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Sinonasal undifferentiated carcinoma(SNUC)

MedGen UID:
313704
Concept ID:
C1710096
Neoplastic Process
Synonyms: Highly aggressive undifferentiated carcinoma of the nasal cavity and paranasal sinuses; SNUC
SNOMED CT: SNUC - sinonasal undifferentiated carcinoma (697993003); Undifferentiated carcinoma of nasal sinus (697993003); Sinonasal undifferentiated carcinoma (697993003)
 
Monarch Initiative: MONDO:0006411

Definition

A rare, highly aggressive carcinoma that arises from the sinonasal tract. It is characterized by the presence of small to medium size malignant cells. The prognosis is poor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSinonasal undifferentiated carcinoma

Professional guidelines

PubMed

Kuan EC, Wang EW, Adappa ND, Beswick DM, London NR Jr, Su SY, Wang MB, Abuzeid WM, Alexiev B, Alt JA, Antognoni P, Alonso-Basanta M, Batra PS, Bhayani M, Bell D, Bernal-Sprekelsen M, Betz CS, Blay JY, Bleier BS, Bonilla-Velez J, Callejas C, Carrau RL, Casiano RR, Castelnuovo P, Chandra RK, Chatzinakis V, Chen SB, Chiu AG, Choby G, Chowdhury NI, Citardi MJ, Cohen MA, Dagan R, Dalfino G, Dallan I, Dassi CS, de Almeida J, Dei Tos AP, DelGaudio JM, Ebert CS, El-Sayed IH, Eloy JA, Evans JJ, Fang CH, Farrell NF, Ferrari M, Fischbein N, Folbe A, Fokkens WJ, Fox MG, Lund VJ, Gallia GL, Gardner PA, Geltzeiler M, Georgalas C, Getz AE, Govindaraj S, Gray ST, Grayson JW, Gross BA, Grube JG, Guo R, Ha PK, Halderman AA, Hanna EY, Harvey RJ, Hernandez SC, Holtzman AL, Hopkins C, Huang Z, Huang Z, Humphreys IM, Hwang PH, Iloreta AM, Ishii M, Ivan ME, Jafari A, Kennedy DW, Khan M, Kimple AJ, Kingdom TT, Knisely A, Kuo YJ, Lal D, Lamarre ED, Lan MY, Le H, Lechner M, Lee NY, Lee JK, Lee VH, Levine CG, Lin JC, Lin DT, Lobo BC, Locke T, Luong AU, Magliocca KR, Markovic SN, Matnjani G, McKean EL, Meço C, Mendenhall WM, Michel L, Na'ara S, Nicolai P, Nuss DW, Nyquist GG, Oakley GM, Omura K, Orlandi RR, Otori N, Papagiannopoulos P, Patel ZM, Pfister DG, Phan J, Psaltis AJ, Rabinowitz MR, Ramanathan M Jr, Rimmer R, Rosen MR, Sanusi O, Sargi ZB, Schafhausen P, Schlosser RJ, Sedaghat AR, Senior BA, Shrivastava R, Sindwani R, Smith TL, Smith KA, Snyderman CH, Solares CA, Sreenath SB, Stamm A, Stölzel K, Sumer B, Surda P, Tajudeen BA, Thompson LDR, Thorp BD, Tong CCL, Tsang RK, Turner JH, Turri-Zanoni M, Udager AM, van Zele T, VanKoevering K, Welch KC, Wise SK, Witterick IJ, Won TB, Wong SN, Woodworth BA, Wormald PJ, Yao WC, Yeh CF, Zhou B, Palmer JN
Int Forum Allergy Rhinol 2024 Feb;14(2):149-608. Epub 2024 Jan 2 doi: 10.1002/alr.23262. PMID: 37658764
Thawani R, Kim MS, Arastu A, Feng Z, West MT, Taflin NF, Thein KZ, Li R, Geltzeiler M, Lee N, Fuller CD, Grandis JR, Floudas CS, Heinrich MC, Hanna E, Chandra RA
CA Cancer J Clin 2023 Jan;73(1):72-112. Epub 2022 Aug 2 doi: 10.3322/caac.21752. PMID: 35916666Free PMC Article
Amit M, Abdelmeguid AS, Watcherporn T, Takahashi H, Tam S, Bell D, Ferrarotto R, Glisson B, Kupferman ME, Roberts DB, Su SY, Raza SM, DeMonte F, Hanna EY
J Clin Oncol 2019 Feb 20;37(6):504-512. Epub 2019 Jan 7 doi: 10.1200/JCO.18.00353. PMID: 30615549Free PMC Article

