26. doi: 10.1007/s11912-019-0776-4. PMID: 30806835
Mendenhall WM, Mendenhall CM, Riggs CE Jr, Villaret DB, Mendenhall NP
Am J Clin Oncol 2006 Feb;29(1):27-31. doi: 10.1097/01.coc.0000189691.04140.02. PMID: 16462499

Clinical prediction guides

Lechner M, Liu J, Lund VJ
Curr Oncol Rep 2020 Jul 29;22(10):106. doi: 10.1007/s11912-020-00947-2. PMID: 32725435Free PMC Article
Faisal M, Seemann R, Lill C, Hamzavi S, Wutzl A, Erovic BM, Janik S
Head Neck 2020 May;42(5):1057-1066. Epub 2020 Jan 10 doi: 10.1002/hed.26077. PMID: 31922316Free PMC Article
Dogan S, Vasudevaraja V, Xu B, Serrano J, Ptashkin RN, Jung HJ, Chiang S, Jungbluth AA, Cohen MA, Ganly I, Berger MF, Momeni Boroujeni A, Ghossein RA, Ladanyi M, Chute DJ, Snuderl M
Mod Pathol 2019 Oct;32(10):1447-1459. Epub 2019 Jun 11 doi: 10.1038/s41379-019-0285-x. PMID: 31186531Free PMC Article
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344
Mendenhall WM, Mendenhall CM, Riggs CE Jr, Villaret DB, Mendenhall NP
Am J Clin Oncol 2006 Feb;29(1):27-31. doi: 10.1097/01.coc.0000189691.04140.02. PMID: 16462499

Recent systematic reviews

Parsel SM, Jawad BA, McCoul ED
World Neurosurg 2020 Apr;136:305-310. Epub 2020 Jan 27 doi: 10.1016/j.wneu.2020.01.130. PMID: 32001406
Faisal M, Seemann R, Lill C, Hamzavi S, Wutzl A, Erovic BM, Janik S
Head Neck 2020 May;42(5):1057-1066. Epub 2020 Jan 10 doi: 10.1002/hed.26077. PMID: 31922316Free PMC Article
Morand GB, Anderegg N, Vital D, Ikenberg K, Huber GF, Soyka MB, Egger M, Holzmann D
Oral Oncol 2017 Dec;75:28-34. Epub 2017 Oct 22 doi: 10.1016/j.oraloncology.2017.10.008. PMID: 29224819
Rawal RB, Farzal Z, Federspiel JJ, Sreenath SB, Thorp BD, Zanation AM
Otolaryngol Head Neck Surg 2016 Sep;155(3):376-86. Epub 2016 May 10 doi: 10.1177/0194599816646968. PMID: 27165676
Kramer D, Durham JS, Sheehan F, Thomson T
J Otolaryngol 2004 Feb;33(1):32-6. doi: 10.2310/7070.2004.00032. PMID: 15291274

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