Recent clinical studies

Etiology

Tam K, Dunn LA, Cohen MA
Curr Opin Otolaryngol Head Neck Surg 2024 Feb 1;32(1):14-19. Epub 2023 Dec 6 doi: 10.1097/MOO.0000000000000951. PMID: 38116847
Kuan EC, Wang EW, Adappa ND, Beswick DM, London NR Jr, Su SY, Wang MB, Abuzeid WM, Alexiev B, Alt JA, Antognoni P, Alonso-Basanta M, Batra PS, Bhayani M, Bell D, Bernal-Sprekelsen M, Betz CS, Blay JY, Bleier BS, Bonilla-Velez J, Callejas C, Carrau RL, Casiano RR, Castelnuovo P, Chandra RK, Chatzinakis V, Chen SB, Chiu AG, Choby G, Chowdhury NI, Citardi MJ, Cohen MA, Dagan R, Dalfino G, Dallan I, Dassi CS, de Almeida J, Dei Tos AP, DelGaudio JM, Ebert CS, El-Sayed IH, Eloy JA, Evans JJ, Fang CH, Farrell NF, Ferrari M, Fischbein N, Folbe A, Fokkens WJ, Fox MG, Lund VJ, Gallia GL, Gardner PA, Geltzeiler M, Georgalas C, Getz AE, Govindaraj S, Gray ST, Grayson JW, Gross BA, Grube JG, Guo R, Ha PK, Halderman AA, Hanna EY, Harvey RJ, Hernandez SC, Holtzman AL, Hopkins C, Huang Z, Huang Z, Humphreys IM, Hwang PH, Iloreta AM, Ishii M, Ivan ME, Jafari A, Kennedy DW, Khan M, Kimple AJ, Kingdom TT, Knisely A, Kuo YJ, Lal D, Lamarre ED, Lan MY, Le H, Lechner M, Lee NY, Lee JK, Lee VH, Levine CG, Lin JC, Lin DT, Lobo BC, Locke T, Luong AU, Magliocca KR, Markovic SN, Matnjani G, McKean EL, Meço C, Mendenhall WM, Michel L, Na'ara S, Nicolai P, Nuss DW, Nyquist GG, Oakley GM, Omura K, Orlandi RR, Otori N, Papagiannopoulos P, Patel ZM, Pfister DG, Phan J, Psaltis AJ, Rabinowitz MR, Ramanathan M Jr, Rimmer R, Rosen MR, Sanusi O, Sargi ZB, Schafhausen P, Schlosser RJ, Sedaghat AR, Senior BA, Shrivastava R, Sindwani R, Smith TL, Smith KA, Snyderman CH, Solares CA, Sreenath SB, Stamm A, Stölzel K, Sumer B, Surda P, Tajudeen BA, Thompson LDR, Thorp BD, Tong CCL, Tsang RK, Turner JH, Turri-Zanoni M, Udager AM, van Zele T, VanKoevering K, Welch KC, Wise SK, Witterick IJ, Won TB, Wong SN, Woodworth BA, Wormald PJ, Yao WC, Yeh CF, Zhou B, Palmer JN
Int Forum Allergy Rhinol 2024 Feb;14(2):149-608. Epub 2024 Jan 2 doi: 10.1002/alr.23262. PMID: 37658764
Neo WL, Hanna EY, Kiong KL
Curr Opin Otolaryngol Head Neck Surg 2023 Apr 1;31(2):89-93. Epub 2023 Feb 7 doi: 10.1097/MOO.0000000000000877. PMID: 36912221
Wang L, Wang J, Tang T, Yan L MD, Song X
Br J Radiol 2023 Jan 1;96(1141):20220244. Epub 2022 Nov 28 doi: 10.1259/bjr.20220244. PMID: 36317997Free PMC Article
Amit M, Abdelmeguid AS, Watcherporn T, Takahashi H, Tam S, Bell D, Ferrarotto R, Glisson B, Kupferman ME, Roberts DB, Su SY, Raza SM, DeMonte F, Hanna EY
J Clin Oncol 2019 Feb 20;37(6):504-512. Epub 2019 Jan 7 doi: 10.1200/JCO.18.00353. PMID: 30615549Free PMC Article

Diagnosis

Agaimy A
Adv Anat Pathol 2023 Mar 1;30(2):95-103. Epub 2022 Oct 20 doi: 10.1097/PAP.0000000000000372. PMID: 36580412
Thawani R, Kim MS, Arastu A, Feng Z, West MT, Taflin NF, Thein KZ, Li R, Geltzeiler M, Lee N, Fuller CD, Grandis JR, Floudas CS, Heinrich MC, Hanna E, Chandra RA
CA Cancer J Clin 2023 Jan;73(1):72-112. Epub 2022 Aug 2 doi: 10.3322/caac.21752. PMID: 35916666Free PMC Article
Kakkar A, Ashraf SF, Rathor A, Adhya AK, Mani S, Sikka K, Jain D
Arch Pathol Lab Med 2022 Sep 1;146(9):1122-1130. doi: 10.5858/arpa.2021-0001-OA. PMID: 34871352
Abdelmeguid AS, Bell D, Hanna EY
Curr Oncol Rep 2019 Feb 26;21(3):26. doi: 10.1007/s11912-019-0776-4. PMID: 30806835
Amit M, Abdelmeguid AS, Watcherporn T, Takahashi H, Tam S, Bell D, Ferrarotto R, Glisson B, Kupferman ME, Roberts DB, Su SY, Raza SM, DeMonte F, Hanna EY
J Clin Oncol 2019 Feb 20;37(6):504-512. Epub 2019 Jan 7 doi: 10.1200/JCO.18.00353. PMID: 30615549Free PMC Article

Therapy

Tam K, Dunn LA, Cohen MA
Curr Opin Otolaryngol Head Neck Surg 2024 Feb 1;32(1):14-19. Epub 2023 Dec 6 doi: 10.1097/MOO.0000000000000951. PMID: 38116847
Neo WL, Hanna EY, Kiong KL
Curr Opin Otolaryngol Head Neck Surg 2023 Apr 1;31(2):89-93. Epub 2023 Feb 7 doi: 10.1097/MOO.0000000000000877. PMID: 36912221
Amit M, Abdelmeguid AS, Watcherporn T, Takahashi H, Tam S, Bell D, Ferrarotto R, Glisson B, Kupferman ME, Roberts DB, Su SY, Raza SM, DeMonte F, Hanna EY
J Clin Oncol 2019 Feb 20;37(6):504-512. Epub 2019 Jan 7 doi: 10.1200/JCO.18.00353. PMID: 30615549Free PMC Article
Mourad WF, Hauerstock D, Shourbaji RA, Hu KS, Culliney B, Li Z, Jacobson A, Tran T, Manolidis S, Schantz S, Urken M, Persky M, Harrison LB
Am J Clin Oncol 2013 Dec;36(6):584-8. doi: 10.1097/COC.0b013e31825eb3a5. PMID: 22992621
Newman SA
Surv Ophthalmol 1993 Nov-Dec;38(3):303-9. doi: 10.1016/0039-6257(93)90079-m. PMID: 8310398

Prognosis

Tam K, Dunn LA, Cohen MA
Curr Opin Otolaryngol Head Neck Surg 2024 Feb 1;32(1):14-19. Epub 2023 Dec 6 doi: 10.1097/MOO.0000000000000951. PMID: 38116847
Jurmeister P, Glöß S, Roller R, Leitheiser M, Schmid S, Mochmann LH, Payá Capilla E, Fritz R, Dittmayer C, Friedrich C, Thieme A, Keyl P, Jarosch A, Schallenberg S, Bläker H, Hoffmann I, Vollbrecht C, Lehmann A, Hummel M, Heim D, Haji M, Harter P, Englert B, Frank S, Hench J, Paulus W, Hasselblatt M, Hartmann W, Dohmen H, Keber U, Jank P, Denkert C, Stadelmann C, Bremmer F, Richter A, Wefers A, Ribbat-Idel J, Perner S, Idel C, Chiariotti L, Della Monica R, Marinelli A, Schüller U, Bockmayr M, Liu J, Lund VJ, Forster M, Lechner M, Lorenzo-Guerra SL, Hermsen M, Johann PD, Agaimy A, Seegerer P, Koch A, Heppner F, Pfister SM, Jones DTW, Sill M, von Deimling A, Snuderl M, Müller KR, Forgó E, Howitt BE, Mertins P, Klauschen F, Capper D
Nat Commun 2022 Nov 28;13(1):7148. doi: 10.1038/s41467-022-34815-3. PMID: 36443295Free PMC Article
Abdelmeguid AS, Bell D, Hanna EY
Adv Otorhinolaryngol 2020;84:168-184. Epub 2020 Jul 30 doi: 10.1159/000457936. PMID: 32731236
Contrera KJ, Woody NM, Rahman M, Sindwani R, Burkey BB
Head Neck 2020 Aug;42(8):2202-2212. Epub 2020 Mar 25 doi: 10.1002/hed.26150. PMID: 32212360
Abdelmeguid AS, Bell D, Hanna EY
Curr Oncol Rep 2019 Feb 26;21(3):26. doi: 10.1007/s11912-019-0776-4. PMID: 30806835

Clinical prediction guides

Lechner M, Liu J, Lund VJ
Curr Oncol Rep 2020 Jul 29;22(10):106. doi: 10.1007/s11912-020-00947-2. PMID: 32725435Free PMC Article
Faisal M, Seemann R, Lill C, Hamzavi S, Wutzl A, Erovic BM, Janik S
Head Neck 2020 May;42(5):1057-1066. Epub 2020 Jan 10 doi: 10.1002/hed.26077. PMID: 31922316Free PMC Article
Dogan S, Vasudevaraja V, Xu B, Serrano J, Ptashkin RN, Jung HJ, Chiang S, Jungbluth AA, Cohen MA, Ganly I, Berger MF, Momeni Boroujeni A, Ghossein RA, Ladanyi M, Chute DJ, Snuderl M
Mod Pathol 2019 Oct;32(10):1447-1459. Epub 2019 Jun 11 doi: 10.1038/s41379-019-0285-x. PMID: 31186531Free PMC Article
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344
Mendenhall WM, Mendenhall CM, Riggs CE Jr, Villaret DB, Mendenhall NP
Am J Clin Oncol 2006 Feb;29(1):27-31. doi: 10.1097/01.coc.0000189691.04140.02. PMID: 16462499

Recent systematic reviews

See ASY, Chu C, Lim ICZY, Tan BKJ, Ang SXQ, Xu S, Teo NWY, Charn TC
Clin Otolaryngol 2024 Jan;49(1):29-40. Epub 2023 Oct 20 doi: 10.1111/coa.14100. PMID: 37859617
Parsel SM, Jawad BA, McCoul ED
World Neurosurg 2020 Apr;136:305-310. Epub 2020 Jan 27 doi: 10.1016/j.wneu.2020.01.130. PMID: 32001406
Faisal M, Seemann R, Lill C, Hamzavi S, Wutzl A, Erovic BM, Janik S
Head Neck 2020 May;42(5):1057-1066. Epub 2020 Jan 10 doi: 10.1002/hed.26077. PMID: 31922316Free PMC Article
Morand GB, Anderegg N, Vital D, Ikenberg K, Huber GF, Soyka MB, Egger M, Holzmann D
Oral Oncol 2017 Dec;75:28-34. Epub 2017 Oct 22 doi: 10.1016/j.oraloncology.2017.10.008. PMID: 29224819
Rawal RB, Farzal Z, Federspiel JJ, Sreenath SB, Thorp BD, Zanation AM
Otolaryngol Head Neck Surg 2016 Sep;155(3):376-86. Epub 2016 May 10 doi: 10.1177/0194599816646968. PMID: 27165676

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